Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0039 | 0.0117 | 0.0117 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0039 | 0.0117 | 0.0297 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0525 | 0.2981 | 0.7653 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0277 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0301 | 0.0301 |
Schistosoma mansoni | tyrosine kinase | 0.0671 | 0.3837 | 0.584 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0074 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | RNA binding protein | 0.0651 | 0.3719 | 0.3719 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0349 | 0.1711 |
Schistosoma mansoni | unc-13 (munc13) | 0.004 | 0.0122 | 0.0183 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0083 | 0.0379 | 0.097 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.007 | 0.0301 | 0.0301 |
Brugia malayi | nuclear receptor RXR | 0.0039 | 0.0117 | 0.0117 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.0191 | 0.4744 |
Echinococcus granulosus | Glycosyltransferase protein LARGE1 | 0.0054 | 0.0209 | 0.0533 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0322 | 0.0322 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.007 | 0.0301 | 0.144 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0035 | 0.0093 | 0.0093 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.007 | 0.0301 | 0.0456 |
Schistosoma mansoni | tar DNA-binding protein | 0.0651 | 0.3719 | 0.5661 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0022 | 0.0018 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0117 | 0.0117 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0035 | 0.0093 | 0.0139 |
Brugia malayi | N-terminal motif family protein | 0.0177 | 0.0931 | 0.0931 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0022 | 0.0018 | 0.0041 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0651 | 0.3719 | 0.3719 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.051 | 0.2894 | 0.2894 |
Loa Loa (eye worm) | SRC-1 | 0.0022 | 0.0018 | 0.0018 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0327 | 0.1813 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0074 | 0.0322 | 0.0487 |
Schistosoma mansoni | coup transcription factor | 0.0074 | 0.0322 | 0.0487 |
Plasmodium falciparum | plasmepsin VII | 0.007 | 0.0301 | 0.144 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0577 | 0.0577 |
Plasmodium falciparum | plasmepsin V | 0.007 | 0.0301 | 0.144 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1717 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0301 | 0.0301 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0327 | 0.1813 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0022 | 0.0018 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.0018 | 0.0041 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0327 | 0.1813 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.4652 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0074 | 0.0322 | 0.0822 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0074 | 0.0322 | 0.0322 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.004 | 0.0122 | 0.0309 |
Brugia malayi | hypothetical protein | 0.0186 | 0.0983 | 0.0983 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.004 | 0.0122 | 0.0309 |
Schistosoma mansoni | smad1 5 8 and | 0.0117 | 0.0577 | 0.0876 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0022 | 0.0018 | 0.0041 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 0.0893 |
Brugia malayi | hypothetical protein | 0.007 | 0.0301 | 0.0301 |
Brugia malayi | nuclear receptor NHR-88 | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | ecdysone receptor | 0.0035 | 0.0093 | 0.0093 |
Plasmodium falciparum | plasmepsin III | 0.007 | 0.0301 | 0.144 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0117 | 0.0577 | 0.1479 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 0.1711 |
Plasmodium falciparum | plasmepsin I | 0.007 | 0.0301 | 0.144 |
Brugia malayi | MH1 domain containing protein | 0.0117 | 0.0577 | 0.0577 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0022 | 0.0018 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0074 | 0.0322 | 0.0322 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0074 | 0.0322 | 0.2733 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.004 | 0.0122 | 0.0122 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0035 | 0.0093 | 0.0234 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0074 | 0.0322 | 0.0322 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.004 | 0.0122 | 0.0183 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.007 | 0.0301 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0035 | 0.0093 | 0.0234 |
Echinococcus multilocularis | smad | 0.0117 | 0.0577 | 0.1479 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0035 | 0.0093 | 0.0139 |
Schistosoma mansoni | hypothetical protein | 0.1135 | 0.6569 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | nuclear receptor RXR | 0.0035 | 0.0093 | 0.0093 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.068 | 0.3894 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0525 | 0.2981 | 0.7653 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0052 | 0.0196 | 0.05 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.0191 | 0.0404 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.007 | 0.0301 | 0.144 |
