Detailed information for compound 156346

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.339 | Formula: C19H16F2N2O3
  • H donors: 1 H acceptors: 4 LogP: 3.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1cc(C(=O)O)c(=O)c2c1c(F)c(c1cc(C)nc(c1)C)c(c2)F
  • InChi: 1S/C19H16F2N2O3/c1-4-23-8-13(19(25)26)18(24)12-7-14(20)15(16(21)17(12)23)11-5-9(2)22-10(3)6-11/h5-8H,4H2,1-3H3,(H,25,26)
  • InChiKey: ZQZJGSJCJYPTBV-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0031 0.0031
Echinococcus multilocularis survival motor neuron protein 1 0.0782 0.1208 0.1207
Brugia malayi GTP-binding protein 0.0144 0.0189 0.0188
Brugia malayi Carboxylesterase family protein 0.6285 1 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0034 0.0014 0.0091
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0054 0.0399
Trypanosoma brucei protein kinase, putative 0.0059 0.0054 0.0399
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.0038
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0077 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0031 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.007 0.007
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0025 0.0081
Toxoplasma gondii DNA topoisomerase I, putative 0.0847 0.1313 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0088
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0016 0.0123
Echinococcus granulosus heat shock protein 0.0033 0.0012 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0077 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0035 0.0016 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Onchocerca volvulus 0.1062 0.1656 1
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0077 0.0076
Brugia malayi Carboxylesterase family protein 0.1062 0.1656 0.1655
Trichomonas vaginalis receptor histidine kinase, putative 0.0033 0.0012 0.003
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0028 0.0198
Schistosoma mansoni pyruvate dehydrogenase 0.0033 0.0012 0.0012
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0033 0.0012 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0088 0.0327
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Echinococcus multilocularis inositol monophosphatase 1 0.0122 0.0154 0.0153
Brugia malayi jmjC domain containing protein 0.0067 0.0067 0.0066
Schistosoma mansoni endoplasmin 0.0033 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0035 0.0016 0.0092
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Trypanosoma cruzi DNA topoisomerase III, putative 0.0034 0.0014 0.0091
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0034 0.0014 0.0013
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0012 0.0077
Mycobacterium leprae Probable lipase LipE 0.0081 0.0088 0.071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0031 0.0031
Plasmodium vivax SET domain protein, putative 0.0032 0.0011 0.0069
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.007 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0028 0.0198
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0034 0.0014 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0033 0.0012 0.007
Loa Loa (eye worm) CYP4Cod1 0.0084 0.0094 0.0094
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0054 0.0399
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.1366 0.1365
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0033 0.0012 0.0094
Loa Loa (eye worm) endoplasmin 0.0033 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0159 0.0214 0.0214
Echinococcus granulosus neuropeptide s receptor 0.0521 0.0792 0.0791
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0035 0.0016 0.0092
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0035 0.0016 0.0092
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1642 0.2583 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0031 0.0031
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0044 0.0029 0.0028
Echinococcus granulosus acetylcholinesterase 0.6285 1 1
Schistosoma mansoni tsg101-related 0.0063 0.006 0.006
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0072 0.0074 0.0272
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0033 0.0012 0.007
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0028 0.0004 0.0003
Leishmania major DNA polymerase kappa, putative 0.0043 0.0028 0.021
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0077 0.0077
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1062 0.1656 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0033 0.0012 0.007
Brugia malayi intermediate filament protein 0.0091 0.0105 0.0105
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.0257 0.0256
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0034 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0043 0.0043
Echinococcus multilocularis 0.0035 0.0016 0.0015
Trypanosoma brucei DNA topoisomerase III, putative 0.0034 0.0014 0.0091
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0028 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0087 0.0098 0.0098
Schistosoma mansoni cell polarity protein 0.0144 0.0189 0.0189
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0051 0.0041 0.0159
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0035 0.0016 0.0092
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0035 0.0016 0.0092
Echinococcus multilocularis lamin 0.0091 0.0105 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0054 0.0054
Brugia malayi GRF zinc finger family protein 0.0034 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0782 0.1208 0.1208
Trypanosoma cruzi DNA topoisomerase III, putative 0.0034 0.0014 0.0091
Trypanosoma cruzi DNA topoisomerase II, putative 0.0599 0.0917 0.6979
Echinococcus multilocularis aryl hydrocarbon receptor 0.0028 0.0004 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0028 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0133 0.0172 0.0171
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0025 0.0081
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0519 0.0788 0.0788
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0634 0.0971 0.0971
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Chlamydia trachomatis DNA gyrase subunit A 0.0136 0.0177 0.3045
Schistosoma mansoni gliotactin 0.1062 0.1656 0.1656
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0035 0.0016 0.0092
Chlamydia trachomatis DNA gyrase subunit B 0.0292 0.0426 0.7687
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0031 0.003
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0428 0.0643 0.3884
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0043 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0031 0.003
Echinococcus granulosus intermediate filament protein 0.0091 0.0105 0.0104
Echinococcus multilocularis DNA topoisomerase 1 0.0847 0.1313 0.1312
