TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.4 | Formula: C20H21N3O2
H donors: 2 H acceptors: 3 LogP: 2.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)c1ccc2c(c1)ccc(c2)C1(O)c2cncn2CC1(C)C
InChi: 1S/C20H21N3O2/c1-19(2)11-23-12-22-10-17(23)20(19,25)16-7-6-13-8-15(18(24)21-3)5-4-14(13)9-16/h4-10,12,25H,11H2,1-3H3,(H,21,24)
InChiKey: VFQVXPOUVYTBQX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 17, subfamily A, polypeptide 1	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	References
Rattus norvegicus	Cytochrome P450 17A1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	cytochrome P450 similar to phenylacetate hydroxylase	Cytochrome P450 17A1	507 aa	510 aa	19.6 %
Loa Loa (eye worm)	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	454 aa	25.3 %
Candida albicans	cytochrome P450 similar to phenylacetate hydroxylase	Cytochrome P450 17A1	507 aa	510 aa	19.6 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	532 aa	25.4 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	490 aa	20.4 %
Trypanosoma cruzi	cytochrome P450, putative	Cytochrome P450 17A1	507 aa	428 aa	22.9 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	502 aa	23.1 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	502 aa	22.5 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	485 aa	24.3 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	502 aa	25.5 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	518 aa	24.7 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	413 aa	24.5 %
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	424 aa	24.3 %
Drosophila melanogaster	Cytochrome P450-4d1	Cytochrome P450 17A1	507 aa	465 aa	24.1 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	423 aa	22.9 %
Drosophila melanogaster	shadow	Cytochrome P450 17A1	507 aa	470 aa	23.0 %
Onchocerca volvulus		Cytochrome P450 17A1	507 aa	453 aa	24.1 %
Trypanosoma cruzi	cytochrome P450, putative	Cytochrome P450 17A1	507 aa	428 aa	22.7 %
Drosophila melanogaster	CG7241 gene product from transcript CG7241-RA	Cytochrome P450 17A1	507 aa	477 aa	27.9 %
Brugia malayi	Cytochrome P450 family protein	Cytochrome P450 17A1	507 aa	434 aa	25.6 %
Brugia malayi	Cytochrome P450 family protein	cytochrome P450, family 17, subfamily A, polypeptide 1	508 aa	468 aa	25.2 %
Drosophila melanogaster	CG1829 gene product from transcript CG1829-RB	Cytochrome P450 17A1	507 aa	476 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3081
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0146	0.0928	0.3084
Plasmodium vivax	ferrodoxin reductase, putative	0.0039	0.0117	0.039
Schistosoma mansoni	glutamate synthase	0.0039	0.0117	0.0074
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0039	0.0117	0.1153
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0177	0.0178
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0146	0.0928	0.3084
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0117	0.0386
Schistosoma mansoni	sulfide quinone reductase	0.0039	0.0117	0.0074
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0039	0.0117	0.039
Brugia malayi	jmjC domain containing protein	0.0035	0.009	0.0199
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0177	0.0178
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0039	0.0117	0.1265
Echinococcus granulosus	glutamate synthase	0.0039	0.0117	0.0148
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0109	0.0651	0.0824
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0083	0.0449	0.0406
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.009	0.0079
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0167	0.0209
Echinococcus granulosus	dna polymerase kappa	0.0135	0.0847	0.1619
Trypanosoma brucei	DNA polymerase IV, putative	0.0129	0.0798	0.2653
Loa Loa (eye worm)	hypothetical protein	0.016	0.1031	0.2297
Schistosoma mansoni	rotamase	0.0066	0.0321	0.0278
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0088	0.0493	0.0764
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.03	0.2091	0.695
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0095	0.0544	0.0852
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0039	0.0117	0.0148
Loa Loa (eye worm)	hypothetical protein	0.005	0.0201	0.0446
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0039	0.0117	0.0149
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0039	0.0117	0.0259
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Toxoplasma gondii	hypothetical protein	0.0048	0.019	0.0632
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0087	0.0431
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0142	0.0896	0.1134
Schistosoma mansoni	glutamate synthase	0.0039	0.0117	0.0074
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.001	0.003
Wolbachia endosymbiont of Brugia malayi	NADPH-dependent glutamate synthase beta chain	0.0039	0.0117	0.1265
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Echinococcus granulosus	tumor protein p63	0.033	0.2314	0.4576
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0039	0.0117	0.1265
Giardia lamblia	Thioredoxin reductase	0.0039	0.0117	0.0371
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0189	0.0145
