TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 423.483 | Formula: C23H26FN5O2
H donors: 2 H acceptors: 2 LogP: 5.3 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Nc1nc(Nc2ccc(c(c2)F)OC)cc(n1)N1CCCCC1
InChi: 1S/C23H26FN5O2/c1-30-18-9-6-16(7-10-18)26-23-27-21(15-22(28-23)29-12-4-3-5-13-29)25-17-8-11-20(31-2)19(24)14-17/h6-11,14-15H,3-5,12-13H2,1-2H3,(H2,25,26,27,28)
InChiKey: BKSLIZMQZRUQNA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	galanin receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	allatostatin A receptor	Get druggable targets OG5_128775	All targets in OG5_128775
Schistosoma mansoni	peptide (allatostatin)-like receptor	Get druggable targets OG5_128775	All targets in OG5_128775
Echinococcus multilocularis	allatostatin A receptor	Get druggable targets OG5_128775	All targets in OG5_128775
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128775	All targets in OG5_128775
Schistosoma japonicum	ko:K04233 galanin receptor, invertebrate, putative	Get druggable targets OG5_128775	All targets in OG5_128775
Onchocerca volvulus		Get druggable targets OG5_128775	All targets in OG5_128775

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	myosin xvIII	0.0051	0.0572	0.0572
Echinococcus granulosus	dro:myosuppressin receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	follicle stimulating hormone receptor	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Giardia lamblia	Prenyltransferase	0.0054	0.0624	0.3913
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0572	0.0572
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0572	0.0651
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0022	0.0041	0.012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Brugia malayi	Serotonin receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Schistosoma mansoni	hypothetical protein	0.0022	0.003	0.003
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	adenoreceptor	0.0051	0.0572	0.0572
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0572	0.0572
Brugia malayi	hypothetical protein	0.0045	0.0462	0.0526
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0572	0.0572
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0572	0.0651
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0572	0.0651
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0572	0.0572
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	hypothetical protein	0.0051	0.0572	0.0572
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1705	0.1941
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0022	0.0039	0.0048
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0572	0.0651
Plasmodium vivax	aspartyl proteinase, putative	0.0045	0.0462	0.1468
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	hypothetical protein	0.0045	0.0462	0.0526
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Echinococcus granulosus	neuroendocrine convertase 2	0.0181	0.2954	0.3363
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0056	0.0654	0.2076
Brugia malayi	larval opioid receptor	0.0051	0.0572	0.0651
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Schistosoma mansoni	growth hormone secretagogue receptor	0.0051	0.0572	0.0572
Schistosoma mansoni	hypothetical protein	0.0208	0.3443	0.3443
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0051	0.0572	0.0651
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0054	0.0624	0.1983
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0192	0.3148	0.3584
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Schistosoma mansoni	hypothetical protein	0.0051	0.0572	0.0572
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Schistosoma mansoni	histamine h1 receptor	0.0051	0.0572	0.0572
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0056	0.0654	0.2076
Brugia malayi	ORL1-like opioid receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	TK/ROR protein kinase	0.0024	0.0078	0.0089
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Giardia lamblia	High cysteine membrane protein Group 2	0.0107	0.1596	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0192	0.3148	1
Schistosoma mansoni	hypothetical protein	0.0396	0.69	0.69
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Onchocerca volvulus		0.0051	0.0572	0.0709
Onchocerca volvulus		0.0051	0.0572	0.0709
Echinococcus multilocularis	neuropeptide s receptor	0.0051	0.0572	0.0651
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Plasmodium vivax	plasmepsin V, putative	0.0045	0.0462	0.1468
Plasmodium falciparum	plasmepsin VIII, putative	0.0045	0.0462	0.1468
Echinococcus multilocularis	tissue type plasminogen activator	0.0022	0.0039	0.0044
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0192	0.3148	0.3148
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0054	0.0624	0.1983
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0051	0.0572	0.0651
Echinococcus granulosus	MAM	0.0022	0.003	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0572	0.0572
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0068	0.088	0.2794
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0054	0.0624	0.1983
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0068	0.088	0.2794
Onchocerca volvulus		0.0051	0.0572	0.0709
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0039	0.0355	0.1127
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0045	0.0462	0.0526
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0045	0.0462	0.0573
Plasmodium falciparum	plasmepsin V	0.0045	0.0462	0.1468
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0051	0.0572	0.0651
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.69	0.7856
Echinococcus granulosus	7TM GPCR rhodopsin	0.0051	0.0572	0.0651
