Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0066 | 0.055 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0113 | 0.1237 | 0.1283 |
Schistosoma mansoni | DNA topoisomerase II | 0.0113 | 0.1237 | 0.2088 |
Brugia malayi | nuclear hormone receptor | 0.0311 | 0.4123 | 0.6963 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0161 | 0.1947 | 0.3288 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0151 | 0.1792 | 0.3027 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0113 | 0.1237 | 0.2088 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0113 | 0.1237 | 0.1237 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0704 | 0.1189 |
Entamoeba histolytica | dual specificity protein phosphatase, putative | 0.0688 | 0.9638 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0434 | 0.5921 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0434 | 0.5921 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0076 | 0.0703 | 0.1659 |
Plasmodium vivax | topoisomerase I, putative | 0.0151 | 0.1792 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0107 | 0.1148 | 0.6403 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0434 | 0.5921 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0113 | 0.1237 | 0.2088 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.0688 | 0.9638 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0066 | 0.055 | 0.5 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0151 | 0.1792 | 0.3027 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0151 | 0.1792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0259 | 0.0438 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0151 | 0.1792 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0151 | 0.1792 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0076 | 0.0703 | 0.1659 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0704 | 0.1189 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0151 | 0.1792 | 0.3027 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0127 | 0.1438 | 0.8024 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0151 | 0.1792 | 0.3027 |
Brugia malayi | DNA topoisomerase I | 0.0151 | 0.1792 | 0.3027 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0161 | 0.1947 | 0.3288 |
Brugia malayi | Probable DNA topoisomerase II | 0.0113 | 0.1237 | 0.2088 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0161 | 0.1947 | 0.1947 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0076 | 0.0703 | 0.1659 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0259 | 0.0438 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0113 | 0.1237 | 0.5527 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0113 | 0.1237 | 0.1283 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.4024 | 0.6795 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0127 | 0.1438 | 0.8024 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0113 | 0.1237 | 0.5527 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0161 | 0.1947 | 0.3288 |
Leishmania major | DNA topoisomerase ii | 0.0107 | 0.1148 | 0.6403 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0311 | 0.4123 | 0.6963 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0318 | 0.4235 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0066 | 0.055 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0434 | 0.5921 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0161 | 0.1947 | 0.3288 |
Plasmodium falciparum | topoisomerase I | 0.0151 | 0.1792 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0127 | 0.1438 | 0.8024 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0113 | 0.1237 | 0.2088 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0127 | 0.1438 | 0.8024 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0066 | 0.055 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0107 | 0.1148 | 0.6403 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0151 | 0.1792 | 0.3027 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0161 | 0.1947 | 0.3288 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0151 | 0.1792 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0029 | 0.0017 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0434 | 0.5921 | 0.5921 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0107 | 0.1148 | 0.6403 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0113 | 0.1237 | 0.5527 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0066 | 0.055 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0113 | 0.1237 | 0.2088 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0107 | 0.1148 | 0.6403 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0161 | 0.1947 | 0.1947 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0151 | 0.1792 | 0.1792 |
Giardia lamblia | DNA topoisomerase II | 0.0107 | 0.1151 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 12 % | Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry | ChEMBL. | 22136336 |
Inhibition (binding) | = 15 % | Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry | ChEMBL. | 22136336 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.