Detailed information for compound 1567223

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.568 | Formula: C27H31N5O
  • H donors: 1 H acceptors: 2 LogP: 5.18 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C/C=C/CCOc2cccc(c2)c2nc(Nc3cc(C1)ccc3)nc(c2)N1CCCC1
  • InChi: 1S/C27H31N5O/c1-31-13-3-2-6-16-33-24-12-8-10-22(18-24)25-19-26(32-14-4-5-15-32)30-27(29-25)28-23-11-7-9-21(17-23)20-31/h2-3,7-12,17-19H,4-6,13-16,20H2,1H3,(H,28,29,30)/b3-2+
  • InChiKey: LKYBNWASGDSVOP-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin A2 References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0019 0.0814 0.079
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.3933 0.3933
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.3933 0.5247
Echinococcus multilocularis lipoxygenase domain containing protein 0.0015 0.0486 0.0462
Schistosoma mansoni gliotactin 0.002 0.0911 0.0888
Echinococcus multilocularis Immunoglobulin 0.0019 0.0814 0.079
Schistosoma mansoni netrin receptor unc5 0.0044 0.3189 0.3172
Echinococcus multilocularis carboxylesterase 5A 0.0117 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.3933 0.3917
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0026 0.0026
Echinococcus multilocularis roundabout 2 0.0019 0.0814 0.079
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.002 0.0911 0.0888
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0091 0.7574 0.7574
Echinococcus granulosus acetylcholinesterase 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.009 0.7472 0.7343
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3933 0.3917
Schistosoma mansoni vesicular amine transporter 0.0019 0.0814 0.079
Brugia malayi Carboxylesterase family protein 0.002 0.0911 0.0447
Echinococcus multilocularis cyclins 0.0038 0.2569 0.2549
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Trichomonas vaginalis cyclin B, putative 0.009 0.7472 1
Trichomonas vaginalis cyclins, putative 0.009 0.7472 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.002 0.0911 0.5
Trypanosoma brucei mitotic cyclin 6 0.009 0.7472 1
Brugia malayi hypothetical protein 0.0019 0.0814 0.0344
Echinococcus granulosus Immunoglobulin 0.0019 0.0814 0.0814
Brugia malayi hypothetical protein 0.002 0.0911 0.0447
Loa Loa (eye worm) hypothetical protein 0.002 0.0911 0.0447
Echinococcus granulosus para nitrobenzyl esterase 0.002 0.0911 0.0911
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.3189 0.2841
Echinococcus multilocularis cyclins 0.0038 0.2569 0.2549
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0044 0.3189 0.3172
Giardia lamblia Cyclin A 0.0038 0.2569 0.3425
Schistosoma mansoni BC026374 protein (S09 family) 0.002 0.0911 0.0888
Echinococcus granulosus cyclins 0.0038 0.2569 0.2569
Echinococcus granulosus cyclins 0.0038 0.2569 0.2569
Trichomonas vaginalis cyclin B, putative 0.009 0.7472 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.3933 0.3623
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.3933 0.5247
Loa Loa (eye worm) hypothetical protein 0.0052 0.3967 0.3659
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.3933 0.3933
Schistosoma mansoni cyclin B3 0.0038 0.2569 0.2549
Echinococcus granulosus Polycystic kidney disease protein 0.0015 0.0486 0.0486
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3933 0.3917
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Echinococcus granulosus RUN 0.0015 0.0486 0.0486
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.2569 0.2189
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.7472 0.7343
Echinococcus granulosus cyclins 0.0038 0.2569 0.2569
Echinococcus granulosus carboxylesterase 5A 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Brugia malayi Carboxylesterase family protein 0.002 0.0911 0.0447
Schistosoma mansoni tumor necrosis factor receptor related 0.0067 0.536 0.5348
Trichomonas vaginalis cyclins, putative 0.009 0.7472 1
Leishmania major cyclin 0.009 0.7472 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0117 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0911 0.0447
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.2569 0.2569
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.3933 0.5247
Echinococcus granulosus neuroligin 0.002 0.0911 0.0911
Mycobacterium tuberculosis Carboxylesterase LipT 0.002 0.0911 0.5
Echinococcus granulosus BC026374 protein S09 family 0.002 0.0911 0.0911
Giardia lamblia Kinase, CMGC CDK 0.0052 0.3933 0.5254
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.3933 0.5247
Trichomonas vaginalis cyclin B3, putative 0.0038 0.2569 0.2526
Brugia malayi Death domain containing protein 0.0044 0.3189 0.2841
Loa Loa (eye worm) hypothetical protein 0.002 0.0911 0.0447
Loa Loa (eye worm) carboxylesterase 0.002 0.0911 0.0447
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.7472 1
Brugia malayi Fibronectin type III domain containing protein 0.0019 0.0814 0.0344
