Detailed information for compound 1564387

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.495 | Formula: C20H25N3O4S
  • H donors: 4 H acceptors: 4 LogP: 2.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(Nc1cc2NC(=O)CCc2cc1S(=O)(=O)Nc1ccc(c(c1)C)C)C
  • InChi: 1S/C20H25N3O4S/c1-12-4-6-16(8-13(12)2)23-28(26,27)19-9-15-5-7-20(25)22-17(15)10-18(19)21-14(3)11-24/h4,6,8-10,14,21,23-24H,5,7,11H2,1-3H3,(H,22,25)
  • InChiKey: FTLNYBCPHCLODH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.1684 0.6958
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.1355 0.1355
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.1684 1
Brugia malayi Transient-receptor-potential like protein 0.0035 0.1355 0.2603
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0649 0.1991
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0234 0.0441
Schistosoma mansoni sodium/chloride dependent transporter 0.0088 0.4819 0.4819
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.2318 1
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.1684 0.6958
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0905 0.5372
Schistosoma mansoni intermediate filament proteins 0.0026 0.0763 0.0763
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0037 0.0037
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.5205 0.5205
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0234 0.1389
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2246 0.4233
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0088 0.4819 0.9259
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.3177 0.3177
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.1302 0.1302
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2318 1
Loa Loa (eye worm) pyruvate kinase 0.004 0.1684 0.3173
Loa Loa (eye worm) hypothetical protein 0.006 0.2967 0.559
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.2318 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0649 0.2799
Schistosoma mansoni ap endonuclease 0.0018 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0029 0.0905 0.0905
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.1684 0.5
Schistosoma mansoni serine/threonine protein kinase 0.005 0.2318 0.2318
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.5097 0.5097
Brugia malayi jmjC domain containing protein 0.0035 0.1302 0.2502
Brugia malayi TAR-binding protein 0.0062 0.3121 0.5997
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1224 0.2351
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0385 0.2285
Loa Loa (eye worm) hypothetical protein 0.0095 0.5307 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.0385 0.0385
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.1302 0.1302
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.007
Schistosoma mansoni transient receptor potential channel 0.0063 0.3177 0.3177
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1645 0.1645
Schistosoma mansoni lamin 0.0026 0.0763 0.0763
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0385 0.166
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0037
Echinococcus multilocularis lamin 0.0026 0.0763 0.0763
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0234 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.2318 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3121 0.5881
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0649 0.3852
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1684 0.3494
Echinococcus granulosus peregrin 0.0029 0.0905 0.0905
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0905 0.0905
Onchocerca volvulus Alhambra homolog 0.0029 0.0905 0.1877
Plasmodium vivax pyruvate kinase, putative 0.004 0.1684 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0037 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2318 1
Schistosoma mansoni hypothetical protein 0.0033 0.1224 0.1224
Schistosoma mansoni hypothetical protein 0.0166 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.1224 0.2306
Loa Loa (eye worm) pyruvate kinase 0.004 0.1684 0.3173
Giardia lamblia Pyruvate kinase 0.0021 0.0385 0.0724
Schistosoma mansoni hypothetical protein 0.0166 1 1
Echinococcus multilocularis lamin dm0 0.0026 0.0763 0.0763
Echinococcus granulosus mitogen activated protein kinase 0.005 0.2318 0.2318
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0037
Plasmodium falciparum phd finger protein, putative 0.0029 0.0905 0.5372
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0037 0.0037
Echinococcus multilocularis serotonin transporter 0.0088 0.4819 0.4819
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.1302 0.2454
Brugia malayi jmjC domain containing protein 0.0093 0.5205 1
Loa Loa (eye worm) norepinephrine transporter 0.0088 0.4819 0.9081
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.1684 0.6958
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3121 0.3121
Echinococcus granulosus pyruvate kinase 0.004 0.1684 0.1684
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0649 0.3852
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.2318 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0905 0.1705
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0037 0.0037
Echinococcus multilocularis pyruvate kinase 0.004 0.1684 0.1684
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0037
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.5097 0.5097
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0037 0.0071
Schistosoma mansoni ap endonuclease 0.0018 0.0234 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3121 0.3121
Echinococcus granulosus lamin 0.0026 0.0763 0.0763
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.3177 0.3177
Onchocerca volvulus 0.0088 0.4819 1
Giardia lamblia Kinase, CMGC MAPK 0.005 0.2318 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.0385 0.0385
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0763 0.1438
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0763 0.1438
Chlamydia trachomatis pyruvate kinase 0.004 0.1684 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0905 0.3903
Loa Loa (eye worm) serotonin transporter b 0.0088 0.4819 0.9081
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0649 0.1991
Schistosoma mansoni pyruvate kinase 0.0021 0.0385 0.0385
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.1684 0.7265
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.1684 0.3236
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.003 0.003
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.1684 0.6958
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2318 1
Echinococcus multilocularis geminin 0.0166 1 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0385 0.0385
Echinococcus granulosus serotonin transporter 0.0088 0.4819 0.4819
Giardia lamblia Pyruvate kinase 0.004 0.1684 0.6958
