Detailed information for compound 1563983

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.929 | Formula: C25H26ClF2NO3
  • H donors: 2 H acceptors: 2 LogP: 4.92 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(COc1ccc(cc1C(=O)CCc1ccc(cc1)F)F)CNCc1ccccc1.Cl
  • InChi: 1S/C25H25F2NO3.ClH/c26-20-9-6-18(7-10-20)8-12-24(30)23-14-21(27)11-13-25(23)31-17-22(29)16-28-15-19-4-2-1-3-5-19;/h1-7,9-11,13-14,22,28-29H,8,12,15-17H2;1H
  • InChiKey: GSFPIBPWABRYGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.07 0.3828 0.7515
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0096 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Onchocerca volvulus Neuropeptide F receptor homolog 0.07 0.3828 1
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.07 0.3828 0.3774
Echinococcus multilocularis two pore calcium channel protein 2 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0059 0.0151 0.0065
Toxoplasma gondii beta tubulin 0.0841 0.4637 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.005 0.0096 0.0009
Onchocerca volvulus 0.07 0.3828 1
Echinococcus granulosus rhodopsin orphan GPCR 0.07 0.3828 0.3774
Schistosoma mansoni hypothetical protein 0.07 0.3828 0.6914
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.07 0.3828 0.6914
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni amine GPCR 0.07 0.3828 0.6914
Echinococcus multilocularis transient receptor potential cation channel 0.0059 0.0151 0.0065
Echinococcus multilocularis potassium voltage gated channel protein 0.0059 0.0151 0.0065
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0096 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Echinococcus granulosus peptide allatostatin:somatostatin 0.07 0.3828 0.3774
Onchocerca volvulus 0.0056 0.0133 0.016
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0096 0.0009
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi A-macroglobulin complement component family protein 0.0124 0.052 0.1021
Schistosoma mansoni myosin xvIII 0.07 0.3828 0.6914
Schistosoma mansoni tubulin subunit beta 0.0841 0.4637 0.8378
Echinococcus granulosus g protein coupled receptor 0.07 0.3828 0.3774
Echinococcus multilocularis allatostatin A receptor 0.07 0.3828 0.3774
Echinococcus multilocularis beta tubulin 0.0841 0.4637 0.459
Echinococcus granulosus Tubulin beta 2C chain 0.0841 0.4637 0.459
Echinococcus granulosus sex peptide receptor 0.07 0.3828 0.3774
Schistosoma mansoni amine GPCR 0.07 0.3828 0.6914
Schistosoma mansoni hypothetical protein 0.0115 0.0468 0.0831
Echinococcus granulosus tubulin subunit beta 0.0841 0.4637 0.459
Brugia malayi Protein kinase domain containing protein 0.0533 0.2868 0.5629
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0059 0.0151 0.0296
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0059 0.0151 0.0065
Echinococcus granulosus tm gpcr rhodopsin 0.07 0.3828 0.3774
Trypanosoma brucei beta tubulin 0.0841 0.4637 1
Echinococcus multilocularis orexin receptor type 2 0.07 0.3828 0.3774
Trypanosoma brucei aurora B kinase 0.0112 0.0453 0.0674
Onchocerca volvulus 0.07 0.3828 1
Echinococcus multilocularis neuropeptide Y receptor 0.07 0.3828 0.3774
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.07 0.3828 0.3774
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.07 0.3828 0.6914
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Onchocerca volvulus 0.07 0.3828 1
Echinococcus multilocularis transient receptor potential cation channel 0.0059 0.0151 0.0065
Echinococcus granulosus potassium large conductance calcium activated 0.0059 0.0151 0.0065
Loa Loa (eye worm) voltage-gated calcium channel 0.0059 0.0151 0.0296
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.005 0.0096 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.07 0.3828 0.6914
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0059 0.0151 0.0296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus granulosus sodium leak channel non selective protein 0.0059 0.0151 0.0065
Brugia malayi GnHR receptor homolog 0.07 0.3828 0.7515
Loa Loa (eye worm) ion channel NompC 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni hypothetical protein 0.07 0.3828 0.6914
Schistosoma mansoni vesicular amine transporter 0.0059 0.0151 0.0256
Echinococcus granulosus g protein coupled receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0059 0.0151 0.0065
Schistosoma mansoni nAChR subunit 0.005 0.0096 0.0156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0096 0.0188
Echinococcus granulosus tubulin beta 1 chain 0.0841 0.4637 0.459
Echinococcus multilocularis neuropeptide receptor 0.07 0.3828 0.3774
Brugia malayi Cyclic-nucleotide gated cation channel 0.0059 0.0151 0.0296
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0096 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0059 0.0151 0.0296
