TDR Targets

Basic information

Technical information

TDR Targets ID: 1567607
Name: 5-[2-butoxy-5-(4-ethylpiperazin-1-yl)sulfonyl pyridin-3-yl]-2-(2-dimethylaminoethyl)-3-ethy l-4H-pyrazolo[3,4-e]pyrimidin-7-one
MW: 560.712 | Formula: C26H40N8O4S
H donors: 1 H acceptors: 5 LogP: 1.61 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCCCOc1ncc(cc1c1[nH]c(=O)c2c(n1)c(CC)n(n2)CCN(C)C)S(=O)(=O)N1CCN(CC1)CC
InChi: 1S/C26H40N8O4S/c1-6-9-16-38-26-20(17-19(18-27-26)39(36,37)33-13-11-32(8-3)12-14-33)24-28-22-21(7-2)34(15-10-31(4)5)30-23(22)25(35)29-24/h17-18H,6-16H2,1-5H3,(H,28,29,35)
InChiKey: KYLOFMQLLNEPBT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[2-butoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-3-pyridyl]-2-(2-dimethylaminoethyl)-3-ethyl-4H-pyrazolo[3,4-e]pyrimidin-7-one
5-[2-butoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridyl]-2-(2-dimethylaminoethyl)-3-ethyl-4H-pyrazolo[3,4-e]pyrimidin-7-one
5-[2-butoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-pyridin-3-yl]-2-(2-dimethylaminoethyl)-3-ethyl-4H-pyrazolo[3,4-e]pyrimidin-7-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0096	0.4349	0.4349
Loa Loa (eye worm)	carboxylesterase	0.004	0.0533	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0096	0.4349	0.4349
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.1214	0.1214
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0058	0.1751	0.3335
Loa Loa (eye worm)	hypothetical protein	0.012	0.6015	0.6015
Echinococcus granulosus	carboxylesterase 5A	0.004	0.0533	0.0533
Loa Loa (eye worm)	AMP deaminase	0.0058	0.1751	0.1751
Plasmodium falciparum	adenosine deaminase	0.0178	1	1
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0096	0.4349	0.3642
Leishmania major	adenine aminohydrolase	0.0178	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0533	0.0533
Echinococcus granulosus	AMP deaminase 2	0.0058	0.1751	0.1751
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1751	0.1751
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Schistosoma mansoni	AMP deaminase	0.0058	0.1751	0.1751
Plasmodium vivax	adenosine/AMP deaminase, putative	0.0058	0.1751	0.0719
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0096	0.4349	0.4349
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.2826	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.2359	0.2359
Echinococcus multilocularis	sterol O acyltransferase 1	0.0102	0.4752	0.4752
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.2204	0.2204
Echinococcus granulosus	acetylcholinesterase	0.004	0.0533	0.0533
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.2826	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Trypanosoma cruzi	AMP deaminase, putative	0.0058	0.1751	0.3335
Trypanosoma cruzi	AMP deaminase, putative	0.0058	0.1751	0.3335
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.2826	0.2826
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0067	0.2359	0.0736
Leishmania major	farnesyltransferase beta subunit	0.0067	0.2359	0.0736
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Brugia malayi	Carboxylesterase family protein	0.004	0.0533	0.0533
Loa Loa (eye worm)	hypothetical protein	0.004	0.0533	0.0533
Echinococcus granulosus	acetylcholinesterase	0.004	0.0533	0.0533
Brugia malayi	Carboxylesterase family protein	0.004	0.0533	0.0533
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0096	0.4349	0.3149
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0058	0.1751	0.3335
Onchocerca volvulus	Adenosine deaminase homolog	0.0178	1	1
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0096	0.4349	0.3149
Mycobacterium ulcerans	adenosine deaminase	0.0178	1	0.5
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0096	0.4349	0.4349
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Echinococcus multilocularis	acetylcholinesterase	0.004	0.0533	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0178	1	1
Toxoplasma gondii	hypothetical protein	0.0071	0.2643	0.108
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0067	0.2359	0.0736
Trypanosoma cruzi	AMP deaminase, putative	0.0058	0.1751	0.3335
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0074	0.2826	0.2826
Entamoeba histolytica	adenosine deaminase, putative	0.0178	1	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.004	0.0533	0.0533
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0074	0.2826	0.2826
Loa Loa (eye worm)	hypothetical protein	0.0092	0.407	0.407
Entamoeba histolytica	adenosine deaminase, putative	0.0178	1	1
