Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 0.2826 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.2826 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.2826 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.2826 | 0.5 | |
Schistosoma mansoni | lamin | 0.0027 | 0.2826 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.2826 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0058 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.2826 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.0058 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.2826 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2715 | 0.2715 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.2826 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2826 | 0.2826 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.2826 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.2826 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.2826 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.2826 | 0.2826 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.2826 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.2826 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED150 (functional) | = 0.6 mg kg-1 | Effective dose against aconitine-induced arrhythmia after intravenal administration in anesthetized rats | ChEMBL. | 3806567 |
LD50 (ADMET) | = 9 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
LD50 (ADMET) | = 9 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
No. of positive cases (functional) | = 10 | Tested for incidence of arrhythmias in rats after a intravenal administration of 2 mg/kg of the compound expressed as no. of positive cases out of no. of tested cases (10) | ChEMBL. | 3806567 |
Relative potency (functional) | = 19.8 | Relative potency with reference to quinidine | ChEMBL. | 3806567 |
Therapeutic index (ADMET) | = 14.3 | Therapeutic index calculated as the ratio of LD50 in mice to ED 150 in rat when administered intravenously | ChEMBL. | 3806567 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.