Detailed information for compound 1568427

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.429 | Formula: C24H20N2
  • H donors: 0 H acceptors: 1 LogP: 5.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)/C=C/Cn1c(/C=C\c2ccccc2)nc2c1cccc2
  • InChi: 1S/C24H20N2/c1-3-10-20(11-4-1)14-9-19-26-23-16-8-7-15-22(23)25-24(26)18-17-21-12-5-2-6-13-21/h1-18H,19H2/b14-9+,18-17-
  • InChiKey: FEHAXRBZQGMLEQ-QPYPEQPVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable dehydrogenase 0.0224 0.0864 0.1836
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.0493 0.0597
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0598 0.0683
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0355 0.0405
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0224 0.0864 0.1836
Loa Loa (eye worm) hypothetical protein 0.0174 0.0631 0.072
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.19 0.8763 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0771 0.3444 0.7378
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0545 0.2378 0.2916
Echinococcus multilocularis Chromobox protein 3 0.0046 0.0024 0.002
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0172 0.1385
Giardia lamblia PHD finger protein 15 0.0236 0.0919 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0262 0.1046 0.223
Loa Loa (eye worm) hypothetical protein 0.0042 0.0008 0.0009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0598 0.0657
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0273 0.1093 0.1336
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.015 0.0305
Echinococcus multilocularis zinc finger protein 0.0179 0.0651 0.0792
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0027
Brugia malayi beta-lactamase 0.0145 0.0493 0.0537
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0271 0.2316
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0271 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0329 0.0306
Loa Loa (eye worm) hypothetical protein 0.0646 0.2852 0.3254
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0355 0.0405
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0428 0.1827 0.2239
Brugia malayi Pre-SET motif family protein 0.19 0.8763 1
Echinococcus granulosus geminin 0.0187 0.0692 0.1469
Brugia malayi PHD-finger family protein 0.0227 0.0881 0.0981
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0167 0.0537
Loa Loa (eye worm) hypothetical protein 0.0428 0.1827 0.2085
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.0493 0.0922
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0093 0.0249 0.0298
Trypanosoma brucei trypanothione reductase 0.0098 0.0271 0.3197
Onchocerca volvulus 0.0151 0.052 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0544 0.0522
Brugia malayi Thioredoxin reductase 0.0098 0.0271 0.0284
Mycobacterium tuberculosis Probable reductase 0.0224 0.0864 0.1836
Plasmodium vivax SET domain protein, putative 0.0273 0.1093 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0493 0.047
Loa Loa (eye worm) hypothetical protein 0.0145 0.0493 0.0563
Echinococcus granulosus phd:f box containing protein 0.0076 0.0167 0.0343
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0063 0.0106 0.0121
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0087 0.0219 0.0731
Echinococcus granulosus zinc finger protein 0.0179 0.0651 0.1382
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0174 0.0631 0.2273
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.0636 0.07
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0598 0.0727
Schistosoma mansoni alpha-glucosidase 0.0144 0.0488 0.1738
Loa Loa (eye worm) hypothetical protein 0.0145 0.0493 0.0563
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0771 0.3444 0.4228
Schistosoma mansoni hypothetical protein 0.0053 0.006 0.0137
Loa Loa (eye worm) hypothetical protein 0.0081 0.0192 0.0219
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0271 0.031
Onchocerca volvulus 0.0097 0.0265 0.0242
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.0493 0.0922
Loa Loa (eye worm) hypothetical protein 0.0257 0.1018 0.1162
Brugia malayi glutathione reductase 0.0098 0.0271 0.0284
Echinococcus granulosus neuropeptide receptor A26 0.05 0.2166 0.4634
Echinococcus multilocularis tumor protein p63 0.1031 0.4665 0.5731
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.0493 0.1042
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0174 0.0631 0.1339