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0572	0.0651
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0034
Schistosoma mansoni	neuropeptide f receptor 76f	0.0051	0.0572	0.0572
Loa Loa (eye worm)	TYRA-2 protein	0.0051	0.0572	0.0651
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0499	0.8783	1
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Schistosoma mansoni	amine GPCR	0.0051	0.0572	0.0572
Echinococcus granulosus	G protein coupled receptor 139	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Brugia malayi	RE15519p	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0039	0.0536
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0192	0.3148	0.3584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Loa Loa (eye worm)	TK/ALK protein kinase	0.0024	0.0069	0.0079
Onchocerca volvulus		0.0051	0.0572	0.0709
Onchocerca volvulus		0.0051	0.0572	0.0709
Echinococcus granulosus	neuropeptide receptor A26	0.0051	0.0572	0.0651
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0192	0.3148	0.3584
Echinococcus granulosus	hypothetical protein	0.0051	0.0572	0.0651
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0572	0.0651
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0051	0.0572	0.0709
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0051	0.0572	0.0651
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0572	0.0572
Leishmania major	lanosterol synthase, putative	0.0045	0.0451	0.7229
Echinococcus granulosus	sex peptide receptor	0.0051	0.0572	0.0651
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0045	0.0462	0.1468
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0051	0.0572	0.0572
Trypanosoma cruzi	lanosterol synthase, putative	0.0059	0.0721	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0572	0.0651
Trypanosoma brucei	RNA helicase, putative	0.0208	0.3443	1
Brugia malayi	AKH receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Echinococcus multilocularis	dro:myosuppressin receptor	0.0051	0.0572	0.0651
Echinococcus granulosus	ephrin type A receptor 4 A	0.0195	0.3213	0.3658
Echinococcus multilocularis	neuropeptide receptor A26	0.0051	0.0572	0.0651
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0572	0.0572
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Echinococcus multilocularis	Furin 1	0.0068	0.088	0.1001
Plasmodium falciparum	plasmepsin VII	0.0045	0.0462	0.1468
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0054	0.0624	0.1813
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	TK/EPH protein kinase	0.0248	0.4185	0.4764
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0068	0.088	0.2794
Plasmodium falciparum	plasmepsin III	0.0045	0.0462	0.1468
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0572	0.0651
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0051	0.0572	0.0651
Echinococcus multilocularis	G protein coupled receptor 139	0.0051	0.0572	0.0651
Brugia malayi	sulfakinin receptor protein	0.0051	0.0572	0.0651
Toxoplasma gondii	aspartyl protease ASP1	0.0192	0.3148	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0034
Echinococcus multilocularis	allatostatin A receptor	0.046	0.8069	0.9187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0462	0.0526
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0051	0.0572	0.0651
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0572	0.0651
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0051	0.0572	0.0651
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0499	0.8783	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0039	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0572	0.0572
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.046	0.8069	0.9187
Toxoplasma gondii	kringle domain-containing protein	0.0022	0.0039	0.0123
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0054	0.0624	0.0624
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	memapsin-2 (A01 family)	0.0045	0.0462	0.0462
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0572	0.0651
Echinococcus granulosus	g-protein coupled receptor	0.0051	0.0572	0.0651
Plasmodium falciparum	plasmepsin IX	0.0045	0.0462	0.1468
Trypanosoma cruzi	lanosterol synthase, putative	0.0059	0.0721	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	G protein-coupled receptor F59B2.13	0.0051	0.0572	0.0651
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0051	0.0572	0.0651
Echinococcus multilocularis	sex peptide receptor	0.0051	0.0572	0.0651
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0069	0.0079
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Schistosoma mansoni	amine GPCR	0.0051	0.0572	0.0572
Brugia malayi	neuroendocrine convertase 1 precursor	0.0181	0.2954	0.3363
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0192	0.3148	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Schistosoma mansoni	furin-1 (S08 family)	0.0125	0.1931	0.1931
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0572	0.0651
Brugia malayi	neuropeptide F receptor	0.0051	0.0572	0.0651
Brugia malayi	ephrin receptor 1 precursor	0.0093	0.134	0.1525
Plasmodium vivax	aspartyl protease, putative	0.0045	0.0462	0.1468
Trypanosoma brucei	lanosterol synthase	0.0059	0.0721	0.2093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0022	0.003	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3174	0.3614
Brugia malayi	G-protein coupled receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Schistosoma mansoni	ephrin receptor	0.0195	0.3213	0.3213
Brugia malayi	G protein-coupled receptor	0.0051	0.0572	0.0651
Brugia malayi	Melatonin receptor type 1A	0.0051	0.0572	0.0651
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0051	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0288	0.4918	0.56
