Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 4 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Metabotropic glutamate receptor 4 | 912 aa | 841 aa | 21.0 % | |
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 4 | 912 aa | 881 aa | 20.9 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 4 | 912 aa | 874 aa | 39.1 % |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 4 | 912 aa | 903 aa | 25.6 % |
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 4 | 912 aa | 826 aa | 34.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor type 2 | 0.006 | 0.1592 | 0.1592 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0209 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.015 | 0.6717 | 0.4522 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0209 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0209 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0209 | 1 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0122 | 0.5124 | 0.5124 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0209 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0209 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0209 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0209 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0209 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0209 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0209 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0209 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.015 | 0.6717 | 0.4522 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0209 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0111 | 0.4476 | 0.4476 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0209 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0209 | 1 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0048 | 0.0944 | 0.0944 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0122 | 0.5124 | 0.5124 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0139 | 0.6069 | 0.5324 |
Trypanosoma brucei | protein kinase, putative | 0.0209 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0209 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0209 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0209 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0102 | 0.4006 | 0.2871 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.6717 | 0.6717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 49.9 % | Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization relative to PHCCC | ChEMBL. | 21247167 |
Activity (binding) | = 87.1 % | Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization relative to PHCCC | ChEMBL. | 21247167 |
EC50 (binding) | = 2970 nM | Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | ChEMBL. | 21247167 |
EC50 (binding) | = 4720 nM | Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | ChEMBL. | 21247167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.