TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.355 | Formula: C19H16N4O3
H donors: 2 H acceptors: 4 LogP: 2.04 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)Cn1c(=O)[nH]c2c1nc(cn2)c1ccc(cc1)O
InChi: 1S/C19H16N4O3/c1-26-15-4-2-3-12(9-15)11-23-18-17(22-19(23)25)20-10-16(21-18)13-5-7-14(24)8-6-13/h2-10,24H,11H2,1H3,(H,20,22,25)
InChiKey: BQSOSOCDHDKBBQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0446	0.0365
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.073	0.0652
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0128	0.0272
Brugia malayi	Intermediate filament tail domain containing protein	0.0059	0.0903	0.135
Schistosoma mansoni	lamin	0.0059	0.0903	0.0826
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0507	0.108
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0414	0.0334
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0414	0.0334
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0111	0.1875	0.295
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0128	0.0045
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0026	0.0278	0.1261
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.0083	0.000000043559
Brugia malayi	hypothetical protein	0.0081	0.1319	0.2035
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0446	0.0365
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0599	0.3962
Entamoeba histolytica	transcription factor BTF3, putative	0.0038	0.0507	0.0195
Trichomonas vaginalis	adenylate cyclase, putative	0.0026	0.0278	0.0592
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.073	0.0652
Brugia malayi	Pre-SET motif family protein	0.0033	0.0414	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0507	0.108
Entamoeba histolytica	hypothetical protein	0.0156	0.2718	1
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0026	0.0278	0.1261
Trichomonas vaginalis	guanylate cyclase, putative	0.0026	0.0278	0.0592
Schistosoma mansoni	cpg binding protein	0.0031	0.0378	0.0297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0128	0.0272
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0599	0.3962
Schistosoma mansoni	hypothetical protein	0.0541	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0156	0.2718	0.2657
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0032	0.0383	0.0623
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0599	0.1275
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.073	0.1186
Loa Loa (eye worm)	ICD-1 protein	0.0038	0.0507	0.0824
Schistosoma mansoni	single-minded	0.0101	0.1683	0.1613
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0278	0.0592
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0029	0.0324	0.0243
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0808	0.5713
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0808	0.1194
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.073	0.0652
Trichomonas vaginalis	rotamase, putative	0.0037	0.0479	0.1021
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0036	0.0463	0.2815
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.0083	0.0135
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0036	0.0463	0.2815
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.039	0.0831
Schistosoma mansoni	intermediate filament proteins	0.0059	0.0903	0.0826
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0111	0.1875	0.295
Loa Loa (eye worm)	hypothetical protein	0.0259	0.4673	0.7591
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0278	0.0451
Schistosoma mansoni	transcription factor LCR-F1	0.0156	0.2718	0.2657
Trichomonas vaginalis	rotamase, putative	0.0036	0.0463	0.0986
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0278	0.0592
Echinococcus multilocularis	lamin	0.0059	0.0903	0.0826
Brugia malayi	hypoxia-induced factor 1	0.0312	0.5662	0.9187
Toxoplasma gondii	NAC domain-containing protein	0.0038	0.0507	0.3844
Brugia malayi	cytoplasmic intermediate filament protein	0.0032	0.0383	0.0494
Onchocerca volvulus		0.0074	0.119	0.2398
Onchocerca volvulus		0.0031	0.0378	0.0638
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0229	0.41	0.666
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0414	0.0334
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0414	0.0334
Schistosoma mansoni	hypothetical protein	0.0035	0.0446	0.0365
Echinococcus multilocularis	cpg binding protein	0.0033	0.0412	0.0331
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0414	0.0334
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0449	0.0956
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0059	0.0903	0.1467
Schistosoma mansoni	hypothetical protein	0.0035	0.0446	0.0365
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0446	0.0365
Trypanosoma cruzi	transcription factor btf3, putative	0.0038	0.0507	0.3185
Schistosoma mansoni	hypothetical protein	0.0541	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0808	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0882	0.1434
Toxoplasma gondii	LsmAD domain-containing protein	0.0081	0.1319	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0081	0.1319	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0546	0.1163
Trichomonas vaginalis	guanylate cyclase, putative	0.0026	0.0278	0.0592
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.073	0.0652
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0268	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1875	0.3046
Entamoeba histolytica	hypothetical protein	0.0038	0.0507	0.0195
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0546	0.4139
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0546	0.1163
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0808	0.1531
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.1048	0.7725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0059	0.0126
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0808	0.1531
Echinococcus multilocularis	transfer RNA-Lys	0.0074	0.119	0.1116
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0546	0.1163
Brugia malayi	PAS domain containing protein	0.0101	0.1683	0.2635
