Detailed information for compound 1567135

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.915 | Formula: C23H16ClFN4O2S
  • H donors: 1 H acceptors: 2 LogP: 4.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NN=C(/C/1=C/c1cn(c2c1c(ccc2)OCc1c(F)cccc1Cl)C)c1nccs1
  • InChi: 1S/C23H16ClFN4O2S/c1-29-11-13(10-14-21(27-28-22(14)30)23-26-8-9-32-23)20-18(29)6-3-7-19(20)31-12-15-16(24)4-2-5-17(15)25/h2-11H,12H2,1H3,(H,28,30)/b14-10-
  • InChiKey: XSFWLDBGHUVCOR-UVTDQMKNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens anaplastic lymphoma receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) TK/ALK protein kinase Get druggable targets OG5_132231 All targets in OG5_132231
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_132231 All targets in OG5_132231
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132231 All targets in OG5_132231
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0144 0.0304
Trichomonas vaginalis rotamase, putative 0.013 0.0545 0.1177
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0106 0.0394
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0196 0.0486
Loa Loa (eye worm) hypothetical protein 0.025 0.1139 0.2824
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0248 0.0928
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0093
Echinococcus multilocularis MAM 0.0034 0.0074 0.0074
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0052 0.0161 0.0603
Echinococcus granulosus transcription factor btf3 0.0069 0.0248 0.0248
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.015 0.0648 0.1607
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0049 0.0108
Treponema pallidum thioredoxin reductase (trxB) 0.0052 0.0161 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0831
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0257 0.0637
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0434 0.0434
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.0161 0.0603
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0052 0.0161 0.0161
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0052 0.0161 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Leishmania major DNA damage repair protein, putative 0.0047 0.0137 0.0511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0498 0.0498
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0867 0.4181 1
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0133 0.0133
Schistosoma mansoni lamin 0.0027 0.0037 0.0037
Loa Loa (eye worm) RGS-3 protein 0.002 0.0004 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2916
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Brugia malayi AF-10 protein 0.0019 0.0001 0.0003
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0386 0.1443
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0005 0.0013
Echinococcus multilocularis glutamate synthase 0.0052 0.0161 0.0161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0133 0.0133
Schistosoma mansoni kinase 0.0049 0.015 0.015
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0195 0.0866 0.1073
Trichomonas vaginalis DNA polymerase eta, putative 0.0177 0.078 0.1687
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0137 0.0513
Trypanosoma brucei unspecified product 0.0171 0.0747 0.2794
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0935
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0498 0.0498
Echinococcus granulosus peregrin 0.0059 0.0196 0.0196
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0005 0.0013
Schistosoma mansoni hypothetical protein 0.0059 0.0196 0.0196
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0161 0.0603
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0498 0.1864
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0004 0.001
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0001 0.0004
Treponema pallidum fructose-bisphosphate aldolase 0.0867 0.4181 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0052 0.0161 0.0035
Brugia malayi phosphofructokinase 0.0107 0.0434 0.1076
Schistosoma mansoni sulfide quinone reductase 0.0052 0.0161 0.0161
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0309 0.0309
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0703 0.0834
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0144 0.0304
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0257 0.0257
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0052 0.0161 0.0035
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0195 0.0866 0.3237
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0185 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0837 0.4033 1
Schistosoma mansoni transcription factor btf3 0.0069 0.0248 0.0248
Entamoeba histolytica thioredoxin reductase, putative 0.0052 0.0161 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0004 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0264 0.0264
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0195 0.0866 0.3237
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0052 0.0161 0.0161
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0052 0.0161 0.0161
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.0268 0.0663
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Echinococcus multilocularis thioredoxin glutathione reductase 0.0565 0.269 0.269
Leishmania major trypanothione reductase 0.0561 0.2675 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0099 0.0392 0.1467
Giardia lamblia NADH oxidase lateral transfer candidate 0.0195 0.0866 0.1976
Mycobacterium ulcerans ferredoxin reductase 0.0052 0.0161 0.0132
Leishmania major DNA polymerase eta, putative 0.0202 0.0904 0.3379
