Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.5326 | 0.616 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.8073 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2139 | 0.2052 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2139 | 0.2052 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.0868 | 0.0579 |
Echinococcus granulosus | ferritin | 0.0009 | 0.0868 | 0.0579 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0868 | 0.0767 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.0868 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.4619 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0754 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0868 | 0.0767 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.2139 | 0.372 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0868 | 0.0767 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4678 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.2139 | 0.1704 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.8073 | 1 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0868 | 0.0767 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0868 | 0.0767 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0531 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0009 | 0.0868 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.2139 | 0.372 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4393 | 0.4331 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0009 | 0.0868 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0.0868 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.0868 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0.0868 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.4393 | 0.4842 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.8867 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5326 | 0.615 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.8073 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.6047 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.0754 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0868 | 0.0767 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.4619 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.4393 | 0.4856 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.2139 | 0.372 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.0868 | 0.0579 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0868 | 0.0767 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 0.6047 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.2139 | 0.1681 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.0868 | 0.0579 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.2139 | 0.372 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.2139 | 0.1704 |
Onchocerca volvulus | 0.0029 | 0.4393 | 0.5 | |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0868 | 0.0767 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4678 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0.0868 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2139 | 0.1681 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0.0868 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5326 | 0.5275 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.8073 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2139 | 0.2052 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.2139 | 0.2052 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.6047 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.2139 | 0.372 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.2139 | 0.372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 8.5 % | Inhibition of human thrombin using Boc-VPR-AMC as substrate at 25 uM preincubated for 15 mins before substrate addition measured up to 10 mins by spectrofluorimetry | ChEMBL. | 22094280 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.