Detailed information for compound 1566664

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.573 | Formula: C13H9BrClNO2
  • H donors: 0 H acceptors: 2 LogP: 3.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)OCC(=O)c1ccc(nc1)Cl
  • InChi: 1S/C13H9BrClNO2/c14-10-2-1-3-11(6-10)18-8-12(17)9-4-5-13(15)16-7-9/h1-7H,8H2
  • InChiKey: OAHDDRYOGWUGCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, metabotropic 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0897 0.0902
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0265 0.0266
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0103 0.0103
Loa Loa (eye worm) endoplasmin 0.0045 0.0479 0.0479
Brugia malayi Cathepsin L-like precursor 0.0016 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0811 0.0811
Schistosoma mansoni hypothetical protein 0.0034 0.0316 0.0317
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.011 0.0111
Brugia malayi Hsp90 protein 0.003 0.0265 0.0265
Schistosoma mansoni chromobox protein 0.0069 0.0811 0.0816
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0045 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0227 0.0228
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0103 0.0103
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0387 0.1019
Leishmania major hypothetical protein, conserved 0.0013 0.0023 0.0003
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0122 0.1556 0.1565
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0227
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0103 0.0103
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.0526 0.233
Schistosoma mansoni coup transcription factor 0.0052 0.0572 0.0575
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0073 0.0073
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0344 0.0344
Echinococcus granulosus peregrin 0.0029 0.0247 0.0248
Schistosoma mansoni thyroid hormone receptor 0.0312 0.4244 0.4268
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0572 0.0575
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0479 0.1262
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.032 0.435 0.8958
Brugia malayi Cation transporter family protein 0.0019 0.0103 0.0103
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0186 0.0187
Leishmania major C-8 sterol isomerase-like protein 0.072 1 1
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0479 0.2121
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0209 0.0209
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0212 0.0939
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0023 0.0102
Schistosoma mansoni glutamate synthase 0.0013 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0103 0.0103
Schistosoma mansoni lamin 0.0026 0.0215 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Echinococcus granulosus geminin 0.0333 0.4546 0.4571
Brugia malayi Cation transporter family protein 0.0019 0.0103 0.0103
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0103 0.0103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0572 0.0575
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.028 0.3797 0.3797
Trypanosoma brucei unspecified product 0.0013 0.0027 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.011 0.0111
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0265 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.028 0.3797 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0018 0.0018
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0175 0.0462
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0103 0.0103
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0075 0.0903 0.0908
Echinococcus multilocularis lamin dm0 0.0026 0.0215 0.0216
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0215 0.0215
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0572 0.0572
Onchocerca volvulus 0.0019 0.0103 0.0086
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0023 0.0102
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.3797 0.3785
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0387 0.0368
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0061
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.011 0.011
Onchocerca volvulus 0.0716 0.9945 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.011 0.023
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0572 0.0558
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.011 0.0111
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.044 0.0421
Echinococcus multilocularis peregrin 0.0029 0.0247 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Treponema pallidum NADH oxidase 0.0049 0.0526 0.0507
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0023 0.0061
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.0262 0.0263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0227
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0247 0.0248
Giardia lamblia Kinase, PLK 0.028 0.3797 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0186 0.0187
Loa Loa (eye worm) hypothetical protein 0.0029 0.0247 0.0247
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0067 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.052 0.7183 0.7183
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0013 0.0023 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0175 0.0462
Loa Loa (eye worm) hypothetical protein 0.0075 0.0903 0.0903
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0479 0.046
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0013 0.0023 0.0061
Onchocerca volvulus 0.0026 0.0215 0.0199
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0122 0.1556 0.1556
Entamoeba histolytica cysteine protease, putative 0.0016 0.0073 0.0192
Schistosoma mansoni smad1 5 8 and 0.0016 0.0067 0.0067
Brugia malayi Cathepsin L-like precursor 0.0016 0.0073 0.0073
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0572 0.0575
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0479 0.046
Leishmania major DNA polymerase kappa, putative 0.0019 0.011 0.009
Leishmania major cathepsin L-like protease 0.0063 0.0725 0.0706
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0186 0.0187
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0186 0.0186
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.011 0.024
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0103 0.0103
Echinococcus multilocularis smad 0.0016 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0061
Echinococcus granulosus cpg binding protein 0.006 0.0682 0.0686
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0103 0.0103
Schistosoma mansoni Smad4 0.0016 0.0067 0.0067
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0572 0.0572
Onchocerca volvulus Alhambra homolog 0.0029 0.0247 0.0231
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0103 0.0103
Brugia malayi SET domain containing protein 0.0012 0.0017 0.0017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0103 0.0103
Loa Loa (eye worm) DR-78 0.0024 0.0186 0.0186