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Brugia malayi Endoplasmin precursor 0.0033 0.0012 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0067 0.0067
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0802 0.1241 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0035 0.0016 0.0092
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0124 0.0931
Plasmodium falciparum DNA topoisomerase 3, putative 0.0034 0.0014 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0035 0.0016 0.0092
Mycobacterium tuberculosis Conserved protein 0.0081 0.0088 0.0532
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0034 0.0014 0.0094
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0088 0.0327
Brugia malayi beta-lactamase 0.0081 0.0088 0.0088
Loa Loa (eye worm) inositol-1 0.0122 0.0154 0.0154
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0035 0.0016 0.0092
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0033 0.0012 0.003
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0033 0.0012 0.0011
Brugia malayi bHLH-PAS transcription factor 0.008 0.0087 0.0087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0028 0.0027
Schistosoma mansoni coup transcription factor 0.0045 0.0031 0.0031
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0028 0.0027
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0124 0.0124
Trypanosoma brucei polo-like protein kinase 0.0103 0.0124 0.0931
Leishmania major DNA topoisomerase 1A 0.0034 0.0014 0.0103
Plasmodium vivax ubiquitin activating enzyme, putative 0.0052 0.0043 0.0312
Schistosoma mansoni hypothetical protein 0.0381 0.0567 0.0567
Mycobacterium leprae putative cytochrome p450 0.0035 0.0016 0.0123
Onchocerca volvulus 0.0034 0.0014 0.0081
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0088 0.0532
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0012 0.0077
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0046 0.0045
Echinococcus granulosus carboxylesterase 5A 0.6285 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Brugia malayi GTP-binding protein, identical 0.0144 0.0189 0.0188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0025 0.0096
Brugia malayi PAS domain containing protein 0.0108 0.0132 0.0132
Brugia malayi hypothetical protein 0.0364 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.1062 0.1656 0.1655
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0035 0.0016 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0031 0.0031
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0033 0.0012 0.003
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0054 0.0411
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0025 0.0081
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0004 0.0019
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0634 0.0971 0.0971
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0035 0.0016 0.0092
Treponema pallidum cell division protein FtsZ 0.0329 0.0484 0.1838
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0034 0.0014 0.0013
Giardia lamblia Fructose-bisphosphate aldolase 0.1642 0.2583 1
Schistosoma mansoni DNA polymerase eta 0.0043 0.0028 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.007 0.007
Brugia malayi hypothetical protein 0.0027 0.0002 0.0002
Schistosoma mansoni acetylcholinesterase 0.1062 0.1656 0.1656
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0094 0.0702
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0049 0.0037 0.0037
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0088 0.071
Brugia malayi DNA topoisomerase III beta-1 0.0034 0.0014 0.0013
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0031 0.0031
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0088 0.0532
Echinococcus granulosus survival motor neuron protein 1 0.0782 0.1208 0.1207
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0031 0.003
Leishmania major DNA topoisomerase IB, large subunit 0.0847 0.1313 1
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0012 0.0045
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0035 0.0016 0.0092
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0004 0.0019
Plasmodium falciparum DNA gyrase subunit A 0.0136 0.0177 0.1335
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Loa Loa (eye worm) hypothetical protein 0.1062 0.1656 0.1655
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0031 0.0031
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0072 0.0074 0.0074
Schistosoma mansoni aryl hydrocarbon receptor 0.0108 0.0132 0.0132
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0039 0.0039
Schistosoma mansoni alpha-glucosidase 0.016 0.0215 0.0215
Echinococcus multilocularis geminin 0.0381 0.0567 0.0567
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0034 0.0014 0.0109
Plasmodium falciparum telomerase reverse transcriptase 0.0567 0.0865 0.6587
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0031 0.0031
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0025 0.0081
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0031 0.0031
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0031 0.003
Mycobacterium tuberculosis Possible two component sensor kinase 0.0033 0.0012 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0088 0.0327
Echinococcus granulosus dna polymerase kappa 0.0043 0.0028 0.0027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0122 0.0154 0.1162
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.1062 0.1656 0.1655
Loa Loa (eye worm) hypothetical protein 0.0258 0.0371 0.0371
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0004 0.0016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0088 0.0532
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0031 0.003
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0076 0.008 0.0079
Schistosoma mansoni neuroligin 3 (S09 family) 0.1062 0.1656 0.1656
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0088 0.0087
Leishmania major hypothetical protein, conserved 0.0081 0.0088 0.0671
Echinococcus multilocularis sentrin specific protease 8 0.0072 0.0074 0.0073
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0028 0.0167
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0034 0.0014 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0011 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0521 0.0792 0.0791
Chlamydia trachomatis DNA gyrase subunit B 0.0369 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.1062 0.1656 0.1655
Schistosoma mansoni lamin 0.0091 0.0105 0.0105
Brugia malayi Muscleblind-like protein 0.0333 0.0491 0.0491
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0035 0.0016 0.0105
Loa Loa (eye worm) GTP-binding protein 0.0144 0.0189 0.0188
Loa Loa (eye worm) hypothetical protein 0.6285 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0046 0.0045
Toxoplasma gondii RNA-directed DNA polymerase 0.0092 0.0106 0.0791
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.0082
