Detailed information for compound 1565871

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 514.614 | Formula: C34H30N2O3
  • H donors: 1 H acceptors: 1 LogP: 6.7 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)[C@]12C[C@@H]3[C@H](N2[C@@H](c2c(C1)c1ccccc1[nH]2)c1ccc(cc1)C)c1c(OC3)ccc2c1cccc2
  • InChi: 1S/C34H30N2O3/c1-20-11-13-22(14-12-20)32-30-26(25-9-5-6-10-27(25)35-30)18-34(33(37)38-2)17-23-19-39-28-16-15-21-7-3-4-8-24(21)29(28)31(23)36(32)34/h3-16,23,31-32,35H,17-19H2,1-2H3/t23-,31-,32+,34-/m0/s1
  • InChiKey: WUQREEMWBMTXIQ-UPKVVRCYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0031 0.0567 0.2741
Loa Loa (eye worm) hypothetical protein 0.0149 0.4025 0.4025
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.1571 0.5024
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1042 0.3123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0857 0.0857
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.022
Schistosoma mansoni hypothetical protein 0.0073 0.1792 0.1792
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.064 0.064
Schistosoma mansoni tsg101-related 0.0124 0.3293 0.3293
Brugia malayi Pax transcription factor protein 2 0.0275 0.7742 1
Brugia malayi MH1 domain containing protein 0.0017 0.0159 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Trypanosoma brucei polo-like protein kinase 0.0094 0.2417 0.8073
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0838 0.225
Echinococcus granulosus GPCR family 2 0.0034 0.064 0.064
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Schistosoma mansoni hypothetical protein 0.0034 0.064 0.064
Trypanosoma brucei unspecified product 0.0081 0.2021 0.6647
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0178 0.0178
Giardia lamblia Sgs1 DNA helicase, putative 0.0031 0.0567 0.1748
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.7164 0.7164
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0116
Echinococcus granulosus dna polymerase eta 0.0112 0.2953 0.2953
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.064 0.064
Echinococcus granulosus Smad4 0.0017 0.0159 0.0159
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.2417 0.9178
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.1234 0.6723
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0379 0.0928
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Giardia lamblia Kinase, PLK 0.0094 0.2417 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.2417 0.3122
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0051 0.1154 0.9298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.2786 0.2786
Echinococcus multilocularis Smad4 0.0017 0.0159 0.0159
Trichomonas vaginalis hypothetical protein 0.0072 0.1779 0.6871
Brugia malayi MH2 domain containing protein 0.0017 0.0159 0.0205
Brugia malayi RNA, U transporter 1 0.0094 0.2405 0.3106
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0159 0.0159
Brugia malayi Bloom's syndrome protein homolog 0.0076 0.1876 0.2423
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0397 0.169
Loa Loa (eye worm) hypothetical protein 0.0278 0.7827 0.7827
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0178 0.0706
Loa Loa (eye worm) RecQ helicase 0.0076 0.1876 0.1876
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0072 0.1779 1
Schistosoma mansoni tsg101-related 0.0101 0.2625 0.2625
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Brugia malayi MH1 domain containing protein 0.0017 0.0159 0.0205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0857 0.0857
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.2417 0.2417
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0433 0.0265
Schistosoma mansoni smad1 5 8 and 0.0017 0.0159 0.0159
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0838 0.2545
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.1571 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0076 0.1876 0.7344
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.3003
Brugia malayi Ets-domain containing protein 0.0083 0.2082 0.269
Schistosoma mansoni importin beta-1 0.0033 0.0617 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Loa Loa (eye worm) hypothetical protein 0.0033 0.0617 0.0617
Echinococcus multilocularis GPCR, family 2 0.0034 0.064 0.064
Brugia malayi MH2 domain containing protein 0.0017 0.0159 0.0205
Loa Loa (eye worm) hypothetical protein 0.0071 0.1729 0.1729
Loa Loa (eye worm) hypothetical protein 0.0073 0.1792 0.1792
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.1349 0.1349
Entamoeba histolytica recQ family helicase, putative 0.004 0.0838 0.2927
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.064 0.064
Schistosoma mansoni smad1 5 8 and 0.0017 0.0159 0.0159
Brugia malayi Latrophilin receptor protein 2 0.0034 0.064 0.0827
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.2243 0.7446
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0433 0.0265
Echinococcus multilocularis dna polymerase eta 0.0112 0.2953 0.2953
Brugia malayi Fli-1 protein 0.0251 0.7041 0.9096
Trypanosoma cruzi DNA polymerase eta, putative 0.0112 0.2953 1
Schistosoma mansoni hypothetical protein 0.0034 0.064 0.064
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0011
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0178 0.0375
Loa Loa (eye worm) pax transcription factor protein 2 0.0275 0.7742 0.7742
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2243 0.7499
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.3003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0031 0.0567 0.0567