Loa Loa (eye worm)	glutathione reductase	0.0422	0.3009	0.6713
Echinococcus granulosus	L aminoadipate semialdehyde	0.0083	0.0449	0.0815
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0039	0.0117	0.0386
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0039	0.0117	0.0149
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0146	0.0928	0.1507
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0167	0.0369
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0039	0.0117	0.1153
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0109	0.0651	0.1035
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0039	0.0117	0.0371
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0064	0.031	0.1025
Trypanosoma brucei	chrX additional, unordered contigs	0.0034	0.0081	0.0269
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3081
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.004	0.013	0.0431
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0039	0.0117	0.0061
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0039	0.0117	0.0148
Leishmania major	hypothetical protein, conserved	0.0039	0.0117	0.039
Leishmania major	hypothetical protein, conserved	0.0039	0.0117	0.039
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0039	0.0117	0.0386
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0536	0.0891
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0085	0.0468	0.0855
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0084	0.0461	0.1531
Trichomonas vaginalis	glutamate synthase, putative	0.0039	0.0117	0.0061
Plasmodium vivax	glutathione reductase, putative	0.0422	0.3009	1
Trypanosoma brucei	unspecified product	0.0075	0.0395	0.1311
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0083	0.0449	0.0998
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0094	0.0536	0.0838
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.03	0.2091	0.6949
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0806	0.5911	1
Brugia malayi	Pre-SET motif family protein	0.0617	0.4482	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0962	0.7089	0.8974
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0064	0.031	0.1029
Brugia malayi	beta-NAC-like protein	0.0035	0.0087	0.0191
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0039	0.0117	0.0061
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0039	0.0117	0.1153
Leishmania major	DNA polymerase eta, putative	0.016	0.1031	0.3425
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0039	0.0117	0.039
Trichomonas vaginalis	DNA polymerase eta, putative	0.0135	0.0847	0.1508
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0116	0.07	0.2325
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.03	0.2091	0.6949
Trypanosoma cruzi	DNA damage repair protein, putative	0.0034	0.0081	0.0265
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0094	0.0536	0.0968
Plasmodium falciparum	ferrodoxin reductase-like protein	0.0039	0.0117	0.039
Echinococcus multilocularis	microtubule associated protein 2	0.0686	0.5004	0.8454
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.0039	0.0117	0.039
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.001	0.0034
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0039	0.0117	0.0061
Echinococcus multilocularis	geminin	0.0168	0.1096	0.1794
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0146	0.0928	0.3084
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0146	0.0928	0.2068
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0167	0.0123
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0117	0.1153
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0095	0.0544	0.1007
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0039	0.0117	0.0386
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0039	0.0117	0.0061
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Brugia malayi	polk-prov protein	0.006	0.0277	0.0615
Mycobacterium ulcerans	hypothetical protein	0.0158	0.1019	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3081
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0146	0.0928	0.3084
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.009	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0189	0.0419
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0143	0.0472
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0039	0.0117	0.039
Echinococcus multilocularis	glutamate synthase	0.0039	0.0117	0.0125
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0044	0.0146
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0962	0.7089	0.8974
Schistosoma mansoni	hypothetical protein	0.0039	0.0117	0.0074
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0107	0.0635	0.1415
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0109	0.0651	0.3226
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0039	0.0117	0.0582
Mycobacterium tuberculosis	Probable dehydrogenase	0.0962	0.7089	0.8974
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0146	0.0928	0.3084
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0039	0.0117	0.0148
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0443	0.1473