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Brugia malayi nuclear receptor NHR-88 0.0024 0.0186 0.0186
Schistosoma mansoni endoplasmin 0.0045 0.0479 0.0482
Schistosoma mansoni nuclear receptor 0.0024 0.0186 0.0187
Trypanosoma cruzi heat shock protein, putative 0.003 0.0265 0.0246
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0316 0.0297
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0406 0.0408
Brugia malayi Nuclear hormone receptor-like 1 0.052 0.7183 0.7183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0013 0.0023 0.0023
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.011 0.009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0572 0.0575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.018 0.0475
Brugia malayi Endoplasmin precursor 0.0045 0.0479 0.0479
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0103 0.0103
Brugia malayi glutamate synthase 0.0013 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.052 0.7183 0.7183
Onchocerca volvulus 0.0019 0.0103 0.0086
Echinococcus multilocularis sodium and chloride dependent glycine 0.0122 0.1556 0.1565
Loa Loa (eye worm) hypothetical protein 0.0122 0.1556 0.1556
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0316 0.14
Echinococcus granulosus GPCR family 2 0.0016 0.0061 0.0061
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0247 0.0248
Loa Loa (eye worm) hypothetical protein 0.0034 0.0316 0.0316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Trypanosoma brucei NADH dehydrogenase 0.0013 0.0023 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.0526 0.233
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0013 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0227
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0316 0.0297
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0023 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0182 0.0163
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0103 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0227
Loa Loa (eye worm) glutaminase 0.0269 0.3634 0.3634
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0023 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Echinococcus granulosus dna polymerase kappa 0.0019 0.011 0.0111
Loa Loa (eye worm) programmed cell death 8 0.0013 0.0023 0.0023
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0316 0.0318
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0073 0.0073
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0572 0.0575
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0073 0.0324
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0316 0.0297
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.0526 0.233
Echinococcus granulosus chromobox protein 1 0.0069 0.0811 0.0816
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0215 0.0215
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0572 0.0572
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.011 0.0289
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0526 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Schistosoma mansoni hypothetical protein 0.0333 0.4546 0.4571
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0479 0.1262
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0013 0.0023 0.0023
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Echinococcus granulosus sodium and chloride dependent glycine 0.0122 0.1556 0.1565
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.032 0.435 0.8958
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0122 0.1556 0.1565
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.032 0.435 0.8958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0572 0.0572
Echinococcus multilocularis sodium and chloride dependent glycine 0.0122 0.1556 0.1565
Schistosoma mansoni kinase 0.0142 0.1852 0.1862
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.0526 0.0529
Schistosoma mansoni heat shock protein 0.0045 0.0479 0.0482
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0572 0.0575
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0023 0.0023
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0316 0.0316
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0023 0.0061
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0103 0.0103
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0316 0.14
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Schistosoma mansoni nAChR subunit 0.0019 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.026 0.3514 0.3534
Brugia malayi Heterochromatin protein 1 0.0069 0.0811 0.0811
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.1556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Echinococcus granulosus metabotropic glutamate receptor 5 0.0075 0.0903 0.0908
Echinococcus multilocularis chromobox protein 1 0.0069 0.0811 0.0816
Loa Loa (eye worm) glutamate receptor 0.0024 0.0181 0.0181
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.0526 0.0529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0479 0.1208
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.0526 0.0507
Onchocerca volvulus 0.0122 0.1556 0.155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0572 0.0575
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0062 0.0062
Brugia malayi TAR-binding protein 0.0062 0.0723 0.0723
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.011 0.009
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0385 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0021 0.0022
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0572 0.0575
Schistosoma mansoni nAChR subunit 0.0019 0.0103 0.0103
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.044 0.8285
Leishmania major cathepsin L-like protease 0.0063 0.0725 0.0706
Schistosoma mansoni nuclear receptor 0.0024 0.0186 0.0187
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0171 0.0172
Schistosoma mansoni hypothetical protein 0.0333 0.4546 0.4571
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0572 0.0572
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.1523 0.3105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0073 0.0073
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0045 0.0046
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0045 0.0046
Loa Loa (eye worm) glutathione reductase 0.014 0.1818 0.1818
Plasmodium vivax hypothetical protein, conserved 0.0122 0.1556 0.6891
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0526 0.0507
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0103 0.0103
Onchocerca volvulus 0.0024 0.0186 0.017
Leishmania major hypothetical protein, conserved 0.0034 0.0316 0.0297
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0061
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0572 0.0575
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0342 0.0344
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0023 0.0102
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0378 0.038