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2417 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Brugia malayi hypothetical protein 0.0149 0.4025 0.52
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0567 0.2713
Loa Loa (eye worm) hypothetical protein 0.0034 0.064 0.064
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0617 0.0617
Plasmodium falciparum importin beta, putative 0.0033 0.0617 0.3088
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0567 0.0732
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0617 0.159
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Echinococcus granulosus importin subunit beta 1 0.0033 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.0352 1 1
Schistosoma mansoni kinase 0.0048 0.1055 0.1055
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0617 0.159
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1779 0.5863
Echinococcus multilocularis GA binding protein alpha chain 0.0083 0.2082 0.2082
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.2417 0.8113
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1069 0.322
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.2786 0.3598
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.1349 0.1742
Schistosoma mansoni hypothetical protein 0.0024 0.0359 0.0359
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0178 0.0178
Trypanosoma brucei DNA polymerase eta, putative 0.0112 0.2953 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1069 0.1069
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.1234 1
Brugia malayi polk-prov protein 0.0048 0.1069 0.1381
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0116 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2243 0.7499
Brugia malayi Ets-domain containing protein 0.0083 0.2082 0.269
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.2021 0.6647
Plasmodium vivax importin-beta 2, putative 0.0033 0.0617 0.4566
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.1349 0.8406
Schistosoma mansoni Smad4 0.0017 0.0159 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.2243 0.7446
Mycobacterium ulcerans DNA polymerase IV 0.0088 0.2243 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1018 0.3136
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0567 0.2713
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0159 0.0159
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0031 0.0567 0.0567
Schistosoma mansoni DNA polymerase eta 0.0112 0.2953 0.2953
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0178 0.023
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0159 0.0159
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0101 0.2625 1
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0617 0.3011
Leishmania major hypothetical protein, conserved 0.0054 0.1234 0.3812
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.3003
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0175 0.0209
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.1349 0.4949
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0567 0.0732
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0048 0.1047 0.3283
Brugia malayi STAT protein, DNA binding domain containing protein 0.0131 0.3504 0.4526
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0178 0.022
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0159 0.0159
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1234 0.7403
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 1 1
Leishmania major importin beta-1 subunit, putative 0.0027 0.0433 0.093
Schistosoma mansoni tsg101-related 0.0124 0.3293 0.3293
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1234 0.3941
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.0107 0.2786 0.2786
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1069 0.322
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0175 0.0209
Entamoeba histolytica hypothetical protein 0.0025 0.0379 0.1113
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2417 1
Mycobacterium ulcerans DNA polymerase IV 0.0088 0.2243 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0031 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.0041 0.0857 0.0857
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0083 0.2082 0.2082
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0178 0.0178
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0149 0.4025 0.4025
Entamoeba histolytica hypothetical protein 0.0025 0.0379 0.1113
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1792 0.2315
Echinococcus granulosus dna polymerase kappa 0.0088 0.2243 0.2243
Echinococcus multilocularis snurportin 1 0.0352 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0359 0.0359
Schistosoma mansoni ets-related 0.0251 0.7041 0.7041
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1042 0.3123
Leishmania major DNA polymerase eta, putative 0.0112 0.2953 1
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.1234 0.3812
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.1349 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2417 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0178 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0112 0.2953 0.3814
Entamoeba histolytica hypothetical protein 0.0025 0.0379 0.1113
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0838 0.2386
Schistosoma mansoni smad1 5 8 and 0.0017 0.0159 0.0159
Treponema pallidum ATP-dependent DNA helicase 0.0016 0.0116 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0178 0.0178
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Leishmania major DNA polymerase eta, putative 0.0072 0.1779 0.5774