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0039	0.0117	0.1153
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.001	0.0034
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0039	0.0117	0.039
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0088	0.0493	0.0764
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0039	0.0117	0.0149
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0088	0.0493	0.1637
Leishmania major	DNA polymerase kappa, putative	0.0116	0.07	0.2325
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0146	0.0928	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.009	0.0046
Echinococcus multilocularis	expressed protein	0.0066	0.0321	0.0472
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Toxoplasma gondii	peptidylprolyl isomerase	0.0064	0.031	0.1029
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0146	0.0928	0.3084
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0039	0.0117	0.0582
Brugia malayi	MH2 domain containing protein	0.0119	0.0721	0.1605
Echinococcus granulosus	jumonji domain containing protein	0.004	0.013	0.0173
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.0897	0.2979
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0039	0.0117	0.0061
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0146	0.0928	1
Onchocerca volvulus		0.0039	0.0117	0.0144
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0146	0.0928	1
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0117	0.039
Leishmania major	cytochrome p450-like protein	0.0023	0.0001	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0094	0.0536	0.0992
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0001	0.0004
Schistosoma mansoni	hypothetical protein	0.0168	0.1096	0.1057
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0081	0.0269
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0087	0.0289
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0039	0.0117	0.0582
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0001	0.0012
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.1069	0.79	1
Schistosoma mansoni	hypothetical protein	0.0168	0.1096	0.1057
Loa Loa (eye worm)	hypothetical protein	0.006	0.0277	0.0615
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0146	0.0928	0.4478
Trypanosoma brucei	unspecified product	0.0075	0.0395	0.1311
Trypanosoma brucei	DNA polymerase kappa, putative	0.0116	0.07	0.2325
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0396	0.0353
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0088	0.0493	0.045
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0087	0.0285
Echinococcus multilocularis	dna polymerase eta	0.016	0.1031	0.1682
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0044	0.0146
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.029	0.2018	1
Schistosoma mansoni	microtubule-associated protein tau	0.0686	0.5004	0.4982
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0039	0.0117	0.0582
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0167	0.0369
Plasmodium falciparum	thioredoxin reductase	0.0146	0.0928	0.3084
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0039	0.0117	0.0061
Mycobacterium ulcerans	monoxygenase	0.0039	0.0117	0.1153
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0087	0.0191
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0039	0.0117	0.039
Plasmodium falciparum	DNA repair protein REV1, putative	0.0034	0.0081	0.0269
Trypanosoma cruzi	trypanothione reductase, putative	0.0422	0.3009	1
Onchocerca volvulus		0.0048	0.0189	0.0285
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0039	0.0117	0.0061
Trypanosoma brucei	DNA damage repair protein, putative	0.0034	0.0081	0.0269
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0039	0.0117	0.039
Schistosoma mansoni	kinase	0.0048	0.0186	0.0143
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0117	0.0386
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0109	0.0651	0.1224
Brugia malayi	PHD-finger family protein	0.0029	0.0044	0.0096
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0039	0.0117	0.0149
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0039	0.0117	0.1153
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0321	0.0465
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0146	0.0928	0.3084
Leishmania major	NADH dehydrogenase, putative	0.0039	0.0117	0.039
Mycobacterium ulcerans	DNA polymerase IV	0.0135	0.0847	0.8316
Trypanosoma brucei	trypanothione reductase	0.0422	0.3009	1
Leishmania major	hypothetical protein, conserved	0.0025	0.001	0.0034
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0135	0.0847	0.2812
Onchocerca volvulus		0.0083	0.0449	0.0796
Trichomonas vaginalis	set domain proteins, putative	0.0702	0.5126	1
Brugia malayi	glutamate synthase	0.0039	0.0117	0.0259
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3081
Echinococcus multilocularis	tumor protein p63	0.033	0.2314	0.3869
Mycobacterium ulcerans	ferredoxin reductase	0.0039	0.0117	0.1153
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0044	0.0096
Mycobacterium ulcerans	NADH dehydrogenase	0.0039	0.0117	0.1153
Loa Loa (eye worm)	programmed cell death 8	0.0039	0.0117	0.0259