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0051	0.0572	0.0651
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Schistosoma mansoni	hypothetical protein	0.0051	0.0572	0.0572
Onchocerca volvulus		0.0045	0.0462	0.0573
Brugia malayi	neuropeptide F receptor	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0572	0.0651
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0068	0.088	0.2794
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0054	0.0624	0.1983
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0572	0.0572
Echinococcus multilocularis	neuroendocrine convertase 2	0.0181	0.2954	0.3363
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0054	0.0624	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0051	0.0572	0.0651
Echinococcus granulosus	furin	0.0288	0.4918	0.56
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0068	0.088	0.2794
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1434	0.1633
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	endoprotease bli-4 precursor	0.0288	0.4918	0.56
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Echinococcus multilocularis	serotonin receptor	0.0051	0.0572	0.0651
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Brugia malayi	GnHR receptor homolog	0.0051	0.0572	0.0651
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0051	0.0572	0.0572
Loa Loa (eye worm)	endoprotease bli-4	0.0288	0.4918	0.56
Plasmodium falciparum	cysteine repeat modular protein 1	0.0022	0.0039	0.0123
Echinococcus granulosus	serotonin receptor	0.0051	0.0572	0.0651
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0054	0.0624	0.0711
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0051	0.0572	0.0572
Brugia malayi	hypothetical protein	0.0022	0.003	0.0034
Echinococcus granulosus	tissue type plasminogen activator	0.0022	0.0039	0.0044
Schistosoma mansoni	hypothetical protein	0.0051	0.0572	0.0572
Echinococcus granulosus	allatostatin A receptor	0.046	0.8069	0.9187
Echinococcus granulosus	orexin receptor type 2	0.0051	0.0572	0.0651
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0175	0.2844	0.9037
Brugia malayi	aspartic protease BmAsp-1, identical	0.0045	0.0462	0.0526
Echinococcus granulosus	neuropeptide FF receptor 2	0.0499	0.8783	1
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Echinococcus multilocularis	MAM	0.0022	0.003	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Schistosoma mansoni	hypothetical protein	0.0056	0.0654	0.0654
Brugia malayi	Dopamine receptor protein 2	0.0051	0.0572	0.0651
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0572	0.0572
Echinococcus granulosus	Furin 1	0.0068	0.088	0.1001
Schistosoma mansoni	hypothetical protein	0.0022	0.0039	0.0039
Onchocerca volvulus		0.0029	0.0163	0.0203
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0051	0.0572	0.0651
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0054	0.0624	0.1983
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0051	0.0572	0.0651
Toxoplasma gondii	aspartyl protease	0.0045	0.0462	0.1468
Toxoplasma gondii	aspartyl protease ASP3	0.0045	0.0462	0.1468
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.69	0.7856
Schistosoma mansoni	hypothetical protein	0.0022	0.003	0.003
Plasmodium vivax	plasmepsin IV, putative	0.0192	0.3148	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0051	0.0572	0.0651
Brugia malayi	proprotein convertase 2	0.0181	0.2954	0.3363
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0068	0.088	0.088
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0054	0.0624	0.0711
Echinococcus multilocularis	serotonin receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0572	0.0651
Leishmania major	farnesyltransferase beta subunit	0.0054	0.0624	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0068	0.088	0.2794
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	G-protein coupled receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0051	0.0572	0.0651
Schistosoma mansoni	opsin-like receptor	0.0051	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0499	0.8783	1
Echinococcus multilocularis	somatostatin receptor	0.0051	0.0572	0.0651
Plasmodium vivax	aspartyl proteinase, putative	0.0192	0.3148	1
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0572	0.0572
Schistosoma mansoni	amine GPCR	0.0051	0.0572	0.0572
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0572	0.0651
Brugia malayi	Pepsin A precursor	0.0045	0.0462	0.0526
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0051	0.0572	0.0651
Brugia malayi	putative neuropeptide receptor NPR1	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0192	0.3148	0.3584
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0045	0.0462	0.0526
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0175	0.2844	0.3238
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0572	0.0651
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0022	0.0041	0.0572
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0054	0.0624	0.0711
Brugia malayi	Dopamine receptor protein 1	0.0051	0.0572	0.0651
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	amine GPCR	0.0051	0.0572	0.0572
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0051	0.0572	0.0651
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0054	0.0624	0.1983
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0193	0.3174	0.3933
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0572	0.0651
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.046	0.8069	0.8069
Plasmodium falciparum	plasmepsin VI	0.0192	0.3148	1
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0054	0.0624	0.0711
Schistosoma mansoni	opsin-like receptor	0.0051	0.0572	0.0572
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0572	0.0651
