Detailed information for compound 1563536

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 535.01 | Formula: C19H12Br2Cl2O4
  • H donors: 4 H acceptors: 4 LogP: 6.51 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1cc(O)c(cc1C(c1c(Cl)cccc1Cl)c1cc(Br)c(cc1O)O)Br
  • InChi: 1S/C19H12Br2Cl2O4/c20-10-4-8(14(24)6-16(10)26)18(19-12(22)2-1-3-13(19)23)9-5-11(21)17(27)7-15(9)25/h1-7,18,24-27H
  • InChiKey: FXVGJORNNXWQIL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) Get druggable targets OG5_129572 All targets in OG5_129572
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) Get druggable targets OG5_129572 All targets in OG5_129572
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) Get druggable targets OG5_129572 All targets in OG5_129572
Candida albicans isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C) Get druggable targets OG5_129572 All targets in OG5_129572
Candida albicans isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C) Get druggable targets OG5_129572 All targets in OG5_129572
Mycobacterium ulcerans isocitrate lyase AceAb Get druggable targets OG5_129572 All targets in OG5_129572
Mycobacterium ulcerans isocitrate lyase Icl Get druggable targets OG5_129572 All targets in OG5_129572
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) Get druggable targets OG5_129572 All targets in OG5_129572
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi wnt family protein 0.0027 0.0128 0.0224
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0159 0.0759
Echinococcus granulosus protein Wnt 2 0.0027 0.0128 0.0224
Onchocerca volvulus 0.001 0.0022 0.0145
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0035 0.0034
Brugia malayi Pre-SET motif family protein 0.0211 0.1267 0.2227
Schistosoma mansoni wnt-5 0.0027 0.0128 0.0517
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0022 0.0145
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0011 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0129 0.0225
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0118 0.6237
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.001 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0057 0.2997
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0007 0.0006 0.0294
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0031 0.003
Brugia malayi hypothetical protein 0.0036 0.018 0.0316
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0627
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0627
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0184
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0159 0.8452
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0042 0.0196
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.1267 0.2227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0022 0.0087
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0057 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0021
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0099
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0087
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0189 1
Echinococcus multilocularis endoplasmin 0.0026 0.0119 0.0118
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Echinococcus granulosus GPCR family 2 0.0032 0.0155 0.0272
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0107 0.0622 0.1093
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0106 0.0619 0.1088
Schistosoma mansoni heat shock protein 0.0032 0.0159 0.0643
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0151 0.0608
Toxoplasma gondii exonuclease III APE 0.0037 0.0189 0.6261
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0011 0.0018
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0007 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.003 0.0146 0.059
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0159 0.8452
Brugia malayi intermediate filament protein 0.0027 0.0129 0.0225
Onchocerca volvulus 0.0028 0.0136 0.0917
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0007 0.0006 0.0043
Schistosoma mansoni heat shock protein 0.0013 0.0042 0.0167
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.02 0.1385
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0042 0.0278
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0007 0.0006 0.0026
Giardia lamblia hypothetical protein 0.0007 0.0006 0.0026
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0042 0.0289
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0264
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.0006 0.0043
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0016
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0011 0.001
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0118 0.6237
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0057 0.2997
Schistosoma mansoni intermediate filament proteins 0.0027 0.0129 0.052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0224
Mycobacterium leprae Isocitrate lyase 0.0294 0.1782 0.4631
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0007 0.0006 0.0006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0038
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0011 0.0018
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0011 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0007 0.0006 0.0294
Schistosoma mansoni endoplasmin 0.0032 0.0159 0.0643
Trypanosoma brucei RNA editing exonuclease 2 0.0007 0.0006 0.0294
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Echinococcus granulosus geminin 0.0339 0.206 0.3623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0038
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0184
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0119 0.0307
Onchocerca volvulus Putative neutral sphingomyelinase 0.0007 0.0006 0.0037
Trypanosoma cruzi mitochondrial protein 99, putative 0.0007 0.0006 0.0294
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0022 0.0038
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0022 0.0145
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0007 0.0006 0.0006
Brugia malayi hypothetical protein 0.0245 0.1479 0.2599
Giardia lamblia Inositol 5-phosphatase 4 0.0007 0.0006 0.0026
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0007 0.0006 0.0294
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0007 0.0006 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0246 0.0996
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0007 0.0006 0.0043
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.0006 0.0026
Plasmodium vivax SET domain protein, putative 0.0031 0.0151 0.799
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0022 0.0038
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0006 0.001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.014 0.0245
