Detailed information for compound 1565178

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 534.998 | Formula: C28H30ClF3N2O3
  • H donors: 1 H acceptors: 2 LogP: 5.58 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(CN1CCN(CC1)c1ccc(cc1)F)COc1ccc(cc1C(=O)CCc1ccc(cc1)F)F.Cl
  • InChi: 1S/C28H29F3N2O3.ClH/c29-21-4-1-20(2-5-21)3-11-27(35)26-17-23(31)8-12-28(26)36-19-25(34)18-32-13-15-33(16-14-32)24-9-6-22(30)7-10-24;/h1-2,4-10,12,17,25,34H,3,11,13-16,18-19H2;1H
  • InChiKey: UVYYBRIGEOLLHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0615 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.071 0.0954
Schistosoma mansoni cpg binding protein 0.003 0.0611 0.0488
Trichomonas vaginalis rotamase, putative 0.0033 0.0709 0.0953
Brugia malayi hypothetical protein 0.0033 0.0694 0.0839
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.1061 0.1452
Brugia malayi hypothetical protein 0.0236 0.6862 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0509 0.066
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0076 0.0609
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0076 0.0026
Brugia malayi Pre-SET motif family protein 0.0208 0.6021 0.8751
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1543 0.1433
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.015 0.0972
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1543 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.1245 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.1061 0.0993
Brugia malayi PAS domain containing protein 0.0049 0.1174 0.1553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.015 0.0135
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0129 0.0053
Schistosoma mansoni lamin 0.0054 0.1331 0.1218
Schistosoma mansoni hypothetical protein 0.0032 0.066 0.0538
Echinococcus granulosus lamin dm0 0.0054 0.1331 0.1265
Onchocerca volvulus 0.0048 0.1153 0.1579
Echinococcus multilocularis transcription factor btf3 0.0035 0.0751 0.068
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0129 0.0053
Echinococcus granulosus single minded 2 0.0036 0.0789 0.0718
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1077 0.1409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0431 0.0545
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.1061 0.8524
Leishmania major basic transcription factor 3a, putative 0.0035 0.0751 0.4864
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.1061 0.6879
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0339 0.2719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.071 0.0954
Entamoeba histolytica hypothetical protein 0.0109 0.3001 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.015 0.1204
Schistosoma mansoni survival motor neuron protein 0.0048 0.1153 0.1038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0615 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.071 0.0954
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0482 0.0409
Schistosoma mansoni intermediate filament proteins 0.0054 0.1331 0.1218
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.1245 1
Schistosoma mansoni hypothetical protein 0.0339 1 1
Echinococcus multilocularis lamin dm0 0.0054 0.1331 0.1265
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0482 0.0598
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.1061 0.0993
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.1245 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1543 1
Brugia malayi Cytochrome P450 family protein 0.0045 0.1071 0.1399
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.3001 0.291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0781 0.1057
Loa Loa (eye worm) hypothetical protein 0.0164 0.467 0.677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0509 0.066
Brugia malayi beta-NAC-like protein 0.0035 0.0751 0.0923
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0076 0.0026
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0076 0.0026
Trichomonas vaginalis rotamase, putative 0.0033 0.0685 0.0918
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.015 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0431 0.0545
Entamoeba histolytica hypothetical protein 0.0109 0.3001 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.015 0.1204
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0751 0.6027
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0751 0.1013
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0129 0.0053
Onchocerca volvulus 0.0054 0.1331 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0431 0.0545
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.015 0.0972
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0789 0.0718
Echinococcus granulosus expressed protein 0.0033 0.0709 0.0638
Brugia malayi CXXC zinc finger family protein 0.0029 0.0561 0.0642
Leishmania major hypothetical protein, conserved 0.0051 0.1245 0.8071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1077 0.1009
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.1061 0.8524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.015 0.0135
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0751 0.6027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1543 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.015 0.1204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0781 0.1057
Loa Loa (eye worm) hypothetical protein 0.0054 0.1331 0.1849
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.015 0.0031
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0782 0.628
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0076 0.0026
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0685 0.5503
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1543 0.1478
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0615 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.015 0.0135
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0562 0.049
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0569 0.0727
Schistosoma mansoni hypothetical protein 0.0069 0.1786 0.1679
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0076 0.0609
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0076 0.0026
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0076 0.0609
Schistosoma mansoni hypothetical protein 0.0032 0.066 0.0538
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0685 0.5503
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0388 0.0314
Echinococcus multilocularis lamin 0.0054 0.1331 0.1265
Brugia malayi Death domain containing protein 0.0014 0.0129 0.000000094097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1077 0.0961
Schistosoma mansoni hypothetical protein 0.0103 0.2837 0.2743
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0569 0.0654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.1061 0.1385
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.015 0.0109
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.1061 0.6879
Echinococcus granulosus lamin 0.0054 0.1331 0.1265
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.1245 1
Echinococcus multilocularis expressed protein 0.0033 0.0709 0.0638
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0078
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1543 1
Entamoeba histolytica hypothetical protein 0.0109 0.3001 1
Schistosoma mansoni hypothetical protein 0.0032 0.066 0.0538
Echinococcus granulosus intermediate filament protein 0.0054 0.1331 0.1265
Mycobacterium leprae Possible regulatory protein 0.0013 0.0076 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.071 0.0954
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0751 0.0282
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0482 0.0409
Trichomonas vaginalis set domain proteins, putative 0.0237 0.6893 1
Entamoeba histolytica hypothetical protein 0.0109 0.3001 1
Brugia malayi hypothetical protein 0.0164 0.467 0.6744
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1543 0.1478
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0685 0.5503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.058 0.0764
Schistosoma mansoni hypothetical protein 0.0023 0.0388 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0076 0.0026
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0751 0.6027
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.1937 0.1876
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.1331 0.1785
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.015 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1077 0.0961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0429 0.0543
Onchocerca volvulus 0.0237 0.6897 1
Leishmania major protein kinase, putative 0.0013 0.0076 0.0492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1077 0.0961
