Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0157 | 0.0166 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0072 | 0.0065 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.0539 | 0.0859 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0072 | 0.0065 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0072 | 0.0056 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0072 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1716 | 0.6041 |
Echinococcus multilocularis | transcription factor eb | 0.0107 | 0.1174 | 0.1159 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.015 | 0.1709 | 0.6017 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0424 | 0.0481 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0235 | 0.2788 | 0.3273 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0271 | 0.0418 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0581 | 0.0666 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0017 | 0.0062 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.098 | 0.1137 |
Onchocerca volvulus | 0.0049 | 0.044 | 0.1326 | |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.0436 | 0.0495 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0072 | 0.0056 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0349 | 0.0333 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0072 | 0.0065 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0135 | 0.4656 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0072 | 0.0065 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0072 | 0.0255 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.098 | 0.0964 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0271 | 0.0418 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0424 | 0.0481 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0135 | 0.4656 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.033 | 0.037 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.1074 | 0.1248 |
Onchocerca volvulus | 0.0027 | 0.0157 | 0.0306 | |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0157 | 0.0166 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0072 | 0.0255 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | lamin | 0.0027 | 0.0157 | 0.0166 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0017 | 0.006 |
Brugia malayi | Pax transcription factor protein 2 | 0.0239 | 0.284 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0072 | 0.0065 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0107 | 0.1167 | 0.4109 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0581 | 0.0666 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0072 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0151 | 0.0532 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0581 | 0.0928 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) | 0.0496 | 0.6087 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0581 | 0.0929 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0271 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1167 | 0.4109 |
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | 0.0496 | 0.6087 | 1 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0349 | 0.0392 |
Brugia malayi | hypoxia-induced factor 1 | 0.015 | 0.1709 | 0.6017 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0686 | 0.8483 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0157 | 0.014 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0349 | 0.1229 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0017 | 0.006 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.0539 | 0.0859 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.014 | 0.1585 | 0.1571 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.0539 | 0.0616 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0072 | 0.0065 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0271 | 0.0953 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0017 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.2788 | 0.9814 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0157 | 0.0553 |
Echinococcus granulosus | tumor protein p63 | 0.0336 | 0.4061 | 0.4777 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.027 | 0.0299 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0271 | 0.0254 |
Onchocerca volvulus | 0.0239 | 0.284 | 1 | |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0017 | 0.006 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0107 | 0.1174 | 0.4133 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0271 | 0.0254 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1946 | 0.2279 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0271 | 0.03 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0072 | 0.0065 |
Echinococcus granulosus | geminin | 0.0168 | 0.1946 | 0.2279 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0157 | 0.0553 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0271 | 0.03 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0271 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.0539 | 0.0523 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0072 | 0.0255 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0349 | 0.0392 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0072 | 0.0255 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0271 | 0.0418 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0072 | 0.0255 |
Echinococcus granulosus | lamin | 0.0027 | 0.0157 | 0.0166 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0072 | 0.0255 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0135 | 0.4656 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0072 | 0.0255 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.049 | 0.1726 |
Onchocerca volvulus | 0.015 | 0.1716 | 0.5937 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1946 | 0.2279 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0072 | 0.0255 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0135 | 0.0195 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0271 | 0.0417 |
Chlamydia trachomatis | DNA-directed RNA polymerase subunit beta | 0.0496 | 0.6087 | 0.5 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta | 0.0496 | 0.6087 | 0.5 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta | 0.0496 | 0.6087 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.0496 | 0.6087 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0072 | 0.0065 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0072 | 0.0255 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0271 | 0.0418 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0072 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.044 | 0.1548 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0271 | 0.0953 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0271 | 0.0953 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.2707 | 0.4431 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0271 | 0.4498 |
Onchocerca volvulus | 0.0036 | 0.0277 | 0.074 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0072 | 0.0056 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0072 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0271 | 0.0953 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0072 | 0.0065 |
Onchocerca volvulus | 0.0048 | 0.0424 | 0.1271 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.044 | 0.0499 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0072 | 0.0065 |
Trypanosoma brucei | cytochrome P450, putative | 0.0016 | 0.0017 | 0.002 |
Echinococcus multilocularis | tumor protein p63 | 0.0336 | 0.4061 | 0.4051 |
Onchocerca volvulus | 0.0027 | 0.0157 | 0.0306 | |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0057 | 0.0539 | 0.9253 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.033 | 0.037 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0072 | 0.0056 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0424 | 0.0408 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0157 | 0.014 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0239 | 0.284 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0072 | 0.0065 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0072 | 0.0255 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0017 | 0.002 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0271 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0349 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0072 | 0.0065 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0157 | 0.0166 |
