TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.614 | Formula: C28H35FN6O4
H donors: 2 H acceptors: 3 LogP: 5.47 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1)Nc1nc(Nc2ccc(c(c2)F)OC)cc(n1)N1CCCN(CC1)C(=O)OC(C)(C)C
InChi: 1S/C28H35FN6O4/c1-28(2,3)39-27(36)35-14-6-13-34(15-16-35)25-18-24(30-20-9-12-23(38-5)22(29)17-20)32-26(33-25)31-19-7-10-21(37-4)11-8-19/h7-12,17-18H,6,13-16H2,1-5H3,(H2,30,31,32,33)
InChiKey: DGAHYYLIRNCMBX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	galanin receptor 1	Starlite/ChEMBL	References
Homo sapiens	galanin receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_128775	All targets in OG5_128775
Schistosoma mansoni	peptide (allatostatin)-like receptor	Get druggable targets OG5_128775	All targets in OG5_128775
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128775	All targets in OG5_128775
Echinococcus granulosus	allatostatin A receptor	Get druggable targets OG5_128775	All targets in OG5_128775
Echinococcus multilocularis	allatostatin A receptor	Get druggable targets OG5_128775	All targets in OG5_128775
Schistosoma japonicum	ko:K04233 galanin receptor, invertebrate, putative	Get druggable targets OG5_128775	All targets in OG5_128775

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	galanin receptor 1	349 aa	381 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0484	0.0954
Trichomonas vaginalis	rotamase, putative	0.0036	0.0483	0.0953
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0052	0.0026
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0049	0.0723	0.0675
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0734	0.0685
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0723	0.1469
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1051	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0388	0.0727
Echinococcus granulosus	lamin dm0	0.0058	0.0906	0.0859
Brugia malayi	hypothetical protein	0.0254	0.4673	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0023	0.0231	0.1744
Loa Loa (eye worm)	ICD-1 protein	0.0038	0.0511	0.0994
Echinococcus multilocularis	cpg binding protein	0.0033	0.0416	0.0366
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0418	0.0369
Onchocerca volvulus		0.0177	0.3185	0.6745
Entamoeba histolytica	hypothetical protein	0.0153	0.2721	1
Brugia malayi	Pre-SET motif family protein	0.0224	0.41	0.8751
Schistosoma mansoni	hypothetical protein	0.0036	0.0477	0.0393
Echinococcus multilocularis	musashi	0.0058	0.0906	0.0859
Brugia malayi	Pre-SET motif family protein	0.0033	0.0418	0.0721
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0102	0.0135
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0036	0.0477	0.0427
Entamoeba histolytica	hypothetical protein	0.0153	0.2721	1
Trypanosoma brucei	transcription factor BTF3, putative	0.0038	0.0511	0.3863
Schistosoma mansoni	hypothetical protein	0.0034	0.045	0.0365
Schistosoma mansoni	hypothetical protein	0.0531	1	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0058	0.0906	0.185
Loa Loa (eye worm)	hypothetical protein	0.0034	0.045	0.0861
Schistosoma mansoni	hypothetical protein	0.0034	0.045	0.0365
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0729	0.1466
Schistosoma mansoni	hypothetical protein	0.0034	0.045	0.0365
Trichomonas vaginalis	rotamase, putative	0.0035	0.0467	0.0918
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.045	0.0789
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0418	0.3163
Leishmania major	basic transcription factor 3a, putative	0.0038	0.0511	0.3863
Brugia malayi	bHLH-PAS transcription factor	0.0039	0.0537	0.0981
Schistosoma mansoni	transcription factor LCR-F1	0.0153	0.2721	0.2657
Echinococcus granulosus	lamin	0.0058	0.0906	0.0859
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0014	0.0052	0.0391
Schistosoma mansoni	single-minded	0.0053	0.08	0.0719
Onchocerca volvulus		0.0052	0.0785	0.1579
Trichomonas vaginalis	guanylate cyclase, putative	0.0014	0.0052	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0532	0.1058
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0014	0.0052	0.0391
Schistosoma mansoni	aryl hydrocarbon receptor	0.0053	0.08	0.0719
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0049	0.0723	0.0641
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0293	0.0545
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0088	0.000000094118
Trypanosoma cruzi	PAB1-binding protein , putative	0.008	0.1323	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.1877	0.3903
Echinococcus multilocularis	transfer RNA-Lys	0.0039	0.0537	0.0488
Brugia malayi	intermediate filament protein	0.0058	0.0906	0.1786
Onchocerca volvulus		0.0058	0.0906	0.184
Echinococcus multilocularis	transcription factor btf3	0.0038	0.0511	0.0462
Schistosoma mansoni	hypothetical protein	0.0034	0.045	0.0365
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0016	0.0102	0.0031
Loa Loa (eye worm)	phosphatidylinositol 3	0.0049	0.0723	0.1453
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.1877	0.3903
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.045	0.04
