Detailed information for compound 1567438

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.589 | Formula: C30H34O4
  • H donors: 0 H acceptors: 3 LogP: 7.02 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Oc1cccc2c1C(=O)C=CC2=O
  • InChi: 1S/C30H34O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-29(33)34-28-21-19-20-25-26(31)23-24-27(32)30(25)28/h3-4,6-7,9-10,12-13,15-16,19-21,23-24H,2,5,8,11,14,17-18,22H2,1H3/b4-3-,7-6-,10-9-,13-12-,16-15-
  • InChiKey: KVQGLINVYSESIA-JLNKQSITSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.1814 0.3137
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0178 0.0623
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0117 0.0758 0.0758
Schistosoma mansoni amine GPCR 0.0117 0.0758 0.0758
Onchocerca volvulus 0.0036 0.0152 0.1324
Onchocerca volvulus 0.0117 0.0758 0.6587
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0145 0.025
Echinococcus multilocularis musashi 0.0027 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0091 0.0562 0.0972
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0267 0.0592
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0117 0.0758 0.0758
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0267 0.6054
Echinococcus granulosus neuropeptide receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0267 0.0267
Schistosoma mansoni smad 0.0025 0.0067 0.0067
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0067 0.0067
Mycobacterium tuberculosis Conserved protein 0.0073 0.0425 0.1206
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0425 1
Brugia malayi beta-lactamase family protein 0.0073 0.0425 0.1034
Brugia malayi Dopamine receptor protein 2 0.0117 0.0758 0.1846
Schistosoma mansoni Smad4 0.0025 0.0067 0.0067
Leishmania major hypothetical protein, conserved 0.0073 0.0425 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0045
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0145 0.0145
Brugia malayi putative neuropeptide receptor NPR1 0.0117 0.0758 0.1846
Brugia malayi G protein-coupled receptor F59B2.13 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0267 0.6054
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0574 0.1659
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0308 0.0308
Echinococcus granulosus neuropeptide Y receptor 0.0117 0.0758 0.0758
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0117 0.0758 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0091 0.0562 0.0972
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0036 0.0152 0.0371
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0036 0.0152 0.0371
Echinococcus multilocularis serotonin transporter 0.0091 0.0562 0.0562
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0152 0.031
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0117 0.0758 0.6587
Onchocerca volvulus 0.0117 0.0758 0.6587
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0152 0.3173
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1814 0.4382
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0267 0.6054
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0308 0.0308
Brugia malayi Thioredoxin reductase 0.0037 0.0157 0.0382
Schistosoma mansoni neuropeptide f receptor 76f 0.0117 0.0758 0.0758
Treponema pallidum sodium- and chloride- dependent transporter 0.0091 0.0562 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0145 0.0145
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0267 0.0267
Loa Loa (eye worm) G-protein coupled receptor 0.0117 0.0758 0.1311
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0152 0.031
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0267 0.0592
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0099 0.0621 0.2433
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0117 0.0758 0.0758
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0267 0.6054
Schistosoma mansoni neuropeptide F-like receptor 0.0117 0.0758 0.0758
Schistosoma mansoni biogenic amine (5HT) receptor 0.0117 0.0758 0.0758
Plasmodium vivax potassium channel, putative 0.0036 0.0152 0.3588
Onchocerca volvulus 0.0073 0.0425 0.369
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0036 0.0152 0.3173
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0164 0.1106 0.4416
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0036 0.0152 0.0152
Brugia malayi Tachykinin-like peptides receptor 99D 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Brugia malayi Dopamine receptor protein 1 0.0117 0.0758 0.1846
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Leishmania major potassium channel subunit-like protein 0.0036 0.0152 0.3173
Schistosoma mansoni opsin-like receptor 0.0117 0.0758 0.0758
Echinococcus granulosus neuropeptides capa receptor 0.0117 0.0758 0.0758
Brugia malayi jmjC domain containing protein 0.0057 0.0308 0.0749
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0425 0.0977
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0117 0.0758 0.0758
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0117 0.0758 0.1311
Echinococcus granulosus biogenic amine 5HT receptor 0.0239 0.1663 0.1663
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0117 0.0758 0.1311