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.002 0.0911 0.0888
Echinococcus multilocularis cyclin B 0.009 0.7472 0.7466
Echinococcus granulosus defective proboscis extension response 0.0019 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.002 0.0911 0.0447
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.7472 1
Trichomonas vaginalis cyclin B, putative 0.0038 0.2569 0.2526
Trichomonas vaginalis cyclin B, putative 0.009 0.7472 1
Echinococcus granulosus twitchin 0.0019 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0044 0.3189 0.3189
Onchocerca volvulus Netrin receptor homolog 0.0044 0.3189 0.3869
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0052 0.3881 0.3568
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.3933 0.3917
Plasmodium falciparum protein kinase 5 0.0052 0.3933 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3933 0.4605
Plasmodium falciparum LCCL domain-containing protein 0.0015 0.0486 0.1178
Echinococcus granulosus cyclins 0.0038 0.2569 0.2569
Entamoeba histolytica cyclin family protein 0.0038 0.2569 0.3415
Schistosoma mansoni cyclins 0.0038 0.2569 0.2549
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.002 0.0911 0.0888
Loa Loa (eye worm) hypothetical protein 0.002 0.0911 0.0447
Echinococcus multilocularis cyclins 0.0038 0.2569 0.2549
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Echinococcus multilocularis cyclins 0.0038 0.2569 0.2549
Echinococcus multilocularis Polycystic kidney disease protein 0.0015 0.0486 0.0462
Schistosoma mansoni cell adhesion molecule 0.0019 0.0814 0.079
Trichomonas vaginalis cyclin B, putative 0.009 0.7472 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.7472 1
Echinococcus multilocularis Immunoglobulin 0.0019 0.0814 0.079
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.7472 0.7343
Entamoeba histolytica cyclin, putative 0.0038 0.2569 0.3415
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.002 0.0911 0.5
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.2569 0.2549
Echinococcus multilocularis cyclin B3 1 0.0038 0.2569 0.2549
Trypanosoma cruzi cyclin, putative 0.009 0.7472 1
Echinococcus granulosus cyclin B 0.009 0.7472 0.7472
Brugia malayi Carboxylesterase family protein 0.0117 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.2569 0.2189
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0019 0.0814 0.079
Echinococcus multilocularis cyclins 0.0038 0.2569 0.2549
Trichomonas vaginalis cyclin D, putative 0.0038 0.2569 0.2526
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0022 0.1132 0.0678
Echinococcus granulosus cyclin b3 0.0038 0.2569 0.2569
Trichomonas vaginalis cyclins, putative 0.0038 0.2569 0.2526
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0019 0.0814 0.079
Trichomonas vaginalis cyclins, putative 0.0062 0.4813 0.5947
Echinococcus multilocularis cyclins 0.0038 0.2569 0.2549
Echinococcus multilocularis neuroligin 0.002 0.0911 0.0888
Loa Loa (eye worm) hypothetical protein 0.002 0.0911 0.0447
Echinococcus multilocularis neuroglian 0.0019 0.0814 0.079
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3933 0.4605
Loa Loa (eye worm) hypothetical protein 0.0044 0.3189 0.2841
Echinococcus multilocularis RUN 0.0015 0.0486 0.0462
Echinococcus granulosus acetylcholinesterase 0.0117 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.3933 0.5247
Echinococcus granulosus lipoxygenase domain containing protein 0.0015 0.0486 0.0486
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0117 1 1
Trichomonas vaginalis cyclins, putative 0.009 0.7472 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.3933 0.3623
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.3933 0.3623
Echinococcus granulosus Ankyrin 0.0044 0.3189 0.3189
Schistosoma mansoni cyclin B 0.009 0.7472 0.7466
Onchocerca volvulus 0.002 0.0911 0.0609
Echinococcus granulosus lipoxygenase domain containing protein 0.0015 0.0486 0.0486
Toxoplasma gondii hypothetical protein 0.0028 0.1723 0.4343
Schistosoma mansoni lipoxygenase 0.0091 0.7574 0.7568
Echinococcus multilocularis netrin receptor unc 5 0.0044 0.3189 0.3172
Echinococcus granulosus neuroglian 0.0019 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Brugia malayi Carboxylesterase family protein 0.002 0.0911 0.0447
Echinococcus granulosus roundabout 2 0.0019 0.0814 0.0814
Schistosoma mansoni acetylcholinesterase 0.002 0.0911 0.0888
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.3933 0.5247
Schistosoma mansoni lipoxygenase 0.0064 0.5013 0.5
Schistosoma mansoni loxhd1 0.0015 0.0486 0.0462
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0067 0.536 0.536
Trichomonas vaginalis cyclin D, putative 0.0038 0.2569 0.2526
Echinococcus multilocularis lipoxygenase domain containing protein 0.0015 0.0486 0.0462
Schistosoma mansoni rab6-interacting 0.0015 0.0486 0.0462
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.3933 0.3623