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0143 0.0611 0.1515
Mycobacterium ulcerans DNA polymerase IV 0.0177 0.078 0.3462
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0137 0.1078
Brugia malayi glutamate synthase 0.0052 0.0161 0.04
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.015 0.0648 0.0648
Trichomonas vaginalis rotamase, putative 0.0133 0.0561 0.1211
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.013 0.0545 0.2039
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1424 0.6925 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0161 0.0342
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0049 0.0183
Brugia malayi PHD-finger family protein 0.0019 0.0001 0.0003
Echinococcus granulosus MAM 0.0034 0.0074 0.0074
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0004 0.0004
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0049 0.0183
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0257 0.0257
Echinococcus granulosus expressed protein 0.0384 0.1801 0.1801
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0137 0.0002
Brugia malayi Pre-SET motif family protein 0.0837 0.4033 1
Leishmania major hypothetical protein, conserved 0.0052 0.0161 0.0603
Entamoeba histolytica deoxycytidyl transferase, putative 0.015 0.0648 0.1542
Toxoplasma gondii hypothetical protein 0.0049 0.015 0.0563
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0137 0.0511
Schistosoma mansoni jumonji domain containing protein 0.0153 0.066 0.066
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0137 0.0511
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0052 0.0161 0.0603
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0386 0.0386
Echinococcus multilocularis L aminoadipate semialdehyde 0.0166 0.0726 0.0726
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0106 0.0394
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0143 0.0611 0.1515
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0386 0.0386
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0052 0.0161 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0133 0.0133
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0052 0.0161 0.0035
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0195 0.0866 0.3237
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.004 0.0106 0.0394
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0166 0.0412
Loa Loa (eye worm) glutathione reductase 0.0561 0.2675 0.6631
Plasmodium vivax thioredoxin reductase, putative 0.0561 0.2675 1
Trypanosoma brucei DNA polymerase IV, putative 0.0171 0.0747 0.2794
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0386 0.0957
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0052 0.0161 0.0132
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0052 0.0161 0.0377
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0137 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0052 0.0161 0.0603
Echinococcus granulosus lamin 0.0027 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0074 0.0184
Leishmania major DNA polymerase kappa, putative 0.0047 0.0137 0.0511
Schistosoma mansoni hypothetical protein 0.0339 0.1577 0.1577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0133 0.0133
Echinococcus granulosus axis inhibition protein axin 0.002 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Echinococcus granulosus intermediate filament protein 0.0027 0.0037 0.0037
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0004 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.015 0.0648 0.1607
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0052 0.0161 0.0603
Schistosoma mansoni axis inhibition protein axin 0.002 0.0004 0.0004
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0133 0.0561 0.1391
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0004 0.0004
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0166 0.0726 0.0726
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0831
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0052 0.0161 0.0132
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0004 0.0004
Schistosoma mansoni glutamate synthase 0.0052 0.0161 0.0161
Echinococcus multilocularis tumor protein p63 0.034 0.1583 0.1583
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0052 0.0161 0.04
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0161 0.0342
Brugia malayi polk-prov protein 0.0073 0.0269 0.0666
Mycobacterium tuberculosis Conserved hypothetical protein 0.015 0.0648 0.0753
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0049 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Mycobacterium tuberculosis Probable reductase 0.1281 0.6221 0.8962
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1419 0.5304
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0052 0.0161 0.0603
Schistosoma mansoni hypothetical protein 0.0052 0.0161 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0133 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0831
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0052 0.0161 0.0161
Trypanosoma brucei unspecified product 0.0104 0.0418 0.1563
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0195 0.0866 0.2147
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0248 0.0531
Echinococcus multilocularis peregrin 0.0059 0.0196 0.0196
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0052 0.0161 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2916
Echinococcus multilocularis dna polymerase kappa 0.0177 0.078 0.078
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0196 0.0486