Brugia malayi beta-lactamase family protein 0.0145 0.0493 0.0537
Plasmodium falciparum glutathione reductase 0.0098 0.0271 0.2768
Echinococcus multilocularis chromobox protein 2 0.0046 0.0024 0.002
Onchocerca volvulus 0.0046 0.0024 0.000000053922
Schistosoma mansoni lamin 0.0087 0.022 0.0736
Onchocerca volvulus Alhambra homolog 0.0236 0.0919 0.0897
Onchocerca volvulus 0.0087 0.022 0.0197
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0119 0.0355
Echinococcus multilocularis lysine specific demethylase 5A 0.0285 0.1152 0.1409
Echinococcus multilocularis lysine specific demethylase 6a 0.0076 0.0167 0.0197
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0063 0.0106 0.0307
Trichomonas vaginalis esterase, putative 0.0145 0.0493 0.047
Mycobacterium ulcerans lipase LipD 0.0145 0.0493 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0077 0.0172 0.1385
Echinococcus granulosus lamin dm0 0.0087 0.022 0.0457
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0493 0.047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0224 0.0864 0.1836
Loa Loa (eye worm) hypothetical protein 0.035 0.146 0.1666
Brugia malayi MH2 domain containing protein 0.0116 0.0355 0.0379
Echinococcus granulosus JmjC domain containing protein 4 0.0076 0.0167 0.0343
Echinococcus multilocularis GPCR, family 2 0.0081 0.0192 0.0227
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0027
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0271 0.0377
Brugia malayi PHD-finger family protein 0.0094 0.0254 0.0264
Loa Loa (eye worm) PHD-finger family protein 0.0236 0.0919 0.1049
Schistosoma mansoni hypothetical protein 0.0175 0.0636 0.2289
Loa Loa (eye worm) hypothetical protein 0.0156 0.0544 0.0621
Echinococcus granulosus chromobox protein 2 0.0046 0.0024 0.0035
Schistosoma mansoni zinc finger protein 0.0179 0.0651 0.2348
Mycobacterium ulcerans beta-lactamase 0.0145 0.0493 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0192 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0493 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0303 0.1235 0.453
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0224 0.0864 0.7591
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0271 0.0567
Toxoplasma gondii thioredoxin reductase 0.0098 0.0271 0.2316
Schistosoma mansoni hypothetical protein 0.0188 0.0697 0.2518
Echinococcus granulosus neuropeptide s receptor 0.05 0.2166 0.4634
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0156 0.0543 0.0659
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0236 0.0919 0.3349
Trypanosoma brucei ISWI complex protein 0.014 0.0467 0.921
Loa Loa (eye worm) pip kinase 2 0.0174 0.0631 0.072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.0493 0.0922
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0077 0.0172 0.1655
Loa Loa (eye worm) hypothetical protein 0.0145 0.0493 0.0563
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0168 0.06 0.0577
Mycobacterium tuberculosis Conserved protein 0.0145 0.0493 0.0922
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.1018 0.1162
Loa Loa (eye worm) hypothetical protein 0.0404 0.1712 0.1953
Echinococcus granulosus chromobox protein 1 0.0278 0.112 0.2388
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0318 0.1308 0.4804
Loa Loa (eye worm) bromodomain containing protein 0.0161 0.0569 0.0649
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0192 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0428 0.1827 0.6746
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0192 0.0395
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1767 0.8135 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0249 0.0981 0.2125
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0493 0.1756
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.0493 1
Schistosoma mansoni alpha-glucosidase 0.0144 0.0488 0.1738
Loa Loa (eye worm) beta-lactamase 0.0145 0.0493 0.0563
Echinococcus granulosus intermediate filament protein 0.0087 0.022 0.0457
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0119 0.0238
Loa Loa (eye worm) hypothetical protein 0.0327 0.1349 0.154
Schistosoma mansoni hypothetical protein 0.0072 0.015 0.0471
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0598 0.0727
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0156 0.0544 0.0522
Onchocerca volvulus 0.0327 0.1349 0.1329
Loa Loa (eye worm) hypothetical protein 0.0145 0.0493 0.0563