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0119 0.629
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0038
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0159 0.8452
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0022 0.0087
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0246 0.0996
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0021
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0057 0.1877
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0151 0.5003
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0007 0.0006 0.0294
Treponema pallidum hypothetical protein 0.0007 0.0006 0.0294
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0627 0.3847 1
Brugia malayi Smad1 0.0008 0.001 0.0016
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0217 0.0381
Leishmania major hypothetical protein, conserved 0.0007 0.0006 0.0294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0119 0.0565
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0022 0.0038
Echinococcus granulosus neutral sphingomyelinase 0.0007 0.0006 0.001
Echinococcus granulosus zinc finger transcription factor gli2 0.0924 0.5686 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0001 0.0005
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0246 0.0996
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0057 0.1877
Brugia malayi MH2 domain containing protein 0.0118 0.0692 0.1217
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0022 0.0087
Brugia malayi Pre-SET motif family protein 0.0031 0.0151 0.0264
Plasmodium falciparum DNase I-like protein, putative 0.0007 0.0006 0.0294
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0007 0.0006 0.0294
Brugia malayi hypothetical protein 0.0025 0.0118 0.0206
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0037
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0007 0.0006 0.0294
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Echinococcus granulosus synaptojanin 1 0.0007 0.0006 0.001
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0159 0.8452
Onchocerca volvulus 0.0031 0.0151 0.1016
Onchocerca volvulus 0.0007 0.0006 0.0037
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0119 0.0822
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0011 0.0076
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0007 0.0006 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Echinococcus multilocularis Smad4 0.0008 0.001 0.0009
Echinococcus multilocularis transcription factor eb 0.0107 0.0622 0.0622
Brugia malayi ecdysteroid receptor 0.001 0.0022 0.0038
Brugia malayi Endoplasmin precursor 0.0032 0.0159 0.0279
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0577 0.1014
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0119 0.0822
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0246 0.0432
Echinococcus granulosus protein Wnt 1 0.0027 0.0128 0.0224
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0026
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0038
Schistosoma mansoni heat shock protein 0.0032 0.0159 0.0643
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0038
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Echinococcus granulosus Smad4 0.0008 0.001 0.0016
Brugia malayi Wnt-2 protein precursor 0.0027 0.0128 0.0224
Onchocerca volvulus Huntingtin homolog 0.0245 0.1479 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0692 0.1217
Schistosoma mansoni wnt related 0.0027 0.0128 0.0517
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0224
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0078 0.4103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0151 0.0608
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0007 0.0006 0.0294
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0022 0.0021
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Plasmodium falciparum endoplasmin, putative 0.002 0.0082 0.4349
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0241 0.0973
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0129 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0038
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0006 0.001
Brugia malayi Hsp90 protein 0.0013 0.0042 0.0072
Schistosoma mansoni synaptojanin 0.0007 0.0006 0.0023
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0159 0.8452
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.0567 0.2706
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0225
Mycobacterium ulcerans isocitrate lyase Icl 0.0627 0.3847 1
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0042 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0038
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0246 0.0432
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0057 0.0056
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0056
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0026
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.0006 0.0294
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0007 0.0001 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0022 0.0087
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0051 0.0088
Echinococcus granulosus Protein Wnt-5 0.0027 0.0128 0.0224
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0066
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0011 0.0042
Echinococcus multilocularis heat shock protein 90 0.0032 0.0159 0.0159
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Echinococcus granulosus intermediate filament protein 0.0027 0.0129 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0022 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0035 0.0138
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0007 0.0006 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0056
Trichomonas vaginalis Phospholipase C precursor, putative 0.0007 0.0006 0.0043
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0035 0.0138
Echinococcus granulosus Protein Wnt-111 0.0027 0.0128 0.0224
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0159 0.8452
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0224
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0301 1
Plasmodium vivax exodeoxyribonuclease III, putative 0.0007 0.0006 0.0294
Loa Loa (eye worm) hypothetical protein 0.0027 0.0126 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0241 0.0973
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0022 0.0021
Trypanosoma cruzi mitochondrial protein 99, putative 0.0007 0.0006 0.0294
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0066
Treponema pallidum heat shock protein 90 0.0026 0.0119 0.629
Mycobacterium tuberculosis Probable exported protein 0.0007 0.0006 0.0014
Echinococcus multilocularis heat shock protein 0.0032 0.0159 0.0159
Echinococcus multilocularis wingless type MMTV integration site family 0.0027 0.0128 0.0128