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0049	0.0723	0.5467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0102	0.0135
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0153	0.2721	0.2683
Schistosoma mansoni	cpg binding protein	0.0033	0.0416	0.0331
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.045	0.04
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0293	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0052	0.0026
Brugia malayi	Death domain containing protein	0.0016	0.0088	0.000000094118
Brugia malayi	hypoxia-induced factor 1	0.0163	0.2919	0.6175
Echinococcus granulosus	netrin receptor unc 5	0.0016	0.0088	0.0036
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0016	0.0102	0.0772
Schistosoma mansoni	hypothetical protein	0.0531	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0532	0.1058
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0383	0.0333
Loa Loa (eye worm)	phosphatidylinositol 3	0.0016	0.0102	0.0109
Trypanosoma cruzi	transcription factor btf3, putative	0.0038	0.0511	0.3863
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0511	0.1013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0734	0.0652
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0418	0.0334
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.0088	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0328	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0418	0.0793
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0163	0.2919	0.6204
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.1877	0.3951
Brugia malayi	beta-NAC-like protein	0.0038	0.0511	0.0923
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0532	0.1058
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0049	0.0723	0.1137
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0049	0.0723	0.0675
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0014	0.0052	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0342	0.0649
Toxoplasma gondii	peptidylprolyl isomerase	0.0035	0.0467	0.353
Toxoplasma gondii	NAC domain-containing protein	0.0038	0.0511	0.3863
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.045	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0177	0.3185	0.678
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0734	0.1476
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.0088	0.000000043534
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0483	0.0953
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0035	0.0467	0.353
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1217	0.2521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0484	0.0954
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0347	0.0661
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0153	0.2721	0.2683
Loa Loa (eye worm)	hypothetical protein	0.0254	0.4673	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1051	0.0972
Trichomonas vaginalis	adenylate cyclase, putative	0.0014	0.0052	0.0026
Onchocerca volvulus		0.0058	0.0906	0.184
Echinococcus multilocularis	survival motor neuron protein 1	0.0254	0.4673	0.4645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0416	0.0808
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0342	0.0649
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1051	0.1005
Schistosoma mansoni	rotamase	0.0036	0.0483	0.0399
Echinococcus multilocularis	netrin receptor unc 5	0.0016	0.0088	0.0036
Schistosoma mansoni	hypothetical protein	0.0052	0.0785	0.0703
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0347	0.0661
Leishmania major	protein kinase, putative	0.0014	0.0052	0.0391
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0039	0.0533	0.4027
Trypanosoma cruzi	PAB1-binding protein , putative	0.008	0.1323	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0293	0.0545
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1051	0.1005
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0014	0.0052	0.0391
Brugia malayi	hypothetical protein	0.0153	0.2721	0.5744
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0035	0.0467	0.353
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0014	0.0052	0.0391
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.107	0.0991
Onchocerca volvulus		0.0039	0.0537	0.1046
Schistosoma mansoni	hypothetical protein	0.0111	0.1932	0.1861
Onchocerca volvulus	Netrin receptor homolog	0.0016	0.0088	0.0078
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0049	0.0723	0.5467
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0308	0.0554
Trichomonas vaginalis	set domain proteins, putative	0.0255	0.4694	1
Trypanosoma brucei	PAB1-binding protein , putative	0.008	0.1323	1
Schistosoma mansoni	lamin	0.0058	0.0906	0.0826
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0049	0.0723	0.5467
Mycobacterium leprae	Possible regulatory protein	0.0014	0.0052	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0052	0.0391
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0785	0.0703
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0395	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0088	0.0078