Entamoeba histolytica thioredoxin reductase, putative 0.0013 0.0023 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0572 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Echinococcus multilocularis heat shock protein 90 0.0045 0.0479 0.0482
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0186 0.0187
Trypanosoma brucei unspecified product 0.0013 0.0027 0.0007
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0479 0.046
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0073 0.0056
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0186 0.0186
Plasmodium vivax vivapain-2 0.0016 0.0073 0.0324
Plasmodium falciparum amino acid transporter, putative 0.0122 0.1556 0.6891
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.1556
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.0526 0.0529
Brugia malayi tailless protein 0.0024 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0208
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0265 0.0266
Leishmania major cathepsin L-like protease 0.0016 0.0073 0.0053
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0023 0.0102
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0378 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.028 0.3797 0.3818
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0013 0.0023 0.0023
Echinococcus granulosus heat shock protein 90 0.0039 0.0387 0.0389
Brugia malayi PHD-finger family protein 0.0013 0.0019 0.0019
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0023 0.0003
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0103 0.0103
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0073 0.0073
Trichomonas vaginalis apoptosis inducing factor, putative 0.0013 0.0023 0.0061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0572 0.0575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0572 0.0572
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0067 0.0067
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.3797 0.3785
Leishmania major NADH dehydrogenase, putative 0.0013 0.0023 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0073 0.0073
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0021 0.0022
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0023 0.0061
Leishmania major hypothetical protein, conserved 0.021 0.2803 0.2788
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0023 0.0061
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0122 0.1556 0.1556
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0479 0.046
Trichomonas vaginalis CAMK family protein kinase 0.028 0.3797 1
Brugia malayi steroid hormone receptor 0.0052 0.0572 0.0572
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0061 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0572 0.0575
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0045 0.0046
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Brugia malayi chromobox protein homolog 3 0.0039 0.0385 0.0385
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.0526 0.1333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.011 0.009
Onchocerca volvulus 0.0016 0.0073 0.0056
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Toxoplasma gondii selenide, water dikinase 0.0013 0.0023 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Loa Loa (eye worm) serotonin transporter b 0.0716 0.9945 0.9945
Echinococcus granulosus heat shock protein 0.0045 0.0479 0.0482
Loa Loa (eye worm) thioredoxin reductase 0.014 0.1818 0.1818
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.011 0.0111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.1523 0.6741
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.1523 0.1506
Echinococcus granulosus intermediate filament protein 0.0026 0.0215 0.0216
Leishmania major heat shock protein, putative 0.003 0.0265 0.0246
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0526 0.0507
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.0526 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0572 0.0572
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1523 0.4152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0572 0.0575
Schistosoma mansoni smad1 5 8 and 0.0016 0.0067 0.0067
Schistosoma mansoni cpg binding protein 0.006 0.0682 0.0686
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0073 0.0192
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0479 0.2121
Loa Loa (eye worm) hypothetical protein 0.0049 0.0537 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0227
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0355 0.4853 1
Onchocerca volvulus 0.003 0.0267 0.0252
Mycobacterium tuberculosis Probable reductase 0.032 0.435 0.8958
Echinococcus multilocularis dna polymerase kappa 0.0019 0.011 0.0111
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.0526 0.233
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0103 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.0526 0.1393
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Onchocerca volvulus 0.0024 0.0186 0.017
Schistosoma mansoni metabotropic glutamate receptor 0.0051 0.0564 0.0567
Brugia malayi Bromodomain containing protein 0.0029 0.0247 0.0247
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0316 0.14
Toxoplasma gondii hypothetical protein 0.0122 0.1556 0.6891
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0122 0.1556 0.1565
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.0385
Entamoeba histolytica recQ family helicase, putative 0.0013 0.002 0.0052
Echinococcus multilocularis serotonin transporter 0.0716 0.9945 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0023 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.028 0.3797 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0023 0.0003
Brugia malayi CXXC zinc finger family protein 0.0056 0.0637 0.0637
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0061 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.018 0.0475
Brugia malayi Cathepsin L-like precursor 0.0016 0.0073 0.0073
Schistosoma mansoni heat shock protein 0.003 0.0265 0.0266
Echinococcus multilocularis heat shock protein 0.0045 0.0479 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0027 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0572 0.0572
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.011 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.0526 0.233
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0426 0.1122
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0013 0.0023 0.0102
Plasmodium falciparum phd finger protein, putative 0.0029 0.0247 0.1094
Echinococcus granulosus tar DNA binding protein 0.0062 0.0723 0.0727
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0122 0.1556 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0186 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0103 0.0103
Brugia malayi Cathepsin L-like precursor 0.0016 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.018 0.0475