Echinococcus multilocularis protein Wnt 1 0.0027 0.0128 0.0128
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0038
Plasmodium falciparum heat shock protein 90 0.0032 0.0159 0.8452
Leishmania major hypothetical protein, conserved 0.0025 0.0118 0.6237
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0057 0.2997
Leishmania major RNA-editing complex protein MP100, putative 0.0007 0.0006 0.0294
Onchocerca volvulus Huntingtin homolog 0.0245 0.1479 1
Schistosoma mansoni wnt related 0.0027 0.0128 0.0517
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0022 0.0145
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0022 0.0021
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0042 0.2187
Schistosoma mansoni nuclear hormone receptor 0.001 0.0022 0.0087
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0577 0.1014
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0011 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.2469 0.2469
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0042 0.2187
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0007 0.0001 0.0005
Leishmania major hypothetical protein, conserved 0.0007 0.0006 0.0294
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0011 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0382 0.0671
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0057 0.0099
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0057 0.2997
Brugia malayi Wnt-4 protein precursor 0.0027 0.0128 0.0224
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0119 0.0208
Brugia malayi nuclear hormone receptor 0.001 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0068 0.0382 0.0671
Onchocerca volvulus 0.0027 0.0129 0.0867
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0189 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0159 0.0759
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0011 0.001
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0042 0.2187
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0136 0.0238
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0035 0.006
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0001 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0627
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0026
Mycobacterium ulcerans isocitrate lyase AceAb 0.0627 0.3847 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.018 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0038
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0011 0.0042
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0119 0.0822
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0031 0.0053
Schistosoma mansoni endoplasmin 0.0032 0.0159 0.0643
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0007 0.0001 0.5
Schistosoma mansoni smad 0.0008 0.001 0.0038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0246 0.0432
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0007 0.0001 0.0005
Leishmania major endonuclease/exonuclease protein-like protein 0.0007 0.0006 0.0294
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0026
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0011 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0246 0.0432
Echinococcus multilocularis WNT 0.0027 0.0128 0.0128
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0627 0.3847 1
Schistosoma mansoni ap endonuclease 0.0037 0.0189 0.0761
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0129 0.0225
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0344 0.2093 1
Echinococcus granulosus dnaJ subfamily B 0.0405 0.2469 0.4342
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0189 0.1303
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0155 0.0155
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0007 0.0006 0.0294
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0007 0.0006 0.0294
Loa Loa (eye worm) hypothetical protein 0.0245 0.1479 0.2599
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0155 0.0155
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Schistosoma mansoni Smad4 0.0008 0.001 0.0038
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.001 0.0016
Trypanosoma brucei heat shock protein, putative 0.0032 0.0159 0.8452
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0189 0.0898
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0217 0.0217
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0189 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0057 0.2997
Echinococcus granulosus heat shock protein 90 0.0032 0.0159 0.0279
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0011 0.0018
Echinococcus granulosus lamin 0.0027 0.0129 0.0225
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0184
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0151 0.015
Brugia malayi Zinc finger, C2H2 type family protein 0.0924 0.5686 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0021
Onchocerca volvulus 0.0007 0.0006 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0151 0.0608
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0007 0.0006 0.0294
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0007 0.0006 0.0294
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.018 0.018
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0087
Echinococcus granulosus FTZ F1 alpha 0.001 0.0022 0.0038
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0007 0.0006 0.0026
Echinococcus granulosus cpg binding protein 0.003 0.0146 0.0256
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0151 0.0608
Echinococcus granulosus transcription factor eb 0.0107 0.0622 0.1093
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0006 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0155 0.0272
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0118 0.6237
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0022 0.0087
Trichomonas vaginalis set domain proteins, putative 0.024 0.1447 1
Leishmania major hypothetical protein, conserved 0.0007 0.0006 0.0294
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0007 0.0006 0.0294
Schistosoma mansoni cpg binding protein 0.003 0.0146 0.059
Trichomonas vaginalis endoplasmin, putative 0.002 0.0082 0.057
Onchocerca volvulus 0.0027 0.0129 0.0867
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0189 0.0488
Schistosoma mansoni coup transcription factor 0.001 0.0022 0.0087
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0022 0.0038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0159 0.0759
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0011 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0155 0.0272
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0021
Echinococcus granulosus endoplasmin 0.0026 0.0119 0.0208
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0042 0.2187