Echinococcus granulosus peptide allatostatin:somatostatin 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0239 0.1663 0.2875
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0164 0.1106 0.4416
Echinococcus granulosus serotonin receptor 0.0117 0.0758 0.0758
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0425 0.1206
Brugia malayi MH1 domain containing protein 0.0025 0.0067 0.0164
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Echinococcus granulosus sex peptide receptor 0.0117 0.0758 0.0758
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0157 0.3694
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0145 0.0292
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0117 0.0758 0.0758
Brugia malayi putative neuropeptide receptor 0.0117 0.0758 0.1846
Echinococcus multilocularis Smad4 0.0025 0.0067 0.0067
Brugia malayi ORL1-like opioid receptor 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0899 0.1555
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0425 0.1206
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0425 0.0734
Plasmodium falciparum thioredoxin reductase 0.0037 0.0157 0.8807
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0015 0 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1056 0.2571
Echinococcus multilocularis neuropeptide receptor 0.0117 0.0758 0.0758
Brugia malayi G-protein coupled receptor 0.0117 0.0758 0.1846
Onchocerca volvulus 0.0036 0.0152 0.1324
Echinococcus multilocularis g-protein coupled receptor 0.0117 0.0758 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1151 0.2757
Toxoplasma gondii thioredoxin reductase 0.0037 0.0157 0.3694
Schistosoma mansoni amine GPCR 0.0117 0.0758 0.0758
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0161 0.0161
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0036 0.0152 0.0371
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0.0758 0.0758
Brugia malayi glutathione reductase 0.0037 0.0157 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0332 0.2352 0.4067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0117 0.0758 0.1846
Trypanosoma brucei calcium-activated potassium channel, putative 0.0036 0.0152 0.3173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0117 0.0758 0.0758
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0117 0.0758 0.0758
Echinococcus granulosus Smad4 0.0025 0.0067 0.0067
Brugia malayi intermediate filament protein 0.0027 0.0087 0.0213
Brugia malayi Melatonin receptor type 1A 0.0117 0.0758 0.1846
Schistosoma mansoni hypothetical protein 0.0036 0.0152 0.0152
Mycobacterium tuberculosis Probable reductase 0.0083 0.0505 0.145
Schistosoma mansoni biogenic amine (5HT) receptor 0.0239 0.1663 0.1663
Brugia malayi larval opioid receptor 0.0117 0.0758 0.1846
Mycobacterium ulcerans beta-lactamase 0.0073 0.0425 0.0977
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0117 0.0758 0.0758
Onchocerca volvulus 0.0091 0.0562 0.4885
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0117 0.0758 0.0758
Echinococcus multilocularis neuropeptide receptor 0.0117 0.0758 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0145 0.0292
Leishmania major hypothetical protein, conserved 0.0036 0.0152 0.3173
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Onchocerca volvulus 0.0027 0.0087 0.0759
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Onchocerca volvulus 0.0036 0.0152 0.1324
Onchocerca volvulus 0.0036 0.0152 0.1324
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0145 0.0353
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0463 0.3333 1
Brugia malayi RE15519p 0.0117 0.0758 0.1846
Echinococcus multilocularis g protein coupled receptor 0.0117 0.0758 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni smad1 5 8 and 0.0025 0.0067 0.0067
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0157 0.0271
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0267 0.0987
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0117 0.0758 0.0758
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0505 0.5378
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0425 0.1206
Schistosoma mansoni amine GPCR 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0145 0.0487
Schistosoma mansoni hypothetical protein 0.0681 0.4952 0.4952
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0505 0.145
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.0562 0.1369
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0.0758 0.0758
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0178 1
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0036 0.0152 0.0152
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0308 0.0308
Loa Loa (eye worm) norepinephrine transporter 0.0091 0.0562 0.0972
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0308 0.0308
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Echinococcus multilocularis potassium channel subfamily K 8 0.0036 0.0152 0.0152
Echinococcus granulosus twik family of potassium channels 0.0036 0.0152 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0425 1
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0036 0.0152 0.0517
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0899 0.219