Leishmania major cathepsin L-like protease 0.0016 0.0073 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0572 0.0575
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0526 0.0507
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0103 0.0103
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0103 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0186 0.0187
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.1523 0.1531
Brugia malayi nuclear receptor RXR 0.0024 0.0186 0.0186
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0182 0.048
Echinococcus granulosus dna polymerase eta 0.0019 0.011 0.0111
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.1556
Brugia malayi MH1 domain containing protein 0.0016 0.0067 0.0067
Onchocerca volvulus 0.0016 0.0073 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0572 0.0572
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0084 0.022
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0073 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0572 0.0572
Trichomonas vaginalis CAMK family protein kinase 0.028 0.3797 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0387 0.0368
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0023 0.0003
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.6891
Plasmodium falciparum thioredoxin reductase 0.0049 0.0526 0.233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0073 0.0192
Plasmodium vivax ferrodoxin reductase, putative 0.0013 0.0023 0.0102
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Toxoplasma gondii hypothetical protein 0.0122 0.1556 0.6891
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Brugia malayi Cation transporter family protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0122 0.1556 0.1556
Schistosoma mansoni hypothetical protein 0.0035 0.0342 0.0344
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0186 0.0187
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0021
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0022 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0073 0.0053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0535 0.0535
Brugia malayi nuclear hormone receptor 0.0024 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Plasmodium vivax endoplasmin, putative 0.0045 0.0479 0.2121
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Echinococcus granulosus cathepsin l1 0.0016 0.0073 0.0073
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.011 0.024
Trichomonas vaginalis helicase, putative 0.0013 0.0021 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0572 0.0575
Trichomonas vaginalis CAMK family protein kinase 0.028 0.3797 1
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0023 0.0023
Echinococcus granulosus nAChR subunit 0.0019 0.0103 0.0103
Schistosoma mansoni smad 0.0016 0.0067 0.0067
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0247 0.0247
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0186 0.0187
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0122 0.1556 0.1556
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0067 0.0067
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.1348 0.5968
Trichomonas vaginalis CAMK family protein kinase 0.028 0.3797 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0723 0.0727
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0716 0.9945 0.9945
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0217 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.018 0.0475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0648 0.0629
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0067 0.0067
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Schistosoma mansoni nAChR subunit 0.0019 0.0103 0.0103
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0103 0.0103
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0479 0.046
Entamoeba histolytica serine/threonine protein kinase, putative 0.028 0.3797 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.011 0.009
Onchocerca volvulus Putative nachr subunit 0.0019 0.0103 0.0086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0186 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.018 0.0475
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0572 0.0572
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0186 0.0187
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0186 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1523 0.4152
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0103 0.0103
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0103 0.0103
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.028 0.3797 0.3785
Brugia malayi hypothetical protein 0.0024 0.0186 0.0186
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0679 0.0679
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0182 0.0163
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0023 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Entamoeba histolytica hypothetical protein 0.0035 0.0342 0.0901
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0355 0.4853 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0723 0.0727
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0122 0.1556 0.1565
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0186 0.0187
Echinococcus granulosus heat shock protein 90 0.0045 0.0479 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0103 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0023 0.0003
Brugia malayi MH1 domain containing protein 0.0016 0.0067 0.0067
Leishmania major cathepsin L-like protease 0.0016 0.0073 0.0053
Onchocerca volvulus 0.0016 0.0073 0.0056
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0186 0.0187
Mycobacterium tuberculosis Putative ferredoxin reductase 0.032 0.435 0.8958
Leishmania major cathepsin L-like protease 0.0016 0.0073 0.0053
Schistosoma mansoni endoplasmin 0.0045 0.0479 0.0482
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0811 0.2136
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0265 0.0698
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0572 0.0575
Brugia malayi ecdysteroid receptor 0.0052 0.0572 0.0572
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0013 0.0023 0.0003
Trichomonas vaginalis glutaminase, putative 0.0269 0.3634 0.9572
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0535 0.0535
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0226 0.0596
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.011 0.018
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0186 0.0187
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0023 0.0061
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0062 0.0062
Toxoplasma gondii Hsp90 domain-containing protein 0.0171 0.2259 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1523 0.1523
Echinococcus granulosus thioredoxin glutathione reductase 0.014 0.1818 0.1828
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0019
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0135 0.0597
