Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | neuropeptide receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | biogenic amine receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4049 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | histamine h1 receptor | 0.0022 | 0.0275 | 0.035 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0351 | 0.0111 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7186 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | opsin-like receptor | 0.0022 | 0.0275 | 0.035 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | biogenic amine receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3698 | 0.4014 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0022 | 0.0275 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | amine GPCR | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | myosin xvIII | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0787 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | amine GPCR | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9213 | 1 |
Schistosoma mansoni | amine GPCR | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | amine GPCR | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | neuropeptide receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0351 | 0.0111 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0022 | 0.0275 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | amine GPCR | 0.0022 | 0.0275 | 0.035 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2814 | 0.3674 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | adenoreceptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0022 | 0.0275 | 0.035 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.7844 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3249 | 0.3059 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0351 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | opsin-like receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | biogenic amine receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0022 | 0.0275 | 0.035 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | neuropeptide receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0022 | 0.0275 | 0.035 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2814 | 0.3674 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7186 | 1 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0022 | 0.0275 | 0.035 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Schistosoma mansoni | neuropeptide receptor | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0.0275 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3262 | 0.3541 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0275 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0275 | 0.0298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 10 % | Inhibition of human placental 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate at 1 uM after 10 mins by radio flow detector-based HPLC analysis in presence of NADH as cofactor | ChEMBL. | 22037253 |
Inhibition (binding) | < 10 % | Inhibition of 17beta-HSD1 in human placental cytosolic fraction using [3H]E1 as substrate after 10 mins at 1 uM by HPLC analysis | ChEMBL. | 23145773 |
Inhibition (binding) | = 42 % | Inhibition of human placental 17beta-HSD2 assessed as formation of [2,4,6,7-3H]-estrone using [2,4,6,7-3H]-estradiol as substrate at 1 uM after 20 mins by radio flow detector-based HPLC analysis in presence of NAD+ as cofactor | ChEMBL. | 22037253 |
Inhibition (binding) | = 42 % | Inhibition of 17beta-HSD2 in human placental microsomal fraction using [3H]E2 as substrate at 1 uM after 20 mins by HPLC analysis | ChEMBL. | 23145773 |
RBA (binding) | < 0.1 % | Displacement of [3H]estradiol from human recombinant ERalpha assessed as relative binding affinity after 1 hr by liquid scintillation counting relative to estradiol | ChEMBL. | 22037253 |
RBA (binding) | < 0.1 % | Displacement of [3H]estradiol from human recombinant ERbeta assessed as relative binding affinity after 1 hr by liquid scintillation counting relative to estradiol | ChEMBL. | 22037253 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.