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0574 0.1659
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0267 0.0267
Echinococcus granulosus geminin 0.0681 0.4952 0.4952
Echinococcus multilocularis neuropeptide Y receptor 0.0117 0.0758 0.0758
Echinococcus multilocularis calcium activated potassium channel variant 0.0036 0.0152 0.0152
Schistosoma mansoni alpha glucosidase 0.0035 0.0145 0.0145
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0036 0.0152 0.0371
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1814 0.4382
Schistosoma mansoni hypothetical protein 0.0793 0.5784 0.5784
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Echinococcus multilocularis lamin dm0 0.0027 0.0087 0.0087
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0972 0.0972
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1151 0.2757
Echinococcus multilocularis serotonin receptor 0.0239 0.1663 0.1663
Schistosoma mansoni growth hormone secretagogue receptor 0.0117 0.0758 0.0758
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0.0758 0.0758
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0505 0.145
Echinococcus multilocularis allatostatin A receptor 0.0117 0.0758 0.0758
Schistosoma mansoni histamine h1 receptor 0.0117 0.0758 0.0758
Brugia malayi jmjC domain containing protein 0.0057 0.0308 0.0749
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0087 0.0151
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0267 0.0592
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0036 0.0152 0.0371
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0036 0.0152 0.0152
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0036 0.0152 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0152 0.3173
Loa Loa (eye worm) uncoordinated protein 58 0.0036 0.0152 0.0263
Loa Loa (eye worm) acetyltransferase 0.0146 0.0972 0.1681
Onchocerca volvulus 0.0117 0.0758 0.6587
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0036 0.0152 0.0371
Echinococcus granulosus dro:myosuppressin receptor 0.0117 0.0758 0.0758
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0267 0.0592
Echinococcus granulosus lamin dm0 0.0027 0.0087 0.0087
Echinococcus multilocularis g protein coupled receptor 0.0117 0.0758 0.0758
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0036 0.0152 0.3173
Brugia malayi GnHR receptor homolog 0.0117 0.0758 0.1846
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni lamin 0.0027 0.0087 0.0087
Echinococcus granulosus neuropeptides capa receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1056 0.1056
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1056 0.1056
Onchocerca volvulus 0.0073 0.0425 0.369
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Echinococcus multilocularis lamin 0.0027 0.0087 0.0087
Echinococcus granulosus lamin 0.0027 0.0087 0.0087
Schistosoma mansoni neuropeptide F-like receptor 0.0117 0.0758 0.0758
Onchocerca volvulus 0.0117 0.0758 0.6587
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Brugia malayi neuropeptide F receptor 0.0117 0.0758 0.1846
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0505 0.145
Echinococcus multilocularis small conductance calcium activated potassium 0.0793 0.5784 0.5784
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0267 0.0462
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0152 0.031
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0087 0.0213
Brugia malayi AKH receptor 0.0117 0.0758 0.1846
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0036 0.0152 0.3173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0899 0.0899
Trypanosoma brucei protein kinase, putative 0.0051 0.0267 0.6054
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0425 0.1206
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.037 0.2634 0.4554
Echinococcus multilocularis twik family of potassium channels 0.0036 0.0152 0.0152
Mycobacterium ulcerans transmembrane cation transporter 0.0036 0.0152 0.031
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0117 0.0758 0.0758
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0145 0.0292
Onchocerca volvulus Neuropeptide F receptor homolog 0.0117 0.0758 0.6587
Onchocerca volvulus 0.0117 0.0758 0.6587
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0425 0.0977
Loa Loa (eye worm) beta-lactamase 0.0073 0.0425 0.0734
Toxoplasma gondii exonuclease III APE 0.0019 0.0026 0.0608
Toxoplasma gondii ion channel protein 0.0036 0.0152 0.3588
Trypanosoma brucei trypanothione reductase 0.0037 0.0157 0.3286
Echinococcus granulosus potassium channel subfamily K 8 0.0036 0.0152 0.0152
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0117 0.0758 0.1311
Echinococcus multilocularis neuropeptide Y receptor 0.0117 0.0758 0.0758
Schistosoma mansoni hypothetical protein 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0205 0.4822
Onchocerca volvulus 0.0117 0.0758 0.6587
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.2563 0.4431
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0734
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0036 0.0152 0.0383
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Schistosoma mansoni lamin 0.0027 0.0087 0.0087