Echinococcus multilocularis shaker cognate 0.0059 0.0151 0.0065
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0059 0.0151 0.0065
Schistosoma mansoni neuropeptide receptor 0.07 0.3828 0.6914
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0096 0.0188
Echinococcus granulosus Tubulin beta 2C chain 0.0841 0.4637 0.459
Echinococcus multilocularis voltage dependent calcium channel 0.0059 0.0151 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.07 0.3828 0.3774
Schistosoma mansoni hypothetical protein 0.07 0.3828 0.6914
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0059 0.0151 0.0296
Echinococcus granulosus transient receptor potential cation channel 0.0059 0.0151 0.0065
Schistosoma mansoni opsin-like receptor 0.07 0.3828 0.6914
Loa Loa (eye worm) tubulin beta-2A chain 0.0841 0.4637 0.9102
Schistosoma mansoni voltage-gated cation channel 0.0059 0.0151 0.0256
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0059 0.0151 0.0256
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0059 0.0151 0.0256
Echinococcus granulosus transient receptor potential cation channel 0.0059 0.0151 0.0065
Brugia malayi hypothetical protein 0.0059 0.0151 0.0296
Echinococcus granulosus short transient receptor potential channel 6 0.0059 0.0151 0.0065
Loa Loa (eye worm) tubulin beta-4 chain 0.0841 0.4637 0.9102
Brugia malayi Transient-receptor-potential like protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) voltage-gated potassium channel 0.0059 0.0151 0.0296
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.07 0.3828 0.3774
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0059 0.0151 0.0256
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Echinococcus granulosus potassium voltage gated channel protein 0.0059 0.0151 0.0065
Loa Loa (eye worm) follicle stimulating hormone receptor 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Echinococcus granulosus neuropeptide Y receptor 0.07 0.3828 0.3774
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0096 0.0009
Brugia malayi Cation transporter family protein 0.005 0.0096 0.0188
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.005 0.0096 0.0009
Onchocerca volvulus 0.07 0.3828 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.005 0.0096 0.0188
Echinococcus granulosus aurora kinase A 0.0112 0.0453 0.037
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0096 0.0156
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Loa Loa (eye worm) A-macroglobulin complement component family protein 0.0124 0.052 0.1021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0096 0.0188
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0059 0.0151 0.0256
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0059 0.0151 0.0065
Echinococcus multilocularis g protein coupled receptor 0.07 0.3828 0.3774
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.005 0.0096 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0453 0.0674
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0059 0.0151 0.0065
Trypanosoma cruzi beta tubulin, putative 0.0841 0.4637 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0917 0.5071 0.5028
Echinococcus multilocularis fmrfamide receptor 0.07 0.3828 0.3774
Echinococcus granulosus short transient receptor potential channel 6 0.0059 0.0151 0.0065
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0059 0.0151 0.0296
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0096 0.0188
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0059 0.0151 0.0256
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0059 0.0151 0.0256
Echinococcus multilocularis G protein coupled receptor 139 0.0997 0.5533 0.5493
Onchocerca volvulus 0.005 0.0096 0.006
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Schistosoma mansoni nAChR subunit 0.005 0.0096 0.0156
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) tubulin beta-1 chain 0.0841 0.4637 0.9102
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0059 0.0151 0.0296
Echinococcus multilocularis tubulin subunit beta 0.0841 0.4637 0.459
Brugia malayi Serotonin receptor 0.07 0.3828 0.7515
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Echinococcus granulosus voltage gated hydrogen channel 1 0.0059 0.0151 0.0065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0096 0.0188
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.005 0.0096 0.0188
Echinococcus multilocularis conserved hypothetical protein 0.0059 0.0151 0.0065
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.07 0.3828 0.3774
Schistosoma mansoni two-pore calcium channel 0.0059 0.0151 0.0256
Echinococcus multilocularis short transient receptor potential channel 6 0.0059 0.0151 0.0065
