Detailed information for compound 1563911

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.532 | Formula: C22H26N4O3S
  • H donors: 2 H acceptors: 4 LogP: 4.8 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NC(=O)c1cnn(c1NS(=O)(=O)c1ccccc1C)c1ccccc1)CC
  • InChi: 1S/C22H26N4O3S/c1-4-17(5-2)24-22(27)19-15-23-26(18-12-7-6-8-13-18)21(19)25-30(28,29)20-14-10-9-11-16(20)3/h6-15,17,25H,4-5H2,1-3H3,(H,24,27)
  • InChiKey: UBIPXJMGZGJHMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens formyl peptide receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum serine repeat antigen 5 0.002 0.0088 0.088
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.05 0.1178
Echinococcus multilocularis cysteine protease 0.0052 0.05 0.1163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0112
Plasmodium vivax vivapain-2 0.0052 0.05 1
Echinococcus multilocularis tumor protein p63 0.0344 0.4294 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.002 0.0088 0.088
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0048 0.0048
Loa Loa (eye worm) cysteine protease 0.0052 0.05 0.05
Plasmodium falciparum histone deacetylase, putative 0.0042 0.0372 0.7169
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0372 0.0325
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.05 0.1163
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0048 0.0114
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0372
Schistosoma mansoni cpg binding protein 0.003 0.0212 0.05
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0088
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.008 0.0869 0.2024
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0055 0.0155
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0372 0.0866
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0238 0.0554
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0088 0.0088
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.062 0.1462
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1126 0.1126
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0088 0.0088
Plasmodium vivax vivapain-1 0.002 0.0088 0.088
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.05 0.0453
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.05 0.0453
Plasmodium vivax unspecified product 0.002 0.0088 0.088
Plasmodium vivax vivapain-3 0.002 0.0088 0.088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Brugia malayi Kringle domain containing protein 0.0018 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Brugia malayi CXXC zinc finger family protein 0.0028 0.0191 0.0191
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.05 1
Loa Loa (eye worm) cathepsin B 0.0101 0.1132 0.1132
Brugia malayi Histone deacetylase family protein 0.0042 0.0372 0.0372
Brugia malayi Cathepsin L-like cysteine proteinase 0.0052 0.05 0.05
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0088 0.004
Echinococcus granulosus cysteine protease 0.002 0.0088 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3464 0.8169
Schistosoma mansoni hypothetical protein 0.0018 0.0055 0.013
Echinococcus granulosus tumor protein p63 0.0344 0.4294 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Echinococcus granulosus baculoviral IAP repeat containing protein 0.008 0.0869 0.2024
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0088 0.088
Echinococcus granulosus cathepsin l1 0.0052 0.05 0.1163
Echinococcus granulosus cathepsin b 0.028 0.3464 0.8068
Loa Loa (eye worm) hypothetical protein 0.008 0.0869 0.0869
Schistosoma mansoni hypothetical protein 0.0032 0.0238 0.0561
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0088 0.0207
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0238 0.0238
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0088 0.0207
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.028 0.3464 0.3433
Leishmania major C-8 sterol isomerase-like protein 0.0784 1 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0061 0.062 0.1444
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0088 0.088
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0088 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0238 0.0238
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.05 0.1178
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0088 0.0088
Onchocerca volvulus Cathepsin L homolog 0.0052 0.05 0.2706
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.018 0.1586
Echinococcus granulosus histone deacetylase 6 0.0042 0.0372 0.0866
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0088
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3464 0.8169
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.018 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Toxoplasma gondii cathepsin CPC1 0.002 0.0088 0.0777
Loa Loa (eye worm) hypothetical protein 0.0027 0.018 0.018
Plasmodium falciparum serine repeat antigen 8 0.002 0.0088 0.088
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0088 0.0207
Leishmania major hypothetical protein, conserved 0.0027 0.018 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.05 0.3941