Echinococcus multilocularis	adenosine deaminase	0.0178	1	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.2359	0.7101
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2826	1
Echinococcus granulosus	adenosine deaminase	0.0178	1	1
Schistosoma mansoni	sterol O-acyltransferase 1	0.0102	0.4752	0.4752
Loa Loa (eye worm)	hypothetical protein	0.012	0.6015	0.6015
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0096	0.4349	0.4349
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0178	1	1
Echinococcus multilocularis	AMP deaminase 2	0.0058	0.1751	0.1751
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2826	1
Giardia lamblia	Rab geranylgeranyltransferase	0.0096	0.4349	1
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0067	0.2359	0.5651
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0067	0.2359	0.1402
Trypanosoma cruzi	AMP deaminase, putative	0.0058	0.1751	0.3335
Brugia malayi	adenosine monophosphate deaminase	0.0058	0.1751	0.1751
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0067	0.2359	0.2359
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Toxoplasma gondii	hypothetical protein	0.0065	0.2204	0.0548
Echinococcus multilocularis	carboxylesterase 5A	0.004	0.0533	0.0533
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2826	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.2204	0.2204
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.2204	0.2204
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.2359	0.7101
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0096	0.4349	0.4349
Echinococcus multilocularis	acetylcholinesterase	0.004	0.0533	0.0533
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0096	0.4349	0.4349
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0067	0.2359	0.2359
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0067	0.2359	0.2359
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0178	1	1
Treponema pallidum	adenosine deaminase	0.0178	1	0.5
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0074	0.2826	0.2826
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.2359	0.2359
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0067	0.2359	0.2359
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0067	0.2359	0.2359
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.004	0.0533	0.0533
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0096	0.4349	0.4349
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0067	0.2359	0.0736
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.0178	1	0.5
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trypanosoma cruzi	AMP deaminase 2, putative	0.0058	0.1751	0.3335
Echinococcus granulosus	sterol O acyltransferase 1	0.0102	0.4752	0.4752
Loa Loa (eye worm)	hypothetical protein	0.0102	0.4752	0.4752
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0096	0.4349	0.4349
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Schistosoma mansoni	adenosine deaminase	0.0178	1	1
Trypanosoma cruzi	AMP deaminase, putative	0.0058	0.1751	0.3335
Loa Loa (eye worm)	hypothetical protein	0.012	0.6015	0.6015
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0067	0.2359	0.2359
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.1214	0.1214
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.0178	1	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Schistosoma mansoni	adenosine deaminase-related	0.0178	1	1
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0067	0.2359	0.2359
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.2826	0.2826
Loa Loa (eye worm)	hypothetical protein	0.012	0.6015	0.6015
Plasmodium vivax	adenosine deaminase, putative	0.0178	1	1
Trichomonas vaginalis	adenosine deaminase, putative	0.0178	1	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0071	0.2643	0.2643
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0067	0.2359	0.2359
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.2826	0.2826
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2826	0.2826
Trichomonas vaginalis	adenosine deaminase, putative	0.0178	1	1
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.2359	0.2359

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 nM	Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method	ChEMBL.	22100260
Papp (ADMET)	= 2.8 10'-6 cm/s	Apparent permeability from apical to basolateral side of human Caco2 cells at 25 uM	ChEMBL.	22100260

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1928263

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1567607