TDR Targets

Basic information

Technical information

TDR Targets ID: 1565063
Name: 2-[2-(2-fluoro-5-hydroxyphenyl)ethyl]guanidin e
MW: 197.209 | Formula: C9H12FN3O
H donors: 3 H acceptors: 1 LogP: 0.76 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)NCCc1cc(O)ccc1F
InChi: 1S/C9H12FN3O/c10-8-2-1-7(14)5-6(8)3-4-13-9(11)12/h1-2,5,14H,3-4H2,(H4,11,12,13)
InChiKey: UBVBXMAWHHHZFH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-(2-fluoro-5-hydroxy-phenyl)ethyl]guanidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	neuropeptide receptor	0.0214	0.0745	0.0745
Loa Loa (eye worm)	endoprotease bli-4	0.2332	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0067	0.0101	0.0101
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0066	0.0096	0.0096
Toxoplasma gondii	subtilisin SUB9	0.0106	0.0272	0.7217
Schistosoma mansoni	neuropeptide F-like receptor	0.0066	0.0096	0.0096
Plasmodium falciparum	tubulin beta chain	0.0067	0.0101	0.3713
Toxoplasma gondii	subtilisin SUB6	0.0106	0.0272	0.7217
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	neuropeptide receptor	0.0214	0.0745	0.0943
Echinococcus granulosus	fmrfamide receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	neuropeptide receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	g-protein coupled receptor	0.0066	0.0096	0.0122
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0066	0.0096	0.0096
Toxoplasma gondii	subtilisin SUB2	0.0106	0.0272	0.7217
Mycobacterium leprae	Possible secreted protease	0.0106	0.0272	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.2482	0.432
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.0139	0.0242
Loa Loa (eye worm)	tubulin beta chain	0.0067	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Echinococcus multilocularis	neuropeptides capa receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Brugia malayi	Hypothetical WD-repeat protein F21H12.1 in chromosome II	0.0076	0.0139	0.0139
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	7tm_1 domain containing protein	0.0066	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Toxoplasma gondii	subtilisin SUB1	0.0106	0.0272	0.7217
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0066	0.0096	0.0096
Brugia malayi	AKH receptor	0.0066	0.0096	0.0096
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0066	0.0096	0.0096
Echinococcus granulosus	G protein coupled receptor 139	0.0066	0.0096	0.0096
Brugia malayi	Dopamine receptor protein 1	0.0066	0.0096	0.0096
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0066	0.0096	0.0096
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0106	0.0272	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Brugia malayi	proprotein convertase 2	0.1585	0.6737	0.6737
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus granulosus	allatostatin A receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	neuropeptide receptor A26	0.0066	0.0096	0.0122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0506	0.2018	0.3513
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Trichomonas vaginalis	retinoblastoma binding protein, putative	0.0076	0.0139	0.0242
Echinococcus granulosus	7TM GPCR rhodopsin	0.0066	0.0096	0.0096
Echinococcus multilocularis	tubulin subunit beta	0.0067	0.0101	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0066	0.0096	0.0096
Echinococcus granulosus	Tubulin beta 2C chain	0.0067	0.0101	0.0101
Toxoplasma gondii	subtilisin SUB4	0.0106	0.0272	0.7217
Brugia malayi	beta-tubulin, identical	0.0067	0.0101	0.0101
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Schistosoma mansoni	hypothetical protein	0.0071	0.0119	0.0119
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Brugia malayi	Serotonin receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	opsin-like receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	Tubulin beta 2C chain	0.0067	0.0101	0.0128
Echinococcus multilocularis	allatostatin A receptor	0.0066	0.0096	0.0122
Trypanosoma brucei	subtilisin peptidase	0.0106	0.0272	1
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0272	0.0473
Trichomonas vaginalis	tubulin beta chain, putative	0.0067	0.0101	0.0176
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.2482	0.432
Echinococcus granulosus	neuropeptides capa receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0066	0.0096	0.0096
Schistosoma mansoni	tubulin subunit beta	0.0067	0.0101	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Schistosoma mansoni	tubulin subunit beta	0.0067	0.0101	0.0101
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0106	0.0272	0.5
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Leishmania major	subtilisin-like serine peptidase	0.0106	0.0272	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus multilocularis	neuroendocrine convertase 2	0.1585	0.6737	0.8526
Giardia lamblia	High cysteine membrane protein Group 2	0.0772	0.3183	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	beta tubulin	0.0067	0.0101	0.0128
Toxoplasma gondii	subtilisin SUB10	0.0106	0.0272	0.7217
Echinococcus granulosus	beta tubulin	0.0067	0.0101	0.0101
Echinococcus granulosus	Tubulin beta 2C chain	0.0067	0.0101	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Brugia malayi	Dopamine receptor	0.0066	0.0096	0.0096
Brugia malayi	neuropeptide F receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	neuropeptide receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0066	0.0096	0.0122
