Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0413 | 0.0165 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0252 | 0.2465 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0252 | 0.2465 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0021 | 0.1023 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1378 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0758 | 0.0416 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0413 | 0.4041 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0357 | 0.3494 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0011 | 0.0357 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.1378 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0011 | 0.0357 | 0.0108 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.0252 | 0.5 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0027 | 0.1395 | 0.1076 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0357 | 0.3494 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0027 | 0.1395 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1378 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0252 | 0.2465 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0357 | 0.2593 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.1378 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0011 | 0.0357 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1378 | 0.1059 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0.0252 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.1378 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0357 | 0.2593 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0252 | 0.2465 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0252 | 0.2465 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0011 | 0.0357 | 0.0108 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0.0252 | 1 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0252 | 0.2465 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8519 | 0.8464 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0027 | 0.1395 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0009 | 0.0252 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1378 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0.0252 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0014 | 0.0572 | 0.2799 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0572 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0027 | 0.1395 | 0.1172 |
Brugia malayi | hypothetical protein | 0.0026 | 0.1378 | 0.1059 |
Loa Loa (eye worm) | RecQ helicase | 0.0027 | 0.1395 | 0.1076 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0.0252 | 0.5 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0009 | 0.0252 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0018 | 0.0808 | 0.5865 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.118 | 0.8057 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0357 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.1378 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0252 | 0.2465 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1378 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0413 | 0.0165 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0252 | 0.2465 |
Echinococcus multilocularis | bloom syndrome protein | 0.0027 | 0.1395 | 0.1172 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.