Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.4551 | 0.6274 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0091 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0785 | 0.0772 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0785 | 0.0953 |
Echinococcus multilocularis | GPCR, family 2 | 0.0123 | 0.2695 | 0.3314 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0378 | 0.0449 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0123 | 0.2695 | 0.3314 |
Trypanosoma cruzi | ISWI complex protein | 0.0034 | 0.0378 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0031 | 0.0304 | 0.0357 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0785 | 0.0953 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0081 | 0.1606 | 0.1968 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0038 | 0.0479 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0123 | 0.2695 | 0.3314 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.1606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0304 | 0.0289 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0025 | 0.0151 | 0.4 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0194 | 0.4551 | 0.4543 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0023 | 0.0091 | 0.2637 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.4267 | 0.526 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2695 | 0.3314 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0204 | 0.4823 | 0.6657 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0151 | 0.0085 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0186 | 0.0629 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0038 | 0.0479 | 0.0574 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.4551 | 0.6274 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1706 | 0.1693 |
Echinococcus granulosus | geminin | 0.0183 | 0.4267 | 0.526 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2695 | 0.3314 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0091 | 0.0076 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0026 | 0.0186 | 0.0212 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0023 | 0.0091 | 0.0094 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0039 | 0.0514 | 0.05 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0091 | 0.0076 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.1701 | 0.1689 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0296 | 0.72 | 0.7196 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0091 | 0.2403 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0304 | 0.7408 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.4267 | 0.526 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.0304 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0091 | 0.2403 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0479 | 0.0574 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0123 | 0.2695 | 0.3314 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0123 | 0.2695 | 0.2684 |
Leishmania major | GTP-binding protein, putative | 0.0023 | 0.0091 | 0.2403 |
Echinococcus granulosus | zinc finger protein | 0.0043 | 0.0624 | 0.0754 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0038 | 0.0479 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.3567 | 0.3558 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1842 | 0.183 |
Leishmania major | importin beta-1 subunit, putative | 0.0025 | 0.0151 | 0.4 |
Echinococcus granulosus | snurportin 1 | 0.033 | 0.81 | 1 |
Toxoplasma gondii | FATC domain-containing protein | 0.0026 | 0.0186 | 0.5938 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.0378 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0031 | 0.0304 | 0.0357 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0038 | 0.0479 | 0.0574 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0038 | 0.0479 | 0.0574 |
Brugia malayi | Importin beta-1 subunit | 0.0031 | 0.0304 | 0.0289 |
Echinococcus multilocularis | zinc finger protein | 0.0043 | 0.0624 | 0.0754 |
Trypanosoma brucei | ISWI complex protein | 0.0034 | 0.0378 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0034 | 0.0378 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0079 | 0.1565 | 0.1918 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.72 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0081 | 0.1606 | 0.1968 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.72 | 1 |
Schistosoma mansoni | ran | 0.0023 | 0.0091 | 0.0094 |
Echinococcus granulosus | GPCR family 2 | 0.0123 | 0.2695 | 0.3314 |
Brugia malayi | Bromodomain containing protein | 0.0166 | 0.3813 | 0.3804 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0785 | 0.0953 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.005 | 0.0795 | 0.0965 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0151 | 0.0398 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0403 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.72 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.72 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0026 | 0.0186 | 0.0212 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.0186 | 0.3321 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1606 | 0.1968 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0151 | 0.0085 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0296 | 0.72 | 0.7196 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0685 | 0.0829 |
Echinococcus multilocularis | geminin | 0.0183 | 0.4267 | 0.526 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.1606 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.033 | 0.81 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0388 | 0.9601 | 0.9601 |
Schistosoma mansoni | zinc finger protein | 0.0043 | 0.0624 | 0.0754 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.4551 | 0.6274 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0026 | 0.0186 | 0.0172 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0123 | 0.2695 | 0.2684 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2695 | 0.2684 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.9601 | 0.9601 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2695 | 0.3314 |
Schistosoma mansoni | bromodomain containing protein | 0.014 | 0.3139 | 0.3864 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1952 | 0.194 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.72 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0785 | 0.0953 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0023 | 0.0091 | 0.0094 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0123 | 0.2695 | 0.2684 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0038 | 0.0479 | 0.0574 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2695 | 0.3314 |
Brugia malayi | PHD-finger family protein | 0.0055 | 0.0931 | 0.0918 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0123 | 0.2695 | 0.3314 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0046 | 0.0685 | 0.0671 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0079 | 0.1565 | 0.1918 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.4551 | 0.6274 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0026 | 0.0186 | 0.4927 |
Brugia malayi | RNA, U transporter 1 | 0.0088 | 0.1789 | 0.1777 |
Schistosoma mansoni | hypothetical protein | 0.0265 | 0.6404 | 0.7903 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0785 | 0.0953 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0132 | 0.2933 | 0.3609 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.4551 | 0.6274 |
Brugia malayi | hypothetical protein | 0.0081 | 0.1606 | 0.1594 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0785 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0479 | 0.0465 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0296 | 0.72 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.1606 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0034 | 0.0378 | 0.0449 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0785 | 0.0953 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.005 | 0.0795 | 0.0965 |
Trichomonas vaginalis | importin beta-1, putative | 0.0025 | 0.0151 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.009 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.6404 | 0.6399 |
Echinococcus granulosus | importin subunit beta 1 | 0.0031 | 0.0304 | 0.0357 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0479 | 0.0574 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.0304 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.005 | 0.0795 | 0.0965 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0388 | 0.9601 | 0.9601 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0388 | 0.9601 | 0.9601 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.033 | 0.81 | 0.8097 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.81 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.4551 | 0.6274 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.4551 | 0.6274 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0023 | 0.009 | 0.2376 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0081 | 0.1606 | 0.1968 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.0304 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0785 | 0.0772 |
Schistosoma mansoni | ran | 0.0023 | 0.0091 | 0.0094 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.1606 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0304 | 0.7408 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0204 | 0.4823 | 0.6657 |
Echinococcus granulosus | serine protein kinase ATM | 0.0026 | 0.0186 | 0.0212 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0265 | 0.6404 | 0.6399 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0186 | 0.0134 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0132 | 0.2933 | 0.3609 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.