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0022 0.0021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0043 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0091 0.0105 0.0105
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0061 0.0057 0.0805
Echinococcus granulosus hypothetical protein 0.0771 0.1191 0.119
Mycobacterium leprae Probable two-component sensor kinase 0.0033 0.0012 0.0094
Mycobacterium ulcerans DNA gyrase subunit A 0.0136 0.0177 0.1067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0039 0.0038
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0634 0.0971 0.0971
Echinococcus granulosus microtubule associated protein 2 0.3083 0.4884 0.4883
Echinococcus granulosus p2X purinoceptor 4 0.0397 0.0593 0.0592
Brugia malayi hypothetical protein 0.0039 0.0022 0.0021
Brugia malayi cytochrome P450 0.0035 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0077 0.0077
Schistosoma mansoni endoplasmin 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.1062 0.1656 0.1655
Echinococcus granulosus neuropeptide receptor A26 0.0521 0.0792 0.0791
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0124 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0039 0.0038
Echinococcus multilocularis ras gtpase 0.0144 0.0189 0.0188
Onchocerca volvulus Huntingtin homolog 0.0133 0.0172 0.1035
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0028 0.0198
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0004 0.003
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0035 0.0016 0.0092
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0035 0.0016 0.0092
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0012 0.0077
Onchocerca volvulus 0.0081 0.0088 0.0532
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0035 0.0016 0.0092
Trichomonas vaginalis set domain proteins, putative 0.0257 0.037 0.1419
Loa Loa (eye worm) hypothetical protein 0.0044 0.0029 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0031 0.003
Echinococcus granulosus DNA topoisomerase 1 0.0847 0.1313 0.1312
Brugia malayi DnaJ domain containing protein 0.007 0.0071 0.0071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0026 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0012 0.0077
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0136 0.0177 0.1335
Leishmania major protein kinase, putative 0.0029 0.0006 0.004
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0369 0.0549 0.4177
Echinococcus multilocularis dna polymerase eta 0.0043 0.0028 0.0027
Plasmodium vivax topoisomerase I, putative 0.0847 0.1313 1
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.0082
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0033 0.0012 0.007
Mycobacterium ulcerans beta-lactamase 0.0081 0.0088 0.0532
Echinococcus multilocularis heat shock protein 0.0033 0.0012 0.0011
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0136 0.0177 0.3069
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0088
Brugia malayi hypothetical protein 0.0782 0.1208 0.1208
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0122 0.0154 0.0582
Schistosoma mansoni alpha glucosidase 0.0041 0.0025 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0054 0.0399
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0054 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0124 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0007 0.0036
Trypanosoma brucei DNA topoisomerase ii 0.0711 0.1095 0.834
Loa Loa (eye worm) carboxylesterase 0.1062 0.1656 0.1655
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0077 0.0077
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1062 0.1656 0.1656
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0802 0.1241 0.7493
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0033 0.0012 0.007
Mycobacterium ulcerans two component regulator - sensor kinase 0.0033 0.0012 0.007
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0124 0.0747
Schistosoma mansoni hypothetical protein 0.0035 0.0016 0.0016
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0028 0.0028
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0124 0.0123
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0052 0.0043 0.0042
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0067 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0088 0.066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0088 0.0088
Brugia malayi TAR-binding protein 0.0074 0.0077 0.0076
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0025 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0025 0.0081
Loa Loa (eye worm) hypothetical protein 0.0429 0.0644 0.0644
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1062 0.1656 1
Mycobacterium tuberculosis Conserved protein 0.0081 0.0088 0.0532
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0004 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0031 0.0031
Echinococcus granulosus lamin 0.0091 0.0105 0.0104
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0035 0.0016 0.0092
Trypanosoma cruzi hypothetical protein 0.0072 0.0074 0.0553
Brugia malayi Bromodomain containing protein 0.0044 0.003 0.003
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0004 0.0018
Plasmodium falciparum topoisomerase I 0.0847 0.1313 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0159 0.0214 0.0214
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0369 0.0549 0.2091
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0802 0.1241 0.7493
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0711 0.1095 0.834
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0094 0.0094
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0031 0.003
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0033 0.0012 0.007
Brugia malayi MAP kinase sur-1 0.0059 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0133 0.0172 0.0171
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Trypanosoma brucei glucosidase, putative 0.0041 0.0025 0.0178
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0006 0.0028
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0012 0.0077
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0165 0.0222 0.1789
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0033 0.0012 0.007
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0847 0.1313 1
Echinococcus multilocularis carboxylesterase 5A 0.6285 1 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1062 0.1656 0.1656
Plasmodium vivax DNA topoisomerase 3, putative 0.0034 0.0014 0.0091
Echinococcus multilocularis microtubule associated protein 2 0.3083 0.4884 0.4883
Echinococcus granulosus lysosomal alpha glucosidase 0.0186 0.0257 0.0256
Schistosoma mansoni DNA topoisomerase type I 0.0847 0.1313 0.1313
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0034 0.0014 0.0014
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0335 0.0495 0.1915