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0785	0.1521
Giardia lamblia	GTOR	0.0049	0.0723	0.5
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0036	0.0483	0.0934
Toxoplasma gondii	LsmAD domain-containing protein	0.008	0.1323	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0293	0.0544
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0734	0.0685
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.0088	0.0078
Plasmodium falciparum	ataxin-2 like protein, putative	0.008	0.1323	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0511	0.1013
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.045	0.04
Loa Loa (eye worm)	intermediate filament protein	0.0058	0.0906	0.185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0102	0.0135
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.0011	0	0.5
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0467	0.353
Echinococcus granulosus	intermediate filament protein	0.0058	0.0906	0.0859
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0484	0.0954
Echinococcus granulosus	GPCR family 2	0.0034	0.045	0.04
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1877	0.3951
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0418	0.0334
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0418	0.0369
Trichomonas vaginalis	guanylate cyclase, putative	0.0014	0.0052	0.0026
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0014	0.0052	0.0391
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0467	0.353
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0102	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0308	0.0554
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1051	0.7947
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.0084
Brugia malayi	hypothetical protein	0.0052	0.0779	0.1508
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0484	0.0954
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0016	0.0102	0.0772
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0734	0.0652
Onchocerca volvulus		0.0033	0.0418	0.0789
Entamoeba histolytica	hypothetical protein	0.0153	0.2721	1
Schistosoma mansoni	lamin	0.0058	0.0906	0.0826
Echinococcus granulosus	expressed protein	0.0036	0.0483	0.0434
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.0088	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0723	0.1469
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1051	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0177	0.3185	0.3124
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.045	0.0861
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0052	0.0391
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0014	0.0052	0.0026
Plasmodium falciparum	ataxin-2 like protein, putative	0.008	0.1323	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0511	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0484	0.0954
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1051	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0014	0.0052	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0293	0.0545
Schistosoma mansoni	cpg binding protein	0.0031	0.0382	0.0297
Onchocerca volvulus		0.0255	0.4697	1
Brugia malayi	hypothetical protein	0.0176	0.3182	0.6748
Echinococcus granulosus	allatostatin A receptor	0.0177	0.3185	0.3149
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0036	0.0477	0.0427
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.008	0.132	0.1275
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0418	0.0369
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0935	0.7071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0347	0.0661
Entamoeba histolytica	transcription factor BTF3, putative	0.0038	0.0511	0.0196
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.009	0.0003
Plasmodium vivax	basic transcription factor 3b, putative	0.0038	0.0511	0.1024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0586	0.1175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0484	0.0954
Schistosoma mansoni	cpg binding protein	0.0033	0.0416	0.0331
Brugia malayi	Uncoordinated protein 44	0.0016	0.0088	0.000000094118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0723	0.1469
Echinococcus multilocularis	Ankyrin	0.0016	0.009	0.0039
Echinococcus multilocularis	lamin	0.0058	0.0906	0.0859
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0049	0.0723	0.5467
Brugia malayi	hypothetical protein	0.008	0.1323	0.2694
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0016	0.0102	0.0772
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0532	0.1058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0734	0.0685
Echinococcus granulosus	single minded 2	0.0039	0.0537	0.0488
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.1217	0.2462
Echinococcus granulosus	death domain containing protein	0.0016	0.0088	0.0036
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0014	0.0052	0.0026
Echinococcus multilocularis	expressed protein	0.0036	0.0483	0.0434
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.045	0.04