Schistosoma mansoni zinc finger protein 0.014 0.0467 0.1659
Brugia malayi Bromodomain containing protein 0.0685 0.3036 0.3447
Onchocerca volvulus 0.0145 0.0493 0.047
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0027
Brugia malayi SET domain containing protein 0.0056 0.0071 0.0054
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.1041 0.2218
Trichomonas vaginalis chromobox protein, putative 0.0278 0.112 0.1099
Onchocerca volvulus 0.0122 0.0385 0.0362
Schistosoma mansoni phosphatidylserine receptor 0.0076 0.0167 0.0537
Echinococcus granulosus peregrin 0.0257 0.1021 0.2175
Mycobacterium ulcerans hypothetical protein 0.0145 0.0493 1
Trichomonas vaginalis chromobox protein, putative 0.0168 0.06 0.0577
Plasmodium falciparum phd finger protein, putative 0.0236 0.0919 1
Trichomonas vaginalis chromobox protein, putative 0.0278 0.112 0.1099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0303 0.1235 0.453
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0046 0.0024 0.002
Schistosoma mansoni hypothetical protein 0.0187 0.0692 0.2499
Trichomonas vaginalis chromobox protein, putative 0.0168 0.06 0.0577
Echinococcus granulosus histone lysine methyltransferase setb 0.0428 0.1827 0.3906
Echinococcus granulosus Chromobox protein 3 0.0046 0.0024 0.0035
Echinococcus multilocularis chromobox protein 1 0.0278 0.112 0.1369
Brugia malayi jmjC domain containing protein 0.0076 0.0167 0.0164
Brugia malayi jmjC domain containing protein 0.0076 0.0167 0.0164
Schistosoma mansoni cellular tumor antigen P53 0.0151 0.052 0.1856
Loa Loa (eye worm) hypothetical protein 0.0122 0.0385 0.044
Brugia malayi AF-10 protein 0.0077 0.0172 0.017
Schistosoma mansoni hypothetical protein 0.0081 0.0192 0.0629
Echinococcus multilocularis jumonji domain containing 1A 0.0076 0.0167 0.0197
Brugia malayi Pip kinase protein 2 0.0174 0.0631 0.0695
Echinococcus multilocularis lamin dm0 0.0087 0.022 0.0262
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0119 0.0887
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0192 0.0219
Schistosoma mansoni phd/f-box containing protein 0.0076 0.0167 0.0537
Trichomonas vaginalis set domain proteins, putative 0.2162 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0156 0.0543 0.1942
Loa Loa (eye worm) helicase 0.0046 0.0024 0.0027
Entamoeba histolytica hypothetical protein 0.0072 0.015 1
Onchocerca volvulus 0.0087 0.022 0.0197
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0119 0.0137
Schistosoma mansoni chromobox protein 0.0278 0.112 0.4101
Echinococcus granulosus jumonji domain containing 1A 0.0076 0.0167 0.0343
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0191
Brugia malayi hypothetical protein 0.0327 0.1349 0.1517
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0493 0.047
Loa Loa (eye worm) hypothetical protein 0.0236 0.0919 0.1049
Trypanosoma cruzi ISWI complex protein 0.014 0.0467 0.921
Echinococcus multilocularis lamin 0.0087 0.022 0.0262
Onchocerca volvulus 0.0145 0.0493 0.047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.015 0.0175
Loa Loa (eye worm) hypothetical protein 0.0086 0.0213 0.0243
Onchocerca volvulus 0.0053 0.006 0.0037
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0598 0.1268
Trypanosoma cruzi ISWI complex protein 0.014 0.0467 0.921
Brugia malayi F/Y-rich N-terminus family protein 0.0104 0.0301 0.0318
Echinococcus multilocularis neuropeptide receptor A26 0.05 0.2166 0.2656
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0046 0.0024 0.0035
Loa Loa (eye worm) heterochromatin protein 1 0.0278 0.112 0.1278
Leishmania major hypothetical protein, conserved 0.0145 0.0493 1
Leishmania major trypanothione reductase 0.0098 0.0271 0.4083
Echinococcus granulosus lamin 0.0087 0.022 0.0457
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0029 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0329 0.0306
Schistosoma mansoni hypothetical protein 0.0187 0.0692 0.2499
Brugia malayi CHD4 protein 0.0063 0.0106 0.0094
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0493 0.047
Brugia malayi jmjC domain containing protein 0.0303 0.1235 0.1386
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0493 0.4388
Echinococcus multilocularis JmjC domain containing protein 4 0.0076 0.0167 0.0197
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0372 0.1562 0.1782
Schistosoma mansoni hypothetical protein 0.0081 0.0192 0.0629