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0035 0.0016 0.0092
Loa Loa (eye worm) carboxylesterase 0.6285 1 1
Brugia malayi ThiF family protein 0.0052 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0012
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0033 0.0012 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0336 0.0495 0.0495
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0031 0.0031
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0034 0.0014 0.0037
Entamoeba histolytica hypothetical protein 0.0335 0.0495 0.1915
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0043 0.0043
Leishmania major cytochrome p450-like protein 0.0035 0.0016 0.0117
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0054 0.0054
Treponema pallidum DNA topoisomerase I (topA) 0.0034 0.0014 0.0007
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Plasmodium vivax DNA topoisomerase II, putative 0.0634 0.0971 0.7395
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0035 0.0016 0.0092
Leishmania major developmentally regulated phosphoprotein-like protein 0.0033 0.0012 0.0088
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0012 0.0045
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0033 0.0012 0.0077
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0016 0.0015
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0428 0.0643 0.3884
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0033 0.0012 0.007
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0847 0.1313 1
Trypanosoma brucei telomerase reverse transcriptase 0.0092 0.0106 0.0791
Brugia malayi DNA topoisomerase I 0.0847 0.1313 0.1313
Trichomonas vaginalis spcc417.12 protein, putative 0.1062 0.1656 0.6405
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.003 0.0007 0.0036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0026 0.0025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0044 0.0029 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0054 0.0194
Onchocerca volvulus Huntingtin homolog 0.0133 0.0172 0.1035
Mycobacterium tuberculosis Cell division protein FtsZ 0.0329 0.0484 0.2925
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0031 0.0031
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Echinococcus granulosus acetylcholinesterase 0.6285 1 1
Mycobacterium ulcerans cell division protein FtsZ 0.0329 0.0484 0.2925
Mycobacterium tuberculosis Conserved protein 0.0081 0.0088 0.0532
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0031 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.007 0.007
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0025 0.0096
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0711 0.1095 0.834
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0031 0.003
Schistosoma mansoni glutaminase 0.029 0.0422 0.0422
Brugia malayi Intermediate filament tail domain containing protein 0.0091 0.0105 0.0105
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.007 0.0069
Loa Loa (eye worm) glutaminase 2 0.029 0.0422 0.0422
Brugia malayi cytoplasmic intermediate filament protein 0.0049 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.1062 0.1656 0.1655
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0035 0.0016 0.0092
Leishmania major DNA topoisomerase ii 0.0599 0.0917 0.6982
Brugia malayi nuclear receptor NHR-88 0.0045 0.0031 0.0031
Giardia lamblia DNA topoisomerase III 0.0034 0.0014 0.0037
Brugia malayi glutaminase DH11.1 0.029 0.0422 0.0422
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0072 0.0074 0.0272
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0124 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0031 0.0031
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0031 0.0186
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0092 0.0106 0.0791
Echinococcus granulosus flap endonuclease 1 0.0028 0.0004 0.0003
Schistosoma mansoni inositol monophosphatase 0.0122 0.0154 0.0154
Echinococcus granulosus tar DNA binding protein 0.0074 0.0077 0.0076
Loa Loa (eye worm) DNA topoisomerase I 0.0847 0.1313 0.1313
Trichomonas vaginalis protein kinase inhibitor, putative 0.007 0.0071 0.0259
Loa Loa (eye worm) cytochrome P450 0.0035 0.0016 0.0015
Echinococcus multilocularis p2X purinoceptor 4 0.0397 0.0593 0.0592
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0052 0.0043 0.0312
Trypanosoma cruzi DNA topoisomerase II, putative 0.0599 0.0917 0.6979
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0028 0.0028
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0012 0.0077
Brugia malayi beta-lactamase family protein 0.0081 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0037 0.0018 0.0018
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0012 0.0077
Leishmania major protein kinase, putative 0.0029 0.0006 0.004
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0122 0.0154 0.2648
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0084 0.0094 0.0565
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0035 0.0016 0.0105
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0033 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.0082
Schistosoma mansoni DNA topoisomerase II 0.0634 0.0971 0.0971
Echinococcus multilocularis neuropeptide s receptor 0.0521 0.0792 0.0791
Loa Loa (eye worm) hypothetical protein 0.0054 0.0046 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0031 0.0031
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0012 0.0077
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1062 0.1656 0.1655
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Onchocerca volvulus 0.0108 0.0131 0.0791
Leishmania major hypothetical protein, conserved 0.0033 0.0012 0.0088
Mycobacterium ulcerans hypothetical protein 0.0081 0.0088 0.0532
Plasmodium vivax telomerase reverse transcriptase, putative 0.0567 0.0865 0.6587
Schistosoma mansoni cell polarity protein 0.0144 0.0189 0.0189
Echinococcus multilocularis acetylcholinesterase 0.6285 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0088 0.0532
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0109 0.0134 0.0806
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0028 0.0092
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0067 0.0066
Schistosoma mansoni P2X receptor subunit 0.0397 0.0593 0.0593
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0124 0.0464
Loa Loa (eye worm) ThiF family protein 0.0034 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0087 0.0098 0.0098
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0034 0.0014 0.0014
Brugia malayi Pre-SET motif family protein 0.0226 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0088
Trypanosoma brucei DNA topoisomerase IA, putative 0.0034 0.0014 0.0091
Loa Loa (eye worm) hypothetical protein 0.0089 0.0102 0.0102
Brugia malayi Flap endonuclease-1 0.0028 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0028 0.0028