Onchocerca volvulus 0.002 0.0911 0.0609
Loa Loa (eye worm) hypothetical protein 0.009 0.7472 0.7343
Trichomonas vaginalis cyclins, putative 0.009 0.7472 1
Onchocerca volvulus 0.002 0.0911 0.0609
Echinococcus multilocularis acetylcholinesterase 0.0117 1 1
Brugia malayi cell division control protein 2 homolog 0.0052 0.3933 0.3623
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0019 0.0814 0.0814
Schistosoma mansoni polycystin 1-related 0.0015 0.0486 0.0462
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.3933 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.3933 0.4605
Trypanosoma cruzi cyclin, putative 0.009 0.7472 1
Onchocerca volvulus 0.002 0.0911 0.0609
Plasmodium falciparum cyclin 0.0038 0.2569 0.6508
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0091 0.7574 0.7568
Schistosoma mansoni nephrin 0.0019 0.0814 0.079
Giardia lamblia Hypothetical protein 0.0038 0.2569 0.3425
Echinococcus multilocularis cyclins 0.0038 0.2569 0.2549
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.3933 0.5247
Trichomonas vaginalis cyclin A, putative 0.009 0.7472 1
Echinococcus granulosus death domain containing protein 0.0044 0.3189 0.3189
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0067 0.536 0.5348
Loa Loa (eye worm) carboxylesterase 0.0117 1 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0015 0.0486 0.1178
Loa Loa (eye worm) hypothetical protein 0.0117 1 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.3933 0.3933
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0067 0.536 0.5348
Loa Loa (eye worm) hypothetical protein 0.0044 0.3189 0.2841
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0067 0.536 0.536
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.3933 0.5247
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.3933 0.3917
Brugia malayi Protein kinase domain containing protein 0.0045 0.3241 0.2896
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0044 0.3189 0.3172
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0814 0.0344
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.002 0.0911 0.0888
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Echinococcus granulosus cyclin dependent kinase 0.0052 0.3933 0.3933
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Entamoeba histolytica cyclin, putative 0.009 0.7472 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.002 0.0911 0.0888
Onchocerca volvulus 0.002 0.0911 0.0609
Echinococcus granulosus cyclins 0.0038 0.2569 0.2569
Echinococcus multilocularis acetylcholinesterase 0.0117 1 1
Echinococcus multilocularis Ankyrin 0.0044 0.3189 0.3172
Echinococcus multilocularis para nitrobenzyl esterase 0.002 0.0911 0.0888
Schistosoma mansoni ankyrin 23/unc44 0.0044 0.3189 0.3172
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.3933 0.5247
Brugia malayi Carboxylesterase family protein 0.002 0.0911 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.2569 0.2526
Schistosoma mansoni hypothetical protein 0.0044 0.3189 0.3172
Schistosoma mansoni hypothetical protein 0.0015 0.0486 0.0462
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.3933 0.3917
Mycobacterium ulcerans carboxylesterase, LipT 0.002 0.0911 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.1132 0.0678
Echinococcus multilocularis cyclin b3 0.0038 0.2569 0.2549
Schistosoma mansoni rab6-interacting 0.0015 0.0486 0.0462
Entamoeba histolytica cyclin family protein 0.0038 0.2569 0.3415
Echinococcus granulosus family S9 non peptidase ue S09 family 0.002 0.0911 0.0911
Loa Loa (eye worm) carboxylesterase 0.002 0.0911 0.0447
Giardia lamblia Kinase, CMGC CDK 0.0052 0.3933 0.5254
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.3933 0.5247
Loa Loa (eye worm) hypothetical protein 0.0019 0.0814 0.0344
Echinococcus granulosus netrin receptor unc 5 0.0044 0.3189 0.3189
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0044 0.3189 0.2841
Loa Loa (eye worm) hypothetical protein 0.002 0.0911 0.0447
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0026 0.0026
Onchocerca volvulus 0.009 0.7472 1
Brugia malayi Uncoordinated protein 44 0.0044 0.3189 0.2841
Plasmodium vivax protein kinase Crk2 0.0052 0.3933 1
Echinococcus granulosus cyclin B3 1 0.0038 0.2569 0.2569
Trypanosoma cruzi cyclin 6, putative 0.009 0.7472 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.002 0.0911 0.0888

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of recombinant Cdk2/cyclin A using RbING as substrate after 2 hrs by luminescence assay ChEMBL. 22148278
IC50 (binding) > 10 uM Inhibition of recombinant Flt3 using poly(Glu,Tyr) as substrate after 2 hrs by luminescence assay ChEMBL. 22148278
IC50 (binding) > 10 uM Inhibition of recombinant JAK2 using poly(Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assay ChEMBL. 22148278

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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