Detailed information for compound 1565246

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.397 | Formula: C16H29BrN4S
  • H donors: 2 H acceptors: 1 LogP: 4.54 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN/C(=N/C1CCCC1)/SCCCc1c[nH]cn1.Br
  • InChi: 1S/C16H28N4S.BrH/c1-2-3-10-18-16(20-14-7-4-5-8-14)21-11-6-9-15-12-17-13-19-15;/h12-14H,2-11H2,1H3,(H,17,19)(H,18,20);1H
  • InChiKey: HQGVDQKFJYWFIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H4 Starlite/ChEMBL References
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pax transcription factor protein 2 0.0266 0.7755 0.7755
Schistosoma mansoni tsg101-related 0.012 0.3349 0.3349
Brugia malayi RNA, U transporter 1 0.0091 0.2451 0.3161
Schistosoma mansoni smad1 5 8 and 0.0017 0.0222 0.0222
Entamoeba histolytica recQ family helicase, putative 0.0015 0.016 0.0597
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0702 0.0702
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0897 0.2984
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.2488 0.3208
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0441 0.1774
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1085 0.4363
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0065 0.1662 1
Brugia malayi hypothetical protein 0.0145 0.408 0.526
Schistosoma mansoni DNA helicase recq1 0.003 0.0628 0.0628
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0222 0.0222
Brugia malayi hypothetical protein 0.004 0.0913 0.1177
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0237 0.129
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.1852 0.2387
Schistosoma mansoni hypothetical protein 0.0033 0.0702 0.0702
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Loa Loa (eye worm) hypothetical protein 0.0109 0.3007 0.3007
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0239 0.0006
Schistosoma mansoni hypothetical protein 0.0033 0.0702 0.0702
Entamoeba histolytica hypothetical protein 0.0024 0.0441 0.1645
Loa Loa (eye worm) hypothetical protein 0.0052 0.1294 0.1294
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2488 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0222 0.0222
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.2488 0.3208
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Brugia malayi hypothetical protein 0.0034 0.0733 0.0945
Echinococcus multilocularis smad 0.0017 0.0222 0.0222
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.2075 0.69
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.7211 0.7211
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0628 0.3415
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Mycobacterium ulcerans DNA polymerase IV 0.0086 0.2296 1
Echinococcus granulosus dna polymerase kappa 0.0086 0.2296 0.2296
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2488 1
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0237 0.0788
Leishmania major DNA polymerase eta, putative 0.007 0.1837 0.5777
Trypanosoma brucei unspecified product 0.0078 0.2075 0.69
Echinococcus granulosus Smad4 0.0017 0.0222 0.0222
Trichomonas vaginalis DNA helicase recq1, putative 0.0074 0.1932 0.7766
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0062 0.0062
Loa Loa (eye worm) Smad1 0.0017 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.027 0.7871 0.7871
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2488 0.8273
Echinococcus multilocularis protein C ets 2 0.0012 0.0062 0.0062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0178 0.0592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.2843 0.3665
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.005 0.1213 0.937
Schistosoma mansoni Smad4 0.0017 0.0222 0.0222
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.2131 0.2131
Entamoeba histolytica hypothetical protein 0.004 0.0913 0.3404
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0674 0.2242
Plasmodium falciparum importin beta, putative 0.0032 0.0674 0.4057
Mycobacterium ulcerans DNA polymerase IV 0.0086 0.2296 1
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0239 0.0239
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0702 0.0702
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0239 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0441 0.1468
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0098 0.2682 1
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0062 0.0062
Toxoplasma gondii ImpB/MucB/SamB family protein 0.007 0.1837 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.2488 0.2488
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0237 0.0788
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0913 0.0913
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0222 0.0222
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0492 0.1978
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.1627 0.5019
Echinococcus granulosus bloom syndrome protein 0.0074 0.1932 0.1932
Entamoeba histolytica recQ family helicase, putative 0.0039 0.0897 0.3345
Loa Loa (eye worm) fli-1 protein 0.0243 0.706 0.706
Brugia malayi ImpB/MucB/SamB family protein 0.0109 0.3007 0.3878
Entamoeba histolytica hypothetical protein 0.0026 0.0492 0.1834
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Loa Loa (eye worm) hypothetical protein 0.0033 0.0702 0.0702
Schistosoma mansoni DNA polymerase eta 0.0109 0.3007 0.3007
Schistosoma mansoni smad 0.0017 0.0222 0.0222
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0702 0.0905
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0458 0.249
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2488 0.8273
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0628 0.0809
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0913 0.0913
Trichomonas vaginalis DNA polymerase eta, putative 0.0086 0.2296 0.9228
Onchocerca volvulus 0.0266 0.7755 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0062 0.0062
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0145 0.408 0.408
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0062 0.0062
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0178 0.0663
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.1852 0.1852
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.1407 0.8412
Trichomonas vaginalis hypothetical protein 0.007 0.1839 0.739
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0237 0.0788
Echinococcus granulosus GPCR family 2 0.0033 0.0702 0.0702
Trypanosoma brucei unspecified product 0.0039 0.088 0.2927
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0239 0.0794
Schistosoma mansoni gabp alpha 0.008 0.2131 0.2131
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0239 0.0308