Echinococcus granulosus intermediate filament protein 0.0026 0.0763 0.0763
Echinococcus granulosus tar DNA binding protein 0.0062 0.3121 0.3121
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0234 0.0449
Loa Loa (eye worm) hypothetical protein 0.0049 0.2255 0.4249
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.3177 0.3177
Echinococcus granulosus pyruvate kinase 0.0021 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0049 0.2246 0.4233
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0905 0.1705
Treponema pallidum sodium- and chloride- dependent transporter 0.0088 0.4819 1
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.5307 0.5307
Schistosoma mansoni lamin 0.0026 0.0763 0.0763
Echinococcus granulosus pyruvate kinase 0.004 0.1684 0.1684
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2246 0.4316
Schistosoma mansoni transient receptor potential channel 0.0095 0.5307 0.5307
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0234 0.0234
Toxoplasma gondii exonuclease III APE 0.0018 0.0234 0.1009
Echinococcus multilocularis musashi 0.0026 0.0763 0.0763
Brugia malayi hypothetical protein 0.0016 0.007 0.0134
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0763 0.1438
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.2318 0.4368
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.2318 0.2318
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0649 0.1991
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0037 0.007
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3121 0.3121
Brugia malayi hypothetical protein 0.0025 0.0649 0.1246
Echinococcus multilocularis pyruvate kinase 0.004 0.1684 0.1684
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0905 0.0905
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.5205 0.5205
Echinococcus granulosus lamin dm0 0.0026 0.0763 0.0763
Echinococcus granulosus GPCR family 2 0.0015 0.0037 0.0037
Brugia malayi RNA binding protein 0.0062 0.3121 0.5997
Onchocerca volvulus 0.0026 0.0763 0.1583
Brugia malayi MAP kinase sur-1 0.005 0.2318 0.4453
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.2318 0.2318
Loa Loa (eye worm) hypothetical protein 0.004 0.1684 0.3173
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0234 0.1389
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0088 0.4819 0.4819
Schistosoma mansoni pyruvate kinase 0.004 0.1684 0.1684
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2318 1
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0385 0.2285
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.2318 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.2917 0.5497
Brugia malayi PHD-finger family protein 0.0029 0.0905 0.1738
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3121 0.3121
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1684 0.3494
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0905 0.0905
Mycobacterium ulcerans pyruvate kinase 0.004 0.1684 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0731 0.1377
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.2318 1
Leishmania major pyruvate kinase 0.004 0.1684 0.6958
Echinococcus multilocularis peregrin 0.0029 0.0905 0.0905
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.3177 0.3177
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.1684 0.6958
Loa Loa (eye worm) hypothetical protein 0.0088 0.4819 0.9081
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.2318 0.2318
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.1302 0.1302
Onchocerca volvulus 0.0026 0.0763 0.1583
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0876 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0037 0.0071
Brugia malayi intermediate filament protein 0.0026 0.0763 0.1466
Plasmodium falciparum pyruvate kinase 0.004 0.1684 1
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.5307 0.5307
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0876 0.1651
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0234 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3121 0.5997
Loa Loa (eye worm) hypothetical protein 0.0025 0.0649 0.1222
Loa Loa (eye worm) hypothetical protein 0.0032 0.1145 0.2158
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3121 0.3121
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1684 0.3494
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.1684 0.3236
Loa Loa (eye worm) hypothetical protein 0.0028 0.0876 0.1651
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3121 0.5881
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.1355 0.1355
Giardia lamblia PHD finger protein 15 0.0029 0.0905 0.3219
Loa Loa (eye worm) hypothetical protein 0.0035 0.1355 0.2553
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0088 0.4819 0.9081
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.1302 0.1302
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0763 0.1466
Loa Loa (eye worm) RNA binding protein 0.0062 0.3121 0.5881
Leishmania major hypothetical protein, conserved 0.0025 0.0649 0.1991
Loa Loa (eye worm) solute carrier family 6 member 4 0.0088 0.4819 0.9081
Loa Loa (eye worm) pyruvate kinase 0.004 0.1684 0.3173
Echinococcus granulosus jumonji domain containing protein 0.004 0.1645 0.1645
Brugia malayi Bromodomain containing protein 0.0029 0.0905 0.1738
Echinococcus granulosus pyruvate kinase 0.0021 0.0385 0.0385
Trypanosoma brucei pyruvate kinase 1 0.004 0.1684 0.6958
Echinococcus multilocularis pyruvate kinase 0.0021 0.0385 0.0385
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2318 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.4819 0.9081
Schistosoma mansoni pyruvate kinase 0.004 0.1684 0.1684
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2318 1
Schistosoma mansoni transient receptor potential channel 0.0063 0.3177 0.3177
Schistosoma mansoni jumonji domain containing protein 0.0074 0.3933 0.3933
Echinococcus multilocularis pyruvate kinase 0.0032 0.1122 0.1122
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0649 0.3852
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2246 0.4316
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3121 0.3121
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0905 0.3903
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.5307 0.5307
Leishmania major pyruvate kinase 0.004 0.1684 0.6958
Trypanosoma brucei protein kinase, putative 0.005 0.2318 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.23 uM Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assay ChEMBL. 21958545
Emax (binding) = 124 % Activation of human PKM2 assessed as ATP product formation at 57 mM after 1 hr by luminescent pyruvate kinase-luciferase coupled assay ChEMBL. 21958545

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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