Brugia malayi MH2 domain containing protein 0.0255 0.7164 0.9253
Brugia malayi hypothetical protein 0.0035 0.0671 0.0867
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0838 0.2386
Brugia malayi hypothetical protein 0.0041 0.0857 0.1107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0567 0.0567
Schistosoma mansoni DNA helicase recq5 0.0031 0.0567 0.0567
Brugia malayi isocitrate dehydrogenase 0.0018 0.0178 0.023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0067 0.1605 1
Schistosoma mansoni gabp alpha 0.0083 0.2082 0.2082
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2417 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0178 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.7164 0.7164
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2417 1
Loa Loa (eye worm) Smad1 0.0017 0.0159 0.0159
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0116 0.0071
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0048 0.1047 0.314
Echinococcus granulosus GA binding protein alpha chain 0.0083 0.2082 0.2082
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.2417 0.2417
Trichomonas vaginalis DNA polymerase eta, putative 0.0088 0.2243 0.9146
Brugia malayi Importin beta-1 subunit 0.0033 0.0617 0.0796
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.3003
Giardia lamblia DINP protein human, muc B family 0.0065 0.1571 0.6224
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0359 0.0359
Brugia malayi hypothetical protein 0.0054 0.1234 0.1594
Entamoeba histolytica hypothetical protein 0.0025 0.0379 0.1113
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.1571 0.5024
Echinococcus granulosus bloom syndrome protein 0.0076 0.1876 0.1876
Loa Loa (eye worm) hypothetical protein 0.0054 0.1234 0.1234
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0034 0.064 0.064
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0159 0.0159
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0159 0.0159
Brugia malayi Smad1 0.0017 0.0159 0.0205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.2786 0.3598
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0031 0.0567 0.0567
Schistosoma mansoni DNA helicase recq1 0.0031 0.0567 0.0567
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.1349 0.1349
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0112 0.2953 0.2953
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0433 0.0265
Trichomonas vaginalis DNA helicase recq, putative 0.0076 0.1876 0.7344
Echinococcus multilocularis smad 0.0017 0.0159 0.0159
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0735
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.2417 0.8073
Trypanosoma brucei unspecified product 0.004 0.082 0.2324
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0149 0.4025 0.4025
Schistosoma mansoni hypothetical protein 0.0034 0.064 0.064
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2417 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.064 0.064
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0175 0.0209
Echinococcus multilocularis dna polymerase kappa 0.0088 0.2243 0.2243
Schistosoma mansoni blooms syndrome DNA helicase 0.006 0.1407 0.1407
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0088 0.2243 0.9146
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0379 0.0928
Onchocerca volvulus 0.0275 0.7742 1
Loa Loa (eye worm) STAT protein 0.0131 0.3504 0.3504
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.2417 0.8113
Entamoeba histolytica hypothetical protein 0.0027 0.0433 0.1327
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.064 0.064
Loa Loa (eye worm) fli-1 protein 0.0251 0.7041 0.7041
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Leishmania major hypothetical protein, conserved 0.0048 0.1047 0.314
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0857 0.0857
Schistosoma mansoni smad 0.0017 0.0159 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2243 0.7499
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0433 0.1119
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1234 0.7403
Trypanosoma brucei unspecified product 0.004 0.082 0.2324
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0175 0.0356
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0379 0.0928
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2243 0.7499
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1018 0.3136
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0175 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1042 0.3123
Leishmania major DNA polymerase kappa, putative 0.0065 0.1571 0.5024
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2243 0.7446
Echinococcus multilocularis bloom syndrome protein 0.0076 0.1876 0.1876
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.1349 0.1349
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.2417 0.2417
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0175 0.0678
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1234 0.3941
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0178 0.0375
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2417 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0051 0.1136 0.6136
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.064 0.0827
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.2417 0.2417
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0031 0.0567 0.0567
Echinococcus granulosus smad 0.0017 0.0159 0.0159

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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