Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.3568 | 0.3568 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0169 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2775 | 0.2775 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2775 | 0.2775 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2775 | 0.2775 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2775 | 0.2775 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0068 | 0.3568 | 0.3568 |
Echinococcus granulosus | carboxylesterase 5A | 0.0068 | 0.3568 | 0.3568 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.3568 | 0.3568 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2775 | 0.2775 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2775 | 0.2775 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3568 | 0.3568 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2775 | 0.2775 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0169 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.3568 | 0.3568 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0169 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0169 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.3568 | 0.3568 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0169 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0169 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.3568 | 0.3568 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3568 | 0.3568 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2775 | 0.2775 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0068 | 0.3568 | 0.3568 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.3568 | 0.3568 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0068 | 0.3568 | 0.3568 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0068 | 0.3568 | 0.3568 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2775 | 0.2775 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of mouse recombinant iNOS assessed as conversion of oxyhemoglobin to methemoglobin at 500 uM by UV spectrophotometer analysis | ChEMBL. | 22280820 | |
Ki (binding) | > 500 uM | Inhibition of rat recombinant nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of oxyhemoglobin to methemoglobin by UV spectrophotometer analysis | ChEMBL. | 22280820 |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.