Trypanosoma brucei unspecified product 0.0104 0.0418 0.1563
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0052 0.0161 0.0132
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0052 0.0161 0.0342
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.0268 0.0663
Echinococcus multilocularis lamin 0.0027 0.0037 0.0037
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0004 0.0004
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0005 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0196 0.0733
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0159 0.0693 0.0693
Brugia malayi 6-phosphofructokinase 0.0107 0.0434 0.1076
Trypanosoma brucei DNA polymerase IV, putative 0.0177 0.078 0.2916
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0161 0.0603
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0195 0.0866 0.3237
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0935
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0424 0.1995 0.2737
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0052 0.0161 0.0342
Echinococcus multilocularis geminin 0.0339 0.1577 0.1577
Echinococcus multilocularis musashi 0.0027 0.0037 0.0037
Echinococcus multilocularis 0.0021 0.0008 0.0008
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0434 0.103
Loa Loa (eye worm) TK/INSR protein kinase 0.0159 0.0693 0.1717
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0195 0.0866 0.3237
Leishmania major hypothetical protein, conserved 0.0025 0.0032 0.0118
Loa Loa (eye worm) programmed cell death 8 0.0052 0.0161 0.04
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0052 0.0161 0.0161
Brugia malayi Pre-SET motif family protein 0.012 0.0498 0.1236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0004 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.0565 0.269 0.269
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0504 0.125
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.013 0.0545 0.1296
Entamoeba histolytica hypothetical protein 0.0047 0.0137 0.0319
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.015 0.0648 0.0648
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0268 0.0268
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0052 0.0161 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0133 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.1419 0.5304
Schistosoma mansoni tyrosine kinase 0.0073 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0078
Entamoeba histolytica hypothetical protein 0.0069 0.0248 0.0585
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0434 0.16
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0161 0.0603
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0157 0.0681 0.0801
Plasmodium falciparum glutathione reductase 0.0561 0.2675 1
Onchocerca volvulus 0.012 0.0498 0.101
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1424 0.6925 1
Onchocerca volvulus 0.0034 0.0074 0.0081
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0248 0.0928
Schistosoma mansoni hypothetical protein 0.0339 0.1577 0.1577
Chlamydia trachomatis thioredoxin reductase 0.0052 0.0161 0.1373
Schistosoma mansoni tyrosine kinase 0.0071 0.0255 0.0255
Brugia malayi intermediate filament protein 0.0027 0.0037 0.0093
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0005 0.0005
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0004 0.0004
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0264 0.0264
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0032 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Plasmodium vivax glutathione reductase, putative 0.0561 0.2675 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0269 0.1004
Schistosoma mansoni tyrosine kinase 0.0073 0.0268 0.0268
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0386 0.1443
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0434 0.0434
Trichomonas vaginalis mercuric reductase, putative 0.0195 0.0866 0.1874
Toxoplasma gondii NADPH-glutathione reductase 0.0195 0.0866 0.3237
Trichomonas vaginalis glutamate synthase, putative 0.0052 0.0161 0.0342
Trypanosoma brucei trypanothione reductase 0.0561 0.2675 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0434 0.1623
Loa Loa (eye worm) hypothetical protein 0.0166 0.0726 0.1801
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0161 0.0603
Onchocerca volvulus Alhambra homolog 0.0059 0.0196 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0561 0.1211
Schistosoma mansoni hypothetical protein 0.0034 0.0074 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0137 0.0511
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0196 0.0196
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0052 0.0161 0.0377
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0037 0.0093
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1281 0.6221 0.8962
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0195 0.0866 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0166 0.062
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0159 0.0693 0.0693
Schistosoma mansoni tyrosine kinase 0.0159 0.0693 0.0693
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0161 0.0342
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0004 0.0004
Plasmodium falciparum ferrodoxin reductase-like protein 0.0052 0.0161 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0831
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2916
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0185 0.0259
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0052 0.0161 0.0132