Echinococcus multilocularis neuropeptide s receptor 0.07 0.3828 0.3774
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.07 0.3828 0.3774
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Echinococcus granulosus biogenic amine 5HT receptor 0.07 0.3828 0.3774
Brugia malayi G-protein coupled receptor 0.07 0.3828 0.7515
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0096 0.0009
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0059 0.0151 0.0256
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0059 0.0151 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Brugia malayi olfactory channel protein osm-9 0.0059 0.0151 0.0296
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.07 0.3828 0.6914
Echinococcus multilocularis calcium activated potassium channel 0.006 0.0156 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus multilocularis Tubulin beta 2C chain 0.0841 0.4637 0.459
Echinococcus granulosus neuropeptides capa receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) BEN-1 protein 0.0841 0.4637 0.9102
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0096 0.0009
Echinococcus granulosus somatostatin receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) calcium channel 0.0059 0.0151 0.0296
Onchocerca volvulus 0.0048 0.0087 0.0035
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0453 0.0674
Onchocerca volvulus 0.07 0.3828 1
Toxoplasma gondii beta-1 tubulin, putative 0.0841 0.4637 1
Echinococcus multilocularis transfer RNA-Gly 0.0059 0.0151 0.0065
Echinococcus multilocularis aurora kinase A 0.0112 0.0453 0.037
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus multilocularis neuropeptide FF receptor 2 0.07 0.3828 0.3774
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.005 0.0096 0.0188
Brugia malayi beta-tubulin, identical 0.0841 0.4637 0.9102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0096 0.0188
Schistosoma mansoni macroglobulin/complement 0.0124 0.052 0.0924
Schistosoma mansoni opsin-like receptor 0.07 0.3828 0.6914
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0059 0.0151 0.0065
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Schistosoma mansoni biogenic amine receptor 0.07 0.3828 0.6914
Echinococcus granulosus neuropeptide s receptor 0.07 0.3828 0.3774
Echinococcus granulosus shaker cognate 0.0059 0.0151 0.0065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0096 0.0188
Echinococcus granulosus transient receptor potential cation channel 0.0059 0.0151 0.0065
Echinococcus multilocularis neuropeptide receptor 0.0997 0.5533 0.5493
Schistosoma mansoni nAChR subunit 0.005 0.0096 0.0156
Onchocerca volvulus 0.07 0.3828 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus multilocularis Tubulin beta 2C chain 0.0841 0.4637 0.459
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Brugia malayi serine/threonine protein kinase 6 0.0112 0.0453 0.089
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.005 0.0096 0.0188
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0144
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.07 0.3828 0.6914
Onchocerca volvulus 0.005 0.0096 0.006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0102 0.02
Schistosoma mansoni neuropeptide F-like receptor 0.07 0.3828 0.6914
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0059 0.0151 0.0256
Trypanosoma brucei RNA helicase, putative 0.0211 0.1019 0.1935
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.07 0.3828 0.7515
Schistosoma mansoni opsin-like receptor 0.07 0.3828 0.6914
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis neuropeptide Y receptor 0.07 0.3828 0.3774
Brugia malayi Cation transporter family protein 0.005 0.0096 0.0188
Echinococcus granulosus neuropeptide Y receptor 0.07 0.3828 0.3774
Echinococcus granulosus hypothetical protein 0.07 0.3828 0.3774
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0059 0.0151 0.0065
Schistosoma mansoni protein kinase 0.0112 0.0453 0.0803
Echinococcus multilocularis somatostatin receptor 0.07 0.3828 0.3774
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0059 0.0151 0.0065
Onchocerca volvulus 0.005 0.0096 0.006
Brugia malayi ORL1-like opioid receptor 0.07 0.3828 0.7515
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0096 0.0009
Schistosoma mansoni neuropeptide receptor 0.07 0.3828 0.6914
Schistosoma mansoni calcium-activated potassium channel 0.0059 0.0151 0.0256
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0096 0.0009
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.07 0.3828 0.3774
Brugia malayi putative neuropeptide receptor 0.07 0.3828 0.7515
Onchocerca volvulus 0.005 0.0096 0.006
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.005 0.0096 0.0156
Echinococcus granulosus g-protein coupled receptor 0.07 0.3828 0.3774
