TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 492.957 | Formula: C25H25ClN6O3
H donors: 3 H acceptors: 4 LogP: 2.16 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Cc2cnc(nc2c2c(N1)cc(Cl)cc2)Nc1cccc(c1)C(=O)NCCN1CCOCC1
InChi: 1S/C25H25ClN6O3/c26-18-4-5-20-21(14-18)30-22(33)13-17-15-28-25(31-23(17)20)29-19-3-1-2-16(12-19)24(34)27-6-7-32-8-10-35-11-9-32/h1-5,12,14-15H,6-11,13H2,(H,27,34)(H,30,33)(H,28,29,31)
InChiKey: IZRZENGGACXGJU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Serotonin receptor	0.0056	0.0065	0.0126
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0059	0.0095	0.0344
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0105	0.0731	0.1987
Brugia malayi	ORL1-like opioid receptor	0.0056	0.0065	0.0126
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0175	0.1681	0.5963
Onchocerca volvulus		0.0431	0.5162	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0153	0.138	0.4557
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0116	0.0875	0.3177
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0431	0.5162	1
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0109	0.0776	0.2817
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Mycobacterium tuberculosis	Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g	0.0079	0.0378	0.1373
Toxoplasma gondii	adenosylhomocysteinase, putative	0.0254	0.2755	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0175	0.1681	0.3256
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0731	0.2652
Schistosoma mansoni	adenosylhomocysteinase	0.0157	0.1436	0.269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3507
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3507
Mycobacterium tuberculosis	Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)	0.0254	0.2755	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3507
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0069	0.0229	0.0321
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0127	0.1028	0.3731
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Loa Loa (eye worm)	phosphatidylinositol 3	0.0059	0.0095	0.0059
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0069	0.0229	0.0503
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Echinococcus granulosus	serine protein kinase ATM	0.0069	0.0229	0.0321
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.0731	0.2391
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.5162	0.513
Plasmodium falciparum	adenosylhomocysteinase	0.0254	0.2755	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0431	0.5162	1
Entamoeba histolytica	protein kinase rad3, putative	0.0069	0.0229	0.0503
Loa Loa (eye worm)	6-phosphofructokinase	0.0105	0.0731	0.1306
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0127	0.1028	0.3163
Brugia malayi	G protein-coupled receptor F59B2.13	0.0056	0.0065	0.0126
Brugia malayi	thymidylate synthase	0.0109	0.0776	0.1504
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0116	0.0875	0.2559
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0175	0.1681	0.6102
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0069	0.0229	0.0321
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0069	0.0229	0.0321
Brugia malayi	putative neuropeptide receptor NPR1	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Loa Loa (eye worm)	6-phosphofructokinase	0.0105	0.0731	0.1306
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0254	0.2755	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0431	0.5162	1
Plasmodium vivax	adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative	0.0254	0.2755	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0116	0.0875	0.2559
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0153	0.138	0.4557
Brugia malayi	Dopamine receptor	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0175	0.1681	0.6102
Brugia malayi	neuropeptide F receptor	0.0056	0.0065	0.0126
Schistosoma mansoni	hypothetical protein	0.0069	0.0229	0.0321
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0254	0.2755	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0127	0.1028	0.1889
Loa Loa (eye worm)	hypothetical protein	0.0431	0.5162	1
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Echinococcus multilocularis	thymidylate synthase	0.0109	0.0776	0.0716
Entamoeba histolytica	hypothetical protein	0.0069	0.0229	0.0503
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0069	0.0229	0.0443
Mycobacterium ulcerans	DNA-3-methyladenine glycosylase I TagA	0.016	0.1478	0.3694
Brugia malayi	6-phosphofructokinase	0.0105	0.0731	0.1416
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	larval opioid receptor	0.0056	0.0065	0.0126
Entamoeba histolytica	adenosylhomocysteinase, putative	0.0254	0.2755	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0175	0.1681	0.5749
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0127	0.1028	0.3731
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0105	0.0731	0.2652
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0229	0.083
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Loa Loa (eye worm)	thymidylate synthase	0.0109	0.0776	0.1395
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0175	0.1681	0.6102
Entamoeba histolytica	hypothetical protein	0.0069	0.0229	0.0503
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0127	0.1028	0.0969
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3163
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0153	0.138	0.4557
