Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0058 | 0.0597 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0067 | 0.0725 | 0.0281 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0752 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0224 | 0.2843 | 0.2842 |
Plasmodium falciparum | protein kinase 5 | 0.0224 | 0.2843 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0752 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0224 | 0.2843 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0752 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0224 | 0.2843 | 0.2842 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.0492 | 0.049 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0224 | 0.2843 | 0.2842 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0597 | 0.0146 |
Giardia lamblia | Kinase, CMGC CDK | 0.0224 | 0.2843 | 0.2843 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0224 | 0.2843 | 0.2842 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0752 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0752 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0172 | 0.2147 | 0.2145 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0224 | 0.2843 | 0.2842 |
Loa Loa (eye worm) | matrixin family protein | 0.0105 | 0.1238 | 0.0818 |
Brugia malayi | cell division control protein 2 homolog | 0.0224 | 0.2843 | 0.2501 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0224 | 0.2843 | 0.2842 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0224 | 0.2843 | 0.2842 |
Mycobacterium ulcerans | hydrolase | 0.0058 | 0.0597 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0224 | 0.2843 | 0.2842 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0224 | 0.2843 | 0.2842 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0752 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0224 | 0.2843 | 0.2501 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0058 | 0.0597 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0224 | 0.2843 | 0.2842 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0752 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0752 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.1238 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0752 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0224 | 0.2843 | 0.2842 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0752 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.1366 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.272 | 0.2372 |
Echinococcus granulosus | cyclin dependent kinase | 0.0224 | 0.2843 | 0.2842 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.1366 | 0.0953 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0224 | 0.2843 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0752 | 1 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0224 | 0.2843 | 0.2842 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0224 | 0.2843 | 0.2501 |
Onchocerca volvulus | 0.0067 | 0.0725 | 0.3431 | |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0224 | 0.2843 | 0.2842 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.1238 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0047 | 0.0457 | 0.0455 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0752 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0752 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0224 | 0.2843 | 0.2842 |
Brugia malayi | Protein kinase domain containing protein | 0.0224 | 0.2843 | 0.2501 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0752 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0752 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0725 | 0.0723 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0172 | 0.2147 | 0.2145 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0058 | 0.0597 | 0.0146 |
Giardia lamblia | Kinase, CMGC CDK | 0.0224 | 0.2843 | 0.2843 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0224 | 0.2843 | 0.2842 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0752 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0224 | 0.2843 | 0.2501 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0224 | 0.2843 | 0.2842 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0224 | 0.2843 | 0.2842 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0752 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0752 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0224 | 0.2843 | 0.2842 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0224 | 0.2843 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.