Brugia malayi hypothetical protein 0.002 0.0004 0.001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0052 0.0161 0.0161
Echinococcus granulosus geminin 0.0339 0.1577 0.1577
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0037 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0137 0.0511
Schistosoma mansoni hypothetical protein 0.0034 0.0074 0.0074
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0052 0.0161 0.0035
Echinococcus granulosus axis inhibition protein axin 0.002 0.0004 0.0004
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0434 0.1076
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.1419 0.5304
Trypanosoma cruzi DNA damage repair protein, putative 0.0047 0.0137 0.0511
Giardia lamblia Glutamate synthase 0.0052 0.0161 0.0271
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0248 0.0928
Leishmania major DNA polymerase eta, putative 0.0099 0.0392 0.1467
Toxoplasma gondii selenide, water dikinase 0.0052 0.0161 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0498 0.0498
Onchocerca volvulus 0.0166 0.0726 0.1508
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0133 0.0329
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.013 0.0545 0.2039
Brugia malayi hypothetical protein 0.0025 0.0032 0.0078
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0434 0.0437
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0053 0.0169 0.0634
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0268 0.0268
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0386 0.1443
Echinococcus granulosus insulin receptor 0.0159 0.0693 0.0693
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0434 0.1076
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.004 0.0106 0.0394
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Schistosoma mansoni sulfide quinone reductase 0.0052 0.0161 0.0161
Giardia lamblia Thioredoxin reductase 0.0052 0.0161 0.0271
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0248 0.0585
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0005 0.0013
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0137 0.0213
Toxoplasma gondii thioredoxin reductase 0.0561 0.2675 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0185 0.0691
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0052 0.0161 0.0603
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0177 0.078 0.1687
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1281 0.6221 0.8962
Brugia malayi beta-NAC-like protein 0.0069 0.0248 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Brugia malayi PXA domain containing protein 0.002 0.0004 0.001
Onchocerca volvulus 0.005 0.0152 0.0251
Trypanosoma brucei DNA damage repair protein, putative 0.0047 0.0137 0.0511
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0195 0.0866 0.3237
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0622 0.2326
Brugia malayi glutathione reductase 0.0561 0.2675 0.6631
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0137 0.0513
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0087
Echinococcus multilocularis expressed protein 0.0133 0.0561 0.0561
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0386 0.0957
Trypanosoma cruzi NADH dehydrogenase, putative 0.0052 0.0161 0.0603
Giardia lamblia Fructose-bisphosphate aldolase 0.0867 0.4181 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0137 0.0513
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0137 0.0513
Schistosoma mansoni tyrosine kinase 0.0073 0.0268 0.0268
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0434 0.0437
Mycobacterium ulcerans dehydrogenase 0.0052 0.0161 0.0132
Brugia malayi ImpB/MucB/SamB family protein 0.0202 0.0904 0.2241
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0161 0.0603
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.078 0.2916
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0052 0.0161 0.0603
Treponema pallidum NADH oxidase 0.0195 0.0866 0.1976
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0004 0.0004
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0052 0.0161 0.0161
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0386 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0248 0.0531
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0195 0.0866 0.0866
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Plasmodium falciparum DNA repair protein REV1, putative 0.0047 0.0137 0.0511
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0052 0.0161 0.0035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0823 0.3966 0.3966
Brugia malayi PXA domain containing protein 0.002 0.0004 0.001
Brugia malayi PHD-finger family protein 0.0059 0.0196 0.0486
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0831
Brugia malayi jmjC domain containing protein 0.0192 0.0855 0.2119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0498 0.0498
Echinococcus multilocularis microtubule associated protein 2 0.2047 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0032 0.0118
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0185 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0386 0.0386
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0052 0.0161 0.0732
Mycobacterium ulcerans DNA polymerase IV 0.0177 0.078 0.3462
Trypanosoma brucei polo-like protein kinase 0.0097 0.0386 0.1443
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0248 0.0928
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.013 0.0545 0.2039
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0196 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0248 0.0531
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0498 0.0498