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0127	0.1028	0.3731
Entamoeba histolytica	hypothetical protein	0.0069	0.0229	0.0503
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0127	0.1028	0.1889
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0116	0.0875	0.1695
Mycobacterium ulcerans	thymidylate synthase	0.0109	0.0776	0.0224
Brugia malayi	Melatonin receptor type 1A	0.0056	0.0065	0.0126
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0069	0.0229	0.0165
Echinococcus granulosus	6 phosphofructokinase	0.0105	0.0731	0.1306
Loa Loa (eye worm)	phosphatidylinositol 3	0.0116	0.0875	0.159
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0175	0.1681	0.6102
Schistosoma mansoni	6-phosphofructokinase	0.0105	0.0731	0.1306
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0069	0.0229	0.0443
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.5162	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	phosphofructokinase	0.0105	0.0731	0.1416
Brugia malayi	sulfakinin receptor protein	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Loa Loa (eye worm)	phosphatidylinositol 3	0.0127	0.1028	0.1889
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0127	0.1028	0.3731
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0069	0.0229	0.0321
Brugia malayi	G-protein coupled receptor	0.0056	0.0065	0.0126
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0069	0.0229	0.083
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0105	0.0731	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3507
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0731	0.2652
Mycobacterium leprae	PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g	0.0079	0.0378	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0069	0.0229	0.083
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.016	0.1478	0.5367
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0116	0.0875	0.159
Onchocerca volvulus		0.0431	0.5162	1
Mycobacterium leprae	putative S-adenosyl-L-homocysteine hydrolase SahH	0.0254	0.2755	1
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0127	0.1028	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0109	0.0776	0.1395
Echinococcus multilocularis		0.0116	0.0875	0.0815
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0127	0.1028	0.3731
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0127	0.1028	0.3731
Echinococcus granulosus	thymidylate synthase	0.0109	0.0776	0.1395
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0431	0.5162	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0069	0.0229	0.0165
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0069	0.0229	0.0503
Entamoeba histolytica	hypothetical protein	0.0069	0.0229	0.0503
Brugia malayi	G-protein coupled receptor	0.0056	0.0065	0.0126
Schistosoma mansoni	adenosylhomocysteinase	0.0157	0.1436	0.269
Brugia malayi	Dopamine receptor protein 2	0.0056	0.0065	0.0126
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0116	0.0875	0.2559
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0127	0.1028	0.1889
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0056	0.0065	0.0126
Loa Loa (eye worm)	phosphatidylinositol 3	0.0069	0.0229	0.0321
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0069	0.0229	0.0321
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0069	0.0229	0.0321
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0069	0.0229	0.083
Brugia malayi	6-phosphofructokinase	0.0105	0.0731	0.1416
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0069	0.0229	0.083
Brugia malayi	RE15519p	0.0056	0.0065	0.0126
Loa Loa (eye worm)	phosphatidylinositol 3	0.0069	0.0229	0.0321
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3163
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0254	0.2755	1
Echinococcus multilocularis	6 phosphofructokinase	0.0105	0.0731	0.067
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0127	0.1028	0.3731
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0105	0.0731	0.1987
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.1028	0.1991
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0116	0.0875	0.3177
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0127	0.1028	0.3731
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.5162	1
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0254	0.2755	1
Echinococcus granulosus	adenosylhomocysteinase	0.0254	0.2755	0.5277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trypanosoma brucei	S-adenosylhomocysteine hydrolase, putative	0.0254	0.2755	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0127	0.1028	0.1889
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.0731	0.2391
Schistosoma mansoni	adenosylhomocysteinase	0.0157	0.1436	0.269
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0175	0.1681	0.1626
Schistosoma mansoni	adenosylhomocysteinase	0.0157	0.1436	0.269
Brugia malayi	Adenosylhomocysteinase	0.0254	0.2755	0.5337
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.016	0.1478	0.5367
Trypanosoma cruzi	target of rapamycin kinase 3	0.0069	0.0229	0.083
Onchocerca volvulus		0.0109	0.0776	0.1395
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0127	0.1028	0.1889
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0056	0.0065	0.0126
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0069	0.0229	0.0443
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0056	0.0065	0.0126