Brugia malayi | Pepsin A precursor | 0.007 | 0.0301 | 0.0301 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.0018 | 0.0041 |
Loa Loa (eye worm) | Smad1 | 0.0117 | 0.0577 | 0.0577 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0186 | 0.0983 | 0.5299 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0525 | 0.2981 | 0.2981 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0327 | 0.1813 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0022 | 0.0018 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.0018 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0074 | 0.0322 | 0.0322 |
Plasmodium vivax | plasmepsin V, putative | 0.007 | 0.0301 | 0.144 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0039 | 0.0117 | 0.0297 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0277 | 0.1521 | 0.3904 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0117 | 0.0577 | 0.0577 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0327 | 0.1813 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0018 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0122 | 0.0122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0651 | 0.3719 | 0.5661 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.004 | 0.0122 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0074 | 0.0322 | 0.2733 |
Schistosoma mansoni | hypothetical protein | 0.0525 | 0.2981 | 0.4536 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0074 | 0.0322 | 0.0487 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0074 | 0.0322 | 0.0822 |
Schistosoma mansoni | smad | 0.0052 | 0.0196 | 0.0296 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.4652 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0117 | 0.0117 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0035 | 0.0093 | 0.0093 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0022 | 0.0018 | 0.0025 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.007 | 0.0301 | 0.144 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.166 | 0.9661 | 0.9661 |
Schistosoma mansoni | tar DNA-binding protein | 0.0651 | 0.3719 | 0.5661 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.068 | 0.3894 | 0.3894 |
Echinococcus granulosus | glycosyltransferase protein LARGE2 | 0.0071 | 0.0307 | 0.0784 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0074 | 0.0322 | 0.0822 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0525 | 0.2981 | 0.7653 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.007 | 0.0301 | 0.0301 |
Schistosoma mansoni | hypothetical protein | 0.0525 | 0.2981 | 0.4536 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Brugia malayi | Glycosyl transferase family 8 protein | 0.0073 | 0.0321 | 0.0321 |
Echinococcus granulosus | Glycosyl transferase family 8 | 0.0073 | 0.0321 | 0.0819 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0074 | 0.0322 | 0.0487 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0052 | 0.0196 | 0.05 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0052 | 0.0196 | 0.0196 |
Brugia malayi | tailless protein | 0.0035 | 0.0093 | 0.0093 |
Brugia malayi | MH1 domain containing protein | 0.0065 | 0.0269 | 0.0269 |
Schistosoma mansoni | Smad4 | 0.0117 | 0.0577 | 0.0876 |
Plasmodium vivax | aspartyl protease, putative | 0.007 | 0.0301 | 0.144 |
Brugia malayi | nuclear hormone receptor | 0.0035 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.007 | 0.0301 | 0.0301 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0327 | 0.1813 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0035 | 0.0093 | 0.0139 |
Brugia malayi | steroid hormone receptor | 0.0074 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0117 | 0.0117 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0379 | 0.0575 |
Plasmodium falciparum | plasmepsin X | 0.007 | 0.0301 | 0.144 |
Brugia malayi | nuclear receptor NHR-67 | 0.0035 | 0.0093 | 0.0093 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0035 | 0.0093 | 0.0234 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0071 | 0.0307 | 0.0784 |
Brugia malayi | TAR-binding protein | 0.0651 | 0.3719 | 0.3719 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0022 | 0.0018 | 0.0041 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0525 | 0.2981 | 0.2981 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0035 | 0.0093 | 0.0093 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0035 | 0.0093 | 0.0093 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.0018 | 0.0041 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 0.0893 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0412 | 0.2317 | 0.2317 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.007 | 0.0301 | 0.0456 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0349 | 0.1711 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0052 | 0.0196 | 0.05 |