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1424 0.6925 1
Trypanosoma brucei DNA polymerase eta, putative 0.0202 0.0904 0.3379
Echinococcus multilocularis expressed protein 0.0384 0.1801 0.1801
Echinococcus granulosus Solute carrier family 22 5 0.1019 0.4929 0.4929
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.013 0.0545 0.2039
Trypanosoma cruzi DNA polymerase eta, putative 0.0202 0.0904 0.3379
Leishmania major DNA polymerase kappa, putative 0.0157 0.0681 0.2545
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0152 0.0152
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1281 0.6221 0.8962
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0119 0.0446
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0157 0.0681 0.2545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Trypanosoma brucei chrX additional, unordered contigs 0.0047 0.0137 0.0511
Treponema pallidum oxidoreductase 0.0052 0.0161 0.0271
Giardia lamblia DINP protein human, muc B family 0.0157 0.0681 0.1529
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0052 0.0161 0.0732
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Echinococcus granulosus dna polymerase kappa 0.0177 0.078 0.078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Brugia malayi Protein kinase domain containing protein 0.0287 0.132 0.3273
Plasmodium falciparum glutathione reductase 0.0195 0.0866 0.3237
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0269 0.1004
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0032 0.0118
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0052 0.0161 0.0603
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0434 0.0434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0133 0.0329
Schistosoma mansoni terminal deoxycytidyl transferase 0.015 0.0648 0.0648
Plasmodium vivax DNA repair protein REV1, putative 0.0047 0.0137 0.0511
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0622 0.2326
Mycobacterium tuberculosis Probable oxidoreductase 0.1424 0.6925 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0133 0.0133
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0185 0.0185
Leishmania major NADH dehydrogenase, putative 0.0052 0.0161 0.0603
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Plasmodium falciparum thioredoxin reductase 0.0195 0.0866 0.3237
Echinococcus multilocularis lamin dm0 0.0027 0.0037 0.0037
Schistosoma mansoni rotamase 0.0133 0.0561 0.0561
Leishmania major basic transcription factor 3a, putative 0.0069 0.0248 0.0928
Trypanosoma brucei NADH dehydrogenase 0.0052 0.0161 0.0603
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0935
Trichomonas vaginalis glutathione reductase, putative 0.0195 0.0866 0.1874
Plasmodium falciparum phd finger protein, putative 0.0059 0.0196 0.0733
Loa Loa (eye worm) hypothetical protein 0.0101 0.0403 0.0999
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0001 0.0004
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0052 0.0161 0.0603
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0052 0.0161 0.0603
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0268 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Brugia malayi MH2 domain containing protein 0.0239 0.1084 0.2687
Mycobacterium ulcerans hypothetical protein 0.0052 0.0161 0.0132
Trypanosoma cruzi trypanothione reductase, putative 0.0561 0.2675 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0195 0.0866 0.3237
Loa Loa (eye worm) hypothetical protein 0.0086 0.0332 0.0822
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Brugia malayi Protein kinase domain containing protein 0.0089 0.0344 0.0853
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0004 0.001
Schistosoma mansoni disulfide oxidoreductase 0.0052 0.0161 0.0161
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0052 0.0161 0.04
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0196 0.0733
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0185 0.007
Mycobacterium ulcerans glutamate synthase subunit beta 0.0052 0.0161 0.0132
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0004
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0004 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0177 0.078 0.2916
Loa Loa (eye worm) TK/ALK protein kinase 0.0287 0.1319 0.3271
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0185 0.0259
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0106 0.0394
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0257 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0032 0.0118
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0161 0.0342
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0195 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.012 0.0498 0.1236
Brugia malayi Protein kinase domain containing protein 0.0159 0.0693 0.1717
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0195 0.0866 0.3237
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0248 0.0616
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0119 0.0446
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0052 0.0161 0.04
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0434 0.103
Brugia malayi hypothetical protein 0.0034 0.0074 0.0184
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0001 0.0004
Mycobacterium ulcerans hypothetical protein 0.0162 0.0703 0.3048
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0424 0.1995 1
Schistosoma mansoni tyrosine kinase 0.0071 0.0255 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0157 0.0681 0.2545
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0451 0.1685