Echinococcus granulosus histone deacetylase 7 0.0042 0.0372 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Onchocerca volvulus 0.002 0.0088 0.0476
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0088 0.0207
Echinococcus granulosus cathepsin l1 0.0052 0.05 0.1163
Echinococcus granulosus apoptotic protease activating factor 1 0.0061 0.062 0.1444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0088 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Toxoplasma gondii cathepsin CPL 0.0052 0.05 0.4412
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0088 0.0207
Schistosoma mansoni hypothetical protein 0.034 0.4241 1
Brugia malayi cathepsin L-like precursor 0.0052 0.05 0.05
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0088 0.0207
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0112
Brugia malayi cathepsin L precursor 0.002 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0061 0.062 0.062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0191 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.018 0.2909
Echinococcus granulosus cathepsin L 0.002 0.0088 0.0205
Brugia malayi Cell death protein 3 precursor 0.0061 0.062 0.062
Trypanosoma cruzi cysteine protease, putative 0.002 0.0088 0.004
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.002 0.0088 0.088
Toxoplasma gondii cathepsin CPC2 0.002 0.0088 0.0777
Brugia malayi cathepsin B-like cysteine proteinase 0.028 0.3464 0.3464
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0481 0.1133
Onchocerca volvulus 0.0052 0.05 0.2706
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0088 0.0207
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0088 0.0207
Trypanosoma brucei cysteine peptidase C (CPC) 0.0101 0.1132 0.1089
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.05 0.0453
Trypanosoma brucei histone deacetylase 3 0.0042 0.0372 0.0325
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0055 0.0007
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0101 0.1132 0.1089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.06 0.1414
Schistosoma mansoni hypothetical protein 0.0032 0.0238 0.0561
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.05 0.1163
Entamoeba histolytica cysteine protease, putative 0.0052 0.05 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0238 0.0554
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.05 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0715 0.0715
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.05 0.3941
Onchocerca volvulus 0.0052 0.05 0.2706
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0372 0.0877
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1126 0.1126
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.05 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0088 0.004
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.05 0.05
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0112
Leishmania major histone deacetylase, putative 0.0042 0.0372 0.0325
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0088 0.0207
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453
Schistosoma mansoni histone deacetylase hda2 0.0042 0.0372 0.0877
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.018 0.2909
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Toxoplasma gondii cathepsin B 0.0101 0.1132 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0088 0.0088
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.002 0.0088 0.088
Echinococcus multilocularis cathepsin L 0.002 0.0088 0.0205
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.002 0.0088 0.088
Loa Loa (eye worm) fibroinase 0.0052 0.05 0.05
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0088 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Echinococcus granulosus inhibitor of apoptosis protein 0.008 0.0869 0.2024
Onchocerca volvulus 0.0028 0.0191 0.1036
Brugia malayi hypothetical protein 0.0018 0.0055 0.0055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0088 0.0207
Trypanosoma brucei histone deacetylase 4 0.0042 0.0372 0.0325
Onchocerca volvulus Deterin homolog 0.008 0.0869 0.4708
Echinococcus granulosus caspase 2 0.0061 0.062 0.1444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0052 0.05 0.0453
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.05 0.1163
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0088 0.004
Giardia lamblia Cathepsin B precursor 0.0101 0.1132 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.018 0.0132
Echinococcus granulosus cpg binding protein 0.003 0.0212 0.0494
Loa Loa (eye worm) hypothetical protein 0.0032 0.0238 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Loa Loa (eye worm) hypothetical protein 0.0052 0.05 0.05
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0784 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0088 0.004
Giardia lamblia Cathepsin B precursor 0.0101 0.1132 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0238 0.0554
Echinococcus granulosus histone deacetylase 6 0.0042 0.0372 0.0866
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.05 0.0453