Schistosoma mansoni | nuclear receptor | 0.0035 | 0.0093 | 0.0139 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Loa Loa (eye worm) | DR-78 | 0.0035 | 0.0093 | 0.0093 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0525 | 0.2981 | 0.2981 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.007 | 0.0301 | 0.0301 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0327 | 0.1813 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | SRC-1 | 0.0022 | 0.0018 | 0.0018 |
Plasmodium vivax | aspartyl protease, putative | 0.007 | 0.0301 | 0.144 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0074 | 0.0322 | 0.0322 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0071 | 0.0307 | 0.0784 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0074 | 0.0322 | 0.0322 |
Schistosoma mansoni | nuclear receptor | 0.0035 | 0.0093 | 0.0139 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0035 | 0.0093 | 0.0093 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.007 | 0.0301 | 0.0456 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0022 | 0.0018 | 0.0041 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0039 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0035 | 0.0093 | 0.0234 |
Echinococcus granulosus | Smad4 | 0.0117 | 0.0577 | 0.1479 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.007 | 0.0301 | 0.144 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.004 | 0.0122 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1408 | 0.1408 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0035 | 0.0093 | 0.0234 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0117 | 0.0577 | 0.1479 |
Schistosoma mansoni | thyroid hormone receptor | 0.0074 | 0.0322 | 0.0487 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0983 | 0.0983 |
Loa Loa (eye worm) | hypothetical protein | 0.1135 | 0.6569 | 0.6569 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0327 | 0.1813 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.007 | 0.0301 | 0.2489 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0074 | 0.0322 | 0.0322 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0117 | 0.0577 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Plasmodium vivax | aspartyl proteinase, putative | 0.007 | 0.0301 | 0.144 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0052 | 0.0196 | 0.0196 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.0349 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0515 | 0.2918 | 0.2918 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0301 | 0.0301 |
Plasmodium falciparum | plasmepsin IX | 0.007 | 0.0301 | 0.144 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.4652 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.0191 | 0.0404 |
Schistosoma mansoni | tar DNA-binding protein | 0.0651 | 0.3719 | 0.5661 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0074 | 0.0322 | 0.0487 |
Echinococcus multilocularis | Smad4 | 0.0117 | 0.0577 | 0.1479 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.0191 | 0.0485 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0019 | 0.0002 | 0.0002 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0074 | 0.0322 | 0.0822 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.007 | 0.0301 | 0.0301 |
Brugia malayi | MH1 domain containing protein | 0.0117 | 0.0577 | 0.0577 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0074 | 0.0322 | 0.2733 |
Loa Loa (eye worm) | TAR-binding protein | 0.0651 | 0.3719 | 0.3719 |
Brugia malayi | nuclear hormone receptor | 0.0074 | 0.0322 | 0.0322 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0074 | 0.0322 | 0.0822 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0022 | 0.0018 | 0.0041 |
Plasmodium vivax | plasmepsin IV, putative | 0.007 | 0.0301 | 0.144 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0022 | 0.0018 | 0.0041 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0327 | 0.1813 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.004 | 0.0122 | 0.0122 |
Brugia malayi | conserved hypotetical protein | 0.0035 | 0.0093 | 0.0093 |
Plasmodium falciparum | plasmepsin IV | 0.007 | 0.0301 | 0.144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0651 | 0.3719 | 0.5661 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1135 | 0.6569 | 0.6569 |
Brugia malayi | Variant SH3 domain containing protein | 0.0019 | 0.0002 | 0.0002 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0052 | 0.0196 | 0.1235 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0327 | 0.1813 | 0.4652 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0071 | 0.0307 | 0.0784 |
Loa Loa (eye worm) | nuclear factor I | 0.0065 | 0.0269 | 0.0269 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0074 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Schistosoma mansoni | smad | 0.0117 | 0.0577 | 0.0876 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0117 | 0.0117 |
Echinococcus granulosus | smad | 0.0117 | 0.0577 | 0.1479 |
Echinococcus granulosus | GPCR family 2 | 0.0525 | 0.2981 | 0.7653 |
Brugia malayi | hypothetical protein | 0.007 | 0.0301 | 0.0301 |
