Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0216 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0216 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0216 | 1 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0216 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0216 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0216 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0216 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0216 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0216 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0216 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0216 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0216 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0216 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0202 | 0.8676 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0216 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0216 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0202 | 0.8676 | 0.8676 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0216 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0216 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0202 | 0.8676 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 15.08 uM | Antiproliferative activity against human KB cells after 72 hrs by SRB assay | ChEMBL. | 22265685 |
GI50 (functional) | > 26.59 uM | Antiproliferative activity against human A549 cells after 72 hrs by SRB assay | ChEMBL. | 22265685 |
GI50 (functional) | > 26.59 uM | Antiproliferative activity against human DU145 cells after 72 hrs by SRB assay | ChEMBL. | 22265685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.