Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4645 | 0.4645 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0044 | 0.4645 | 1 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Giardia lamblia | Gamma tubulin | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0044 | 0.4645 | 0.4645 |
Giardia lamblia | Beta tubulin | 0.0044 | 0.4645 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0044 | 0.4645 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0044 | 0.4645 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0044 | 0.4645 | 1 |
Brugia malayi | Tubulin alpha chain | 0.0044 | 0.4645 | 0.4645 |
Trypanosoma brucei | alpha tubulin | 0.0044 | 0.4645 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Brugia malayi | tubulin alpha-2 chain | 0.0044 | 0.4645 | 0.4645 |
Brugia malayi | tubulin alpha chain - mouse | 0.0044 | 0.4645 | 0.4645 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0044 | 0.4645 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0044 | 0.4645 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0044 | 0.4645 | 0.4645 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0044 | 0.4645 | 1 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Plasmodium falciparum | alpha tubulin 1 | 0.0044 | 0.4645 | 0.5 |
Brugia malayi | alpha-tubulin | 0.0044 | 0.4645 | 0.4645 |
Trypanosoma brucei | epsilon tubulin | 0.0044 | 0.4645 | 1 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0044 | 0.4645 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0044 | 0.4645 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0044 | 0.4645 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0044 | 0.4645 | 1 |
Giardia lamblia | Beta tubulin | 0.0044 | 0.4645 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0044 | 0.4645 | 0.5 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0044 | 0.4645 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0044 | 0.4645 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0044 | 0.4645 | 0.4645 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0044 | 0.4645 | 0.5 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0044 | 0.4645 | 0.5 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0044 | 0.4645 | 0.4645 |
Trypanosoma brucei | beta tubulin | 0.0044 | 0.4645 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0044 | 0.4645 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0044 | 0.4645 | 0.4645 |
Brugia malayi | Tubulin beta-1 chain | 0.0044 | 0.4645 | 0.4645 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0044 | 0.4645 | 0.4645 |
Toxoplasma gondii | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Trypanosoma brucei | tubulin gamma chain | 0.0044 | 0.4645 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0044 | 0.4645 | 0.4645 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | alpha-tubulin | 0.0044 | 0.4645 | 0.4645 |
Trypanosoma cruzi | tubulin gamma chain | 0.0044 | 0.4645 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0044 | 0.4645 | 0.5 |
Leishmania major | gamma-tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0044 | 0.4645 | 0.4645 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0044 | 0.4645 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0044 | 0.4645 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0044 | 0.4645 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0044 | 0.4645 | 1 |
Brugia malayi | Tubulin alpha-2 chain | 0.0044 | 0.4645 | 0.4645 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0044 | 0.4645 | 0.5 |
Entamoeba histolytica | tubulin gamma chain | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0044 | 0.4645 | 1 |
Brugia malayi | Tubulin gamma chain | 0.0044 | 0.4645 | 0.4645 |
Trypanosoma brucei | beta tubulin | 0.0044 | 0.4645 | 1 |
Brugia malayi | Tubulin alpha-2 chain | 0.0044 | 0.4645 | 0.4645 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0044 | 0.4645 | 1 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0044 | 0.4645 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0044 | 0.4645 | 0.4645 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0044 | 0.4645 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0044 | 0.4645 | 0.4645 |
Plasmodium falciparum | tubulin beta chain | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0044 | 0.4645 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0044 | 0.4645 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0044 | 0.4645 | 0.4645 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0044 | 0.4645 | 0.4645 |
Trypanosoma brucei | alpha tubulin | 0.0044 | 0.4645 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0044 | 0.4645 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0044 | 0.4645 | 0.4645 |
Trichomonas vaginalis | tubulin, putative | 0.0044 | 0.4645 | 1 |
Leishmania major | alpha tubulin | 0.0044 | 0.4645 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0044 | 0.4645 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0044 | 0.4645 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 1 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0044 | 0.4645 | 0.5 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0044 | 0.4645 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0044 | 0.4645 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 1 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0044 | 0.4645 | 0.5 |
Plasmodium falciparum | alpha tubulin 2 | 0.0044 | 0.4645 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | beta tubulin | 0.0044 | 0.4645 | 0.5 |
Leishmania major | epsilon tubulin, putative | 0.0044 | 0.4645 | 0.5 |
Plasmodium falciparum | tubulin gamma chain | 0.0044 | 0.4645 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0044 | 0.4645 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.2 ug ml-1 | Antituberculosis activity against multidrug-resistant Mycobacterium tuberculosis isolate Spec. 192 by twofold serial dilution method | ChEMBL. | 22153872 |
MIC (functional) | = 6.2 ug ml-1 | Antituberculosis activity against drug-sensitive Mycobacterium tuberculosis isolate Spec. 210 by twofold serial dilution method | ChEMBL. | 22153872 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.