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0277	0.092
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0039	0.0117	0.0148
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0039	0.0117	0.0386
Brugia malayi	Thioredoxin reductase	0.0422	0.3009	0.6713
Entamoeba histolytica	hypothetical protein	0.0035	0.0087	0.0431
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0088	0.0493	0.045
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0493	0.1097
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0142	0.0897	0.2982
Giardia lamblia	Kinase, PLK	0.0094	0.0536	0.2492
Plasmodium vivax	thioredoxin reductase, putative	0.0422	0.3009	1
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0039	0.0117	0.0386
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0142	0.0896	0.8798
Trypanosoma brucei	NADH dehydrogenase	0.0039	0.0117	0.039
Brugia malayi	serine/threonine-protein kinase plk-2	0.0094	0.0536	0.1193
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0146	0.0928	0.3084
Giardia lamblia	DNA damage repair protein	0.0034	0.0081	0.0187
Echinococcus granulosus	transcription factor btf3	0.0035	0.0087	0.0086
Echinococcus granulosus	dna polymerase eta	0.016	0.1031	0.1989
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0039	0.0117	0.0125
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0135	0.0847	0.2812
Plasmodium falciparum	thioredoxin reductase	0.0422	0.3009	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3081
Mycobacterium ulcerans	DNA polymerase IV	0.0135	0.0847	0.8316
Leishmania major	DNA polymerase eta, putative	0.0084	0.0461	0.1531
Echinococcus granulosus	thioredoxin glutathione reductase	0.0424	0.3028	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.0259
Mycobacterium ulcerans	hypothetical protein	0.0034	0.0081	0.0796
Brugia malayi	Bromodomain containing protein	0.0029	0.0044	0.0096
Trichomonas vaginalis	rotamase, putative	0.0064	0.031	0.0442
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0167	0.0209
Toxoplasma gondii	selenide, water dikinase	0.0039	0.0117	0.039
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0039	0.0117	0.0149
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0039	0.0117	0.1153
Trypanosoma brucei	DNA polymerase IV, putative	0.0135	0.0847	0.2815
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0088	0.0493	0.045
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0039	0.0117	0.0148
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0146	0.0928	0.3084
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0143	0.0472
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0039	0.0117	0.039
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0721	0.1605
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0087	0.0289
Trypanosoma brucei	DNA damage repair protein, putative	0.0034	0.0081	0.0269
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0443	0.1473
Mycobacterium tuberculosis	Probable oxidoreductase	0.1069	0.79	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0135	0.0847	0.2815
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0039	0.0117	0.0386
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0039	0.0117	0.039
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0167	0.0123
Treponema pallidum	oxidoreductase	0.0039	0.0117	0.0582
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0143	0.0472
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0617	0.4482	1
Plasmodium vivax	DNA repair protein REV1, putative	0.0034	0.0081	0.0269
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.001	0.0034
Brugia malayi	jmjC domain containing protein	0.0095	0.0544	0.1211
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0213	0.0704
Toxoplasma gondii	thioredoxin reductase	0.0422	0.3009	1
Mycobacterium tuberculosis	Probable reductase	0.0962	0.7089	0.8974
Leishmania major	trypanothione reductase	0.0422	0.3009	1
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0083	0.0449	0.0689
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0146	0.0928	0.3081
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0536	0.0891
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0039	0.0117	0.0148
Trypanosoma cruzi	DNA damage repair protein, putative	0.0034	0.0081	0.0265
Brugia malayi	Pre-SET motif family protein	0.0088	0.0493	0.1097
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0039	0.0117	0.0259
Onchocerca volvulus		0.0702	0.5126	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0443	0.1473
Treponema pallidum	fructose-bisphosphate aldolase	0.029	0.2018	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0084	0.0461	0.1527
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0721	0.1605
Trichomonas vaginalis	mercuric reductase, putative	0.0146	0.0928	0.1669
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0962	0.7089	0.8974
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.0277	0.092
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0039	0.0117	0.0259
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0142	0.0896	0.1134
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3084
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0146	0.0928	0.3084