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0038
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0692 0.1217
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0159 0.1102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0155 0.0272
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0035 0.006
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0119 0.629
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0006 0.0294
Echinococcus multilocularis smad 0.0008 0.001 0.0009
Echinococcus multilocularis protein Wnt 2 0.0027 0.0128 0.0128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0155 0.0272
Loa Loa (eye worm) zinc finger protein 0.0924 0.5686 1
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0007 0.0006 0.001
Loa Loa (eye worm) histone methyltransferase 0.001 0.0021 0.0037
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0119 0.0307
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0119 0.0307
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0042 0.137
Brugia malayi heat shock protein 90 0.0032 0.0159 0.0279
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0051 0.0088
Schistosoma mansoni cpg binding protein 0.0028 0.0136 0.0549
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0042 0.0072
Brugia malayi isocitrate dehydrogenase 0.0016 0.0057 0.0099
Echinococcus multilocularis GPCR, family 2 0.0032 0.0155 0.0155
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0155 0.0272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0246 0.0246
Loa Loa (eye worm) Wnt2 protein 0.0027 0.0128 0.0224
Schistosoma mansoni smad1 5 8 and 0.0008 0.001 0.0038
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0627 0.3847 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0057 0.2997
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.001 0.0016
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0057 0.0146
Entamoeba histolytica hypothetical protein 0.0036 0.018 0.0859
Brugia malayi MH2 domain containing protein 0.0008 0.001 0.0016
Brugia malayi wnt family protein 0.0027 0.0128 0.0224
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0627
Echinococcus multilocularis traf and tnf receptor associated protein 0.0007 0.0006 0.0006
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Giardia lamblia DNA repair protein RAD52 0.0344 0.2093 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0038
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0007 0.0006 0.0294
Echinococcus multilocularis neutral sphingomyelinase 0.0007 0.0006 0.0006
Schistosoma mansoni lamin 0.0027 0.0129 0.052
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0159 0.8452
Schistosoma mansoni hypothetical protein 0.0068 0.0382 0.1545
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0118 0.3905
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.0006 0.0294
Loa Loa (eye worm) hypothetical protein 0.0027 0.0128 0.0224
Onchocerca volvulus 0.024 0.1447 0.9785
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0022 0.0087
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0007 0.0006 0.0026
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0189 0.1303
Brugia malayi CXXC zinc finger family protein 0.0028 0.0136 0.0238
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0006 0.001
Echinococcus multilocularis wnt family member wnt11 2 0.0027 0.0128 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0022 0.0087
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0189 0.0488
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0321
Echinococcus granulosus heat shock protein 90 0.0026 0.0119 0.0208
Echinococcus granulosus Protein Wnt-04 0.0027 0.0128 0.0224
Loa Loa (eye worm) Smad1 0.0008 0.001 0.0016
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0011 0.0018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.02 0.1385
Entamoeba histolytica hypothetical protein 0.0098 0.0567 0.2706
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0038
Trichomonas vaginalis heat shock protein, putative 0.002 0.0082 0.057
Entamoeba histolytica hypothetical protein 0.0036 0.018 0.0859
Schistosoma mansoni ap endonuclease 0.0037 0.0189 0.0761
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0118 0.6237
Echinococcus multilocularis synaptojanin 1 0.0007 0.0006 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0118 0.6237
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0011 0.0076
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0007 0.0006 0.0043
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0035 0.0034
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0011 0.0018
Plasmodium vivax endoplasmin, putative 0.0032 0.0159 0.8452
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Schistosoma mansoni nocturnin 0.0007 0.0006 0.0023
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0217 0.0381
Schistosoma mansoni hypothetical protein 0.0011 0.0031 0.0122
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0057 0.2997
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0189 0.0898
Brugia malayi CCR4 0.0007 0.0006 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0022 0.0038
Brugia malayi wnt family protein 0.0027 0.0128 0.0224
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0189 1
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0011 0.0018
Loa Loa (eye worm) wnt-4 protein 0.0027 0.0128 0.0224
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0001 0.0005
Entamoeba histolytica hypothetical protein 0.0036 0.018 0.0859
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0042 0.2187
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0007 0.0006 0.0294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0011 0.0041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0189 0.033
Giardia lamblia Grp94/Hsp90 0.0026 0.0119 0.0565
Leishmania major heat shock protein, putative 0.0013 0.0042 0.2187
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0119 0.629
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0007 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0001 0.5
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0118 0.0206
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0118 0.6237
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0011 0.0042
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0038
Echinococcus multilocularis WNT 0.0027 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0405 0.2469 1
Schistosoma mansoni hypothetical protein 0.0339 0.206 0.8343
Trichomonas vaginalis DNA topoisomerase II, putative 0.0007 0.0001 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0189 1
Echinococcus multilocularis heat shock protein 90 0.0026 0.0119 0.0118
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0011 0.001
Leishmania major heat shock protein 83-1 0.0032 0.0159 0.8452