Schistosoma mansoni	tubulin subunit beta	0.0067	0.0101	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0106	0.0272	0.0344
Echinococcus granulosus	Furin 1	0.0612	0.2482	0.2482
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	retinoblastoma binding protein	0.0076	0.0139	0.0139
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0066	0.0096	0.0122
Echinococcus granulosus	membrane bound transcription factor site 1	0.0106	0.0272	0.0272
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0066	0.0096	0.0122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Echinococcus multilocularis	epidermal growth factor receptor	0.0134	0.0394	0.0499
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.2332	1	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus granulosus	tubulin subunit beta	0.0067	0.0101	0.0101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0066	0.0096	0.0096
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0106	0.0272	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.0096	0.0096
Brugia malayi	neuroendocrine convertase 1 precursor	0.1747	0.7443	0.7443
Schistosoma mansoni	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	Tubulin beta 2C chain	0.0067	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	neuropeptide receptor A26	0.0066	0.0096	0.0096
Loa Loa (eye worm)	BEN-1 protein	0.0067	0.0101	0.0101
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0066	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1359	0.5745	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Brugia malayi	G-protein coupled receptor	0.0066	0.0096	0.0096
Toxoplasma gondii	subtilisin SUB12	0.0121	0.0338	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0134	0.0394	0.0394
Schistosoma mansoni	tubulin subunit beta	0.0067	0.0101	0.0101
Plasmodium vivax	subtilisin-like protease 1	0.0106	0.0272	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.2482	0.432
Trypanosoma cruzi	subtilisin peptidase	0.0106	0.0272	1
Echinococcus multilocularis	serotonin receptor	0.0066	0.0096	0.0122
Echinococcus multilocularis	G protein coupled receptor 139	0.0214	0.0745	0.0943
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0106	0.0272	0.0272
Echinococcus granulosus	g-protein coupled receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	furin-1 (S08 family)	0.108	0.4527	0.4527
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0139	0.0139
Brugia malayi	Subtilase family protein	0.0106	0.0272	0.0272
Echinococcus multilocularis	wd40 repeat	0.0076	0.0139	0.0176
Toxoplasma gondii	subtilisin SUB11	0.0106	0.0272	0.7217
Echinococcus granulosus	dro:myosuppressin receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	serotonin receptor	0.0066	0.0096	0.0096
Brugia malayi	G protein-coupled receptor F59B2.13	0.0066	0.0096	0.0096
Schistosoma mansoni	histamine h1 receptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	tubulin gamma chain, putative	0.0067	0.0101	0.0176
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0106	0.0272	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0066	0.0096	0.0096
Brugia malayi	sulfakinin receptor protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0106	0.0272	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	somatostatin receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0096	0.0096
Echinococcus multilocularis	fmrfamide receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	neuropeptide Y receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	neuropeptide Y receptor	0.0066	0.0096	0.0122
Trichomonas vaginalis	hypothetical protein	0.048	0.1907	0.3319
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0626	0.0626
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus multilocularis	somatostatin receptor	0.0066	0.0096	0.0122
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	melatonin receptor type 1A	0.0066	0.0096	0.0096
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0066	0.0096	0.0122
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0066	0.0096	0.0096
Brugia malayi	neuropeptide F receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.2332	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Plasmodium falciparum	subtilisin-like protease 3	0.0106	0.0272	1
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0106	0.0272	0.0272
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0067	0.0101	0.0176
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0106	0.0272	0.5
Loa Loa (eye worm)	subtilase	0.0106	0.0272	0.0272
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1359	0.5745	0.5745
Schistosoma mansoni	amine GPCR	0.0066	0.0096	0.0096
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.048	0.1907	0.3319
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Schistosoma mansoni	myosin xvIII	0.0066	0.0096	0.0096
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0106	0.0272	0.0272
Brugia malayi	Melatonin receptor type 1A	0.0066	0.0096	0.0096
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0106	0.0272	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Brugia malayi	larval opioid receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	amine GPCR	0.0066	0.0096	0.0096
Schistosoma mansoni	biogenic amine receptor	0.0066	0.0096	0.0096
Plasmodium falciparum	subtilisin-like protease 2	0.0106	0.0272	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0096	0.0096