Onchocerca volvulus 0.1062 0.1656 1
Brugia malayi hypothetical protein 0.0133 0.0172 0.0171
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0012 0.0077
Loa Loa (eye worm) hypothetical protein 0.0049 0.0037 0.0037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0082 0.009 0.009
Trichomonas vaginalis inositol monophosphatase, putative 0.0122 0.0154 0.0582
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0033 0.0012 0.007
Plasmodium falciparum heat shock protein 90 0.0033 0.0012 0.0077
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0033 0.0012 0.007
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0033 0.0012 0.0011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0011 0.0069
Schistosoma mansoni tsg101-related 0.0063 0.006 0.006
Echinococcus granulosus ras gtpase 0.0144 0.0189 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0031 0.0031
Echinococcus multilocularis p2X purinoceptor 4 0.0397 0.0593 0.0592
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0035 0.0016 0.0092
Loa Loa (eye worm) hypothetical protein 0.0204 0.0286 0.0285
Trypanosoma brucei unspecified product 0.0043 0.0028 0.0198
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0012 0.0012
Plasmodium vivax DNA gyrase subunit A, putative 0.0136 0.0177 0.1335
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0033 0.0012 0.007
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0088 0.0532
Giardia lamblia Telomerase catalytic subunit 0.0092 0.0106 0.0392
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.0124 0.0942
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0369 0.0549 0.3317
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0122 0.0154 0.1162
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0031 0.0186
Treponema pallidum fructose-bisphosphate aldolase 0.1642 0.2583 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0072 0.0074 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0088 0.066
Brugia malayi Pre-SET motif family protein 0.0032 0.0011 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0094 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Echinococcus multilocularis neuroligin 0.1062 0.1656 0.1655
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0039 0.0038
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0035 0.0016 0.0117
Brugia malayi beta-lactamase family protein 0.0081 0.0088 0.0088
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0035 0.0016 0.0092
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0054 0.0411
Schistosoma mansoni P2X receptor subunit 0.0397 0.0593 0.0593
Schistosoma mansoni microtubule-associated protein tau 0.3083 0.4884 0.4884
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0035 0.0016 0.0092
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0028 0.0167
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0025 0.0024
Brugia malayi Bromodomain containing protein 0.0087 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0052 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0031 0.003
Trichomonas vaginalis DNA topoisomerase II, putative 0.0634 0.0971 0.3751
Echinococcus granulosus para nitrobenzyl esterase 0.1062 0.1656 0.1655
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0035 0.0016 0.0092
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0033 0.0012 0.0077
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0092 0.0106 0.0636
Schistosoma mansoni lamin 0.0091 0.0105 0.0105
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0012 0.0077
Schistosoma mansoni single-minded 0.0108 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0004 0.0004
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0006 0.0028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0122 0.0154 0.0582
Schistosoma mansoni DNA topoisomerase type I 0.0847 0.1313 0.1313
Plasmodium falciparum DNA topoisomerase 2 0.0634 0.0971 0.7395
Loa Loa (eye worm) hypothetical protein 0.0076 0.008 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0122 0.0154 0.1162
Brugia malayi Carboxylesterase family protein 0.1062 0.1656 0.1655
Giardia lamblia Pms1-like protein 0.0033 0.0012 0.0029
Schistosoma mansoni heat shock protein 0.0033 0.0012 0.0012
Schistosoma mansoni P2X receptor subunit 0.0397 0.0593 0.0593
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0054 0.0194
Onchocerca volvulus 0.0257 0.037 0.2234
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0088 0.066
Echinococcus multilocularis heat shock protein 90 0.0033 0.0012 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0031 0.0031
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.0035 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0088 0.0327
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0033 0.0012 0.007
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0031 0.003
Echinococcus multilocularis acetylcholinesterase 0.6285 1 1
Toxoplasma gondii ABC1 family protein 0.0081 0.0088 0.066
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0035 0.0016 0.0092
Leishmania major mitochondrial DNA topoisomerase II 0.0711 0.1095 0.8342
Mycobacterium ulcerans lipase LipD 0.0081 0.0088 0.0532
Mycobacterium ulcerans DNA gyrase subunit B 0.0369 0.0549 0.3317
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0369 0.0549 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0006 0.0028
Trypanosoma brucei unspecified product 0.003 0.0007 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0026
Brugia malayi hypothetical protein 0.0076 0.008 0.008
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0054 0.0053
Giardia lamblia Kinase, PLK 0.0103 0.0124 0.0464
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0012 0.0077
Trichomonas vaginalis hypothetical protein 0.0037 0.0018 0.0053
Echinococcus granulosus p2X purinoceptor 4 0.0397 0.0593 0.0592
Loa Loa (eye worm) TOPoisomerase family member 0.0634 0.0971 0.0971
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0088 0.0088
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0072 0.0074 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0054 0.0399
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1062 0.1656 0.6405
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0031 0.0031
Brugia malayi nuclear hormone receptor 0.0045 0.0031 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0031 0.003
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0012 0.0077
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0035 0.0016 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0007 0.0036
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0054 0.0399
Echinococcus multilocularis transfer RNA-Lys 0.008 0.0087 0.0086
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0035 0.0016 0.0092
Echinococcus granulosus neuroligin 0.1062 0.1656 0.1655