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0052 0.0161 0.0035
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1281 0.6221 0.8962
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0268 0.0268
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0001 0.0004
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0052 0.0161 0.0377
Loa Loa (eye worm) hypothetical protein 0.0073 0.0269 0.0666
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0195 0.0866 1
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0052 0.0161 0.0035
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0434 0.103
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0137 0.0513
Trypanosoma cruzi trypanothione reductase, putative 0.0195 0.0866 0.3237
Onchocerca volvulus 0.0953 0.4604 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Mycobacterium ulcerans monoxygenase 0.0052 0.0161 0.0132
Giardia lamblia DNA damage repair protein 0.0047 0.0137 0.0212
Loa Loa (eye worm) thioredoxin reductase 0.0561 0.2675 0.6631
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.0855 0.0855
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0309 0.0309
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0137 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0451 0.1685
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0434 0.1076
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0004 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Entamoeba histolytica disulphide oxidoreductase, putative 0.0052 0.0161 0.0377
Echinococcus granulosus expressed protein 0.0133 0.0561 0.0561
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0032 0.0118
Loa Loa (eye worm) hypothetical protein 0.0202 0.0904 0.2241
Schistosoma mansoni intermediate filament proteins 0.0027 0.0037 0.0037
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0052 0.0161 0.0603
Schistosoma mansoni axis inhibition protein axin 0.002 0.0004 0.0004
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0434 0.0434
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0159 0.0693 0.0693
Brugia malayi hypothetical protein 0.002 0.0004 0.001
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0195 0.0866 0.3924
Onchocerca volvulus 0.0052 0.0161 0.0271
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0248 0.0928
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0137 0.0513
Trichomonas vaginalis apoptosis inducing factor, putative 0.0052 0.0161 0.0342
Loa Loa (eye worm) hypothetical protein 0.0034 0.0074 0.0184
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0052 0.0161 0.0161
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0195 0.0866 0.3924
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0049 0.0183
Schistosoma mansoni DNA polymerase eta 0.0202 0.0904 0.0904
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0004 0.0004
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0434 0.0931
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1419 0.5304
Echinococcus granulosus lamin dm0 0.0027 0.0037 0.0037
Trichomonas vaginalis glutamate synthase, putative 0.0052 0.0161 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0831
Trypanosoma cruzi DNA damage repair protein, putative 0.0047 0.0137 0.0511
Plasmodium vivax SET domain protein, putative 0.012 0.0498 0.1864
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0166 0.0726 0.1801
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0195 0.0866 0.3237
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0004 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0119 0.0446
Trypanosoma brucei DNA damage repair protein, putative 0.0047 0.0137 0.0511
Giardia lamblia PHD finger protein 15 0.0059 0.0196 0.0356
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0004 0.0004
Brugia malayi 6-phosphofructokinase 0.0107 0.0434 0.1076
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0133 0.0561 0.1391
Plasmodium falciparum thioredoxin reductase 0.0561 0.2675 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0052 0.0161 0.0161
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0052 0.0161 0.0342
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0119 0.0446
Brugia malayi Thioredoxin reductase 0.0561 0.2675 0.6631
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0196 0.0196
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0052 0.0161 0.0271
Leishmania major hypothetical protein, conserved 0.0052 0.0161 0.0603
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0023 0.0057
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.0855 0.0855
Trypanosoma cruzi NADH dehydrogenase, putative 0.0052 0.0161 0.0603
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0195 0.0866 0.3237
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0386 0.0831
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0052 0.0161 0.0132
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0196 0.0196
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0185 0.0459
Trypanosoma cruzi DNA polymerase eta, putative 0.0099 0.0392 0.1467
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0052 0.0161 0.0342
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0049 0.0183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0023 0.0023
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.0268 0.0268
Giardia lamblia Kinase, PLK 0.0097 0.0386 0.0815
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0052 0.0161 0.0603
Echinococcus granulosus L aminoadipate semialdehyde 0.0166 0.0726 0.0726
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0052 0.0161 0.0377
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0052 0.0161 0.0603
