Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0161 | 0.8663 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0049 | 0.1765 | 0.1765 |
Brugia malayi | jmjC domain containing protein | 0.0104 | 0.5169 | 0.5967 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0025 | 0.0291 | 0.0354 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0104 | 0.5169 | 0.5967 |
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.124 | 0.1431 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1554 | 0.1793 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.0698 | 0.0698 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.124 | 0.1431 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0161 | 0.8663 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0049 | 0.1765 | 0.1765 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0.0698 | 0.0698 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.124 | 0.1431 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0182 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0252 | 0.0291 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182 | 1 | 0.5 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0032 | 0.0698 | 0.0848 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1155 | 0.1333 |
Brugia malayi | PHD-finger family protein | 0.0032 | 0.0698 | 0.0805 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0043 | 0.1366 | 0.1366 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0698 | 0.0805 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0049 | 0.1765 | 0.1765 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.1467 | 0.1694 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0154 | 0.823 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.124 | 0.1431 |
Echinococcus granulosus | peregrin | 0.0038 | 0.1097 | 0.1332 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.279 | 0.3221 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.1111 | 0.1283 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0023 | 0.0162 | 0.0188 |
Echinococcus multilocularis | peregrin | 0.0038 | 0.1097 | 0.1266 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0252 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1847 | 0.2132 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.0698 | 0.0698 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0049 | 0.1765 | 0.1765 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0032 | 0.0698 | 0.0805 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0032 | 0.0698 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.35 | 0.404 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.1467 | 0.1783 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0049 | 0.1765 | 0.2145 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.124 | 0.1507 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0032 | 0.0698 | 0.0805 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0651 | 0.0751 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0104 | 0.5169 | 0.6282 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1718 | 0.1983 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0161 | 0.8663 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1097 | 0.1266 |
Plasmodium falciparum | phd finger protein, putative | 0.0032 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0698 | 0.0805 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0123 | 0.0142 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0043 | 0.1366 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.3238 | 0.3737 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0123 | 0.0142 |
Onchocerca volvulus | Alhambra homolog | 0.0032 | 0.0698 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0182 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0161 | 0.8663 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0049 | 0.1765 | 0.1765 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2102 | 0.2426 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0252 | 0.0306 |
Schistosoma mansoni | zinc finger protein | 0.0025 | 0.0291 | 0.0336 |
Giardia lamblia | PHD finger protein 15 | 0.0032 | 0.0698 | 0.5106 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.4028 | 0.4649 |
Echinococcus multilocularis | zinc finger protein | 0.0025 | 0.0291 | 0.0336 |
Schistosoma mansoni | jumonji domain containing protein | 0.0083 | 0.3846 | 0.444 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.2996 | 0.3459 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.2996 | 0.3641 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1155 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1319 | 0.1522 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0043 | 0.1366 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 200 uM | Antifungal activity against Saccharomyces cerevisiae ATCC 24657 assessed as growth inhibition after 24 to 48 hrs by agar plate bioassay | ChEMBL. | 22100140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.