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1543 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.1245 0.1723
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.1061 0.1624
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0076 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1077 0.1476
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.1061 0.8524
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0709 0.0933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0501 0.0649
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0129 0.0053
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1543 0.1433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.071 0.0954
Echinococcus granulosus death domain containing protein 0.0014 0.0129 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1571 0.1461
Echinococcus multilocularis Ankyrin 0.0015 0.0133 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1061 0.1468
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0076 0.0609
Echinococcus multilocularis GPCR, family 2 0.0032 0.066 0.0589
Brugia malayi Latrophilin receptor protein 2 0.0032 0.066 0.0789
Loa Loa (eye worm) hypothetical protein 0.0053 0.1301 0.1805
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0615 0.0492
Schistosoma mansoni hypothetical protein 0.0048 0.1153 0.1038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.071 0.0954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0431 0.0545
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.066 0.0589
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.1061 0.1624
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0076 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0133 0.0083
Schistosoma mansoni rotamase 0.0033 0.0709 0.0588
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0751 0.0994
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0615 0.0543
Brugia malayi hypoxia-induced factor 1 0.0151 0.4284 0.6172
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.1071 0.1466
Loa Loa (eye worm) hypothetical protein 0.0025 0.0452 0.0554
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.066 0.0589
Echinococcus multilocularis musashi 0.0054 0.1331 0.1265
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0709 0.0953
Loa Loa (eye worm) intermediate filament protein 0.0054 0.1331 0.1849
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0076 0.0026
Brugia malayi hypothetical protein 0.0109 0.3001 0.4265
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.6862 0.6838
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0429 0.0543
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.1331 0.1849
Schistosoma mansoni single-minded 0.0049 0.1174 0.1059
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.6862 0.6838
Echinococcus granulosus cpg binding protein 0.003 0.0611 0.0539
Brugia malayi Uncoordinated protein 44 0.0014 0.0129 0.000000094097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1077 0.1009
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0709 0.0862
Schistosoma mansoni lamin 0.0054 0.1331 0.1218
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0388 0.0314
Loa Loa (eye worm) hypothetical protein 0.0025 0.0452 0.0554
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0076 0.0609
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0782 0.628
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1374 0.8903
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.066 0.0789
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.2757 0.395
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0076 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0751 0.1013
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.1245 1
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.1245 0.8071
Leishmania major protein kinase, putative 0.0013 0.0076 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0781 0.1057
Schistosoma mansoni hypothetical protein 0.0032 0.066 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0781 0.1057
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1786 0.2462
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.061 0.0807
Echinococcus granulosus Ankyrin 0.0015 0.0133 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0076 0.0026
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0076 0.0492
Loa Loa (eye worm) hypothetical protein 0.0101 0.2757 0.395
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0615 0.3983
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0615 0.0543
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0129 0.000000064186
Schistosoma mansoni hypothetical protein 0.0339 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0501 0.0649
Onchocerca volvulus 0.0036 0.0789 0.1045
Brugia malayi Protein kinase domain containing protein 0.0014 0.0129 0.000000094097
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0129 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.3001 0.2947
Echinococcus granulosus transcription factor btf3 0.0035 0.0751 0.068
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.1061 0.8524
Loa Loa (eye worm) hypothetical protein 0.003 0.0615 0.0794
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0129 0.0078
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.071 0.4602
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0133 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0429 0.0543
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.1937 0.1876
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0751 0.4864
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0782 0.5068
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.1061 0.0945
Onchocerca volvulus 0.0029 0.0561 0.0711
Schistosoma mansoni hypothetical protein 0.0109 0.3001 0.291
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0685 0.4442
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.066 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0076 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1061 0.1468
Giardia lamblia GTOR 0.0045 0.1061 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0781 0.1057
Schistosoma mansoni cpg binding protein 0.003 0.0611 0.0488
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.4284 0.6201
Onchocerca volvulus 0.0054 0.1331 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0509 0.066
Loa Loa (eye worm) hypothetical protein 0.0236 0.6862 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.015 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.1245 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0561 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.071 0.0954
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0685 0.4442
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.3001 0.2947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.015 0.0135
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.2757 0.3903
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.6021 0.8761
Loa Loa (eye worm) hypothetical protein 0.0032 0.066 0.0861
Schistosoma mansoni cpg binding protein 0.0029 0.0561 0.0438
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.1174 0.1059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1061 0.1468
Schistosoma mansoni transcription factor btf3 0.0035 0.0751 0.063
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.066 0.0589
Echinococcus multilocularis geminin 0.0339 1 1
Onchocerca volvulus 0.003 0.0615 0.079
Brugia malayi hypothetical protein 0.0051 0.1245 0.1658
Echinococcus granulosus GPCR family 2 0.0032 0.066 0.0589
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0615 0.0492
Brugia malayi Pre-SET motif family protein 0.003 0.0615 0.0721
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.066 0.0861
Echinococcus multilocularis cpg binding protein 0.003 0.0611 0.0539
Brugia malayi intermediate filament protein 0.0054 0.1331 0.1785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1077 0.1009
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0076 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1077 0.1009
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0751 0.1013
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0751 0.2156
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0789 0.098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.2757 0.3903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0861 0.1175
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.026 0.2085
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.015 0.1204
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1543 1
Entamoeba histolytica hypothetical protein 0.0035 0.0751 0.0282
Loa Loa (eye worm) hypothetical protein 0.0069 0.1786 0.252
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1153 0.1521

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.