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0073
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.0526 0.233
Brugia malayi hypothetical protein 0.0027 0.0227 0.0227
Toxoplasma gondii thioredoxin reductase 0.014 0.1818 0.8048
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0055 0.0623 0.0623
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.011 0.009
Echinococcus granulosus jumonji domain containing protein 0.004 0.0406 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0226 0.0596
Echinococcus multilocularis heat shock protein 90 0.0039 0.0387 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0385 0.1014
Schistosoma mansoni cpg binding protein 0.006 0.0682 0.0686
Echinococcus multilocularis cysteine protease 0.0016 0.0073 0.0073
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0013 0.0023 0.0003
Leishmania major trypanothione reductase 0.014 0.1818 0.1802
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0526 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Brugia malayi Thioredoxin reductase 0.014 0.1818 0.1818
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0056
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0103 0.0103
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0572 0.0575
Trichomonas vaginalis CAMK family protein kinase 0.0139 0.1799 0.4739
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0062
Schistosoma mansoni glutaminase 0.0269 0.3634 0.3654
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0479 0.0479
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0067 0.0067
Trypanosoma brucei polo-like protein kinase 0.028 0.3797 0.3785
Echinococcus granulosus lamin 0.0026 0.0215 0.0216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0572 0.0575
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0186 0.0186
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0342 0.0344
Brugia malayi MH2 domain containing protein 0.0016 0.0067 0.0067
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.0526 0.1386
Echinococcus granulosus sodium and chloride dependent glycine 0.0122 0.1556 0.1565
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Treponema pallidum heat shock protein 90 0.0042 0.044 0.042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0535 0.0535
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0027 0.0007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0637 0.0637
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0186 0.0186
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0013 0.0023 0.0102
Echinococcus granulosus serine:threonine protein kinase PLK1 0.028 0.3797 0.3818
Loa Loa (eye worm) hypothetical protein 0.0122 0.1556 0.1556
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0073 0.0324
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0023 0.0102
Brugia malayi nuclear receptor NHR-88 0.0052 0.0572 0.0572
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0262 0.0262
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0723 0.0727
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0023 0.0023
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0103 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0355 0.4853 1
Brugia malayi CHD4 protein 0.0014 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0103 0.0103
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0073 0.0073
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0479 0.046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Onchocerca volvulus 0.0016 0.0073 0.0056
Brugia malayi Metabotropic glutamate receptor precursor. 0.0061 0.0704 0.0704
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0725 0.0706
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0182 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.2803 0.2788
Schistosoma mansoni lamin 0.0026 0.0215 0.0216
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.014 0.1818 0.3716
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Plasmodium falciparum glutathione reductase 0.0049 0.0526 0.233
Schistosoma mansoni glutamate synthase 0.0013 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1523 0.1531
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.018 0.0475
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) RNA binding protein 0.0062 0.0723 0.0723
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.1523 0.1531
Brugia malayi serine/threonine-protein kinase plk-2 0.028 0.3797 0.3797
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0572 0.0558
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.117 0.1177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Onchocerca volvulus 0.0019 0.0103 0.0086
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0061 0.0061
Brugia malayi hypothetical protein 0.0035 0.0342 0.0342
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0716 0.9945 0.9945
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0073 0.0053
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0013 0.0023 0.0102
Loa Loa (eye worm) glutamate receptor 0.0061 0.0704 0.0704
Entamoeba histolytica hypothetical protein 0.0035 0.0342 0.0901
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0572 0.0572
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0023 0.0061
Plasmodium falciparum thioredoxin reductase 0.014 0.1818 0.8048
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0426 0.1122
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0023 0.0023
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Brugia malayi PHD-finger family protein 0.0029 0.0247 0.0247
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0304 0.0801
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.6891
Loa Loa (eye worm) norepinephrine transporter 0.0716 0.9945 0.9945
Onchocerca volvulus 0.0122 0.1556 0.155
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.011 0.0289
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0572 0.0575
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0073 0.0073
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0049 0.0526 0.3281
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.1556
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0087 0.0087
Plasmodium falciparum transporter, putative 0.0122 0.1556 0.6891
Loa Loa (eye worm) heat shock protein 75 0.003 0.0265 0.0265
Echinococcus multilocularis Smad4 0.0016 0.0067 0.0067
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0332 0.0334
Echinococcus multilocularis geminin 0.0333 0.4546 0.4571
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0535 0.0517
Trypanosoma brucei unspecified product 0.0019 0.011 0.009
Trypanosoma cruzi C-8 sterol isomerase, putative 0.072 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0723 0.0727
Schistosoma mansoni sodium-dependent amino acid transporter 0.0122 0.1556 0.1565
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0175 0.0175