Schistosoma mansoni myosin xvIII 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) serotonin transporter b 0.0091 0.0562 0.0972
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Schistosoma mansoni biogenic amine receptor 0.0117 0.0758 0.0758
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0036 0.0152 0.0371
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0117 0.0758 0.0758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0899 0.0899
Loa Loa (eye worm) G-protein coupled receptor 0.0117 0.0758 0.1311
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0036 0.0152 0.3173
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0036 0.0152 0.0371
Mycobacterium ulcerans ion transport protein 0.0036 0.0152 0.031
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0145 0.0292
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0308 0.0308
Echinococcus multilocularis orexin receptor type 2 0.0117 0.0758 0.0758
Loa Loa (eye worm) TWK-28 protein 0.0036 0.0152 0.0263
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Trypanosoma cruzi ion transport protein, putative 0.0036 0.0152 0.3173
Echinococcus multilocularis G-protein coupled receptor, putative 0.0117 0.0758 0.0758
Schistosoma mansoni adenoreceptor 0.0117 0.0758 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0157 0.0396
Loa Loa (eye worm) hypothetical protein 0.0091 0.0562 0.0972
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0608
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1219 0.2924
Echinococcus granulosus neuropeptide Y receptor 0.0117 0.0758 0.0758
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Schistosoma mansoni smad1 5 8 and 0.0025 0.0067 0.0067
Schistosoma mansoni biogenic amine receptor 0.0117 0.0758 0.0758
Echinococcus granulosus smad 0.0025 0.0067 0.0067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0505 0.145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Brugia malayi hypothetical protein 0.0036 0.0152 0.0371
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0145 0.0292
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0145 0.2984
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0117 0.0758 0.0758
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0026
Echinococcus multilocularis potassium channel subfamily K 0.0036 0.0152 0.0152
Brugia malayi Serotonin receptor 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0036 0.0152 0.0371
Echinococcus granulosus biogenic amine 5HT receptor 0.0117 0.0758 0.0758
Schistosoma mansoni biogenic amine receptor 0.0117 0.0758 0.0758
Echinococcus granulosus alpha 1A adrenergic receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0145 0.0292
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0308 0.0308
Schistosoma mansoni smad1 5 8 and 0.0025 0.0067 0.0067
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0.0758 0.0758
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Echinococcus multilocularis G protein coupled receptor 139 0.0117 0.0758 0.0758
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0145 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1151 0.2757
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0308 0.0308
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0425 1
Mycobacterium ulcerans lipase LipD 0.0073 0.0425 0.0977
Toxoplasma gondii ion channel protein 0.0036 0.0152 0.3588
Onchocerca volvulus 0.0117 0.0758 0.6587
Onchocerca volvulus 0.0036 0.0152 0.1324
Echinococcus multilocularis g protein coupled receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0972 0.2367
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1056 0.1826
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Loa Loa (eye worm) glutathione reductase 0.0037 0.0157 0.0271
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Onchocerca volvulus 0.0117 0.0758 0.6587
Echinococcus granulosus calcium activated potassium channel variant 0.0036 0.0152 0.0152
Loa Loa (eye worm) glutaminase 0.0568 0.4107 0.7101
Echinococcus multilocularis neuropeptides capa receptor 0.0117 0.0758 0.0758
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0026
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0036 0.0152 0.0371
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Brugia malayi sulfakinin receptor protein 0.0117 0.0758 0.1846
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0205 0.0438
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Echinococcus granulosus small conductance calcium activated potassium 0.0793 0.5784 0.5784
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0152 0.031
Echinococcus granulosus twik family of potassium channels 0.0036 0.0152 0.0152
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0063
Mycobacterium tuberculosis Conserved protein 0.0073 0.0425 0.1206
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0178 0.0623
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0425 0.1206
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0145 0.0292
Echinococcus granulosus g protein coupled receptor 0.0117 0.0758 0.0758
Onchocerca volvulus 0.0117 0.0758 0.6587
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0145 0.2984