Plasmodium falciparum serine repeat antigen 4 0.002 0.0088 0.088
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.002 0.0088 0.088
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0088 0.088
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0372 0.0325
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.028 0.3464 0.8169
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0372 0.0877
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0088 0.0088
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0055 0.0488
Schistosoma mansoni inhibitor of apoptosis protein 0.008 0.0869 0.2049
Leishmania major hypothetical protein, conserved 0.0018 0.0055 0.0007
Brugia malayi Histone deacetylase family protein 0.0042 0.0372 0.0372
Plasmodium falciparum serine repeat antigen 7 0.002 0.0088 0.088
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0238 0.0238
Echinococcus multilocularis cathepsin b 0.028 0.3464 0.8068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0032 0.0238 0.0561
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0088 0.004
Onchocerca volvulus 0.0061 0.062 0.336
Onchocerca volvulus 0.005 0.0481 0.2604
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0055 0.0129
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.062 0.336
Onchocerca volvulus 0.0052 0.05 0.2706
Onchocerca volvulus 0.0052 0.05 0.2706
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1126 0.1126
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.002 0.0088 0.088
Plasmodium vivax histone deacetylase, putative 0.0042 0.0372 0.7169
Plasmodium falciparum serine repeat antigen 3 0.002 0.0088 0.088
Plasmodium falciparum serine repeat antigen 2 0.002 0.0088 0.088
Brugia malayi fibroinase precursor 0.002 0.0088 0.0088
Echinococcus granulosus histone deacetylase 0.0042 0.0372 0.0866
Toxoplasma gondii histone deacetylase HDAC1 0.0042 0.0372 0.3284
Loa Loa (eye worm) hypothetical protein 0.0052 0.05 0.05
Echinococcus multilocularis histone deacetylase 0.0042 0.0372 0.0866
Plasmodium vivax histone deacetylase 2, putative 0.0042 0.0372 0.7169
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0048 0.0112
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0088 0.0207
Loa Loa (eye worm) hypothetical protein 0.0156 0.1846 0.1846
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.002 0.0088 0.088
Schistosoma mansoni cpg binding protein 0.0028 0.0191 0.0451
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.05 0.1163
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.002 0.0088 0.088
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0088 0.088
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.018 0.2909
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.05 0.0453
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0055 0.0129
Schistosoma mansoni hypothetical protein 0.034 0.4241 1
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0088 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.018 0.0132
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.002 0.0088 0.088
Brugia malayi hypothetical protein 0.0027 0.018 0.018
Echinococcus multilocularis inhibitor of apoptosis protein 0.008 0.0869 0.2024
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Echinococcus granulosus GPCR family 2 0.0032 0.0238 0.0554
Loa Loa (eye worm) hypothetical protein 0.0061 0.062 0.062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Loa Loa (eye worm) hypothetical protein 0.0052 0.05 0.05
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0238 0.0554
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.05 0.05
Onchocerca volvulus Cathepsin F homolog 0.0052 0.05 0.2706
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.05 1
Onchocerca volvulus 0.0052 0.05 0.2706
Echinococcus granulosus histone deacetylase 6 0.0042 0.0372 0.0866
Plasmodium falciparum serine repeat antigen 1 0.002 0.0088 0.088
Echinococcus granulosus geminin 0.034 0.4241 0.9877
Loa Loa (eye worm) hypothetical protein 0.005 0.0481 0.0481
Onchocerca volvulus Cathepsin L homolog 0.002 0.0088 0.0476
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Trypanosoma brucei C-8 sterol isomerase, putative 0.0784 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0088
Plasmodium falciparum serine repeat antigen 6 0.002 0.0088 0.088
Giardia lamblia Cathepsin B precursor 0.0101 0.1132 1
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.008 0.0869 0.2049
Onchocerca volvulus 0.0052 0.05 0.2706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Echinococcus granulosus cathepsin b 0.028 0.3464 0.8068
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.002 0.0088 0.088
Loa Loa (eye worm) hypothetical protein 0.008 0.0869 0.0869
Echinococcus multilocularis geminin 0.034 0.4241 0.9877
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0088 0.088
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0048 0.0426
Loa Loa (eye worm) hypothetical protein 0.0042 0.0372 0.0372
Schistosoma mansoni hypothetical protein 0.0068 0.0715 0.1685
Onchocerca volvulus Cathepsin L homolog 0.0052 0.05 0.2706
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0715 0.0715