Mycobacterium tuberculosis Probable dehydrogenase 0.1281 0.6221 0.8962
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0037 0.0093
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0867 0.4181 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0386 0.0915
Echinococcus multilocularis insulin receptor 0.0159 0.0693 0.0693
Echinococcus multilocularis dna polymerase eta 0.0202 0.0904 0.0904
Onchocerca volvulus 0.0034 0.0074 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0052 0.0161 0.0603
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0195 0.0866 0.3237
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.015 0.0648 0.0648
Trichomonas vaginalis set domain proteins, putative 0.0953 0.4603 1
Plasmodium vivax ferrodoxin reductase, putative 0.0052 0.0161 0.0603
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0004 0.0004
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0561 0.2675 0.3738
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1281 0.6221 0.8962
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0032 0.0118
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0052 0.0161 0.04
Leishmania major hypothetical protein, conserved 0.0052 0.0161 0.0603
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0004 0.0004
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0052 0.0161 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1084 0.2687
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0257 0.0257
Toxoplasma gondii peptidylprolyl isomerase 0.013 0.0545 0.2039
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0052 0.0161 0.0161
Echinococcus multilocularis transcription factor btf3 0.0069 0.0248 0.0248
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.005 0.0152 0.0377
Brugia malayi jmjC domain containing protein 0.0071 0.0257 0.0637
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0052 0.0161 0.0161
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0195 0.0866 0.0866
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0195 0.0866 0.3237
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0434 0.0935
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0195 0.0866 0.3237
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0004 0.0004
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0434 0.1623
Echinococcus granulosus tumor protein p63 0.034 0.1583 0.1583
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0622 0.2326
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0052 0.0161 0.0603
Schistosoma mansoni tyrosine kinase 0.0071 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0034 0.0074 0.0184
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0195 0.0866 0.3924
Schistosoma mansoni DNA polymerase IV / kappa 0.0047 0.0137 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.011 0.0451 0.1685
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0195 0.0866 1
Schistosoma mansoni microtubule-associated protein tau 0.2047 1 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0052 0.0161 0.0161
Echinococcus granulosus glutamate synthase 0.0052 0.0161 0.0161
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0049 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0137 0.0511
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0161 0.0342
Schistosoma mansoni glutamate synthase 0.0052 0.0161 0.0161
Schistosoma mansoni lamin 0.0027 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0195 0.0866 0.3237
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0052 0.0161 0.0342
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Mycobacterium ulcerans NADH dehydrogenase 0.0052 0.0161 0.0132
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0004 0.0004
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0052 0.0161 0.0132
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1084 0.2687
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0424 0.1995 0.2737
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0004 0.001
Brugia malayi Bromodomain containing protein 0.0059 0.0196 0.0486
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0434 0.1623
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0052 0.0161 0.0603
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0052 0.0161 0.0603
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0049 0.0098
Loa Loa (eye worm) hypothetical protein 0.0052 0.0161 0.04
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0049 0.0098
Schistosoma mansoni regulator of G protein signaling 0.002 0.0004 0.0004
Schistosoma mansoni glutamate synthase 0.0052 0.0161 0.0161
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0032 0.0118
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0052 0.0161 0.0732
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0248 0.0928
Echinococcus granulosus dna polymerase eta 0.0202 0.0904 0.0904
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0498 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.078 0.2916
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0867 0.4181 0.9083
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0049 0.0183

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13 nM Inhibition of ALK ChEMBL. 22061645
IC50 (binding) = 200 nM Inhibition of nucleophosmin-fused ALK autophosphorylation in human Karpas299 cells ChEMBL. 22061645
IC50 (binding) = 1415 nM Inhibition of GST-tagged intracellular domain of IR by homogeneous time-resolved fluorescence assay ChEMBL. 22061645

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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