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni hypothetical protein 0.0117 0.0758 0.0758
Brugia malayi MH1 domain containing protein 0.0025 0.0067 0.0164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0.0758 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Brugia malayi MH2 domain containing protein 0.0025 0.0067 0.0164
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Echinococcus granulosus neuropeptide receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Brugia malayi Serotonin receptor 0.0117 0.0758 0.1846
Onchocerca volvulus 0.0117 0.0758 0.6587
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0036 0.0152 0.0371
Onchocerca volvulus 0.0117 0.0758 0.6587
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni neuropeptide receptor 0.0117 0.0758 0.0758
Echinococcus granulosus G protein coupled receptor 139 0.0117 0.0758 0.0758
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0117 0.0758 0.0758
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0205 0.0438
Onchocerca volvulus 0.0117 0.0758 0.6587
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus multilocularis neuropeptide s receptor 0.0117 0.0758 0.0758
Echinococcus granulosus 7tm_1 domain containing protein 0.0117 0.0758 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1151 0.2757
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Toxoplasma gondii ABC1 family protein 0.0073 0.0425 1
Brugia malayi follicle stimulating hormone receptor 0.0117 0.0758 0.1846
Echinococcus granulosus fmrfamide receptor 0.0117 0.0758 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni alpha-glucosidase 0.0135 0.0893 0.0893
Echinococcus granulosus neuropeptide s receptor 0.0117 0.0758 0.0758
Brugia malayi MH2 domain containing protein 0.036 0.2563 0.624
Schistosoma mansoni sodium/chloride dependent transporter 0.0091 0.0562 0.0562
Echinococcus multilocularis geminin 0.0681 0.4952 0.4952
Schistosoma mansoni neuropeptide receptor 0.0117 0.0758 0.0758
Echinococcus granulosus g-protein coupled receptor 0.0117 0.0758 0.0758
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0505 0.145
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0734
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0117 0.0758 0.0758
Echinococcus granulosus neuropeptide receptor A26 0.0117 0.0758 0.0758
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0267 0.6054
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0036 0.0152 0.3173
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0.0758 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0087 0.0151
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus multilocularis twik family of potassium channels 0.0036 0.0152 0.0152
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0574 0.1659
Onchocerca volvulus 0.0036 0.0152 0.1324
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0205 0.4822
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0067 0.0067
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0425 0.1034
Loa Loa (eye worm) hypothetical protein 0.0164 0.1106 0.1912
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1814 0.4382
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Schistosoma mansoni amine GPCR 0.0117 0.0758 0.0758
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0308 0.0532
Leishmania major calcium/potassium channel (CAKC), putative 0.0036 0.0152 0.3173
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0067 0.0117
Echinococcus multilocularis dro:myosuppressin receptor 0.0117 0.0758 0.0758
Echinococcus granulosus intermediate filament protein 0.0027 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0067 0.0117
Brugia malayi G-protein coupled receptor 0.0117 0.0758 0.1846
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.1814 0.4417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0899 0.0899
Loa Loa (eye worm) glutaminase 2 0.0568 0.4107 0.7101
Loa Loa (eye worm) TWK-7 protein 0.0036 0.0152 0.0263
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0036 0.0152 0.0371
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Schistosoma mansoni hypothetical protein 0.0117 0.0758 0.0758
Plasmodium vivax potassium channel, putative 0.0036 0.0152 0.3588
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0205 0.0205
Onchocerca volvulus 0.0091 0.0562 0.4887
Schistosoma mansoni intermediate filament proteins 0.0027 0.0087 0.0087
Trichomonas vaginalis esterase, putative 0.0073 0.0425 0.0977
Onchocerca volvulus 0.0117 0.0758 0.6587
Giardia lamblia DNA repair protein RAD52 0.0348 0.2472 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0036 0.0152 0.0371
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.2563 0.4431
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0117 0.0758 0.1846
Echinococcus granulosus somatostatin receptor 0.0117 0.0758 0.0758
Leishmania major trypanothione reductase 0.0037 0.0157 0.3286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0899 0.0899
Schistosoma mansoni opsin-like receptor 0.0117 0.0758 0.0758
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0.0758 0.0758
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0425 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0972 0.0972