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0105	0.0731	0.2652
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0069	0.0229	0.0443
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0127	0.1028	0.1889
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0069	0.0229	0.0321
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.1028	0.1991
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0127	0.1028	0.3731
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0116	0.0875	0.2559
Brugia malayi	GnHR receptor homolog	0.0056	0.0065	0.0126
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0127	0.1028	0.3507
Toxoplasma gondii	S-Adenosyl homocysteine hydrolase	0.0254	0.2755	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Echinococcus multilocularis	serine protein kinase ATM	0.0069	0.0229	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0056	0.0065	0.0126
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0153	0.138	0.4557
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0116	0.0875	0.8091
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0175	0.1681	0.317
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0229	0.0321
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0069	0.0229	0.0165
Echinococcus multilocularis	adenosylhomocysteinase	0.0254	0.2755	0.2707
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0127	0.1028	0.3731
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0431	0.5162	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0069	0.0229	0.083
Echinococcus multilocularis	Zinc finger, PHD finger	0.0127	0.1028	0.0969
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0069	0.0229	0.083
Brugia malayi	follicle stimulating hormone receptor	0.0056	0.0065	0.0126
Loa Loa (eye worm)	phosphofructokinase	0.0105	0.0731	0.1306
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0069	0.0229	0.0321
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	hypothetical protein	0.0056	0.0065	0.0126
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.0731	0.2391
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0731	0.2652
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3507
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0127	0.1028	0.0969
Loa Loa (eye worm)	adenosylhomocysteinase	0.0254	0.2755	0.5277
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0069	0.0229	0.0503
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0153	0.138	0.5009
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0127	0.1028	0.3731
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0069	0.0229	0.0503
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0127	0.1028	0.3163
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.008	0.0382	0.1385
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0175	0.1681	0.317
Leishmania major	S-adenosylhomocysteine hydrolase	0.0254	0.2755	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0116	0.0882	0.2586
Schistosoma mansoni	6-phosphofructokinase	0.0105	0.0731	0.1306
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.1028	0.1991
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0069	0.0229	0.0321
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0153	0.138	0.4557
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0127	0.1028	0.3731
Brugia malayi	AKH receptor	0.0056	0.0065	0.0126
Brugia malayi	Serotonin receptor	0.0056	0.0065	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0229	0.0321
Loa Loa (eye worm)	phosphatidylinositol 3	0.0069	0.0229	0.0321
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0175	0.1681	0.5749
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0056	0.0065	0.0126
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0127	0.1028	0.3163
Loa Loa (eye worm)	phosphatidylinositol 3	0.0431	0.5162	1
Schistosoma mansoni	adenosylhomocysteinase	0.0254	0.2755	0.5277
Brugia malayi	G protein-coupled receptor	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0069	0.0229	0.083
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0069	0.0229	0.083
Brugia malayi	neuropeptide F receptor	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0069	0.0229	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Mycobacterium ulcerans	S-adenosyl-L-homocysteine hydrolase	0.0254	0.2755	1
Entamoeba histolytica	hypothetical protein	0.0127	0.1028	0.3507
Leishmania major	ATP-dependent phosphofructokinase	0.0105	0.0731	0.1987
Brugia malayi	putative neuropeptide receptor	0.0056	0.0065	0.0126
Brugia malayi	Dopamine receptor protein 1	0.0056	0.0065	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0109	0.0776	0.2167
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0431	0.5162	0.513
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1028	0.1889
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0175	0.1674	0.5723
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0175	0.1681	0.317
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0731	0.2652
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0069	0.0229	0.083
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0116	0.0875	0.159

Activities

Activity type	Activity value	Assay description	Source	Reference
LD50 (functional)	= 12 uM	Antiproliferative activity against human HT-29 cells after 72 hrs by luminescence assay	ChEMBL.	22070629

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1945028

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1563306