Echinococcus granulosus	neuropeptide Y receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	wd40 repeat	0.0076	0.0139	0.0139
Echinococcus granulosus	neuroendocrine convertase 2	0.1585	0.6737	0.6737
Brugia malayi	celfurPC protein	0.1852	0.7902	0.7902
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0066	0.0096	0.0096
Echinococcus granulosus	furin	0.2332	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus granulosus	g protein coupled receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.0096	0.0096
Plasmodium vivax	subtilisin-like protease 2, putative	0.0106	0.0272	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0067	0.0101	0.0176
Echinococcus multilocularis	dro:myosuppressin receptor	0.0066	0.0096	0.0122
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	opsin-like receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0272	0.0473
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0106	0.0272	0.0272
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.2482	0.432
Echinococcus multilocularis	neuropeptide s receptor	0.0066	0.0096	0.0122
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Brugia malayi	Dopamine receptor protein 2	0.0066	0.0096	0.0096
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0106	0.0272	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.2482	0.432
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0096	0.0096
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0106	0.0272	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.2482	0.432
Loa Loa (eye worm)	beta-tubulin	0.0067	0.0101	0.0101
Onchocerca volvulus		0.0071	0.0119	0.1302
Schistosoma mansoni	tubulin subunit beta	0.0067	0.0101	0.0101
Echinococcus granulosus	beta tubulin	0.0067	0.0101	0.0101
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0066	0.0096	0.0096
Echinococcus granulosus	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.0096	0.0122
Brugia malayi	Serotonin receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0066	0.0096	0.0096
Echinococcus granulosus	orexin receptor type 2	0.0066	0.0096	0.0096
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0066	0.0096	0.0096
Schistosoma mansoni	hypothetical protein	0.048	0.1907	0.1907
Echinococcus granulosus	neuropeptides capa receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0066	0.0096	0.0096
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0999	0.4175	0.4175
Echinococcus granulosus	tubulin beta 1 chain	0.0067	0.0101	0.0101
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus multilocularis	Furin 1	0.0612	0.2482	0.3141
Brugia malayi	ORL1-like opioid receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0612	0.2482	0.2482
Echinococcus multilocularis	fmrfamide receptor	0.0066	0.0096	0.0122
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0066	0.0096	0.0122
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus multilocularis	protein will die slowly	0.0071	0.0119	0.0151
Echinococcus granulosus	Tubulin beta 2C chain	0.0067	0.0101	0.0101
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0066	0.0096	0.0096
Echinococcus granulosus	g protein coupled receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.0096	0.0122
Echinococcus granulosus	neuropeptide receptor	0.0214	0.0745	0.0745
Giardia lamblia	Furin precursor putative serine protease	0.0506	0.2018	0.622
Trichomonas vaginalis	WD repeat domain, putative	0.0071	0.0119	0.0207
Echinococcus granulosus	epidermal growth factor receptor	0.0134	0.0394	0.0394
Loa Loa (eye worm)	tubulin beta-2A chain	0.0067	0.0101	0.0101
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0066	0.0096	0.0122
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0132	0.0384	0.0668
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Schistosoma mansoni	neuropeptide F-like receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.0096	0.0096
Schistosoma mansoni	adenoreceptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0066	0.0096	0.0096
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0066	0.0096	0.0122
Brugia malayi	Will die slowly protein	0.0071	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Loa Loa (eye worm)	BEN-1 protein	0.0067	0.0101	0.0101
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0106	0.0272	0.0272
Echinococcus multilocularis	Tubulin beta 2C chain	0.0067	0.0101	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0096	0.0096
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0106	0.0272	0.0272
Brugia malayi	G-protein coupled receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	orexin receptor type 2	0.0066	0.0096	0.0122
Plasmodium falciparum	subtilisin-like protease 1	0.0106	0.0272	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1359	0.5745	0.7271
Echinococcus granulosus	biogenic amine 5HT receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0134	0.0394	0.0394
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0106	0.0272	0.5
Loa Loa (eye worm)	proprotein convertase 2	0.0612	0.2482	0.2482
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0272	0.0473
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0106	0.0272	1
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0272	0.0473
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Plasmodium vivax	subtilisin-like serine protease, putative	0.0106	0.0272	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0066	0.0096	0.0096