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0425 0.0977
Loa Loa (eye worm) Smad1 0.0025 0.0067 0.0117
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0145 0.3411
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0267 0.6294
Echinococcus granulosus g protein coupled receptor 0.0117 0.0758 0.0758
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0574 1
Onchocerca volvulus 0.0073 0.0425 0.369
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1056 0.1056
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0267 0.6054
Leishmania major ion transport protein-like protein 0.0036 0.0152 0.3173
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0205 0.4822
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1814 0.4382
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Schistosoma mansoni calcium-activated potassium channel 0.0793 0.5784 0.5784
Echinococcus multilocularis fmrfamide receptor 0.0117 0.0758 0.0758
Plasmodium vivax glutathione reductase, putative 0.0037 0.0157 0.3694
Loa Loa (eye worm) hypothetical protein 0.0793 0.5784 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Echinococcus granulosus orexin receptor type 2 0.0117 0.0758 0.0758
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0145 0.0487
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0145 0.0292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0425 0.0425
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0899 0.0899
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0067 0.0067
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0425 0.0977
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0734
Giardia lamblia Hypothetical protein 0.0036 0.0152 0.0517
Brugia malayi MH2 domain containing protein 0.0025 0.0067 0.0164
Echinococcus multilocularis fmrfamide receptor 0.0117 0.0758 0.0758
Leishmania major hypothetical protein, conserved 0.0036 0.0152 0.3173
Entamoeba histolytica hypothetical protein 0.0099 0.0621 0.2433
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1151 0.2757
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1814 0.4382
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus granulosus neuropeptide FF receptor 2 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0734
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0425 0.0977
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0425 0.1206
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0425 0.0977
Onchocerca volvulus 0.0036 0.0152 0.1324
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0145 0.2984
Schistosoma mansoni neuropeptide receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0117 0.0758 0.0758
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0152 0.031
Onchocerca volvulus 0.0036 0.0152 0.1324
Brugia malayi hypothetical protein 0.0036 0.0152 0.0371
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0036 0.0152 0.0263
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Plasmodium falciparum potassium channel 0.0036 0.0152 0.8554
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0151
Brugia malayi beta-lactamase family protein 0.0073 0.0425 0.1034
Echinococcus granulosus serotonin transporter 0.0091 0.0562 0.0562
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0117 0.0758 0.0758
Echinococcus granulosus g protein coupled receptor 0.0117 0.0758 0.0758
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Mycobacterium ulcerans glutaminase 0.0568 0.4107 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0161 0.0161
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0036 0.0152 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1151 0.2757
Brugia malayi Dopamine receptor 0.0117 0.0758 0.1846
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0117 0.0758 0.0758
Schistosoma mansoni glutaminase 0.0568 0.4107 0.4107
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0036 0.0152 0.0371
Brugia malayi neuropeptide F receptor 0.0117 0.0758 0.1846
Schistosoma mansoni neuropeptide receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Brugia malayi MAP kinase sur-1 0.0051 0.0267 0.0651
Trichomonas vaginalis glutaminase, putative 0.0568 0.4107 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Echinococcus multilocularis neuropeptide receptor A26 0.0117 0.0758 0.0758
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0117 0.0758 0.0758
Mycobacterium tuberculosis Conserved protein 0.0073 0.0425 0.1206
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0267 0.0267
Echinococcus granulosus potassium channel subfamily K 8 0.0036 0.0152 0.0152
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0267 0.6054
Schistosoma mansoni alpha-glucosidase 0.0135 0.0893 0.0893
Onchocerca volvulus 0.0027 0.0087 0.0759
Schistosoma mansoni microtubule-associated protein tau 0.136 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0734
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1151 0.2757
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0117 0.0758 0.0758
Schistosoma mansoni amine GPCR 0.0117 0.0758 0.0758
Loa Loa (eye worm) solute carrier family 6 member 4 0.0091 0.0562 0.0972
Echinococcus multilocularis somatostatin receptor 0.0117 0.0758 0.0758