Plasmodium vivax | aspartyl protease, putative | 0.007 | 0.0301 | 0.144 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0074 | 0.0322 | 0.0322 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0525 | 0.2981 | 0.7653 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0022 | 0.0018 | 0.0041 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0035 | 0.0093 | 0.0234 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.4652 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0074 | 0.0322 | 0.0487 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.004 | 0.0122 | 0.0122 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0022 | 0.0018 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0322 | 0.0322 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0054 | 0.0209 | 0.0533 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0074 | 0.0322 | 0.0822 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0022 | 0.0018 | 0.0041 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0186 | 0.0983 | 0.5299 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0074 | 0.0322 | 0.0822 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0052 | 0.0196 | 0.05 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.004 | 0.0122 | 0.2481 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0035 | 0.0093 | 0.0234 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0327 | 0.1813 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0022 | 0.0018 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0019 | 0.0002 | 0.0002 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0544 | 0.3089 | 0.3089 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.007 | 0.0301 | 0.077 |
Loa Loa (eye worm) | hypothetical protein | 0.166 | 0.9661 | 0.9661 |
Toxoplasma gondii | aspartyl protease | 0.007 | 0.0301 | 0.144 |
Schistosoma mansoni | smad1 5 8 and | 0.0117 | 0.0577 | 0.0876 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.0093 | 0.0093 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0022 | 0.0018 | 0.0041 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0577 | 0.0577 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0052 | 0.0196 | 0.0196 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0018 | 0.0025 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0525 | 0.2981 | 0.7653 |
Brugia malayi | Isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.1813 |
Schistosoma mansoni | Smad4 | 0.0052 | 0.0196 | 0.0296 |
Schistosoma mansoni | smad1 5 8 and | 0.0117 | 0.0577 | 0.0876 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0074 | 0.0322 | 0.0487 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.1813 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0074 | 0.0322 | 0.0322 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0018 | 0.0025 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0035 | 0.0093 | 0.0234 |
Onchocerca volvulus | 0.0074 | 0.0322 | 0.2733 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0074 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.166 | 0.9661 | 0.9661 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0117 | 0.0577 | 0.1479 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0074 | 0.0322 | 0.0822 |
Brugia malayi | ecdysteroid receptor | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.004 | 0.0122 | 0.0122 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0074 | 0.0322 | 0.0822 |
Schistosoma mansoni | nuclear hormone receptor | 0.0074 | 0.0322 | 0.0487 |
Schistosoma mansoni | zinc finger protein | 0.0035 | 0.0093 | 0.0139 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0039 | 0.0117 | 0.0176 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0549 | 0.3123 | 0.3123 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.0349 | 0.0349 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.004 | 0.0122 | 0.0309 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0074 | 0.0322 | 0.0487 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.2757 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0931 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0196 | 0.0196 |
Brugia malayi | hypothetical protein | 0.012 | 0.0595 | 0.0595 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0177 | 0.0931 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0035 | 0.0093 | 0.0093 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.0191 | 0.0485 |
Brugia malayi | nuclear receptor NHR-88 | 0.0035 | 0.0093 | 0.0093 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0525 | 0.2981 | 0.2981 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0074 | 0.0322 | 0.0322 |
Schistosoma mansoni | hypothetical protein | 0.0525 | 0.2981 | 0.4536 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.007 | 0.0301 | 0.144 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0074 | 0.0322 | 0.0322 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0074 | 0.0322 | 0.0822 |
Brugia malayi | MH2 domain containing protein | 0.0052 | 0.0196 | 0.0196 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.004 | 0.0122 | 0.0122 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0117 | 0.0577 | 0.1479 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 1 |
Brugia malayi | Smad1 | 0.0117 | 0.0577 | 0.0577 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0035 | 0.0093 | 0.0139 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0186 | 0.0983 | 0.5299 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.166 | 0.9661 | 0.9661 |