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0039	0.0117	0.0149
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0039	0.0117	0.0061
Brugia malayi	ImpB/MucB/SamB family protein	0.0109	0.0651	0.145
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0094	0.0536	0.1781
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.001	0.0034
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0167	0.0247
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.0897	0.2982
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0064	0.031	0.1029
Plasmodium falciparum	glutathione reductase	0.0422	0.3009	1
Echinococcus multilocularis	dna polymerase kappa	0.0135	0.0847	0.1369
Echinococcus multilocularis	expressed protein	0.0372	0.2636	0.4418
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0039	0.0117	0.0061
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0039	0.0117	0.0149
Trichomonas vaginalis	glutathione reductase, putative	0.0146	0.0928	0.1669
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0039	0.0117	0.039
Toxoplasma gondii	NADPH-glutathione reductase	0.0146	0.0928	0.3084
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3081
Trypanosoma brucei	DNA polymerase eta, putative	0.016	0.1031	0.3425
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0039	0.0117	0.039
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0039	0.0117	0.0125
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0135	0.0847	0.2812
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0135	0.0847	0.1508
Mycobacterium ulcerans	dehydrogenase	0.0039	0.0117	0.1153
Brugia malayi	glutathione reductase	0.0422	0.3009	0.6713
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0039	0.0117	0.0149
Echinococcus granulosus	histone lysine methyltransferase setb	0.0088	0.0493	0.0904
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0081	0.0265
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0536	0.0891
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0039	0.0117	0.1153
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0088	0.0493	0.045
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.0536	0.0494
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0146	0.0928	0.9112
Trypanosoma brucei	hypothetical protein, conserved	0.0034	0.0081	0.0269
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0536	0.0891
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0135	0.0847	0.2812
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.1069	0.79	1
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0039	0.0117	0.039
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0087	0.0289
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0536	0.0891
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0158	0.1019	0.1289
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0094	0.0536	0.1193
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0146	0.0928	0.3084
Chlamydia trachomatis	thioredoxin reductase	0.0039	0.0117	0.1265
Schistosoma mansoni	DNA polymerase eta	0.016	0.1031	0.0991
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0087	0.0073
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0039	0.0117	0.0259
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0146	0.0928	0.3084
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.001	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0025	0.001	0.002
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0039	0.0117	0.0149
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0146	0.0928	0.1782
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0087	0.0289
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0167	0.0247
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.1069	0.79	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0064	0.031	0.1025
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0422	0.3009	0.3809
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Leishmania major	DNA polymerase kappa, putative	0.0034	0.0081	0.0269
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0039	0.0117	0.0149
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0039	0.0117	0.0061
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.029	0.2018	1
Treponema pallidum	thioredoxin reductase (trxB)	0.0039	0.0117	0.0582
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0044	0.0146
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0039	0.0117	0.0125
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0039	0.0117	0.0386
Trypanosoma brucei	polo-like protein kinase	0.0094	0.0536	0.1781
Plasmodium falciparum	glutathione reductase	0.0146	0.0928	0.3084
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.009	0.0093
Giardia lamblia	DINP protein human, muc B family	0.0116	0.07	0.3321
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0039	0.0117	0.0061
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0087	0.0289
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.0039	0.0117	0.039
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.0536	0.1778
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0094	0.0536	0.2656
Brugia malayi	ImpB/MucB/SamB family protein	0.016	0.1031	0.2297
