TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 432.897 | Formula: C22H25ClN2O5
H donors: 1 H acceptors: 2 LogP: 4.28 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(ccc1OC)C(=CC#N)c1ccc(c(c1)OC(=O)[C@@H](N)C)OC.Cl
InChi: 1S/C22H24N2O5.ClH/c1-5-28-20-12-15(6-8-18(20)26-3)17(10-11-23)16-7-9-19(27-4)21(13-16)29-22(25)14(2)24;/h6-10,12-14H,5,24H2,1-4H3;1H/t14-;/m0./s1
InChiKey: SFVZZDMVHCPASE-UQKRIMTDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0057	0.0403	0.0354
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0033	0.0145	0.0168
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0171	0.074
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0153	0.1435	0.1405
Brugia malayi	thymidylate synthase	0.0217	0.2113	0.2085
Schistosoma mansoni	lipoxygenase	0.0048	0.0305	0.0271
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0274	0.1185
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0055	0.038	0.0526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0141	0.0609
Mycobacterium tuberculosis	Hypothetical protein	0.0103	0.0893	0.0757
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0106	0.0926	0.3601
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0045	0.0274	0.0365
Toxoplasma gondii	aldehyde dehydrogenase	0.004	0.0211	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0274	0.1185
Schistosoma mansoni	lipoxygenase	0.0069	0.0528	0.0494
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0033	0.0145	0.0168
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0033	0.0145	0.011
Mycobacterium ulcerans	aldehyde dehydrogenase	0.004	0.0211	0.0065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0035	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.038	0.1645
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0665	0.0632
Onchocerca volvulus		0.0217	0.2113	0.5
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0033	0.0145	0.011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0141	0.0609
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0198	0.0856
Brugia malayi	Dihydrofolate reductase	0.0951	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0055	0.038	0.0526
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.0985	0.1301
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0033	0.0145	0.011
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0115	0.1023	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0081	0.0654	0.2828
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0069	0.0528	0.0494
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.038	0.1645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0274	0.1185
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0081	0.0654	0.0943
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0153	0.1435	0.1405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0304	0.1316
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0055	0.038	0.0347
Schistosoma mansoni	dihydrofolate reductase	0.0951	1	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.0985	0.0954
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0635	0.6604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0247	0.1069
Schistosoma mansoni	aldehyde dehydrogenase	0.004	0.0211	0.0177
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0055	0.038	0.0526
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0235	0.2313	0.3468
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0033	0.0145	0.0627
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0033	0.0145	0.011
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0635	0.6604	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0081	0.0654	0.2348
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.0839	0.0807
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0163	0.1532	0.6625
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0951	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0071	0.0547	0.0779
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0035	0.0151
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0235	0.2313	0.3468
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0235	0.2313	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0985	0.0954
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0033	0.0145	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0985	0.0954
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.004	0.0211	0.0177
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0033	0.0145	0.011
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0033	0.0145	0.0168
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0081	0.0654	0.2828
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0112	0.0985	0.9409
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0033	0.0145	0.011
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0635	0.6604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0274	0.1185
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0328	0.3311	0.3287
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0055	0.038	0.0347
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0055	0.038	0.0347
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.0893	0.3863
Echinococcus multilocularis	dihydrofolate reductase	0.0951	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0235	0.2313	0.2286
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.0839	0.0807
Chlamydia trachomatis	dihydrofolate reductase	0.0951	1	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0035	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0141	0.0611
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0055	0.038	0.0526
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0985	0.0954
Schistosoma mansoni	aldehyde dehydrogenase	0.004	0.0211	0.0177
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0034	0.0147	0.0171
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0985	0.0954
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0247	0.1069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0247	0.1069
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0033	0.0145	0.011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0209	0.0905
Mycobacterium ulcerans	aldehyde dehydrogenase	0.004	0.0211	0.0065
Echinococcus granulosus	dihydrofolate reductase	0.0951	1	1
Entamoeba histolytica	hypothetical protein	0.0188	0.1804	0.7652
Loa Loa (eye worm)	phosphatidylinositol 3	0.0281	0.2802	0.2776
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0163	0.1532	0.6625
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0034	0.0147	0.0113
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0033	0.0145	0.0627
Loa Loa (eye worm)	thymidylate synthase	0.0217	0.2113	0.2085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0247	0.1069
Mycobacterium ulcerans	aldehyde dehydrogenase	0.004	0.0211	0.0065
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0235	0.2313	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0247	0.1069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0141	0.0611
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.004	0.0211	0.0177
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0034	0.0147	0.0113
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0034	0.0147	0.0113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0141	0.0609
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0081	0.0654	0.0621
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.0839	0.0807
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0081	0.0654	0.0621
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0055	0.038	0.1086
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0081	0.0654	0.0943
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0225	0.2205	0.9505
Trypanosoma cruzi	target of rapamycin kinase 3	0.0045	0.0274	0.0365
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.004	0.0211	0.0065
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0217	0.2113	0.1995
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0153	0.1435	0.1405
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0328	0.3311	0.3287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0035	0.0151
Brugia malayi	hypothetical protein	0.0103	0.0893	0.0862
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0055	0.038	0.1086
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0045	0.0274	0.0365
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0034	0.0147	0.0113
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0951	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0081	0.0654	0.2828
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0141	0.0611
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0081	0.0654	0.2348
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0043	0.0247	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1435	0.1405
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0635	0.6604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0168	0.0727
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.003	0.0106	0.0109
Echinococcus multilocularis	thymidylate synthase	0.0217	0.2113	0.2085
Loa Loa (eye worm)	dihydrofolate reductase	0.0951	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0328	0.3311	0.3287
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0188	0.1804	0.7652
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0055	0.038	0.0526
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0055	0.038	0.0526
Loa Loa (eye worm)	phosphatidylinositol 3	0.0055	0.038	0.0347
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0093	0.0785	0.0752
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.0839	0.0807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0171	0.074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0168	0.0727
Echinococcus multilocularis	Zinc finger, PHD finger	0.0033	0.0145	0.011
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.004	0.0211	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0171	0.074
Echinococcus granulosus	thymidylate synthase	0.0217	0.2113	0.2085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0247	0.1069
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0055	0.038	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0274	0.1185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0035	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0141	0.0611
Mycobacterium ulcerans	thymidylate synthase	0.0217	0.2113	0.1995
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0235	0.2313	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0235	0.2313	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0031	0.0123	0.0088
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0635	0.6604	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0217	0.2113	0.2085
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0069	0.0528	0.0494
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0027	0.0076	0.0063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0247	0.1069
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0033	0.0145	0.0168
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0635	0.6604	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0103	0.0893	0.1307
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0985	0.0954
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0033	0.0145	0.0168
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.038	0.1645
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0951	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0071	0.0547	0.0514

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.017 uM	Cytotoxicity against human HCT116 cells assessed as reduction of [3H]thymidine incorporation after 72 hrs by scintillation counting	ChEMBL.	21955454
IC50 (functional)	= 0.057 uM	Inhibition of LPS-induced TNFalpha production in human PBMC preincubated 1 hr prior to LPS stimulation measured after 18 to 20 hrs by ELISA	ChEMBL.	21955454
IC50 (binding)	= 0.069 uM	Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins	ChEMBL.	21955454

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	21955454

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1916076

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1568316