Detailed information for compound 156484

Basic information

Technical information
  • TDR Targets ID: 156484
  • Name: 2,5-dimethyl-3-(3-methylbutyl)pyrazine
  • MW: 178.274 | Formula: C11H18N2
  • H donors: 0 H acceptors: 2 LogP: 2.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCc1nc(C)cnc1C)C
  • InChi: 1S/C11H18N2/c1-8(2)5-6-11-10(4)12-7-9(3)13-11/h7-8H,5-6H2,1-4H3
  • InChiKey: WWAYKGYKYHEINT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-isopentyl-2,5-dimethyl-pyrazine
  • 3-isopentyl-2,5-dimethylpyrazine
  • 3-isoamyl-2,5-dimethyl-pyrazine
  • Pyrazine, 2,5-dimethyl-3-(3-methylbutyl)-
  • Pyrazine, 3-isopentyl-2,5-dimethyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible DNA glycosylase 0.0102 0.0305 0.0286
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.1406 0.5267 0.5252
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0174 0.058 0.7011
Mycobacterium tuberculosis Probable conserved polyketide synthase associated protein PapA3 0.0032 0.0039 0.0019
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0025 0.0011 0.0189
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0079 0.0603
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0093 0.0788
Echinococcus multilocularis glycyl tRNA synthetase 0.0115 0.0353 0.3707
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.0037 0.0629
Loa Loa (eye worm) hypothetical protein 0.0049 0.0104 0.1249
Giardia lamblia Threonyl-tRNA synthetase 0.0053 0.0118 0.1276
Onchocerca volvulus 0.0037 0.0058 0.0539
Wolbachia endosymbiont of Brugia malayi valyl-tRNA synthetase 0.0062 0.0152 0.2197
Schistosoma mansoni methionine-tRNA synthetase 0.0258 0.0899 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0079 0.0764
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0299
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0342
Toxoplasma gondii tRNA synthetase, putative 0.0062 0.0152 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0079 0.0764
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0174 0.058 0.7624
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.0037 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0115 0.0353 0.4108
Mycobacterium leprae PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3 0.0032 0.0039 0.0003
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0137 0.0439 0.4699
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0062 0.0152 0.2622
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0031 0.0037 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0037 0.0063
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0062 0.0152 0.154
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0085 0.068
Mycobacterium leprae POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5 0.0032 0.0039 0.0003
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0305 0.0274
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1406 0.5267 0.525
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0076 0.0207 0.0176
Plasmodium vivax methionine--tRNA ligase, putative 0.0035 0.0051 0.0701
Echinococcus granulosus valyl tRNA synthetase 0.0062 0.0152 0.139
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0037 0.0089
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0097 0.0286 0.4637
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0164 0.054 0.9295
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.0037 0.0089
Schistosoma mansoni valine-tRNA ligase 0.0062 0.0152 0.159
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0062 0.0152 0.0141
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0037 0.0017
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.1762 0.662 0.6613
Mycobacterium ulcerans acetyl-CoA synthetase 0.0031 0.0037 0.0005
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0174 0.058 0.057
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.006 0.0146 0.1456
Schistosoma mansoni glycyl-tRNA synthetase 0.0115 0.0353 0.3853
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0025 0.0011 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0342
Leishmania major hypothetical protein, conserved 0.0038 0.0061 0.0537
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0076 0.0207 0.0176
Toxoplasma gondii methionyl-tRNA synthetase 0.005 0.0107 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0037 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0079 0.0544
Trypanosoma cruzi arginyl-tRNA synthetase, putative 0.003 0.0032 0.0363
Giardia lamblia Methyltransferase like 2 0.0038 0.0061 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0097 0.0286 0.4831
Schistosoma mansoni isoleucine--tRNA ligase 0.0174 0.058 0.6412
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0053 0.0118 0.1582
Schistosoma mansoni acetyl-CoA synthetase 0.0031 0.0037 0.0288
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.0037 0.0089
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0174 0.058 1
Toxoplasma gondii valyl-tRNA synthetase 0.0062 0.0152 0.0141