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.1407 0.1407
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0049 0.1195 0.6503
Loa Loa (eye worm) hypothetical protein 0.0104 0.2843 0.2843
Giardia lamblia Kinase, PLK 0.0092 0.2488 1
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.1294 0.4304
Brugia malayi polk-prov protein 0.0047 0.1126 0.1452
Echinococcus multilocularis dna polymerase eta 0.0109 0.3007 0.3007
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0062 0.0062
Echinococcus granulosus GA binding protein alpha chain 0.008 0.2131 0.2131
Brugia malayi Ets-domain containing protein 0.008 0.2131 0.2748
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0222 0.0222
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0086 0.2296 0.9228
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1126 0.3744
Giardia lamblia DNA damage repair protein 0.0017 0.0237 0.0953
Schistosoma mansoni importin beta-1 0.0032 0.0674 0.0674
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0015 0.016 0.1237
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0702 0.0702
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0674 0.2242
Loa Loa (eye worm) hypothetical protein 0.003 0.0628 0.0628
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0674 0.367
Loa Loa (eye worm) hypothetical protein 0.0047 0.1126 0.1126
Echinococcus multilocularis snurportin 1 0.0341 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0702 0.0702
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Echinococcus granulosus importin subunit beta 1 0.0032 0.0674 0.0674
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.1837 0.611
Echinococcus granulosus dna polymerase eta 0.0109 0.3007 0.3007
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0239 0.0794
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0628 0.0809
Plasmodium vivax importin-beta 2, putative 0.0032 0.0674 0.5211
Schistosoma mansoni smad1 5 8 and 0.0017 0.0222 0.0222
Entamoeba histolytica hypothetical protein 0.0024 0.0441 0.1645
Echinococcus granulosus protein C ets 2 0.0012 0.0062 0.0062
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0674 0.0674
Schistosoma mansoni tsg101-related 0.0098 0.2682 0.2682
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.1294 0.7786
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0062 0.0062
Brugia malayi Importin beta-1 subunit 0.0032 0.0674 0.087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0239 0.0239
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.1407 0.1814
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Schistosoma mansoni ets 0.0012 0.0062 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1101 0.3661
Schistosoma mansoni DNA helicase recq5 0.003 0.0628 0.0628
Schistosoma mansoni tsg101-related 0.012 0.3349 0.3349
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0062 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.2843 0.3665
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1085 0.4363
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.1407 0.1407
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.1294 0.7786
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0178 0.0592
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Mycobacterium ulcerans hypothetical protein 0.0017 0.0237 0.1032
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0239 0.1436
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0062 0.0062
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0913 0.0913
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0178 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1101 0.3661
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0628 0.0628
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.1407 0.5245
Schistosoma mansoni elf1 0.0012 0.0062 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0239 0.0239
Echinococcus multilocularis ets variant gene 4 0.0012 0.0062 0.0062
Brugia malayi STAT protein, DNA binding domain containing protein 0.0128 0.3578 0.4613
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.1294 0.4304
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0341 1 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0237 0.1426
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0239 0.0794
Brugia malayi Bloom's syndrome protein homolog 0.0074 0.1932 0.2491
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Trypanosoma brucei DNA polymerase IV, putative 0.0086 0.2296 0.7634
Schistosoma mansoni hypothetical protein 0.0341 1 1
Entamoeba histolytica hypothetical protein 0.0024 0.0441 0.1645
Entamoeba histolytica hypothetical protein 0.004 0.0913 0.3404
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0628 0.0628
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2488 1
Brugia malayi Ets-domain containing protein 0.008 0.2131 0.2748
Brugia malayi Ets-domain containing protein 0.0012 0.0062 0.0079
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0145 0.408 0.408
Brugia malayi MH1 domain containing protein 0.0017 0.0222 0.0286
Trypanosoma cruzi DNA polymerase eta, putative 0.0109 0.3007 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0239 0.0239
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0024 0.0421 0.0421
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0239 0.1844
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0897 0.2384
Echinococcus granulosus smad 0.0017 0.0222 0.0222
Brugia malayi Smad1 0.0017 0.0222 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1101 0.3661
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0492 0.1636
Brugia malayi Fli-1 protein 0.0243 0.706 0.9103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.1407 0.1407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0062
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.1294 1
Leishmania major DNA polymerase eta, putative 0.0109 0.3007 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0062
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0062 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.2488 0.2488
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0237 0.0788
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0237 0.0788
Brugia malayi MH2 domain containing protein 0.0017 0.0222 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2488 0.2488
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Loa Loa (eye worm) hypothetical protein 0.0069 0.178 0.178
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2488 1
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.7211 0.7211
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0239 0.1299
