Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0186 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0186 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0033 | 0.0351 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0351 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.291 | 0.3463 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.084 | 0.5 |
Brugia malayi | hypothetical protein | 0.0132 | 0.6579 | 0.7228 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0033 | 0.0351 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.8403 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.015 | 0.7694 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0033 | 0.0351 | 0.0456 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.2577 | 0.3067 |
Brugia malayi | jmjC domain containing protein | 0.0172 | 0.9101 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0351 | 0.0456 |
Brugia malayi | jmjC domain containing protein | 0.0103 | 0.4784 | 0.5257 |
Echinococcus multilocularis | muscleblind protein | 0.0161 | 0.8403 | 0.9233 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0033 | 0.0351 | 0.0386 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0186 | 1 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0103 | 0.4784 | 0.6218 |
Brugia malayi | hypothetical protein | 0.0041 | 0.084 | 0.0923 |
Giardia lamblia | PHD finger protein 15 | 0.0033 | 0.0351 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.084 | 0.0923 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.084 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0186 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.6579 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0103 | 0.4784 | 0.6218 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0103 | 0.4784 | 0.5694 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0172 | 0.9101 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6579 | 0.7829 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.8403 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0186 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0186 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0351 | 0.0351 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.084 | 0.1092 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.117 | 0.1285 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.0351 | 0.0386 |
Brugia malayi | Muscleblind-like protein | 0.0161 | 0.8403 | 0.9233 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.0351 | 0.0351 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0172 | 0.9101 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.084 | 0.1092 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.0351 | 0.0386 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.0351 | 0.0386 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.084 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0.0351 | 0.0351 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0161 | 0.8403 | 0.9233 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0103 | 0.4784 | 0.5257 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6579 | 0.7829 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.0351 | 0.0351 |
Echinococcus granulosus | peregrin | 0.0033 | 0.0351 | 0.0386 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.6579 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.117 | 0.1285 |
Trichomonas vaginalis | hypothetical protein | 0.0186 | 1 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0103 | 0.4784 | 0.5257 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.084 | 0.0923 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.084 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0161 | 0.8403 | 0.9233 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0186 | 1 | 0.5 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0028 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.