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.07 0.3828 0.3774
Onchocerca volvulus Putative nachr subunit 0.005 0.0096 0.006
Trichomonas vaginalis tubulin, putative 0.0841 0.4637 1
Echinococcus multilocularis fmrfamide receptor 0.07 0.3828 0.3774
Echinococcus granulosus tachykinin peptides receptor 99D 0.07 0.3828 0.3774
Echinococcus multilocularis hyperpolarization activated cyclic 0.0059 0.0151 0.0065
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.0051 0.0102 0.02
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0112 0.0453 0.037
Echinococcus granulosus TRP transient receptor potential channel 0.0059 0.0151 0.0065
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.07 0.3828 0.3774
Brugia malayi G protein-coupled receptor 0.07 0.3828 0.7515
Brugia malayi Unc-6 protein precursor 0.0048 0.0087 0.017
Onchocerca volvulus 0.07 0.3828 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0059 0.0151 0.0296
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Echinococcus granulosus neuropeptide receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0059 0.0151 0.0065
Echinococcus multilocularis biogenic amine (5HT) receptor 0.07 0.3828 0.3774
Schistosoma mansoni hypothetical protein 0.07 0.3828 0.6914
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni biogenic amine (5HT) receptor 0.07 0.3828 0.6914
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Onchocerca volvulus 0.0202 0.0972 0.2393
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Echinococcus granulosus beta tubulin 0.0841 0.4637 0.459
Echinococcus granulosus transient receptor potential cation channel 0.0059 0.0151 0.0065
Echinococcus multilocularis alpha 1A adrenergic receptor 0.07 0.3828 0.3774
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.005 0.0096 0.0188
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.07 0.3828 0.7515
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0059 0.0151 0.0065
Schistosoma mansoni netrin 0.0048 0.0087 0.014
Entamoeba histolytica tubulin family protein 0.0841 0.4637 1
Brugia malayi excitatory GABA receptor EXP-1A 0.005 0.0096 0.0188
Brugia malayi Dopamine receptor 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus granulosus voltage gated potassium channel 0.0059 0.0151 0.0065
Brugia malayi cation channel family protein 0.0059 0.0151 0.0296
Schistosoma mansoni growth hormone secretagogue receptor 0.07 0.3828 0.6914
Loa Loa (eye worm) voltage-gated potassium channel 0.0059 0.0151 0.0296
Schistosoma mansoni nAChR subunit 0.005 0.0096 0.0156
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.005 0.0096 0.0009
Echinococcus multilocularis Tubulin beta 2C chain 0.0841 0.4637 0.459
Echinococcus granulosus neuropeptide receptor A26 0.07 0.3828 0.3774
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0059 0.0151 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Brugia malayi follicle stimulating hormone receptor 0.07 0.3828 0.7515
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.005 0.0096 0.0009
Loa Loa (eye worm) beta-tubulin 0.0841 0.4637 0.9102
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Trichomonas vaginalis tubulin beta chain, putative 0.0841 0.4637 1
Trypanosoma cruzi aurora B kinase, putative 0.0112 0.0453 0.0674
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.07 0.3828 0.7515
Loa Loa (eye worm) BEN-1 protein 0.0841 0.4637 0.9102
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi Melatonin receptor type 1A 0.07 0.3828 0.7515
Onchocerca volvulus 0.07 0.3828 1
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0059 0.0151 0.0296
Echinococcus granulosus orexin receptor type 2 0.07 0.3828 0.3774
Echinococcus granulosus rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus multilocularis serotonin receptor 0.07 0.3828 0.3774
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0059 0.0151 0.0065
Echinococcus multilocularis alpha 2 macroglobulin 0.0124 0.052 0.0437
Brugia malayi sulfakinin receptor protein 0.0921 0.5094 1
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni transient receptor potential channel 0.0059 0.0151 0.0256
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0059 0.0151 0.0256
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis transient receptor potential cation channel 0.0059 0.0151 0.0065
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0096 0.0156
Brugia malayi serine/threonine-protein kinase 6 0.0112 0.0453 0.089
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Echinococcus multilocularis transient receptor potential cation channel 0.0059 0.0151 0.0065
Brugia malayi neuropeptide F receptor 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Echinococcus granulosus alpha 1A adrenergic receptor 0.07 0.3828 0.3774