Echinococcus granulosus	nuclear factor of activated T cells 5	0.008	0.132	0.1275
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0016	0.0102	0.0772
Brugia malayi	PAS domain containing protein	0.0053	0.08	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0176	0.3182	0.6773
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0016	0.0102	0.0015
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0418	0.0334
Schistosoma mansoni	transcription factor btf3	0.0038	0.0511	0.0427
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0382	0.0642
Schistosoma mansoni	hypothetical protein	0.0074	0.1217	0.1139
Echinococcus multilocularis	lamin dm0	0.0058	0.0906	0.0859
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0049	0.0723	0.5467
Onchocerca volvulus		0.0031	0.0382	0.0711
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1051	0.7947
Echinococcus multilocularis	geminin	0.0531	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0293	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0906	0.185
Plasmodium vivax	ataxin-2 like protein, putative	0.008	0.1323	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0382	0.0715
Echinococcus multilocularis	allatostatin A receptor	0.0177	0.3185	0.3149
Trypanosoma cruzi	transcription factor btf3, putative	0.0038	0.0511	0.3863
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0734	0.0685
Entamoeba histolytica	hypothetical protein	0.0153	0.2721	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0039	0.0533	0.4027
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0328	0.0278
Leishmania major	protein kinase, putative	0.0014	0.0052	0.0391
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0036	0.0483	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0102	0.0135
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0016	0.0102	0.0772
Schistosoma mansoni	hypothetical protein	0.0153	0.2721	0.2657
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0016	0.0102	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0511	0.1013
Echinococcus granulosus	cpg binding protein	0.0033	0.0416	0.0366
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0418	0.0334
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0388	0.0654
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0036	0.0484	0.3657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0484	0.0954
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0734	0.1409
Echinococcus granulosus	survival motor neuron protein 1	0.0254	0.4673	0.4645
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0224	0.41	0.8761
Leishmania major	hypothetical protein, conserved	0.008	0.1323	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0052	0.0026
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0014	0.0052	0.5
Echinococcus granulosus	Ankyrin	0.0016	0.009	0.0039
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0016	0.0102	0.0051
Loa Loa (eye worm)	hypothetical protein	0.008	0.1323	0.2751
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.002	0.0177	0.1337
Schistosoma mansoni	intermediate filament proteins	0.0058	0.0906	0.0826
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0734	0.0652
Brugia malayi	Intermediate filament tail domain containing protein	0.0058	0.0906	0.1786
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1051	1
Echinococcus multilocularis	GPCR, family 2	0.0034	0.045	0.04
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1051	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0886	0.1805
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0532	0.1058
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0049	0.0723	0.1386
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0014	0.0052	0.0026
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0016	0.0102	0.0772
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0729	0.1399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0293	0.0544
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0049	0.0723	0.5467
Echinococcus granulosus	transcription factor btf3	0.0038	0.0511	0.0462
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0328	0.0278
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0049	0.0723	0.1137
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0039	0.0533	0.4027

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.82 uM	Displacement of [125I]galanin from GalR1 by gamma counting	ChEMBL.	22018787
IC50 (binding)	= 9.07 uM	Displacement of [125I]galanin from GalR2 by gamma counting	ChEMBL.	22018787
Inhibition (binding)	> 50 %	Displacement of [125I]galanin from GalR2 at 1 uM by gamma counting	ChEMBL.	22018787
Inhibition (binding)	> 50 %	Displacement of [125I]galanin from GalR2 at 10 uM by gamma counting	ChEMBL.	22018787
Inhibition (binding)	= 60 %	Displacement of [125I]galanin from GalR1 at 1 uM by gamma counting	ChEMBL.	22018787
Inhibition (binding)	= 60 %	Displacement of [125I]galanin from GalR1 at 10 uM by gamma counting	ChEMBL.	22018787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1922025

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1565639