Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.362 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.362 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.362 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0503 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.362 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.362 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.362 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.362 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0503 | 0.139 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.362 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 1 | 0.5 |
Onchocerca volvulus | 0.0025 | 0.362 | 0.5 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.362 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.362 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0503 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.362 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.362 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0503 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 1 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.362 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 1 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.362 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 530 nM | Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assay | ChEMBL. | 21924902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.