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.0526 0.1042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0572 0.0575
Mycobacterium ulcerans heat shock protein 90 0.0042 0.044 0.1154
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0182 0.033
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.011 0.018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0013 0.0023 0.0023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0572 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0572 0.0572
Schistosoma mansoni DNA polymerase eta 0.0019 0.011 0.0111
Schistosoma mansoni sodium/chloride dependent transporter 0.0122 0.1556 0.1565
Schistosoma mansoni nAChR subunit 0.0019 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0572 0.0572
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0051 0.0564 0.0567
Mycobacterium ulcerans hypothetical protein 0.0024 0.0182 0.0441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Brugia malayi hypothetical protein 0.0122 0.1556 0.1556
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0108 0.0089
Schistosoma mansoni chromobox protein 0.0069 0.0811 0.0816
Loa Loa (eye worm) hypothetical protein 0.003 0.0267 0.0267
Mycobacterium tuberculosis Probable dehydrogenase 0.032 0.435 0.8958
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0572 0.0558
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0572 0.0572
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0041 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0725 0.0706
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0479 0.046
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0355 0.4853 1
Brugia malayi nuclear hormone receptor 0.0052 0.0572 0.0572
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0265 0.1173
Giardia lamblia PHD finger protein 15 0.0029 0.0247 0.0594
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0103 0.0103
Onchocerca volvulus 0.0122 0.1556 0.155
Plasmodium falciparum heat shock protein 90 0.0045 0.0479 0.2121
Brugia malayi MH2 domain containing protein 0.0235 0.3156 0.3156
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0186 0.0187
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0316 0.0316
Entamoeba histolytica disulphide oxidoreductase, putative 0.0013 0.0023 0.0061
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0023 0.0061
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0122 0.1556 0.1556
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0027 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0067 0.0067
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0023 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.1818 0.1802
Plasmodium falciparum glutathione reductase 0.014 0.1818 0.8048
Onchocerca volvulus 0.0052 0.0572 0.0558
Brugia malayi glutaminase DH11.1 0.0269 0.3634 0.3634
Toxoplasma gondii cathepsin CPL 0.0016 0.0073 0.0324
Loa Loa (eye worm) Smad1 0.0016 0.0067 0.0067
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0182 0.0441
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0387 0.0964
Schistosoma mansoni cpg binding protein 0.0056 0.0637 0.064
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0073 0.0192
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0182 0.0163
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.044 0.0863
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0182 0.0183
Plasmodium vivax thioredoxin reductase, putative 0.014 0.1818 0.8048
Schistosoma mansoni hypothetical protein 0.0029 0.0247 0.0248
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0013 0.0023 0.0023
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0069 0.0822 0.0827
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0247 0.1094
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0073 0.0324
Echinococcus granulosus chromobox protein 1 0.0069 0.0811 0.0816
Trypanosoma brucei C-8 sterol isomerase, putative 0.072 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.0526 0.0526
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0247 0.0248
Onchocerca volvulus 0.0013 0.0023 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.0215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0572 0.0575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Echinococcus granulosus endoplasmin 0.0042 0.044 0.0442
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0013 0.0023 0.0023
Schistosoma mansoni nAChR subunit 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0716 0.9945 0.9945
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.011 0.009
Echinococcus multilocularis GPCR, family 2 0.0016 0.0061 0.0061
Leishmania major cathepsin L-like protease 0.0063 0.0725 0.0706
Onchocerca volvulus 0.0016 0.0073 0.0056
Echinococcus granulosus serotonin transporter 0.0716 0.9945 1
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.2803 0.2788
Trichomonas vaginalis CAMK family protein kinase 0.028 0.3797 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0227 0.0228
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1523 0.4152
Loa Loa (eye worm) hypothetical protein 0.0368 0.5034 0.5034
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0247 0.1094
Trypanosoma brucei hypothetical protein, conserved 0.021 0.2803 0.2788
Schistosoma mansoni nAChR subunit 0.0019 0.0103 0.0103
Brugia malayi jmjC domain containing protein 0.0094 0.117 0.117
Brugia malayi Smad1 0.0016 0.0067 0.0067
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0716 0.9945 1
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0103 0.0103
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0023 0.0003
Brugia malayi Augmenter of liver regeneration 0.0034 0.0316 0.0316
Plasmodium vivax vivapain-2 0.0016 0.0073 0.0324
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0316 0.0297
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.117 0.1177
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0103 0.0103
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0103 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0139 0.1799 0.4739
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.011 0.009
Plasmodium falciparum ferrodoxin reductase-like protein 0.0013 0.0023 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.011 0.009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0087 0.0088
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0344 0.0344
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0103 0.0103
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0039 0.0039
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0103 0.0103
Plasmodium vivax amine transporter, putative 0.0122 0.1556 0.6891
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Brugia malayi jmjC domain containing protein 0.0038 0.0378 0.0378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0572 0.0572
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0103 0.0103
Brugia malayi glutathione reductase 0.014 0.1818 0.1818
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0186 0.0187
