Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0093 | 0.0236 | 0.0236 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | carboxylesterase | 0.3297 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0557 | 0.165 | 0.165 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0018 | 0.0006 | 0.0006 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | FTZ F1 alpha | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0019 | 0.001 | 0.001 |
Trypanosoma brucei | cytochrome P450, putative | 0.0018 | 0.0006 | 0.1941 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0557 | 0.165 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0259 | 0.0743 | 0.0743 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0132 | 0.0132 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0032 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0016 | 0.0016 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0019 | 0.001 | 0.001 |
Brugia malayi | Carboxylesterase family protein | 0.0557 | 0.165 | 0.165 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0016 | 0.0016 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0557 | 0.165 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0557 | 0.165 | 0.165 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0059 | 0.0132 | 0.0132 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0137 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0019 | 0.001 | 0.001 |
Leishmania major | cytochrome p450-like protein | 0.0018 | 0.0006 | 0.0446 |
Echinococcus granulosus | acetylcholinesterase | 0.3297 | 1 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0139 | 0.0139 |
Brugia malayi | Carboxylesterase family protein | 0.0557 | 0.165 | 0.165 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0016 | 0.5111 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0026 | 0.0032 | 0.2325 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0026 | 0.0032 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0132 | 0.0132 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0016 | 0.5111 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0032 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0.0032 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0026 | 0.0032 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0019 | 0.001 | 0.001 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0.0032 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3297 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.0139 | 0.0139 |
Onchocerca volvulus | 0.0557 | 0.165 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0019 | 0.001 | 0.001 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0032 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | nuclear hormone receptor | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0019 | 0.001 | 0.001 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0016 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.0132 | 0.0132 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0137 | 0.0137 |
Schistosoma mansoni | thyroid hormone receptor | 0.0019 | 0.001 | 0.001 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0557 | 0.165 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0026 | 0.0032 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0557 | 0.165 | 0.165 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0032 | 0.0157 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0557 | 0.165 | 0.165 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0019 | 0.001 | 0.001 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0137 | 0.0741 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0016 | 0.1175 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0019 | 0.001 | 0.001 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0006 | 0.0006 |
Brugia malayi | nuclear hormone receptor | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.0115 | 0.0115 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0093 | 0.0236 | 0.0236 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0019 | 0.001 | 0.001 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0006 | 0.0006 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0557 | 0.165 | 0.165 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0026 | 0.0032 | 0.0096 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Onchocerca volvulus | 0.0093 | 0.0236 | 0.1379 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0557 | 0.165 | 0.165 |
Onchocerca volvulus | 0.0557 | 0.165 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0557 | 0.165 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0557 | 0.165 | 0.165 |
Onchocerca volvulus | 0.0557 | 0.165 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.0006 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | carboxylesterase | 0.0557 | 0.165 | 0.165 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0018 | 0.0006 | 0.3798 |
Echinococcus granulosus | acetylcholinesterase | 0.3297 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3297 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3297 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3297 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0016 | 0.0062 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0026 | 0.0032 | 0.2325 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0016 | 0.0016 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0137 | 0.0137 |
Echinococcus granulosus | carboxylesterase 5A | 0.3297 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0137 | 0.0137 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0019 | 0.001 | 0.001 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0026 | 0.0032 | 0.0157 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0137 | 0.0798 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0139 | 0.0808 |
Schistosoma mansoni | thyroid hormone receptor | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0059 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0041 | 0.0041 |
Brugia malayi | steroid hormone receptor | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0557 | 0.165 | 0.165 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0557 | 0.165 | 0.165 |
Brugia malayi | ecdysteroid receptor | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0137 | 0.0137 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0016 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0016 | 0.0016 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | jumonji domain containing protein | 0.0059 | 0.0132 | 0.0132 |
Schistosoma mansoni | acetylcholinesterase | 0.0557 | 0.165 | 0.165 |
Schistosoma mansoni | gliotactin | 0.0557 | 0.165 | 0.165 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0019 | 0.001 | 0.001 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | coup transcription factor | 0.0019 | 0.001 | 0.001 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0139 | 0.0808 |
Brugia malayi | follicle stimulating hormone receptor | 0.0259 | 0.0743 | 0.0743 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Onchocerca volvulus | 0.0557 | 0.165 | 1 | |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0093 | 0.0236 | 0.0236 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0016 | 0.5111 |
Brugia malayi | Carboxylesterase family protein | 0.0557 | 0.165 | 0.165 |
Echinococcus granulosus | neuroligin | 0.0557 | 0.165 | 0.165 |
Brugia malayi | Carboxylesterase family protein | 0.3297 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0132 | 0.0132 |
Brugia malayi | Carboxylesterase family protein | 0.0557 | 0.165 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3297 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.3297 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0132 | 0.0132 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0557 | 0.165 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3297 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0016 | 0.0016 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0019 | 0.001 | 0.001 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.0139 | 0.0139 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0019 | 0.001 | 0.001 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0019 | 0.001 | 0.001 |
Brugia malayi | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Loa Loa (eye worm) | carboxylesterase | 0.0557 | 0.165 | 0.165 |
Onchocerca volvulus | 0.0557 | 0.165 | 1 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0018 | 0.0006 | 0.3798 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0137 | 0.9888 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0019 | 0.001 | 0.001 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.0139 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0557 | 0.165 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0059 | 0.0132 | 0.0132 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0137 | 0.0798 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0137 | 0.0798 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0016 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0093 | 0.0236 | 0.0236 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0557 | 0.165 | 0.165 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.0006 | 0.0006 |
Echinococcus multilocularis | neuroligin | 0.0557 | 0.165 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.165 | 0.165 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.0139 | 0.0751 |
Brugia malayi | nuclear receptor NHR-88 | 0.0019 | 0.001 | 0.001 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0019 | 0.001 | 0.001 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0557 | 0.165 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0019 | 0.001 | 0.001 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0026 | 0.0032 | 0.2299 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.001 | 0.001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.