Echinococcus granulosus transient receptor potential cation channel 0.0059 0.0151 0.0065
Echinococcus granulosus transient receptor potential cation channel 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Echinococcus multilocularis transient receptor potential cation channel 0.0059 0.0151 0.0065
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0059 0.0151 0.0296
Schistosoma mansoni netrin 0.0048 0.0087 0.014
Onchocerca volvulus 0.07 0.3828 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0841 0.4637 1
Plasmodium falciparum tubulin beta chain 0.0841 0.4637 1
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Brugia malayi hypothetical protein 0.0921 0.5094 1
Echinococcus multilocularis neuropeptide receptor A26 0.07 0.3828 0.3774
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0059 0.0151 0.0256
Schistosoma mansoni tubulin subunit beta 0.0841 0.4637 0.8378
Echinococcus multilocularis g-protein coupled receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.017
Echinococcus multilocularis two pore calcium channel protein 1 0.0059 0.0151 0.0065
Echinococcus granulosus sodium channel protein 0.0917 0.5071 0.5028
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Schistosoma mansoni tubulin subunit beta 0.0841 0.4637 0.8378
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Echinococcus multilocularis sex peptide receptor 0.07 0.3828 0.3774
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0059 0.0151 0.0065
Echinococcus granulosus tubulin beta 4A class IVa 0.0841 0.4637 0.459
Brugia malayi Serotonin/octopamine receptor family protein 7 0.07 0.3828 0.7515
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Echinococcus granulosus Tubulin beta 2C chain 0.0841 0.4637 0.459
Echinococcus granulosus g protein coupled receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) G-protein coupled receptor 0.07 0.3828 0.7515
Echinococcus multilocularis potassium large conductance calcium activated 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0096 0.0009
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0059 0.0151 0.0206
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Schistosoma mansoni biogenic amine (dopamine) receptor 0.07 0.3828 0.6914
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.07 0.3828 0.3774
Echinococcus granulosus neuropeptide receptor 0.0997 0.5533 0.5493
Echinococcus granulosus voltage dependent calcium channel 0.0059 0.0151 0.0065
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0059 0.0151 0.0256
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.07 0.3828 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0059 0.0151 0.0256
Echinococcus granulosus serotonin receptor 0.07 0.3828 0.3774
Schistosoma mansoni transient receptor potential channel 0.0059 0.0151 0.0256
Schistosoma mansoni nAChR subunit 0.005 0.0096 0.0156
Echinococcus granulosus hyperpolarization activated cyclic 0.0059 0.0151 0.0065
Giardia lamblia Beta tubulin 0.0841 0.4637 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni peptide (allatostatin)-like receptor 0.07 0.3828 0.6914
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0059 0.0151 0.0256
Schistosoma mansoni voltage-dependent calcium channel 0.0059 0.0151 0.0256
Brugia malayi larval opioid receptor 0.07 0.3828 0.7515
Echinococcus multilocularis ryanodine receptor 44f 0.0059 0.0151 0.0065
Toxoplasma gondii beta-tubulin, putative 0.0841 0.4637 1
Onchocerca volvulus 0.07 0.3828 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.07 0.3828 0.3774
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.005 0.0096 0.0009
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Echinococcus granulosus calcium activated potassium channel 0.006 0.0156 0.007
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.005 0.0096 0.0188
Echinococcus granulosus fmrfamide receptor 0.07 0.3828 0.3774
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0059 0.0151 0.0065
Loa Loa (eye worm) G-protein coupled receptor 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0166 0.0765 0.1502
Giardia lamblia Beta tubulin 0.0841 0.4637 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0059 0.0151 0.0296
Echinococcus granulosus hypothetical protein 0.0059 0.0151 0.0065
Echinococcus granulosus 7TM GPCR rhodopsin 0.07 0.3828 0.3774
Echinococcus granulosus rhodopsin orphan GPCR 0.07 0.3828 0.3774
Loa Loa (eye worm) LGC-31 protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Schistosoma mansoni alpha-1 adrenergic receptor 0.07 0.3828 0.6914
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0059 0.0151 0.0206
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0059 0.0151 0.0065
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1776 1 1
Schistosoma mansoni adenoreceptor 0.07 0.3828 0.6914