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0066	0.0096	0.0122
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	neuropeptide FF receptor 2	0.0066	0.0096	0.0096
Loa Loa (eye worm)	G-protein coupled receptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Toxoplasma gondii	subtilisin SUB5	0.0106	0.0272	0.7217
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0272	0.0473
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0066	0.0096	0.0122
Echinococcus multilocularis	neuropeptides capa receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	TYRA-2 protein	0.0066	0.0096	0.0096
Entamoeba histolytica	tubulin family protein	0.0067	0.0101	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.0096	0.0122
Trichomonas vaginalis	tubulin, putative	0.0067	0.0101	0.0176
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0066	0.0096	0.0122
Schistosoma mansoni	hypothetical protein	0.0066	0.0096	0.0096
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Schistosoma mansoni	tyrosine kinase	0.0134	0.0394	0.0394
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0066	0.0096	0.0122
Entamoeba histolytica	tubulin family protein	0.0067	0.0101	0.5
Plasmodium vivax	tubulin beta chain, putative	0.0067	0.0101	0.3713
Echinococcus granulosus	tubulin beta 4A class IVa	0.0067	0.0101	0.0101
Brugia malayi	RE15519p	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Brugia malayi	putative neuropeptide receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0066	0.0096	0.0096
Toxoplasma gondii	subtilisin SUB7	0.0106	0.0272	0.7217
Echinococcus multilocularis	sex peptide receptor	0.0066	0.0096	0.0122
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0066	0.0096	0.0096
Echinococcus granulosus	sex peptide receptor	0.0066	0.0096	0.0096
Toxoplasma gondii	subtilisin SUB8	0.0106	0.0272	0.7217
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.0096	0.0122
Brugia malayi	G protein-coupled receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	beta tubulin	0.0067	0.0101	0.0128
Schistosoma mansoni	opsin-like receptor	0.0066	0.0096	0.0096
Onchocerca volvulus		0.0106	0.0272	1
Brugia malayi	Tubulin beta-1 chain	0.0067	0.0101	0.0101
Trichomonas vaginalis	tubulin alpha chain, putative	0.0067	0.0101	0.0176
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.0096	0.0096
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0096	0.0122
Schistosoma mansoni	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0066	0.0096	0.0096
Echinococcus granulosus	neuropeptide s receptor	0.0066	0.0096	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.048	0.1907	0.3319
Schistosoma mansoni	biogenic amine receptor	0.0066	0.0096	0.0096
Brugia malayi	GnHR receptor homolog	0.0066	0.0096	0.0096
Echinococcus multilocularis	Tubulin beta 2C chain	0.0067	0.0101	0.0128
Echinococcus multilocularis	Tubulin beta 2C chain	0.0067	0.0101	0.0128
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis		0.1852	0.7902	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0096	0.0096
Schistosoma mansoni	tubulin subunit beta	0.0067	0.0101	0.0101
Echinococcus granulosus	biogenic amine 5HT receptor	0.0066	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus multilocularis	neuropeptide receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0272	0.0272
Schistosoma mansoni	neuropeptide receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	amine GPCR	0.0066	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0066	0.0096	0.0096
Schistosoma mansoni	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	protein will die slowly	0.0071	0.0119	0.0119
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1359	0.5745	1
Brugia malayi	follicle stimulating hormone receptor	0.0066	0.0096	0.0096
Echinococcus multilocularis	Tubulin beta 2C chain	0.0067	0.0101	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0066	0.0096	0.0096
Echinococcus granulosus	g protein coupled receptor	0.0066	0.0096	0.0096
Loa Loa (eye worm)	WD40 repeat protein	0.0071	0.0119	0.0119
Schistosoma mansoni	neuropeptide f receptor 76f	0.0066	0.0096	0.0096
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0132	0.0384	0.0384
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0106	0.0272	0.0473
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0106	0.0272	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0106	0.0272	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0096	0.0096
Schistosoma mansoni	biogenic amine receptor	0.0066	0.0096	0.0096
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0106	0.0272	0.5
Loa Loa (eye worm)	tubulin beta-4 chain	0.0067	0.0101	0.0101
Schistosoma mansoni	amine GPCR	0.0066	0.0096	0.0096
Schistosoma mansoni	amine GPCR	0.0066	0.0096	0.0096
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0067	0.0101	0.0128
Echinococcus multilocularis	tubulin beta 1 chain	0.0067	0.0101	0.0128
Echinococcus multilocularis	serotonin receptor	0.0066	0.0096	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0096	0.0096
Echinococcus granulosus	Tubulin beta 2C chain	0.0067	0.0101	0.0101
Echinococcus granulosus	neuropeptide receptor	0.0066	0.0096	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0096	0.0096
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0506	0.2018	0.3513

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1908872

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1565063