Loa Loa (eye worm) hypothetical protein 0.0122 0.1556 0.1556
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.1556 0.1565
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0186 0.0187
Echinococcus multilocularis cpg binding protein 0.006 0.0682 0.0686
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0182 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Onchocerca volvulus 0.0056 0.0637 0.0624
Leishmania major hypothetical protein, conserved 0.0013 0.0023 0.0003
Echinococcus granulosus glutamate synthase 0.0013 0.0023 0.0023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.028 0.3797 0.3818
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Echinococcus multilocularis chromobox protein 1 0.0069 0.0811 0.0816
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0122 0.1556 0.1565
Echinococcus multilocularis musashi 0.0026 0.0215 0.0216
Entamoeba histolytica hypothetical protein 0.0035 0.0342 0.0901
Plasmodium vivax heat shock protein, putative 0.0171 0.2259 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0572 0.0572
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0013 0.0023 0.0023
Loa Loa (eye worm) ctsf protein 0.0016 0.0073 0.0073
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0426 0.0412
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0087 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0022 0.0099
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0182 0.0441
Treponema pallidum sodium- and chloride- dependent transporter 0.0716 0.9945 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0065 0.0286
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0013 0.0023 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.018 0.0475
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.026 0.3514 0.3534
Onchocerca volvulus 0.0016 0.0073 0.0056
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.011 0.009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0035 0.0342 0.0901
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0103 0.0103
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0103 0.0103
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0023 0.0003
Echinococcus granulosus metabotropic glutamate receptor 2 0.0051 0.0564 0.0567
Echinococcus granulosus Smad4 0.0016 0.0067 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0725 0.0706
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0572 0.0575
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0103 0.0103
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0103 0.0103
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0723 0.0723
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0316 0.14
Brugia malayi MH2 domain containing protein 0.0016 0.0067 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0572 0.0575
Trichomonas vaginalis heat shock protein, putative 0.0042 0.044 0.1159
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0073 0.0056
Onchocerca volvulus 0.0019 0.0103 0.0086
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.044 0.0863
Schistosoma mansoni intermediate filament proteins 0.0026 0.0215 0.0216
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0103 0.0103
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0186 0.017
Brugia malayi Cathepsin L-like precursor 0.0016 0.0073 0.0073
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0067 0.0298
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.0526 0.1393
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0103 0.0103
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0186 0.0187
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0103 0.0103
Echinococcus granulosus smad 0.0016 0.0067 0.0067
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Brugia malayi intermediate filament protein 0.0026 0.0215 0.0215
Leishmania major DNA polymerase eta, putative 0.0019 0.011 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.018 0.0475
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0013 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0479 0.2121
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0023 0.0023
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.3156 0.3156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0385 0.1014
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0122 0.1556 0.1565
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0517 0.7142 0.7142
Echinococcus multilocularis lamin 0.0026 0.0215 0.0216
Schistosoma mansoni disulfide oxidoreductase 0.0013 0.0023 0.0023
Schistosoma mansoni smad1 5 8 and 0.0016 0.0067 0.0067
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0723 0.0723
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.072 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0247 0.1094
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0023 0.0003
Trypanosoma brucei trypanothione reductase 0.014 0.1818 0.1802
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0723 0.0727
Onchocerca volvulus 0.0026 0.0215 0.0199
Brugia malayi heat shock protein 90 0.0045 0.0479 0.0479
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0304 0.0801
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Echinococcus multilocularis endoplasmin 0.0042 0.044 0.0442
Schistosoma mansoni zinc finger protein 0.0024 0.0186 0.0187
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0378 0.038
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0103 0.0103
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0378 0.038
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0023 0.0061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0061
Schistosoma mansoni sodium/chloride dependent transporter 0.0716 0.9945 1
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0479 0.046
Plasmodium falciparum heat shock protein 90, putative 0.0171 0.2259 1
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Echinococcus multilocularis nAChR subunit 0.0019 0.0103 0.0103
Loa Loa (eye worm) glutaminase 2 0.0269 0.3634 0.3634
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Onchocerca volvulus Serine\/threonine kinase homolog 0.028 0.3797 0.3807
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0067 0.0067
Echinococcus multilocularis cysteine protease 0.0016 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0175 0.0176
Onchocerca volvulus 0.0016 0.0073 0.0056
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.0526 0.0507
Loa Loa (eye worm) fibroinase 0.0016 0.0073 0.0073
Plasmodium vivax heat shock protein 90, putative 0.003 0.0265 0.1173
Brugia malayi hypothetical protein 0.0027 0.0227 0.0227
Echinococcus granulosus bloom syndrome protein 0.0024 0.0175 0.0176
Loa Loa (eye worm) RecQ helicase 0.0024 0.0175 0.0175
Loa Loa (eye worm) cysteine protease 0.0016 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.0572
Schistosoma mansoni thyroid hormone receptor 0.0312 0.4244 0.4268
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0725 0.0706