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.07 0.3828 0.7515
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0102 0.02
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.07 0.3828 0.6914
Brugia malayi Dopamine receptor protein 1 0.07 0.3828 0.7515
Onchocerca volvulus 0.07 0.3828 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Loa Loa (eye worm) neuropeptide F receptor 0.07 0.3828 0.7515
Echinococcus granulosus G protein coupled receptor 139 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.005 0.0096 0.0188
Echinococcus multilocularis tachykinin peptides receptor 99D 0.07 0.3828 0.3774
Schistosoma mansoni amine GPCR 0.07 0.3828 0.6914
Trichomonas vaginalis tubulin gamma chain, putative 0.0841 0.4637 1
Echinococcus granulosus allatostatin A receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) ACC-1 protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Brugia malayi G protein-coupled receptor F59B2.13 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.0921 0.5094 1
Echinococcus multilocularis voltage gated potassium channel 0.0059 0.0151 0.0065
Loa Loa (eye worm) TYRA-2 protein 0.07 0.3828 0.7515
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi gonadotropin-releasing hormone receptor 2 0.07 0.3828 0.7515
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0059 0.0151 0.0296
Echinococcus granulosus voltage dependent calcium channel 0.0059 0.0151 0.0065
Echinococcus multilocularis voltage dependent calcium channel 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Echinococcus granulosus rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0841 0.4637 0.459
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0059 0.0151 0.0296
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0102 0.02
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.07 0.3828 0.6914
Echinococcus multilocularis Tubulin beta 2C chain 0.0841 0.4637 0.459
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.0019
Brugia malayi Angiotensin-converting enzyme family protein 0.0166 0.0765 0.1502
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.001 0.0019
Echinococcus granulosus nAChR subunit 0.005 0.0096 0.0009
Plasmodium vivax tubulin beta chain, putative 0.0841 0.4637 1
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Onchocerca volvulus 0.0059 0.0151 0.0206
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0096 0.0009
Echinococcus granulosus hyperpolarization activated cyclic 0.0059 0.0151 0.0065
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Onchocerca volvulus 0.07 0.3828 1
Loa Loa (eye worm) hypothetical protein 0.0532 0.2863 0.5619
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Echinococcus granulosus beta tubulin 0.0841 0.4637 0.459
Echinococcus granulosus potassium voltage gated channel protein 0.0059 0.0151 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0059 0.0151 0.0065
Echinococcus multilocularis potassium voltage gated channel protein 0.0059 0.0151 0.0065
Echinococcus multilocularis dro:myosuppressin receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Loa Loa (eye worm) melatonin receptor type 1A 0.07 0.3828 0.7515
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi complement component C3-like protein 0.0046 0.0074 0.0144
Brugia malayi neuropeptide F receptor 0.07 0.3828 0.7515
Schistosoma mansoni tubulin subunit beta 0.0841 0.4637 0.8378
Echinococcus multilocularis transient receptor potential gamma protein 0.0059 0.0151 0.0065
Brugia malayi Tubulin beta-1 chain 0.0841 0.4637 0.9102
Trypanosoma brucei beta tubulin 0.0841 0.4637 1
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni biogenic amine receptor 0.07 0.3828 0.6914
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0059 0.0151 0.0296
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.07 0.3828 0.6914
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.005 0.0096 0.0009
Echinococcus granulosus transient receptor potential gamma protein 0.0059 0.0151 0.0065
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.07 0.3828 0.3774
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.005 0.0096 0.0188
Schistosoma mansoni nAChR subunit 0.005 0.0096 0.0156
Loa Loa (eye worm) AUR protein kinase 0.0112 0.0453 0.089
Schistosoma mansoni amine GPCR 0.07 0.3828 0.6914
Brugia malayi G-protein coupled receptor 0.07 0.3828 0.7515
Brugia malayi ion channel NompC 0.0059 0.0151 0.0296
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.07 0.3828 0.6914
Echinococcus granulosus potassium voltage gated channel protein 0.0059 0.0151 0.0065
Schistosoma mansoni amine GPCR 0.07 0.3828 0.6914
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Echinococcus granulosus Tubulin beta 2C chain 0.0841 0.4637 0.459
