Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.0021 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.245 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0383 | 0.9749 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Plasmodium vivax | hypothetical protein, conserved | 0.0019 | 0.0021 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.245 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.245 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0019 | 0.0021 | 0.0084 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.0019 | 0.0021 | 0.0021 | |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.0021 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Plasmodium falciparum | transporter, putative | 0.0019 | 0.0021 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0019 | 0.0021 | 0.0084 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0.0021 | 0.5 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.245 | 0.2513 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.245 | 0.2513 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.245 | 0.2513 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0019 | 0.0021 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.0021 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.9524 | 0.977 |
Onchocerca volvulus | 0.0019 | 0.0021 | 0.0021 | |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.245 | 0.2513 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0019 | 0.0021 | 0.0084 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0019 | 0.0021 | 0.0021 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.245 | 0.2513 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0019 | 0.0021 | 0.0084 |
Onchocerca volvulus | 0.0109 | 0.245 | 0.245 | |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.0019 | 0.0021 | 0.0021 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0021 | 0.0021 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.245 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0383 | 0.9749 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.245 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0019 | 0.0021 | 0.0084 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0019 | 0.0021 | 0.0084 |
Plasmodium vivax | amine transporter, putative | 0.0019 | 0.0021 | 0.5 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0019 | 0.0021 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0019 | 0.0021 | 0.0084 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0019 | 0.0021 | 0.0084 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0021 | 0.0021 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0019 | 0.0021 | 0.0084 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.245 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0019 | 0.0021 | 0.0084 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0.0021 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.43 | Displacement of [3H]WIN35428 from human cloned DAT receptor expressed in human HEK293 cells | ChEMBL. | 22300887 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.