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0136 0.0177 0.0642
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0004 0.0018
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0028 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0031 0.0031
Plasmodium falciparum DNA gyrase subunit B 0.0369 0.0549 0.4177
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0016 0.0015
Toxoplasma gondii DNA topoisomerase 2, putative 0.0634 0.0971 0.7395
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0028 0.0198
Mycobacterium ulcerans putative regulatory protein 0.008 0.0087 0.0526
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0012 0.0077
Schistosoma mansoni hypothetical protein 0.0056 0.0048 0.0048
Onchocerca volvulus 0.0159 0.0214 0.129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0033 0.0012 0.003
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0025 0.0178
Brugia malayi Carboxylesterase family protein 0.1062 0.1656 0.1655
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0012 0.0029
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0186 0.0257 0.0256
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0018 0.0018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.0257 0.0256
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0333 0.0491 0.0491
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0039 0.0038
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0092 0.0106 0.0791
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0088 0.0532
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0028 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0031 0.0031
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0428 0.0643 0.3884
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0012 0.0077
Plasmodium falciparum flap endonuclease 1 0.0028 0.0004 0.0019
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0124 0.0931
Brugia malayi Carboxylesterase family protein 0.1062 0.1656 0.1655
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0034 0.0014 0.0094
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0006 0.0028
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0028 0.0092
Brugia malayi Cytochrome P450 family protein 0.0084 0.0094 0.0094
Chlamydia trachomatis DNA gyrase subunit A 0.0136 0.0177 0.3045
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0033 0.0012 0.007
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0072 0.0074 0.0272
Brugia malayi hypothetical protein 0.1062 0.1656 0.1655
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0022 0.0021
Brugia malayi hypoxia-induced factor 1 0.0336 0.0495 0.0495
Schistosoma mansoni survival motor neuron protein 0.0159 0.0214 0.0214
Loa Loa (eye worm) acetylcholinesterase 1 0.6285 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0031 0.0031
Trypanosoma brucei cytochrome P450, putative 0.0084 0.0094 0.0702
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0034 0.0014 0.0094
Brugia malayi Cytochrome P450 family protein 0.0035 0.0016 0.0015
Entamoeba histolytica DNA topoisomerase III, putative 0.0034 0.0014 0.0052
Echinococcus multilocularis rho GTPase activating protein 20 0.0034 0.0014 0.0013
Onchocerca volvulus 0.1062 0.1656 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0076 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0091 0.0105 0.0105
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0025 0.0025
Onchocerca volvulus 0.0091 0.0105 0.0631
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0028 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Schistosoma mansoni cytochrome P450 0.0035 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0011 0.0011
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0033 0.0012 0.007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0088 0.0087
Brugia malayi kinase, mitochondrial precursor 0.0033 0.0012 0.0012
Brugia malayi Inositol-1 0.0122 0.0154 0.0154
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0634 0.0971 0.0971
Brugia malayi Cytochrome P450 family protein 0.0035 0.0016 0.0015
Leishmania major ubiquitin-activating enzyme-like protein 0.0034 0.0014 0.0106
Loa Loa (eye worm) hypothetical protein 0.0087 0.0098 0.0098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0088 0.0088
Schistosoma mansoni kinase 0.0053 0.0043 0.0043
Brugia malayi ERG2 and Sigma1 receptor like protein 0.04 0.0598 0.0598
Echinococcus granulosus p2X purinoceptor 4 0.0397 0.0593 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0025 0.0178
Trypanosoma brucei unspecified product 0.003 0.0007 0.0036
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0016 0.0105
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0012 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0088 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Brugia malayi heat shock protein 90 0.0033 0.0012 0.0012
Schistosoma mansoni inositol monophosphatase 0.0122 0.0154 0.0154
Echinococcus granulosus sentrin specific protease 8 0.0072 0.0074 0.0073
Echinococcus granulosus single minded 2 0.008 0.0087 0.0086
Leishmania major telomerase reverse transcriptase, putative 0.0092 0.0106 0.0802
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0031 0.0031
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0012 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Brugia malayi ThiF family protein 0.0034 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Loa Loa (eye worm) beta-lactamase 0.0081 0.0088 0.0088
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0034 0.0014 0.0013
Leishmania major DNA topoisomerase III, putative 0.0034 0.0014 0.0103
Loa Loa (eye worm) hypothetical protein 0.0364 0.054 0.054
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0025 0.0024
Trichomonas vaginalis sensor histidine kinase, putative 0.0033 0.0012 0.003
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0122 0.0154 0.0596
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0517 0.0785 0.474
Plasmodium vivax endoplasmin, putative 0.0033 0.0012 0.0077
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0002
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0599 0.0917 0.6979
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0122 0.0154 0.1173
Schistosoma mansoni BC026374 protein (S09 family) 0.1062 0.1656 0.1656
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0025 0.0081
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0088 0.0532
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0011 0.001
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0031 0.0186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0072 0.0074 0.0287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0031 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0031 0.0031
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0031 0.003
Onchocerca volvulus 0.1062 0.1656 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0031 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0028 0.0167