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.005 0.0096 0.0156
Echinococcus multilocularis tubulin beta 1 chain 0.0841 0.4637 0.459
Echinococcus granulosus neuropeptide FF receptor 2 0.07 0.3828 0.3774
Onchocerca volvulus 0.07 0.3828 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Schistosoma mansoni transient receptor potential channel 4 0.0059 0.0151 0.0256
Echinococcus multilocularis potassium voltage gated channel protein 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi putative neuropeptide receptor NPR1 0.07 0.3828 0.7515
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Brugia malayi hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) AUR protein kinase 0.0112 0.0453 0.089
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) tubulin beta chain 0.0841 0.4637 0.9102
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Echinococcus multilocularis g protein coupled receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0096 0.0188
Echinococcus multilocularis neuropeptides capa receptor 0.07 0.3828 0.3774
Brugia malayi RE15519p 0.07 0.3828 0.7515
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0059 0.0151 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0453 0.0674
Schistosoma mansoni neuropeptide receptor 0.07 0.3828 0.6914
Brugia malayi Dopamine receptor protein 2 0.07 0.3828 0.7515
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0059 0.0151 0.0256
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.005 0.0096 0.0188
Echinococcus granulosus dro:myosuppressin receptor 0.07 0.3828 0.3774
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0059 0.0151 0.0256
Echinococcus multilocularis Tubulin beta 2C chain 0.0841 0.4637 0.459
Echinococcus multilocularis sodium channel protein 0.0917 0.5071 0.5028
Echinococcus multilocularis potassium voltage gated channel protein 0.0059 0.0151 0.0065
Echinococcus multilocularis cd109 antigen 0.0115 0.0468 0.0385
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0059 0.0151 0.0296
Onchocerca volvulus 0.005 0.0096 0.006
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0059 0.0151 0.0065
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.005 0.0096 0.0009
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Echinococcus multilocularis neuropeptides capa receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Giardia lamblia Beta tubulin 0.0841 0.4637 1
Loa Loa (eye worm) ryanodine receptor 0.0059 0.0151 0.0296
Schistosoma mansoni transient receptor potential channel 0.0059 0.0151 0.0256
Echinococcus multilocularis beta tubulin 0.0841 0.4637 0.459
Echinococcus multilocularis g protein coupled receptor 0.07 0.3828 0.3774
Loa Loa (eye worm) ACC-1 protein 0.005 0.0096 0.0188
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0059 0.0151 0.0065
Brugia malayi serine/threonine kinase 12 0.0112 0.0453 0.089
Brugia malayi Tachykinin-like peptides receptor 99D 0.07 0.3828 0.7515
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0059 0.0151 0.0065
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni hypothetical protein 0.0211 0.1019 0.1827
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0059 0.0151 0.0256
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Echinococcus granulosus ryanodine receptor 44f 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Brugia malayi hypothetical protein 0.0056 0.0133 0.0262
Brugia malayi Cation transporter family protein 0.005 0.0096 0.0188
Echinococcus granulosus two pore calcium channel protein 1 0.0059 0.0151 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus granulosus biogenic amine 5HT receptor 0.07 0.3828 0.3774
Onchocerca volvulus 0.07 0.3828 1
Schistosoma mansoni histamine h1 receptor 0.07 0.3828 0.6914
Echinococcus granulosus voltage gated potassium channel 0.0059 0.0151 0.0065
Onchocerca volvulus 0.005 0.0096 0.006
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Trichomonas vaginalis tubulin alpha chain, putative 0.0841 0.4637 1
Onchocerca volvulus 0.07 0.3828 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.07 0.3828 0.3774
Echinococcus multilocularis nAChR subunit 0.005 0.0096 0.0009
Brugia malayi AKH receptor 0.07 0.3828 0.7515
Entamoeba histolytica tubulin family protein 0.0841 0.4637 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0059 0.0151 0.0065
Toxoplasma gondii aurora kinase 0.0112 0.0453 0.0674
Echinococcus granulosus cd109 antigen 0.0115 0.0468 0.0385
Echinococcus granulosus rhodopsin orphan GPCR 0.07 0.3828 0.3774
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0059 0.0151 0.0065
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.07 0.3828 0.6914
Schistosoma mansoni neuropeptide receptor 0.0997 0.5533 1
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.07 0.3828 0.7515