Brugia malayi	putative neuropeptide receptor	0.0051	0.0572	0.0651
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0051	0.0572	0.0651
Echinococcus granulosus	fmrfamide receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0572	0.0651
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0054	0.0624	0.1983
Brugia malayi	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0572	0.0572
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0572	0.0651
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0051	0.0572	0.0651
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0051	0.0572	0.0572
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	aspartyl protease 6	0.0045	0.0462	0.0526
Echinococcus granulosus	somatostatin receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0051	0.0572	0.0572
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0054	0.0624	0.1983
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	Serotonin receptor	0.0051	0.0572	0.0651
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0195	0.3213	0.3658
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0175	0.2844	0.3238
Plasmodium falciparum	plasmepsin X	0.0045	0.0462	0.1468
Leishmania major	hypothetical protein, conserved	0.0022	0.0039	0.0619
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0572	0.0651
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0175	0.2844	0.9037
Toxoplasma gondii	subtilisin SUB12	0.0027	0.012	0.0383
Schistosoma mansoni	cathepsin D (A01 family)	0.0565	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Echinococcus multilocularis	orexin receptor type 2	0.0051	0.0572	0.0651
Trichomonas vaginalis	hypothetical protein	0.0056	0.0654	0.2076
Brugia malayi	Kringle domain containing protein	0.0022	0.0039	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0078	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0572	0.0651
Plasmodium falciparum	plasmepsin II	0.0192	0.3148	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	celfurPC protein	0.0233	0.3896	0.4435
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0462	0.0526
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Plasmodium vivax	aspartyl protease, putative	0.0045	0.0462	0.1468
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0022	0.0039	0.0123
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0572	0.0572
Loa Loa (eye worm)	melatonin receptor type 1A	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Plasmodium falciparum	plasmepsin IV	0.0192	0.3148	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0572	0.0651
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0572	0.0572
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0572	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Brugia malayi	Dopamine receptor	0.0051	0.0572	0.0651
Plasmodium vivax	aspartyl protease, putative	0.0045	0.0462	0.1468
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0056	0.0654	0.2076
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0127	0.0144
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0051	0.0572	0.0709
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0054	0.0624	0.1983
Onchocerca volvulus		0.0051	0.0572	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0054	0.0624	0.8661
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0654	0.2076
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0288	0.4918	0.4918
Onchocerca volvulus		0.046	0.8069	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0572	0.0651
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0051	0.0572	0.0572
Schistosoma mansoni	opsin-like receptor	0.0051	0.0572	0.0572
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0572	0.0651
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0054	0.0624	0.8661
Echinococcus granulosus	neuropeptide s receptor	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0045	0.0462	0.0462
Loa Loa (eye worm)	proprotein convertase 2	0.0068	0.088	0.1001
Echinococcus multilocularis		0.0233	0.3896	0.4435
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0051	0.0572	0.0651
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0572	0.0572
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0051	0.0572	0.0651
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0059	0.0721	0.5
Plasmodium falciparum	plasmepsin I	0.0192	0.3148	1
Echinococcus multilocularis	g-protein coupled receptor	0.0051	0.0572	0.0651
Giardia lamblia	Furin precursor putative serine protease	0.0056	0.0654	0.4096
Schistosoma mansoni	amine GPCR	0.0051	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0572	0.0651
Onchocerca volvulus		0.0051	0.0572	0.0709
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0022	0.0041	0.0572
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0572	0.0572
Onchocerca volvulus		0.0051	0.0572	0.0709
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0051	0.0572	0.0572
Brugia malayi	aspartic protease BmAsp-2, identical	0.0045	0.0462	0.0526
Onchocerca volvulus		0.0051	0.0572	0.0709

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.43 uM	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL.	22018787
Inhibition (binding)	> 50 %	Displacement of [125I]galanin from GalR2 at 1 uM by gamma counting	ChEMBL.	22018787
Inhibition (binding)	> 50 %	Displacement of [125I]galanin from GalR2 at 10 uM by gamma counting	ChEMBL.	22018787
Inhibition (binding)	= 60 %	Displacement of [125I]galanin from GalR1 at 1 uM by gamma counting	ChEMBL.	22018787
Inhibition (binding)	= 60 %	Displacement of [125I]galanin from GalR1 at 10 uM by gamma counting	ChEMBL.	22018787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1922010

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1564312