Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | flavodoxin domain containing protein | 0.009 | 0.5141 | 0.3907 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0083 | 0.418 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0102 | 0.6639 | 0.6 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0102 | 0.6639 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.009 | 0.5141 | 0.3907 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0083 | 0.418 | 0.5123 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0083 | 0.418 | 0.5123 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0083 | 0.418 | 0.5123 |
Brugia malayi | flavodoxin family protein | 0.0102 | 0.6639 | 1 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0083 | 0.418 | 0.3073 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0083 | 0.418 | 0.3073 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0102 | 0.6639 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0102 | 0.6639 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0102 | 0.6639 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0102 | 0.6639 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0083 | 0.418 | 0.3073 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0102 | 0.6639 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0128 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0083 | 0.418 | 0.3073 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0102 | 0.6639 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0083 | 0.418 | 0.3073 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0102 | 0.6639 | 0.6 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0083 | 0.418 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0102 | 0.6639 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0063 | 0.1598 | 0.1598 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0083 | 0.418 | 0.5123 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0083 | 0.418 | 0.3073 |
Brugia malayi | FAD binding domain containing protein | 0.0102 | 0.6639 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0083 | 0.418 | 0.3073 |
Chlamydia trachomatis | sulfite reductase | 0.0063 | 0.1598 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0102 | 0.6639 | 0.6639 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6639 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0128 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0102 | 0.6639 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.009 | 0.5141 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0102 | 0.6639 | 1 |
Giardia lamblia | Hypothetical protein | 0.009 | 0.5141 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0083 | 0.418 | 0.3073 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0102 | 0.6639 | 1 |
Leishmania major | p450 reductase, putative | 0.0102 | 0.6639 | 1 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0083 | 0.418 | 0.418 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0102 | 0.6639 | 0.6 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0102 | 0.6639 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0083 | 0.418 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0102 | 0.6639 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0051 | 0.01 | 0.01 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0102 | 0.6639 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0089 | 0.5023 | 0.5023 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0102 | 0.6639 | 0.6 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0083 | 0.418 | 0.418 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC10 (binding) | = 366 nM | Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by LC-MS enzyme assay | ChEMBL. | 21924901 |
EC20 (binding) | = 245 nM | Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by FP assay | ChEMBL. | 21924901 |
Inhibition (ADMET) | = 5 % | Inhibition of CYP1A2 at 3 uM | ChEMBL. | 21924901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.