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0425 0.0977
Echinococcus granulosus allatostatin A receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0239 0.1663 0.2875
Schistosoma mansoni twik family of potassium channels-related 0.0036 0.0152 0.0152
Onchocerca volvulus 0.0117 0.0758 0.6587
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0117 0.0758 0.1311
Brugia malayi G protein-coupled receptor 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus multilocularis serotonin receptor 0.0239 0.1663 0.1663
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0036 0.0152 0.0152
Echinococcus granulosus tachykinin peptides receptor 99D 0.0117 0.0758 0.0758
Onchocerca volvulus 0.0117 0.0758 0.6587
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0036 0.0152 0.0263
Echinococcus granulosus 7TM GPCR rhodopsin 0.0117 0.0758 0.0758
Schistosoma mansoni hypothetical protein 0.0681 0.4952 0.4952
Brugia malayi glutaminase DH11.1 0.0568 0.4107 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0117 0.0758 0.1311
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0117 0.0758 0.1311
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.1449
Plasmodium falciparum glutathione reductase 0.0037 0.0157 0.8807
Schistosoma mansoni alpha-1 adrenergic receptor 0.0117 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0942 0.0942
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Echinococcus multilocularis neuropeptides capa receptor 0.0117 0.0758 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0899 0.0899
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1219 0.2924
Echinococcus multilocularis neuropeptide FF receptor 2 0.0117 0.0758 0.0758
Plasmodium falciparum potassium channel 0.0036 0.0152 0.8554
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.0758 0.0758
Schistosoma mansoni calcium-activated potassium channel 0.0036 0.0152 0.0152
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0425 0.0425
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0117 0.0758 0.1846
Onchocerca volvulus 0.0117 0.0758 0.6587
Echinococcus multilocularis potassium channel subfamily K 8 0.0036 0.0152 0.0152
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0117 0.0758 0.0758
Echinococcus multilocularis smad 0.0025 0.0067 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1814 0.4382
Brugia malayi Smad1 0.0025 0.0067 0.0164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0117 0.0758 0.1846
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0.0758 0.0758
Schistosoma mansoni calcium-activated potassium channel 0.0701 0.5101 0.5101
Loa Loa (eye worm) neuropeptide F receptor 0.0117 0.0758 0.1311
Schistosoma mansoni calcium-activated potassium channel 0.0036 0.0152 0.0152
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0117 0.0758 0.0758
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0117 0.0758 0.0758
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0036 0.0152 0.0371
Loa Loa (eye worm) neuropeptide F receptor 0.0117 0.0758 0.1311
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.1311
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0157 0.3286
Brugia malayi hypothetical protein 0.0117 0.0758 0.1846
Mycobacterium ulcerans hypothetical protein 0.0073 0.0425 0.0977
Loa Loa (eye worm) TYRA-2 protein 0.0117 0.0758 0.1311
Brugia malayi beta-lactamase 0.0073 0.0425 0.1034
Echinococcus multilocularis sex peptide receptor 0.0117 0.0758 0.0758
Trypanosoma cruzi ion transport protein, putative 0.0036 0.0152 0.3173
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0348 0.2472 1
Trypanosoma brucei glucosidase, putative 0.0035 0.0145 0.2984
Echinococcus granulosus hypothetical protein 0.0117 0.0758 0.0758
Schistosoma mansoni opsin-like receptor 0.0117 0.0758 0.0758
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0117 0.0758 0.1846
Loa Loa (eye worm) hypothetical protein 0.0027 0.0084 0.0145
Echinococcus granulosus potassium channel subfamily K 0.0036 0.0152 0.0152
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.1151 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0425 0.0734
Onchocerca volvulus 0.0117 0.0758 0.6587
Loa Loa (eye worm) hypothetical protein 0.0056 0.03 0.0519
Loa Loa (eye worm) hypothetical protein 0.0036 0.0152 0.0263
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0117 0.0758 0.0758
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0036 0.0152 0.0371
Echinococcus multilocularis microtubule associated protein 2 0.136 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0425 0.1206

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins ChEMBL. 21903399
Inhibition (binding) Inhibition of recombinant His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins ChEMBL. 21903399
Inhibition (binding) Inhibition of recombinant His-tagged human DNA polymerase lambda using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins ChEMBL. 21903399
Inhibition (binding) Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins ChEMBL. 21903399
LD50 (ADMET) > 10 uM Cytotoxicity against mouse RAW264.7 cells ChEMBL. 21903399

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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