Onchocerca volvulus | 0.0036 | 0.0271 | 0.0716 | |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0271 | 0.0953 |
Brugia malayi | hypothetical protein | 0.0036 | 0.027 | 0.0952 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0581 | 0.0928 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0581 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0581 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.1318 | 0.4639 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0072 | 0.0065 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0072 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1868 | 0.6576 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.027 | 0.0254 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.0271 | 0.0417 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0271 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0072 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0135 | 0.0476 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0157 | 0.0553 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1946 | 0.1932 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0135 | 0.2094 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0581 | 0.0666 |
Brugia malayi | hypothetical protein | 0.015 | 0.1716 | 0.6041 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.027 | 0.0299 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0157 | 0.0553 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0072 | 0.0065 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.1318 | 0.4639 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0072 | 0.0065 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0072 | 0.0056 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0072 | 0.0056 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0072 | 0.0065 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0072 | 0.0255 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0686 | 0.8483 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0271 | 0.0953 |
Onchocerca volvulus | 0.0036 | 0.0271 | 0.0716 | |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0271 | 0.0417 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0057 | 0.0539 | 0.0616 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0072 | 0.0065 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.1055 | 1 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0072 | 0.0255 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0349 | 0.1229 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.0539 | 0.1897 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0271 | 0.0417 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0072 | 0.0255 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0271 | 0.0418 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.1055 | 0.3713 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.1055 | 0.1226 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0271 | 0.0417 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0072 | 0.0255 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0072 | 0.0056 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0429 | 0.1512 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0429 | 0.0487 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0271 | 0.0953 |
Brugia malayi | hypothetical protein | 0.0162 | 0.1868 | 0.6576 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0424 | 0.1493 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0271 | 0.0953 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0072 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0349 | 0.1229 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0686 | 0.8483 | 0.848 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1055 | 0.3713 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0017 | 0.002 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0271 | 0.0418 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0157 | 0.0553 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.1318 | 0.4639 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0057 | 0.0539 | 0.086 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0017 | 0.0062 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0235 | 0.2788 | 0.2775 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0468 | 0.1649 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0135 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Brugia malayi | hypothetical protein | 0.0235 | 0.2788 | 0.9814 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0271 | 0.0953 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0072 | 0.0056 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0271 | 0.0418 |
Leishmania major | cytochrome p450-like protein | 0.0016 | 0.0017 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0271 | 0.0953 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0349 | 0.0333 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0271 | 0.03 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.033 | 0.037 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0072 | 0.0255 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0271 | 0.4498 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0271 | 0.0953 |
Schistosoma mansoni | lamin | 0.0027 | 0.0157 | 0.0166 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0271 | 0.0417 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0135 | 0.2094 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0271 | 0.0953 |
Plasmodium falciparum | DNA-directed RNA polymerase subunit beta, putative | 0.0496 | 0.6087 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0271 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0135 | 0.4656 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0581 | 0.0565 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0072 | 0.0255 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0072 | 0.0255 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0072 | 0.0255 |
Echinococcus granulosus | transcription factor eb | 0.0107 | 0.1174 | 0.1366 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0072 | 0.0255 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0157 | 0.014 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0072 | 0.0056 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0072 | 0.0065 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0072 | 0.0255 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0017 | 0.0062 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0271 | 0.03 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0349 | 0.0392 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0072 | 0.0255 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.1055 | 0.104 |
Onchocerca volvulus | 0.0036 | 0.0271 | 0.0716 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0581 | 0.0928 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0023 | 0.0081 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0135 | 0.0195 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0271 | 0.0418 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0271 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0271 | 0.0953 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.027 | 0.0299 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.033 | 0.037 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.014 | 0.1585 | 0.1852 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0017 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0072 | 0.0255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | > 5.6 uM | Antimicrobial activity against replicating Mycobacterium tuberculosis after 8 days by micro plate alamar blue assay | ChEMBL. | 21903392 |
MIC90 (functional) | = 20.6 uM | Antimicrobial activity against non-replicating Mycobacterium tuberculosis after 11 days by luminescence based low oxygen recovery assay | ChEMBL. | 21903392 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.