Echinococcus multilocularis | Glycosyl transferase, family 8 | 0.0073 | 0.0321 | 0.0819 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0074 | 0.0322 | 0.0322 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.4652 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.007 | 0.0301 | 0.0301 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0035 | 0.0093 | 0.0234 |
Brugia malayi | RNA binding protein | 0.0651 | 0.3719 | 0.3719 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0074 | 0.0322 | 0.0822 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0035 | 0.0093 | 0.0234 |
Echinococcus granulosus | FTZ F1 alpha | 0.0074 | 0.0322 | 0.0822 |
Loa Loa (eye worm) | glycosyl transferase family 8 protein | 0.0073 | 0.0321 | 0.0321 |
Leishmania major | hypothetical protein, conserved | 0.0186 | 0.0983 | 0.509 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0549 | 0.3123 | 0.8018 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.068 | 0.3894 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0651 | 0.3719 | 0.9552 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0074 | 0.0322 | 0.0822 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Echinococcus granulosus | tar DNA binding protein | 0.0651 | 0.3719 | 0.9552 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.007 | 0.0301 | 0.144 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0093 | 0.0093 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0065 | 0.0269 | 0.0269 |
Onchocerca volvulus | 0.007 | 0.0301 | 0.2489 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1717 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.0018 | 0.0025 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0074 | 0.0322 | 0.0322 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0117 | 0.0117 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.007 | 0.0301 | 0.077 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0083 | 0.0379 | 0.097 |
Schistosoma mansoni | nuclear hormone receptor | 0.0035 | 0.0093 | 0.0139 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0074 | 0.0322 | 0.0487 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0322 | 0.0322 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.004 | 0.0122 | 0.0183 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.004 | 0.0122 | 0.0122 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0035 | 0.0093 | 0.0234 |
Plasmodium vivax | aspartyl proteinase, putative | 0.007 | 0.0301 | 0.144 |
Plasmodium falciparum | plasmepsin VI | 0.007 | 0.0301 | 0.144 |
Brugia malayi | Variant SH3 domain containing protein | 0.0019 | 0.0002 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0651 | 0.3719 | 0.3719 |
Schistosoma mansoni | glycosyltransferase-related | 0.0073 | 0.0321 | 0.0486 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.0349 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0349 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 0.3089 | 0.3089 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0074 | 0.0322 | 0.0487 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0039 | 0.0117 | 0.0117 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0022 | 0.0018 | 0.0041 |
Brugia malayi | isocitrate dehydrogenase | 0.0327 | 0.1813 | 0.1813 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0019 | 0.0002 | 0.0002 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0186 | 0.0983 | 0.5299 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0074 | 0.0322 | 0.0322 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0074 | 0.0322 | 0.0822 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0039 | 0.0117 | 0.0176 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.0349 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0269 | 0.0269 |
Schistosoma mansoni | hypothetical protein | 0.0525 | 0.2981 | 0.4536 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0074 | 0.0322 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0349 | 0.0349 |
Schistosoma mansoni | thyroid hormone receptor | 0.0074 | 0.0322 | 0.0487 |
Echinococcus multilocularis | Glycosyltransferase protein LARGE1 | 0.0054 | 0.0209 | 0.0533 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0074 | 0.0322 | 0.0822 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0549 | 0.3123 | 0.8018 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0022 | 0.0018 | 0.0041 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0035 | 0.0093 | 0.0234 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.007 | 0.0301 | 0.0456 |
Schistosoma mansoni | Smad4 | 0.0052 | 0.0196 | 0.0296 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 35.9 % | Inhibition of rat Nav1.2 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at 100 uM and at holding potential of -100 mV by two-electrode voltage-clamp electrophysiology | ChEMBL. | 21962108 |
Inhibition (binding) | = 73.1 % | Inhibition of rat Nav1.2 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at 300 uM and at holding potential of -100 mV by two-electrode voltage-clamp electrophysiology | ChEMBL. | 21962108 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.