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0001 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0151 0.0264
Schistosoma mansoni hypothetical protein 0.0339 0.206 0.8343
Loa Loa (eye worm) hypothetical protein 0.01 0.0577 0.1014
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.0006 0.0043
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.001 0.0016
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0021 0.0035
Echinococcus multilocularis deoxyribonuclease 1 2 0.0007 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0072
Trichomonas vaginalis sensor histidine kinase, putative 0.0007 0.0001 0.0005
Entamoeba histolytica hypothetical protein 0.0036 0.018 0.0859
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0026
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0189 0.033
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0022 0.0087
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0217 0.0381
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.001
Schistosoma mansoni cript-related 0.0007 0.0006 0.0023
Echinococcus multilocularis lamin 0.0027 0.0129 0.0128
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0007 0.0006 0.001
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0119 0.629
Brugia malayi steroid hormone receptor 0.001 0.0022 0.0038
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0159 0.8452
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0159 0.5292
Echinococcus multilocularis musashi 0.0027 0.0129 0.0128
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.0006 0.0043
Leishmania major pantothenate kinase subunit, putative 0.0007 0.0006 0.0294
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0035 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0577 0.1014
Echinococcus multilocularis cpg binding protein 0.003 0.0146 0.0146
Echinococcus granulosus Protein Wnt-11b 0.0027 0.0128 0.0224
Loa Loa (eye worm) hypothetical protein 0.0106 0.0619 0.1088
Brugia malayi nuclear receptor NHR-88 0.001 0.0022 0.0038
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0022 0.0038
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0007 0.0006 0.0294
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0042 0.0041
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0022 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0038
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0159 0.8452
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.001
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0007 0.0006 0.0294
Schistosoma mansoni wnt related 0.0027 0.0128 0.0517
Schistosoma mansoni hypothetical protein 0.0036 0.018 0.0728
Echinococcus multilocularis zinc finger transcription factor gli2 0.0924 0.5686 0.5686
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0016
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0011 0.0042
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0021
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0007 0.0006 0.0026
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0007 0.0006 0.001
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0007 0.0006 0.0294
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0189 0.0188
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0038
Echinococcus multilocularis geminin 0.0339 0.206 0.206
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0007 0.0006 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0038
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0189 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0341 0.1377
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0042 0.137
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0011 0.001
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0007 0.0006 0.001
Schistosoma mansoni lamin 0.0027 0.0129 0.052
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.001 0.0009
Schistosoma mansoni neutral sphingomyelinase 0.0007 0.0006 0.0023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0022 0.0087
Schistosoma mansoni synaptojanin 0.0007 0.0006 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0038
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0007 0.0006 0.001
Plasmodium vivax heat shock protein, putative 0.0013 0.0042 0.2187
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0018
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0189 1
Brugia malayi wnt family protein 0.0027 0.0128 0.0224
Echinococcus granulosus traf and tnf receptor associated protein 0.0007 0.0006 0.001
Loa Loa (eye worm) endoplasmin 0.0032 0.0159 0.0279
Loa Loa (eye worm) hypothetical protein 0.0245 0.1479 0.2599
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.001
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0627 0.3847 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.001 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0189 1
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0001 0.5
Schistosoma mansoni wnt related 0.0027 0.0128 0.0517
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0057 0.0228
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0042 0.0072
Brugia malayi MH1 domain containing protein 0.0008 0.001 0.0016
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0011 0.0018
Echinococcus multilocularis lamin dm0 0.0027 0.0129 0.0128
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.018 0.0728
Echinococcus granulosus smad 0.0008 0.001 0.0016
Brugia malayi hypothetical protein 0.0016 0.0062 0.0108
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0159 0.5292
Echinococcus granulosus lamin dm0 0.0027 0.0129 0.0225
Loa Loa (eye worm) hypothetical protein 0.0032 0.0155 0.0272
Schistosoma mansoni carbon catabolite repressor protein 0.0007 0.0006 0.0023
Loa Loa (eye worm) CWN-2 protein 0.0027 0.0128 0.0224
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0159 0.0279
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0151 0.015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0246 0.0246
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0011 0.0042
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0057 0.0099
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0189 0.033
Schistosoma mansoni hypothetical protein 0.0007 0.0006 0.0023
Echinococcus granulosus heat shock protein 0.0032 0.0159 0.0279
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0007 0.0006 0.0043

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17.9 uM Inhibition of Candida albicans isocitrate lyase after 30 mins ChEMBL. 22001028
MIC (functional) = 100 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold serial dilution method ChEMBL. 22001028
MIC (functional) = 100 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 after 24 to 72 hrs by two fold serial dilution method ChEMBL. 22001028

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.