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0028 0.0107
Echinococcus granulosus muscleblind protein 0.0333 0.0491 0.049
Schistosoma mansoni hypothetical protein 0.007 0.0071 0.0071
Leishmania major hypothetical protein, conserved 0.0027 0.0002 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0025 0.0178
Loa Loa (eye worm) hypothetical protein 0.0258 0.0371 0.0371
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0033 0.0012 0.007
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0025 0.0189
Leishmania major cytochrome p450-like protein 0.0035 0.0016 0.0117
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0035 0.0016 0.0092
Schistosoma mansoni heat shock protein 0.0033 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0381 0.0567 0.0567
Mycobacterium leprae Possible regulatory protein 0.0028 0.0004 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0007 0.0036
Brugia malayi RNA binding protein 0.0074 0.0077 0.0076
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0033 0.0012 0.003
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0109 0.0134 0.1076
Onchocerca volvulus 0.0032 0.0011 0.0064
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0004 0.0031
Onchocerca volvulus 0.0081 0.0088 0.0532
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0028 0.0198
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0034 0.0014 0.0091
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1062 0.1656 0.1655
Trypanosoma brucei DNA topoisomerase III, putative 0.0034 0.0014 0.0091
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0028 0.0028
Onchocerca volvulus 0.008 0.0087 0.0526
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0088
Onchocerca volvulus 0.0091 0.0105 0.0631
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0035 0.0016 0.0092
Echinococcus multilocularis muscleblind protein 0.0333 0.0491 0.049
Brugia malayi ecdysteroid receptor 0.0045 0.0031 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0031 0.003
Echinococcus granulosus aryl hydrocarbon receptor 0.0028 0.0004 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0035 0.0016 0.0092
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.6285 1 1
Onchocerca volvulus 0.1062 0.1656 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0054 0.0194
Brugia malayi jmjC domain containing protein 0.0069 0.007 0.007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0031 0.0031
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0034 0.0014 0.0091
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0124 0.0123
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0034 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.6285 1 1
Schistosoma mansoni bromodomain containing protein 0.0073 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Leishmania major DNA topoisomerase III, putative 0.0034 0.0014 0.0103
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0025 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0031 0.0031
Onchocerca volvulus 0.0028 0.0004 0.0024
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0016 0.0105
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.0082
Mycobacterium ulcerans DNA topoisomerase I 0.0034 0.0014 0.0081
Echinococcus granulosus lamin dm0 0.0091 0.0105 0.0104
Echinococcus multilocularis BC026374 protein (S09 family) 0.1062 0.1656 0.1655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0039 0.0039
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0035 0.0016 0.0092
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1062 0.1656 0.1656
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0034 0.0014 0.0013
Loa Loa (eye worm) DnaJ domain-containing protein 0.007 0.0071 0.0071
Mycobacterium leprae cell division protein FtsZ 0.0329 0.0484 0.3903
Schistosoma mansoni tsg101-related 0.0051 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0047 0.0035 0.0034
Entamoeba histolytica DNA topoisomerase III, putative 0.0034 0.0014 0.0052
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0031 0.003
Loa Loa (eye worm) Ulp1 protease 0.0072 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0035 0.0016 0.0092
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0035 0.0016 0.0092
Echinococcus multilocularis muscleblind protein 1 0.0333 0.0491 0.049
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0124 0.0464
Echinococcus granulosus heat shock protein 90 0.0033 0.0012 0.0011
Echinococcus granulosus geminin 0.0381 0.0567 0.0567
Brugia malayi steroid hormone receptor 0.0045 0.0031 0.0031
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0004 0.0019
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0034 0.0014 0.0013
Toxoplasma gondii cytochrome p450 superfamily protein 0.0035 0.0016 0.0105
Loa Loa (eye worm) glutaminase 0.029 0.0422 0.0422
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0124 0.0464
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0054 0.0193
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0033 0.0012 0.007
Onchocerca volvulus 0.0045 0.0031 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0054 0.0194
Brugia malayi Probable DNA topoisomerase II 0.0634 0.0971 0.0971
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0031 0.0031
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0035 0.0016 0.0092
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0088 0.0532
Mycobacterium tuberculosis Carboxylesterase LipT 0.1062 0.1656 1
Schistosoma mansoni P2X receptor subunit 0.0397 0.0593 0.0593
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0124 0.0464
Mycobacterium ulcerans carboxylesterase, LipT 0.1062 0.1656 1
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0077 0.0076
Echinococcus multilocularis p2X purinoceptor 4 0.0397 0.0593 0.0592
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0122 0.0154 0.1162
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0012 0.003
Brugia malayi Cell division protein ftsZ 0.0158 0.0211 0.0211
Mycobacterium tuberculosis Probable two component sensor kinase 0.0033 0.0012 0.007
Giardia lamblia DINP protein human, muc B family 0.0043 0.0028 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0088 0.0088
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0009 0.0008
Trichomonas vaginalis esterase, putative 0.0081 0.0088 0.0327
Echinococcus multilocularis dnaJ subfamily C 6 0.007 0.0071 0.007
Schistosoma mansoni alpha-glucosidase 0.016 0.0215 0.0215
Leishmania major DNA polymerase eta, putative 0.0043 0.0028 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0025 0.0081
Giardia lamblia DNA repair protein RAD52 0.1178 0.1842 0.7126
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0054 0.0053
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0122 0.0154 0.093
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.007 0.0069