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0059 0.0151 0.0256
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.005 0.0096 0.0188
Loa Loa (eye worm) voltage-dependent calcium channel 0.0059 0.0151 0.0296
Brugia malayi cation channel family protein 0.0059 0.0151 0.0296
Echinococcus multilocularis voltage gated potassium channel 0.0059 0.0151 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0453 0.0803
Echinococcus granulosus two pore calcium channel protein 2 0.0059 0.0151 0.0065
Echinococcus multilocularis sodium leak channel non selective protein 0.0059 0.0151 0.0065
Brugia malayi voltage-dependent calcium channel 0.0059 0.0151 0.0296
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0453 0.0674
Schistosoma mansoni tubulin subunit beta 0.0841 0.4637 0.8378
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.005 0.0096 0.0188
Loa Loa (eye worm) AUR protein kinase 0.0112 0.0453 0.089
Schistosoma mansoni tubulin subunit beta 0.0841 0.4637 0.8378
Trichomonas vaginalis tubulin epsilon chain, putative 0.0841 0.4637 1
Trypanosoma brucei beta tubulin 0.0841 0.4637 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.0056 0.0133 0.0262
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0096 0.0009
Echinococcus granulosus potassium voltage gated channel protein 0.0059 0.0151 0.0065
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0059 0.0151 0.0296
Schistosoma mansoni nAChR subunit 0.005 0.0096 0.0156
Echinococcus multilocularis short transient receptor potential channel 6 0.0059 0.0151 0.0065
Echinococcus multilocularis serotonin receptor 0.07 0.3828 0.3774
Schistosoma mansoni neuropeptide f receptor 76f 0.07 0.3828 0.6914
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.005 0.0096 0.0156
Schistosoma mansoni voltage-gated ion channel 0.0059 0.0151 0.0256
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Echinococcus granulosus potassium voltage gated channel protein 0.0059 0.0151 0.0065
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0112 0.0453 0.037
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Schistosoma mansoni biogenic amine receptor 0.07 0.3828 0.6914
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0059 0.0151 0.0296
Schistosoma mansoni 60S ribosomal protein L21 0.0059 0.0151 0.0256
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.005 0.0096 0.0009
Echinococcus granulosus Tubulin beta 2C chain 0.0841 0.4637 0.459
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.07 0.3828 0.6914
Onchocerca volvulus 0.07 0.3828 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0059 0.0151 0.0065
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0917 0.5071 1
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Trypanosoma brucei beta tubulin 0.0841 0.4637 1
Leishmania major protein kinase, putative 0.0112 0.0453 0.0614
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0151 0.0256
Schistosoma mansoni hypothetical protein 0.0059 0.0151 0.0256
Schistosoma mansoni neuropeptide F-like receptor 0.07 0.3828 0.6914
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.005 0.0096 0.0009
Echinococcus multilocularis hyperpolarization activated cyclic 0.0059 0.0151 0.0065
Onchocerca volvulus 0.07 0.3828 1
Brugia malayi Serotonin receptor 0.07 0.3828 0.7515
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.005 0.0096 0.0188
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus granulosus tm gpcr rhodopsin 0.07 0.3828 0.3774
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Schistosoma mansoni biogenic amine (5HT) receptor 0.07 0.3828 0.6914
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0096 0.0009
Echinococcus multilocularis transient receptor potential cation channel 0.0059 0.0151 0.0065
Loa Loa (eye worm) neuropeptide F receptor 0.07 0.3828 0.7515
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus granulosus neuropeptides capa receptor 0.07 0.3828 0.3774
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0096 0.0009
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.07 0.3828 0.7515
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.005 0.0096 0.0188
Loa Loa (eye worm) hypothetical protein 0.07 0.3828 0.7515
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0096 0.0009
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.07 0.3828 0.6914
Leishmania major beta tubulin 0.0841 0.4637 0.9117
Schistosoma mansoni ryanodine receptor related 0.0059 0.0151 0.0256
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0059 0.0151 0.0065
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0059 0.0151 0.0065
Echinococcus granulosus 7tm_1 domain containing protein 0.07 0.3828 0.3774

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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