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0273 0.1093 0.4001
Schistosoma mansoni hypothetical protein 0.014 0.0467 0.1659
Echinococcus multilocularis PHD finger protein rhinoceros 0.0236 0.0919 0.1121
Loa Loa (eye worm) hypothetical protein 0.0145 0.0493 0.0563
Schistosoma mansoni protein phosphatase 2C 0.0076 0.0167 0.0537
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0029 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0188 0.0697 0.0795
Loa Loa (eye worm) jmjC domain-containing protein 0.0486 0.2101 0.2397
Loa Loa (eye worm) hypothetical protein 0.0087 0.022 0.0251
Toxoplasma gondii ABC1 family protein 0.0145 0.0493 0.4388
Onchocerca volvulus 0.0145 0.0493 0.047
Mycobacterium tuberculosis Probable oxidoreductase 0.0249 0.0981 0.2125
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.0493 1
Echinococcus multilocularis neuropeptide s receptor 0.05 0.2166 0.2656
Brugia malayi chromobox protein homolog 3 0.0156 0.0544 0.0595
Plasmodium falciparum JmjC domain-containing protein, putative 0.0076 0.0167 0.1605
Leishmania major hypothetical protein, conserved 0.014 0.0467 0.9313
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0249 0.0981 1
Echinococcus multilocularis phd:f box containing protein 0.0076 0.0167 0.0197
Toxoplasma gondii PHD-finger domain-containing protein 0.0236 0.0919 0.8369
Echinococcus multilocularis jumonji domain containing protein 0.0328 0.1354 0.1656
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0224 0.0864 0.1836
Echinococcus multilocularis peregrin 0.0257 0.1021 0.1247
Brugia malayi Bromodomain containing protein 0.0257 0.1021 0.1141
Schistosoma mansoni chromobox protein 0.0278 0.112 0.4101
Echinococcus granulosus GPCR family 2 0.0081 0.0192 0.0395
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0027
Leishmania major hypothetical protein, conserved 0.0076 0.0167 0.1302
Brugia malayi hypothetical protein 0.0072 0.015 0.0144
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.022 0.0225
Entamoeba histolytica hypothetical protein 0.0072 0.015 1
Schistosoma mansoni intermediate filament proteins 0.0087 0.022 0.0736
Schistosoma mansoni hypothetical protein 0.0081 0.0192 0.0629
Schistosoma mansoni jumonji domain containing protein 0.0613 0.2697 1
Echinococcus granulosus chromobox protein 1 0.0278 0.112 0.2388
Onchocerca volvulus 0.0174 0.0631 0.0609
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0093 0.0249 0.0519
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0174 0.0631 0.0767
Entamoeba histolytica hypothetical protein 0.0072 0.015 1
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.015 0.0471
Echinococcus granulosus jumonji domain containing protein 0.0328 0.1354 0.289
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0273 0.1093 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0156 0.0543 0.1942
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.0493 0.0922
Schistosoma mansoni hypothetical protein 0.0236 0.0919 0.3349
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.0493 0.0563
Loa Loa (eye worm) hypothetical protein 0.0076 0.0167 0.0191
Schistosoma mansoni survival motor neuron protein 0.0053 0.006 0.0137
Loa Loa (eye worm) intermediate filament protein 0.0087 0.022 0.0251
Echinococcus granulosus tumor protein p63 0.1031 0.4665 1
Plasmodium falciparum thioredoxin reductase 0.0098 0.0271 0.2768
Loa Loa (eye worm) hypothetical protein 0.0151 0.052 0.0593
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0192 0.0227
Schistosoma mansoni hypothetical protein 0.0077 0.0172 0.0554
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0192 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0167 0.0191
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0076 0.0167 0.0537
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0192 0.0395
Loa Loa (eye worm) hypothetical protein 0.0145 0.0493 0.0563
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0224 0.0864 0.1836
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0544 0.0522
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0076 0.0167 0.1343
Loa Loa (eye worm) jmjC domain-containing protein 0.0303 0.1235 0.1409
Loa Loa (eye worm) CHromoDomain protein family member 0.0063 0.0106 0.0121
Onchocerca volvulus 0.0318 0.1308 0.1287
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0174 0.0631 0.2273
Loa Loa (eye worm) glutathione reductase 0.0098 0.0271 0.031
Schistosoma mansoni lamin 0.0087 0.022 0.0736