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0039	0.0117	0.0582
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0087	0.0285
Leishmania major	mitochondrial DNA polymerase beta	0.03	0.2091	0.695
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.013	0.0147
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0116	0.07	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0044	0.0096
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0278	0.0617
Echinococcus granulosus	expressed protein	0.0372	0.2636	0.5226
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0039	0.0117	0.1153
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0146	0.0928	0.9112
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0146	0.0928	0.9112
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0146	0.0928	0.3081
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0039	0.0117	0.039
Brugia malayi	hypothetical protein	0.0025	0.001	0.002
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0109	0.0651	0.145
Trichomonas vaginalis	glutamate synthase, putative	0.0039	0.0117	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0449	0.0998
Echinococcus granulosus	geminin	0.0168	0.1096	0.2122
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0039	0.0117	0.0125
Trypanosoma brucei	hypothetical protein, conserved	0.0034	0.0081	0.0269
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0962	0.7089	0.8974
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0424	0.3028	0.5086
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0066	0.0321	0.0714
Schistosoma mansoni	sulfide quinone reductase	0.0039	0.0117	0.0074
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0039	0.0117	0.039
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0536	0.0891
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0109	0.0651	0.061
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0167	0.0123
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.009	0.0046
Schistosoma mansoni	transcription factor btf3	0.0035	0.0087	0.0043
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0109	0.0651	0.061
Trypanosoma brucei	unspecified product	0.0129	0.0798	0.2653
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0146	0.0928	0.1175
Onchocerca volvulus		0.0088	0.0493	0.0883
Echinococcus granulosus	microtubule associated protein 2	0.0686	0.5004	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.0536	0.1778
Trichomonas vaginalis	rotamase, putative	0.0066	0.0321	0.0465
Leishmania major	DNA damage repair protein, putative	0.0034	0.0081	0.0269
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0039	0.0117	0.0125
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0044	0.0146
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0146	0.0928	0.0888
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0536	0.0891
Schistosoma mansoni	disulfide oxidoreductase	0.0039	0.0117	0.0074
Giardia lamblia	Glutamate synthase	0.0039	0.0117	0.0371
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0039	0.0117	0.0125
Loa Loa (eye worm)	thioredoxin reductase	0.0422	0.3009	0.6713
Entamoeba histolytica	thioredoxin reductase, putative	0.0039	0.0117	0.0582
Giardia lamblia	Fructose-bisphosphate aldolase	0.029	0.2018	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0064	0.031	0.1534
Echinococcus granulosus	expressed protein	0.0066	0.0321	0.0559
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.2018	0.3833
Trypanosoma brucei	DNA polymerase kappa, putative	0.0135	0.0847	0.2815
Leishmania major	hypothetical protein, conserved	0.0039	0.0117	0.039
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0039	0.0117	0.0582
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0143	0.0476
Schistosoma mansoni	glutamate synthase	0.0039	0.0117	0.0074
Trypanosoma cruzi	trypanothione reductase, putative	0.0146	0.0928	0.3081
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0107	0.0635	0.1415
Schistosoma mansoni	DNA polymerase IV / kappa	0.0034	0.0081	0.0037
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.001	0.003
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0066	0.0321	0.0714
Trypanosoma cruzi	DNA polymerase eta, putative	0.016	0.1031	0.3422
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0081	0.0265
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0962	0.7089	0.8974
Treponema pallidum	NADH oxidase	0.0146	0.0928	0.4598
Plasmodium vivax	SET domain protein, putative	0.0088	0.0493	0.1637

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 88 nM	Inhibition of 17,20-lyase of recombinant human CYP17A1 using [1,2-3H]-17a-hydroxypregnenolone as substrate after 15 mins by TLC analysis	ChEMBL.	21978946
IC50 (binding)	= 110 nM	Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A1 using [1,2-3H]-17a-hydroxyprogesterone as substrate after 15 mins by TLC analysis	ChEMBL.	21978946
IC50 (ADMET)	= 3200 nM	Inhibition of recombinant human CYP3A4 assessed as conversion of testosterone into 6-hydroxytestosterone after 30 mins by HPLC analysis	ChEMBL.	21978946

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1921978

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1564366