Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1057 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.0383 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1057 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1057 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.0383 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1057 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0172 | 0.1061 | 0.0327 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.0479 | 0.01 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1057 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.1057 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0142 | 0.0759 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0142 | 0.0759 | 0.0759 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1057 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0142 | 0.0759 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1057 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1057 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.0479 | 0.0479 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1057 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0142 | 0.0759 | 0.0391 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0142 | 0.0759 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1057 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0142 | 0.0759 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0142 | 0.0759 | 0.0759 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1057 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1057 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1057 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1057 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0648 | 0.0276 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1057 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1057 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1057 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0142 | 0.0759 | 0.0391 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0142 | 0.0759 | 0.0391 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1057 | 1 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0142 | 0.0759 | 0.0759 |
Brugia malayi | Protein kinase domain containing protein | 0.0142 | 0.0759 | 0.0759 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1057 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0172 | 0.1061 | 0.0327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.