Echinococcus multilocularis leucyl tRNA synthetase 0.0062 0.0152 0.139
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0062 0.0152 0.248
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0093 0.1103
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0031 0.0037 0.0063
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0035 0.0051 0.0351
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0037 0.0017
Brugia malayi isoleucyl-tRNA synthetase 0.0174 0.058 0.7011
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.0085 0.0065
Mycobacterium ulcerans thioesterase 0.053 0.1932 0.1906
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0174 0.058 1
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0035 0.0051 0.0014
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0076 0.0207 0.0188
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0079 0.0908
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0035 0.0051 0.0535
Chlamydia trachomatis methionine--tRNA ligase 0.0258 0.0899 1
Mycobacterium ulcerans polyketide synthase associated protein PapA3 0.0032 0.0039 0.0008
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0115 0.0353 0.4581
Plasmodium vivax threonine--tRNA ligase, putative 0.0053 0.0118 0.1888
Plasmodium falciparum methionine--tRNA ligase 0.0035 0.0051 0.0701
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0037 0.0017
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.1728 0.649 0.6483
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0076 0.0207 0.2627
Treponema pallidum valyl-tRNA synthetase 0.0062 0.0152 0.154
Plasmodium falciparum valine--tRNA ligase, putative 0.0062 0.0152 0.248
Entamoeba histolytica valyl tRNA synthetase, putative 0.0062 0.0152 0.154
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0025 0.0011 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.0037 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0079 0.0544
Loa Loa (eye worm) hypothetical protein 0.0046 0.0093 0.1103
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0031 0.0037 0.0056
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0031 0.0037 0.0089
Plasmodium falciparum leucine--tRNA ligase, putative 0.0062 0.0152 0.248
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.006 0.0146 0.2076
Loa Loa (eye worm) hypothetical protein 0.0174 0.058 0.7624
Leishmania major isoleucyl-tRNA synthetase, putative 0.0174 0.058 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0031 0.0037 0.0449
Chlamydia trachomatis leucine--tRNA ligase 0.0072 0.0192 0.185
Echinococcus granulosus valyl tRNA synthetase 0.0062 0.0152 0.139
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0037 0.0449
Schistosoma mansoni leucyl-tRNA synthetase 0.0097 0.0286 0.3098
Treponema pallidum leucyl-tRNA synthetase 0.0072 0.0192 0.205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0342
Echinococcus granulosus Threonyl tRNA synthetase C 0.006 0.0146 0.1314
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.006 0.0146 0.1314
Loa Loa (eye worm) hypothetical protein 0.006 0.0145 0.1793
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0174 0.058 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0035 0.0051 0.0019
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0037 0.0058 0.083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0079 0.0544
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0037 0.0058 0.1003
Plasmodium vivax valine--tRNA ligase, putative 0.0062 0.0152 0.248
Toxoplasma gondii pantoate-beta-alanine ligase 0.265 1 1
Mycobacterium tuberculosis Hypothetical protein 0.0038 0.0061 0.0041
Giardia lamblia Leucyl-tRNA synthetase 0.006 0.0145 0.1775
Schistosoma mansoni methyltransferase-related 0.0038 0.0061 0.0564
Onchocerca volvulus 0.0076 0.0207 0.4237
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0037 0.0058 0.1003
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0031 0.0037 0.0056
Schistosoma mansoni methionine-tRNA synthetase 0.0035 0.0051 0.045
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0037 0.0342
Giardia lamblia Isoleucyl-tRNA synthetase 0.0174 0.058 1
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0037 0.0058 0.1003
Brugia malayi Valyl-tRNA synthetase 0.0062 0.0152 0.154
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0061 0.1052
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0174 0.058 0.7011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0031 0.0037 0.0063
Plasmodium falciparum valine--tRNA ligase, putative 0.0062 0.0152 0.248
Brugia malayi Methyltransferase-like protein 4 0.0038 0.0061 0.0376
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0053 0.0118 0.0087
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0076 0.0207 0.0188
Leishmania major leucyl-tRNA synthetase, putative 0.0097 0.0286 0.4637
Treponema pallidum isoleucyl-tRNA synthetase 0.0174 0.058 0.7011
Loa Loa (eye worm) threonyl-tRNA synthetase 0.006 0.0146 0.1802