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0034 0.0014 0.0094
Mycobacterium tuberculosis Conserved protein 0.0033 0.0012 0.007
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0004 0.0004
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0004 0.0019
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0124 0.0124
Plasmodium vivax DNA gyrase subunit B, putative 0.0369 0.0549 0.4177
Giardia lamblia DNA topoisomerase III 0.0034 0.0014 0.0037
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0025 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0039 0.0039
Echinococcus multilocularis lamin dm0 0.0091 0.0105 0.0104
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0046 0.0045
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0599 0.0917 0.6979
Echinococcus multilocularis conserved hypothetical protein 0.0749 0.1156 0.1156
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0088 0.0532
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0033 0.0012 0.007
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0033 0.0012 0.007
Brugia malayi Cytochrome P450 family protein 0.0084 0.0094 0.0094
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1178 0.1842 0.7131
Onchocerca volvulus 0.0081 0.0088 0.0532
Brugia malayi follicle stimulating hormone receptor 0.0519 0.0788 0.0788
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0035 0.0016 0.0092
Echinococcus granulosus dna polymerase eta 0.0043 0.0028 0.0027
Trypanosoma brucei C-8 sterol isomerase, putative 0.04 0.0598 0.4547
Schistosoma mansoni intermediate filament proteins 0.0091 0.0105 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0088 0.066
Schistosoma mansoni DNA topoisomerase type I 0.0847 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0088
Echinococcus multilocularis musashi 0.0091 0.0105 0.0104
Echinococcus granulosus BC026374 protein S09 family 0.1062 0.1656 0.1655
Loa Loa (eye worm) hypothetical protein 0.0429 0.0644 0.0644
Loa Loa (eye worm) carboxylesterase 0.1062 0.1656 0.1655
Echinococcus granulosus inositol monophosphatase 1 0.0122 0.0154 0.0153
Giardia lamblia DNA topoisomerase II 0.0601 0.0919 0.3546
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0077 0.0077
Loa Loa (eye worm) DNA topoisomerase III 0.0034 0.0014 0.0013
Mycobacterium ulcerans glutaminase 0.029 0.0422 0.2548
Loa Loa (eye worm) hypothetical protein 0.1062 0.1656 0.1655
Trypanosoma cruzi C-8 sterol isomerase, putative 0.04 0.0598 0.4547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0039 0.0038
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0035 0.0016 0.0092
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0052 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0333 0.0491 0.0491
Trichomonas vaginalis glutaminase, putative 0.029 0.0422 0.1621
Brugia malayi Glycosyl hydrolases family 31 protein 0.0186 0.0257 0.0256
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0012 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0041 0.0143
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.032 0.032
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0081 0.0088 0.0088
Echinococcus multilocularis para nitrobenzyl esterase 0.1062 0.1656 0.1655
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0094 0.0702
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0035 0.0016 0.0092
Plasmodium falciparum endoplasmin, putative 0.0033 0.0012 0.0077
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0035 0.0016 0.0092
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0031 0.003
Mycobacterium leprae Probable two component sensor kinase MprB 0.0033 0.0012 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0031 0.0031
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0033 0.0012 0.0094
Toxoplasma gondii hypothetical protein 0.0052 0.0043 0.0312
Leishmania major cytochrome p450-like protein 0.0084 0.0094 0.0713
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0329 0.0484 0.8791
Brugia malayi DNA topoisomerase III 0.0034 0.0014 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0124 0.0464
Trypanosoma brucei heat shock protein, putative 0.0033 0.0012 0.0077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0043 0.0042
Trypanosoma brucei developmentally regulated phosphoprotein 0.0033 0.0012 0.0077
Loa Loa (eye worm) intermediate filament protein 0.0091 0.0105 0.0105
Brugia malayi PHD-finger family protein 0.0029 0.0005 0.0005
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0136 0.0177 0.1067
Toxoplasma gondii ThiF family protein 0.0034 0.0014 0.0094
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0052 0.0043 0.0043
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0054 0.0053
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0031 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0028 0.0198
Echinococcus granulosus dnaJ subfamily C 6 0.007 0.0071 0.007
Brugia malayi Cell division protein ftsZ 0.0162 0.0218 0.0218
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1642 0.2583 1
Schistosoma mansoni hypothetical protein 0.0039 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0035 0.0016 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0031 0.0031
Trypanosoma cruzi DNA topoisomerase III, putative 0.0034 0.0014 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0031 0.0031
Toxoplasma gondii DNA topoisomerase family protein 0.0034 0.0014 0.0091
Leishmania major C-8 sterol isomerase-like protein 0.04 0.0598 0.4553
Loa Loa (eye worm) hypothetical protein 0.0043 0.0028 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1642 0.2583 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0035 0.0016 0.0092
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0022 0.0022
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0124 0.0479
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0028 0.0027
Leishmania major heat shock protein 83-1 0.0033 0.0012 0.0088
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0012 0.0077
Loa Loa (eye worm) RNA binding protein 0.0074 0.0077 0.0076
Mycobacterium ulcerans putative regultory protein 0.0033 0.0012 0.007
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0031 0.0031
Mycobacterium ulcerans two component sensor kinase MprB 0.0033 0.0012 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0041 0.0143
Entamoeba histolytica DNA topoisomerase II, putative 0.0634 0.0971 0.3761
Loa Loa (eye worm) hypothetical protein 0.04 0.0598 0.0598
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0039 0.0038

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 110 uM Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assay ChEMBL. 8410993
EC50 (binding) = 110 uM Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assay ChEMBL. 8410993

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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