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0083	0.000000071138
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0808	0.5713
Brugia malayi	Uncoordinated protein 44	0.0016	0.0083	0.000000071138
Trypanosoma cruzi	PAB1-binding protein , putative	0.0081	0.1319	1
Loa Loa (eye worm)	intermediate filament protein	0.0059	0.0903	0.1467
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.0083	0.000000043559
Giardia lamblia	GTOR	0.0054	0.0808	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0304	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0338	0.6156	1
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0026	0.0278	0.1261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0808	0.1722
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0808	0.5713
Plasmodium vivax	ataxin-2 like protein, putative	0.0081	0.1319	1
Mycobacterium leprae	Possible regulatory protein	0.0026	0.0278	0.5
Schistosoma mansoni	transcription factor btf3	0.0038	0.0507	0.0427
Leishmania major	hypothetical protein, conserved	0.0081	0.1319	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0128	0.0272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0396	0.0844
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0128	0.0272
Echinococcus multilocularis	expressed protein	0.0037	0.0479	0.0399
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0808	0.0731
Onchocerca volvulus		0.0053	0.0781	0.1513
Brugia malayi	beta-NAC-like protein	0.0038	0.0507	0.0698
Onchocerca volvulus		0.0059	0.0903	0.1776
Schistosoma mansoni	hypothetical protein	0.0035	0.0446	0.0365
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0932	0.7065
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0446	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0446	0.0724
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0128	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0414	0.0673
Brugia malayi	Pre-SET motif family protein	0.0229	0.41	0.6614
Brugia malayi	hypothetical protein	0.0053	0.0775	0.1139
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0507	0.108
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0037	0.0479	0.0779
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0026	0.0278	0.0451
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0808	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0324	0.0527
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0446	0.0597
Entamoeba histolytica	hypothetical protein	0.0156	0.2718	1
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0312	0.5662	0.9198
Echinococcus granulosus	Ankyrin	0.0016	0.0086	0.0003
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.1066	0.0991
Echinococcus granulosus	single minded 2	0.0074	0.119	0.1116
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0037	0.0479	0.0652
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0446	0.0365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0337	0.0718
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0036	0.0472	0.0392
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0808	0.5713
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.021	0.0688
Onchocerca volvulus		0.0033	0.0414	0.0717
Echinococcus granulosus	lamin dm0	0.0059	0.0903	0.0826
Onchocerca volvulus		0.026	0.4697	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.1048	0.7945
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0337	0.0718
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0111	0.1875	0.3046
Echinococcus granulosus	GPCR family 2	0.0035	0.0446	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0086	0.014
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1213	0.1971
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0599	0.3962
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0029	0.0324	0.0243
Mycobacterium ulcerans	putative regulatory protein	0.0074	0.119	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0026	0.0278	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.039	0.0831
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0599	0.1275
Echinococcus granulosus	expressed protein	0.0037	0.0479	0.0399
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0026	0.0278	0.1261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0337	0.0718
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.1048	0.5
Echinococcus multilocularis	transcription factor btf3	0.0038	0.0507	0.0427
Trypanosoma brucei	transcription factor BTF3, putative	0.0038	0.0507	0.3185
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0026	0.0278	0.0592
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0781	0.0704
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0278	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0903	0.1467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0808	0.1722
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0658	0.1403
Brugia malayi	bHLH-PAS transcription factor	0.0074	0.119	0.1822
Onchocerca volvulus		0.0026	0.0278	0.0421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0599	0.1275
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0026	0.0278	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1319	0.2142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0546	0.1163
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0026	0.0278	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0471	0.1004
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0414	0.3141
Plasmodium falciparum	ataxin-2 like protein, putative	0.0081	0.1319	1
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.0083	0.000000043559
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0446	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0083	0.0135
Echinococcus multilocularis	Ankyrin	0.0016	0.0086	0.0003
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0128	0.0045
Schistosoma mansoni	aryl hydrocarbon receptor	0.0101	0.1683	0.1613
Schistosoma mansoni	cpg binding protein	0.0033	0.0412	0.0331
Schistosoma mansoni	cpg binding protein	0.0033	0.0412	0.0331