Echinococcus multilocularis valyl tRNA synthetase 0.0062 0.0152 0.139
Chlamydia trachomatis valine--tRNA ligase 0.0062 0.0152 0.139
Toxoplasma gondii tRNA ligases class I (M) protein 0.0035 0.0051 0.004
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0201 0.068 0.8964
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Trichomonas vaginalis antibiotic synthetase, putative 0.0031 0.0037 0.0629
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0025 0.0011 0.0189
Brugia malayi protein ZK524.3 0.006 0.0145 0.1447
Brugia malayi methionyl-tRNA synthetase 0.0035 0.0051 0.0246
Echinococcus multilocularis valyl tRNA synthetase 0.0062 0.0152 0.139
Toxoplasma gondii propionate-CoA ligase 0.0031 0.0037 0.0026
Plasmodium falciparum threonine--tRNA ligase 0.0053 0.0118 0.1888
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0031 0.0037 0.0026
Giardia lamblia Valine-tRNA ligase 0.0062 0.0152 0.1913
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.265 1 1
Mycobacterium tuberculosis Unknown protein 0.0032 0.0039 0.0019
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0031 0.0037 0.0063
Loa Loa (eye worm) oxidoreductase 0.0031 0.0037 0.0342
Loa Loa (eye worm) hypothetical protein 0.0221 0.0758 1
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.265 1 1
Leishmania major acetyl-CoA synthetase, putative 0.0031 0.0037 0.0089
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0102 0.0305 0.4984
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0062 0.0152 0.0141
Mycobacterium tuberculosis Possible conserved polyketide synthase associated protein PapA5 0.0032 0.0039 0.0019
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0053 0.0118 0.0099
Mycobacterium tuberculosis Possible conserved polyketide synthase associated protein PapA2 0.0032 0.0039 0.0019
Echinococcus granulosus methionine tRNA synthetase 0.0035 0.0051 0.0222
Echinococcus multilocularis leucyl tRNA synthetase 0.0097 0.0286 0.2933
Loa Loa (eye worm) hypothetical protein 0.0137 0.0439 0.5734
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0236 0.0814 1
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0037 0.0063
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0072 0.0192 0.0161
Chlamydia trachomatis isoleucine--tRNA ligase 0.0174 0.058 0.6327
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0037 0.0017
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0031 0.0037 0.0017
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0045 0.0088 0.0056
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0342
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0037 0.0063
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0031 0.0037 0.0449
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0062 0.0152 0.0132
Brugia malayi leucyl-tRNA synthetase 0.0062 0.0152 0.154
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0174 0.058 0.055
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0053 0.0118 0.1109
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0258 0.0899 1
Echinococcus multilocularis methionine tRNA synthetase 0.0035 0.0051 0.0222
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0207 0.2242
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0174 0.058 0.6327
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Echinococcus granulosus leucyl tRNA synthetase 0.0082 0.023 0.229
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0137 0.0439 0.4699
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0076 0.0207 0.0176
Onchocerca volvulus 0.0062 0.0152 0.2872
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0031 0.0037 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0037 0.0063
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0037 0.0449
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0037 0.0005
Onchocerca volvulus 0.0137 0.0439 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0606 0.2222 0.2197
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0045 0.0088 0.0051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0044 0.0085 0.068
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1406 0.5267 0.5258
Toxoplasma gondii leucyl-tRNA synthetase 0.0062 0.0152 0.0141
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0038 0.0076
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0035 0.0051 0.0701
Leishmania major methionyl-tRNA synthetase, putative 0.0035 0.0051 0.0351
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0025 0.0011 0.0189
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0053 0.0118 0.0082
Mycobacterium ulcerans valyl-tRNA synthetase 0.0062 0.0152 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.006 0.0146 0.2364
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0062 0.0152 0.248
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0053 0.0118 0.2041
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0031 0.0037 0.0026
Brugia malayi valyl-tRNA synthetase family protein 0.0062 0.0152 0.154