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0222 0.0222
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0441 0.1774
Trypanosoma brucei unspecified product 0.0039 0.088 0.2927
Trichomonas vaginalis DNA helicase recq, putative 0.0039 0.0897 0.3607
Brugia malayi MH2 domain containing protein 0.0248 0.7211 0.9298
Schistosoma mansoni hypothetical protein 0.0071 0.1852 0.1852
Treponema pallidum ATP-dependent DNA helicase 0.0015 0.0178 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0628 0.0628
Schistosoma mansoni hypothetical protein 0.004 0.0913 0.0913
Schistosoma mansoni hypothetical protein 0.0012 0.0062 0.0062
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0628 0.3775
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0062 0.0062
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0421 0.0421
Leishmania major DNA polymerase kappa, putative 0.0063 0.1627 0.5019
Chlamydia trachomatis DNA ligase 0.001 0 0.5
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0046 0.1108 0.3684
Giardia lamblia DINP protein human, muc B family 0.0063 0.1627 0.6541
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Brugia malayi hypothetical protein 0.0052 0.1294 0.1669
Loa Loa (eye worm) RecQ helicase 0.0074 0.1932 0.1932
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0239 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0237 0.0788
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.1407 0.1407
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.2131 0.2131
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0178 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1126 0.3744
Loa Loa (eye worm) hypothetical protein 0.0032 0.0674 0.0674
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.2488 0.8125
Schistosoma mansoni blooms syndrome DNA helicase 0.0058 0.1465 0.1465
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0222 0.0222
Trypanosoma brucei DNA polymerase eta, putative 0.0109 0.3007 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0492 0.1978
Trypanosoma brucei polo-like protein kinase 0.0092 0.2488 0.8273
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0441 0.1468
Echinococcus multilocularis Smad4 0.0017 0.0222 0.0222
Echinococcus multilocularis bloom syndrome protein 0.0074 0.1932 0.1932
Schistosoma mansoni hypothetical protein 0.0012 0.0062 0.0062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0897 0.2984
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0237 0.0788
Schistosoma mansoni smad1 5 8 and 0.0017 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0033 0.0702 0.0702
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0237 0.0788
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.2843 0.2843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0628 0.3415
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0628 0.0628
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0024 0.0441 0.1468
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0062 0.0062
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0421 0.0421
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2488 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0702 0.0905
Schistosoma mansoni ets-related 0.0243 0.706 0.706
Leishmania major importin beta-1 subunit, putative 0.0026 0.0492 0.0921
Loa Loa (eye worm) STAT protein 0.0128 0.3578 0.3578
Brugia malayi Pax transcription factor protein 2 0.0266 0.7755 1
Schistosoma mansoni kinase 0.0047 0.1122 0.1122
Entamoeba histolytica hypothetical protein 0.004 0.0913 0.3404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0239 0.0794
Schistosoma mansoni hypothetical protein 0.0033 0.0702 0.0702
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0222 0.0222
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0145 0.408 0.408
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0237 0.1831
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2488 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0239 0.0239
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0062 0.0062
Echinococcus multilocularis GPCR, family 2 0.0033 0.0702 0.0702
Echinococcus multilocularis dna polymerase kappa 0.0086 0.2296 0.2296
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.1627 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0178 0.0178
Brugia malayi isocitrate dehydrogenase 0.0017 0.0239 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.1627 0.5411
Trichomonas vaginalis DNA helicase recq, putative 0.0074 0.1932 0.7766
Schistosoma mansoni ets-related 0.0012 0.0062 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.2296 0.7634
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0062 0.0079
Entamoeba histolytica hypothetical protein 0.004 0.0913 0.3404
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.1294 0.4304
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0492 0.1978
Brugia malayi MH2 domain containing protein 0.0017 0.0222 0.0286
Brugia malayi transcription factor E74 isoform 0.0012 0.0062 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0086 0.2296 0.7634
Entamoeba histolytica hypothetical protein 0.0024 0.0441 0.1645
Leishmania major hypothetical protein, conserved 0.0046 0.1108 0.3143
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0239 0.0239
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0046 0.1108 0.3684
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.2488 0.2488
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0628 0.2523
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0702 0.0702
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0062 0.0062
Brugia malayi MH1 domain containing protein 0.0017 0.0222 0.0286
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0062 0.0062
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0237 0.0237
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.1407 0.1407
Leishmania major hypothetical protein, conserved 0.0052 0.1294 0.3816
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0237 0.0788
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.2488 0.9275
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2488 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0239 0.1299
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0062 0.0062
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.1294 0.7043

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7.33 Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting ChEMBL. 22003888
Ki (binding) = 7.79 Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting ChEMBL. 22003888

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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