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0167 0.0191
Toxoplasma gondii PHD-finger domain-containing protein 0.0236 0.0919 0.8369
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0493 1
Echinococcus granulosus Chromo domain 0.0046 0.0024 0.0035
Brugia malayi jmjC domain containing protein 0.0076 0.0167 0.0164
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.0493 0.0922
Echinococcus multilocularis chromobox protein 1 0.0278 0.112 0.1369
Schistosoma mansoni hypothetical protein 0.0081 0.0192 0.0629
Entamoeba histolytica hypothetical protein 0.0072 0.015 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0545 0.2378 0.5088
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0328 0.1355 0.1658
Brugia malayi Bromodomain containing protein 0.035 0.1457 0.164
Loa Loa (eye worm) hypothetical protein 0.0046 0.0024 0.0027
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0271 0.3197
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0927 0.4178 1
Brugia malayi PHD-finger family protein 0.0236 0.0919 0.1024
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.022 0.0251
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.1041 0.1271
Echinococcus multilocularis geminin 0.0187 0.0692 0.0842
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0249 0.0981 0.2125
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.0493 0.0922
Echinococcus multilocularis Chromo domain 0.0046 0.0024 0.002
Brugia malayi jmjC domain containing protein 0.0771 0.3444 0.3914
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.0493 0.0537
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.006 0.0042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.1018 0.1138
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.0493 0.0922
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.1018 0.1138
Mycobacterium tuberculosis Conserved protein 0.0145 0.0493 0.0922
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0328 0.1355 0.2893
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0428 0.1827 0.6746
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0206 0.0779 0.2825
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0493 1
Brugia malayi jmjC domain containing protein 0.0076 0.0167 0.0164
Echinococcus multilocularis musashi 0.0087 0.022 0.0262
Brugia malayi Pre-SET motif family protein 0.0273 0.1093 0.1224
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0119 0.0355
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0076 0.0167 0.1343
Echinococcus granulosus lysine specific demethylase 5A 0.0303 0.1235 0.2634
Brugia malayi intermediate filament protein 0.0087 0.022 0.0225
Loa Loa (eye worm) hypothetical protein 0.0094 0.0254 0.029
Echinococcus granulosus methyl CpG binding domain protein 2 0.0156 0.0543 0.1149
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0167 0.0191
Echinococcus granulosus PHD finger protein rhinoceros 0.0236 0.0919 0.1957
Loa Loa (eye worm) hypothetical protein 0.0389 0.1644 0.1876
Plasmodium vivax hypothetical protein, conserved 0.0236 0.0919 0.8369
Brugia malayi beta-lactamase family protein 0.0145 0.0493 0.0537
Loa Loa (eye worm) hypothetical protein 0.0261 0.1041 0.1188
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0077 0.0172 0.0139
Echinococcus granulosus fetal alzheimer antigen falz 0.0206 0.0779 0.1656
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0077 0.0172 0.0139
Mycobacterium tuberculosis Conserved protein 0.0145 0.0493 0.0922
Echinococcus granulosus lysine specific demethylase 6a 0.0076 0.0167 0.0343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0493 0.1756
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0206 0.0779 0.0949
Brugia malayi hypothetical protein 0.0261 0.1041 0.1164
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0077 0.0172 0.1385
Loa Loa (eye worm) hypothetical protein 0.0175 0.0636 0.0725
Brugia malayi Heterochromatin protein 1 0.0278 0.112 0.1255
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0493 0.047
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0063 0.0106 0.0211
Plasmodium vivax glutathione reductase, putative 0.0098 0.0271 0.2316
Plasmodium vivax JmjC domain containing protein 0.0076 0.0167 0.1343
Schistosoma mansoni bromodomain containing protein 0.0578 0.2532 0.9381

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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