Echinococcus granulosus leucyl tRNA synthetase 0.0062 0.0152 0.139
Plasmodium falciparum arginine--tRNA ligase 0.003 0.0032 0.0363
Loa Loa (eye worm) hypothetical protein 0.0072 0.0192 0.2425
Chlamydia trachomatis threonine--tRNA ligase 0.006 0.0146 0.1314
Mycobacterium tuberculosis Conserved protein 0.0038 0.0061 0.0041
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0305 0.0274
Brugia malayi glycyl-tRNA synthetase 0.0115 0.0353 0.4108
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0035 0.0051 0.0877
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0174 0.058 0.0546
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0031 0.0037 0.0089
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0062 0.0152 0.2197
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0093 0.0788
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0113 0.0345 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0031 0.0037 0.0089
Schistosoma mansoni valine-tRNA ligase 0.0062 0.0152 0.159
Plasmodium vivax acetyl-CoA synthetase, putative 0.0031 0.0037 0.0449
Entamoeba histolytica acyl-coA synthetase, putative 0.0031 0.0037 0.0063
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0031 0.0037 0.0005
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0031 0.0037 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0079 0.0764
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0035 0.0051 0.0351
Plasmodium vivax methionine--tRNA ligase, putative 0.0035 0.0051 0.0701
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0174 0.058 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0356
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0258 0.0899 1
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0174 0.058 1
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0035 0.0051 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0085 0.0053
Brugia malayi methionyl-tRNA synthetase 0.0236 0.0814 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.1762 0.662 0.6609
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0102 0.0305 0.0286
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0031 0.0037 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0104 0.0928
Leishmania major threonyl-tRNA synthetase, putative 0.006 0.0146 0.2076
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0174 0.058 0.6327
Schistosoma mansoni arginyl-tRNA synthetase 0.003 0.0032 0.0233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0079 0.0544
Treponema pallidum methionyl-tRNA synthetase 0.0236 0.0814 1
Plasmodium vivax arginyl-tRNA synthetase, putative 0.003 0.0032 0.0363
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0102 0.0305 0.0269
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0062 0.0152 0.2197
Onchocerca volvulus 0.0076 0.0207 0.4237
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0342
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0044 0.0085 0.0048
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0062 0.0152 0.154
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0076 0.0207 0.0188
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0031 0.0037 0.0017
Leishmania major valyl-tRNA synthetase, putative 0.0062 0.0152 0.2197
Mycobacterium ulcerans hypothetical protein 0.0031 0.0037 0.0005
Schistosoma mansoni threonyl-tRNA synthetase 0.0048 0.0099 0.0992
Mycobacterium leprae PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI 0.0062 0.0152 0.0116
Plasmodium falciparum methionine--tRNA ligase, putative 0.0035 0.0051 0.0701
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0053 0.0118 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0037 0.0063
Treponema pallidum threonyl-tRNA synthetase 0.0053 0.0118 0.1109
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0102 0.0304 0.3931
Mycobacterium tuberculosis Conserved polyketide synthase associated protein PapA1 0.0032 0.0039 0.0019
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0174 0.058 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0058 0.0632
Onchocerca volvulus 0.0044 0.0085 0.12
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0031 0.0037 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0062 0.0152 0.2622
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0031 0.0037 0.0005
Echinococcus granulosus glycyl tRNA synthetase 0.0115 0.0353 0.3707
Loa Loa (eye worm) hypothetical protein 0.0062 0.0152 0.1891
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.006 0.0146 0.2364
Schistosoma mansoni isoleucine--tRNA ligase 0.0174 0.058 0.6412
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.0037 0.0005

Activities

Activity type Activity value Assay description Source Reference
Log 1/C (functional) 0 Evaluated for its olfactory detection threshold value and indicates quantitative measure of odour impression; No threshold value. ChEMBL. 11495591

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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