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.073	0.0652
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0026	0.0278	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0396	0.0844
Schistosoma mansoni	hypothetical protein	0.0114	0.193	0.1862
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0128	0.0272
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0808	0.5713
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0304	0.0493
Loa Loa (eye worm)	cytochrome P450 family protein	0.0072	0.1138	0.1849
Schistosoma mansoni	rotamase	0.0037	0.0479	0.0399
Entamoeba histolytica	hypothetical protein	0.0156	0.2718	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0446	0.0724
Plasmodium falciparum	ataxin-2 like protein, putative	0.0081	0.1319	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0472	0.0392
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0026	0.0278	0.0592
Brugia malayi	intermediate filament protein	0.0059	0.0903	0.135
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.073	0.0652
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1048	0.0973
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0026	0.0278	0.0592
Brugia malayi	hypothetical protein	0.0338	0.6156	1
Brugia malayi	hypothetical protein	0.0156	0.2718	0.4339
Trypanosoma cruzi	PAB1-binding protein , putative	0.0081	0.1319	1
Brugia malayi	hypothetical protein	0.0259	0.4673	0.7558
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0379	0.0298
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0036	0.0472	0.0392
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0337	0.0718
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0479	0.1021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0546	0.1163
Brugia malayi	Death domain containing protein	0.0016	0.0083	0.000000071138
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.1048	0.0973
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0378	0.0485
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0808	0.5713
Trichomonas vaginalis	set domain proteins, putative	0.026	0.4694	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0036	0.0463	0.2815
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0036	0.0463	0.2815
Plasmodium vivax	basic transcription factor 3b, putative	0.0038	0.0507	0.1025
Echinococcus granulosus	cpg binding protein	0.0033	0.0412	0.0331
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0414	0.0334
Leishmania major	protein kinase, putative	0.0026	0.0278	0.1261
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0026	0.0278	0.0592
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0781	0.1149
Onchocerca volvulus		0.0059	0.0903	0.1776
Schistosoma mansoni	lamin	0.0059	0.0903	0.0826
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0081	0.1317	0.1244
Echinococcus granulosus	aryl hydrocarbon receptor	0.0026	0.0278	0.0196
Echinococcus granulosus	survival motor neuron protein 1	0.0259	0.4673	0.4628
Brugia malayi	latrophilin 2 splice variant baaae	0.0076	0.1213	0.1861
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.0086	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0546	0.1163
Echinococcus granulosus	intermediate filament protein	0.0059	0.0903	0.0826
Brugia malayi	Cytochrome P450 family protein	0.0072	0.1138	0.1737
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.1048	0.0973
Schistosoma mansoni	hypothetical protein	0.0035	0.0446	0.0365
Leishmania major	basic transcription factor 3a, putative	0.0038	0.0507	0.3185
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0026	0.0278	0.1261
Schistosoma mansoni	hypothetical protein	0.0053	0.0781	0.0704
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0546	0.1163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0336	0.0716
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.073	0.0652
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0808	0.1313
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0599	0.1275
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0128	0.0045
Schistosoma mansoni	hypothetical protein	0.0076	0.1213	0.114
Echinococcus granulosus	lamin	0.0059	0.0903	0.0826
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0414	0.0334
Echinococcus granulosus	transcription factor btf3	0.0038	0.0507	0.0427
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0378	0.0614
Echinococcus multilocularis	musashi	0.0059	0.0903	0.0826
Leishmania major	protein kinase, putative	0.0026	0.0278	0.1261
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0156	0.2718	0.2657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0336	0.0716
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0808	0.1722
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0026	0.0278	0.0196
Echinococcus multilocularis	geminin	0.0541	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1048	0.0973
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0396	0.0844
Echinococcus multilocularis	survival motor neuron protein 1	0.0259	0.4673	0.4628
Trypanosoma cruzi	transcription factor btf3, putative	0.0038	0.0507	0.3185
Entamoeba histolytica	hypothetical protein	0.0156	0.2718	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0599	0.1275
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.073	0.1065
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0081	0.1317	0.1244
Echinococcus multilocularis	lamin dm0	0.0059	0.0903	0.0826
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0026	0.0278	0.0196
Schistosoma mansoni	hypothetical protein	0.0156	0.2718	0.2657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0336	0.0716
Toxoplasma gondii	peptidylprolyl isomerase	0.0036	0.0463	0.351
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0128	0.0207
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0026	0.0278	0.1261

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.27 uM	Inhibition of mTOR	ChEMBL.	21978683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1945491

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1566332