Loa Loa (eye worm) histone deacetylase 0.0042 0.0372 0.0372
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453
Trypanosoma brucei histone deacetylase, putative 0.0042 0.0372 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.05 0.1163
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.05 0.1163
Plasmodium falciparum serine repeat antigen 9 0.002 0.0088 0.088
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Loa Loa (eye worm) hypothetical protein 0.0401 0.5026 0.5026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.05 0.1178
Plasmodium vivax vivapain-2 0.0052 0.05 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.008 0.0869 0.0869
Loa Loa (eye worm) hypothetical protein 0.0784 1 1
Schistosoma mansoni hypothetical protein 0.0061 0.062 0.1462
Toxoplasma gondii preprocathepsin c precursor, putative 0.002 0.0088 0.0777
Plasmodium falciparum histone deacetylase 2 0.0042 0.0372 0.7169
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0088
Onchocerca volvulus 0.0052 0.05 0.2706
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0238 0.0554
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0088 0.0088
Onchocerca volvulus 0.008 0.0869 0.4708
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Echinococcus multilocularis histone deacetylase 7 0.0042 0.0372 0.0866
Onchocerca volvulus 0.0052 0.05 0.2706
Schistosoma mansoni cpg binding protein 0.003 0.0212 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Echinococcus multilocularis cysteine protease 0.0052 0.05 0.1163
Echinococcus multilocularis caspase 2 0.0061 0.062 0.1444
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0101 0.1132 0.267
Loa Loa (eye worm) ctsf protein 0.0052 0.05 0.05
Plasmodium vivax unspecified product 0.002 0.0088 0.088
Onchocerca volvulus 0.0018 0.0055 0.0299
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0372 0.0866
Brugia malayi isocitrate dehydrogenase 0.0017 0.0048 0.0048
Echinococcus multilocularis cpg binding protein 0.003 0.0212 0.0494
Schistosoma mansoni hypothetical protein 0.008 0.0869 0.2049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0088 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0088 0.004
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0088 0.0088
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.05 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.05 0.05
Loa Loa (eye worm) hypothetical protein 0.01 0.1126 0.1126
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.008 0.0869 0.0869
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0088 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0048 0.0112
Leishmania major cysteine peptidase A (CPA) 0.0052 0.05 0.0453
Loa Loa (eye worm) hypothetical protein 0.0052 0.05 0.05
Schistosoma mansoni cathepsin C 0.002 0.0088 0.0207
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0372 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.05 0.0453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0048 0.5
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0088 0.0088
Echinococcus multilocularis cathepsin b 0.028 0.3464 0.8068
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0088 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0101 0.1132 1
Brugia malayi Protein kinase domain containing protein 0.0018 0.0055 0.0055
Leishmania major histone deacetylase, putative 0.0042 0.0372 0.0325
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.05 0.3941
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0372 0.0325
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0048 0.0426
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0101 0.1132 0.1089
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0517 0.4568
Brugia malayi hypothetical protein 0.0156 0.1846 0.1846
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.05 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0048 0.0112
Loa Loa (eye worm) histone deacetylase 7A 0.0042 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.028 0.3464 0.3464
Brugia malayi Cathepsin L-like precursor 0.0052 0.05 0.05
Echinococcus multilocularis cathepsin L 0.002 0.0088 0.0205
Onchocerca volvulus 0.0156 0.1846 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0048 0.0048
Echinococcus granulosus cathepsin L 0.002 0.0088 0.0205
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0088 0.0207
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.028 0.3464 0.8169
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Schistosoma mansoni hypothetical protein 0.0032 0.0238 0.0561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.05 0.3941
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.002 0.0088 0.088
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0055 0.0155
Brugia malayi hypothetical protein 0.0061 0.062 0.062
Leishmania major cathepsin L-like protease 0.0052 0.05 0.0453

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.2 Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay ChEMBL. 21955939

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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