Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | cyclin domain-containing protein | Get druggable targets OG5_133273 | All targets in OG5_133273 |
Brugia malayi | Cyclin, N-terminal domain containing protein | Get druggable targets OG5_133273 | All targets in OG5_133273 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.0104 | 0.2268 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0104 | 0.2268 | 0.2268 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0104 | 0.2268 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0111 | 0.2568 | 0.5 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0104 | 0.2268 | 0.872 |
Trypanosoma brucei | AMP deaminase, putative | 0.0104 | 0.2268 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.03 | 0.03 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0104 | 0.2268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.03 | 0.03 |
Leishmania major | AMP deaminase, putative | 0.0104 | 0.2268 | 0.872 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.03 | 0.03 |
Schistosoma mansoni | adenosine deaminase | 0.0111 | 0.2568 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.029 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0111 | 0.2568 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0104 | 0.2268 | 0.872 |
Mycobacterium ulcerans | adenosine deaminase | 0.0111 | 0.2568 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0111 | 0.2568 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0104 | 0.2268 | 0.872 |
Leishmania major | adenine aminohydrolase | 0.0111 | 0.2568 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0104 | 0.2268 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0104 | 0.2268 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0104 | 0.2268 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0111 | 0.2568 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0221 | 0.0221 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0111 | 0.2568 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0104 | 0.2268 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0111 | 0.2568 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0111 | 0.2568 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0104 | 0.2268 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0111 | 0.2568 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0104 | 0.2268 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0111 | 0.2568 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0111 | 0.2568 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0111 | 0.2568 | 1 |
Treponema pallidum | adenosine deaminase | 0.0111 | 0.2568 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0104 | 0.2268 | 0.872 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0111 | 0.2568 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0111 | 0.2568 | 0.5 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0111 | 0.2568 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.03 | 0.03 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0104 | 0.2268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2568 | 0.2568 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0111 | 0.2568 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5355 nM | Inhibition of human CDK2/CyclinE expressed in baculovirus insect cell system using Rb as substrate after 30 mins by scintillation counting | ChEMBL. | 12659774 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.