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0073 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Schistosoma mansoni heat shock protein 0.0045 0.0479 0.0482
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0227 0.0228
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.032 0.435 0.8958
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0103 0.0103
Brugia malayi nuclear receptor NHR-67 0.0024 0.0186 0.0186
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0073 0.0192
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0122 0.1556 0.1565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0023 0.0003
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0097 0.0255
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0013 0.0023 0.0023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0526 0.0507
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.011 0.0289
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0265 0.0249
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0023 0.0061
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0018 0.0018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.0526 0.1393
Echinococcus multilocularis thioredoxin glutathione reductase 0.014 0.1818 0.1828
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.3156 0.3156
Brugia malayi Cytochrome P450 family protein 0.0026 0.0209 0.0209
Brugia malayi nuclear receptor RXR 0.0027 0.0227 0.0227
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0572 0.0575
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0097 0.0255
Plasmodium falciparum endoplasmin, putative 0.0033 0.0304 0.1347
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0061
Mycobacterium tuberculosis Conserved protein 0.0024 0.0182 0.033
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0039 0.0039
Brugia malayi RNA binding protein 0.0062 0.0723 0.0723
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.002 0.0052
Mycobacterium ulcerans hypothetical protein 0.0024 0.0182 0.0441
Mycobacterium ulcerans glutaminase 0.0269 0.3634 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0212 0.0558
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0725 0.0706
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.011 0.009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1528 0.1537
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.6891
Echinococcus multilocularis glutamate synthase 0.0013 0.0023 0.0023
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0103 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0023 0.0003
Schistosoma mansoni glutamate synthase 0.0013 0.0023 0.0023
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0316 0.0318
Schistosoma mansoni sodium/chloride dependent transporter 0.0122 0.1569 0.1578
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0716 0.9945 0.9945
Brugia malayi Nuclear hormone receptor-like 1 0.0545 0.7528 0.7528
Brugia malayi hypothetical protein 0.0024 0.0186 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0723 0.0727
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0479 0.1262
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0023 0.0003
Brugia malayi Cathepsin L-like precursor 0.0016 0.0073 0.0073
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0342 0.0344
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.011 0.011
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0073 0.0073
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0227 0.0228
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0013 0.0023 0.0061
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0186 0.017
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0387 0.0389
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0041 0.0041
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0122 0.1556 0.1556
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0572 0.0575
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0186
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0023 0.0003
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0023 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1523 0.1531
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.026 0.3514 0.3534
Brugia malayi conserved hypotetical protein 0.0024 0.0186 0.0186
Giardia lamblia Grp94/Hsp90 0.0042 0.044 0.1105
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0013 0.0023 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0312 0.4244 0.4268
Onchocerca volvulus 0.0019 0.0103 0.0086
Leishmania major hypothetical protein, conserved 0.0013 0.0023 0.0003
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0103 0.0103
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0811 0.2136
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0013 0.0023 0.0061
Loa Loa (eye worm) solute carrier family 6 member 4 0.0716 0.9945 0.9945
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0105 0.0106
Leishmania major heat shock protein 83-1 0.0045 0.0479 0.046
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0103 0.0103
Schistosoma mansoni nAChR subunit 0.0019 0.0103 0.0103
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.0526 0.1386
Onchocerca volvulus 0.0019 0.0103 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0073 0.0192
Plasmodium vivax glutathione reductase, putative 0.014 0.1818 0.8048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0572 0.0572
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0103 0.0103
Trichomonas vaginalis heat shock protein, putative 0.0042 0.044 0.1159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0073 0.0192
Loa Loa (eye worm) hypothetical protein 0.0049 0.0535 0.0535
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0572 0.0575
Echinococcus multilocularis dna polymerase eta 0.0019 0.011 0.0111
Leishmania major cathepsin L-like protease 0.0016 0.0073 0.0053
Trypanosoma brucei heat shock protein, putative 0.0045 0.0479 0.046
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0186 0.0186
Echinococcus granulosus lamin dm0 0.0026 0.0215 0.0216
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0572 0.0575
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0103 0.0103
Brugia malayi ecdysone receptor 0.0024 0.0186 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0572 0.0572
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0023 0.0061

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.7 uM Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobilization after 2.5 mins ChEMBL. 22030026
Inhibition (functional) Antagonist activity at human muscarinic acetylcholine receptor 4 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC20 acetylcholine-induced calcium mobilization ChEMBL. 22030026
Inhibition (functional) = 58.5 % Antagonist activity at human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of EC80 glutamate-induced calcium mobilization after 2.5 mins ChEMBL. 22030026

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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