Detailed information for compound 1568529

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 669.133 | Formula: C35H36ClF3N4O4
  • H donors: 2 H acceptors: 3 LogP: 5.25 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Cc1ccc(c(c1)CN(C(=O)[C@H]1CNCC(=O)N1c1ccc(cc1)CCCOc1c(F)ccc(c1F)F)C1CC1)Cl)NC1CC1
  • InChi: 1S/C35H36ClF3N4O4/c36-27-12-5-22(17-31(44)41-24-6-7-24)16-23(27)20-42(25-10-11-25)35(46)30-18-40-19-32(45)43(30)26-8-3-21(4-9-26)2-1-15-47-34-29(38)14-13-28(37)33(34)39/h3-5,8-9,12-14,16,24-25,30,40H,1-2,6-7,10-11,15,17-20H2,(H,41,44)/t30-/m1/s1
  • InChiKey: PKBWJGCWECKSCQ-SSEXGKCCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei AMP deaminase, putative 0.062 0.3351 1
Schistosoma mansoni adenosine deaminase 0.0663 0.3595 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0059 0.0181 0.0504
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0031 0.0022 0.0053
Onchocerca volvulus Bile acid receptor homolog 0.036 0.1879 0.5226
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0051 0.0105
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Brugia malayi hypothetical protein 0.0031 0.0022 0.0062
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0003 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0059 0.0181 0.0504
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.0766 0.0763
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0051 0.0142
Schistosoma mansoni hypothetical protein 0.0319 0.1647 0.4576
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0397 0.1105
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0051 0.0142
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0489 0.1353
Treponema pallidum adenosine deaminase 0.0663 0.3595 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0061 0.0027
Trypanosoma cruzi AMP deaminase, putative 0.062 0.3351 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Brugia malayi nuclear hormone receptor 0.0059 0.0181 0.0504
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0051 0.0142
Brugia malayi beta-lactamase family protein 0.0036 0.0051 0.0142
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0059 0.0181 0.0178
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0061 0.0169
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0142
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0051 0.0133
Entamoeba histolytica adenosine deaminase, putative 0.0663 0.3595 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0061 0.0057
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.062 0.3351 0.9321
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0059 0.0181 0.0495
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.002 0.0055
Trypanosoma cruzi AMP deaminase, putative 0.062 0.3351 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0059 0.0181 0.0178
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0454 0.1253
Trypanosoma cruzi AMP deaminase 2, putative 0.0326 0.1688 0.496
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0059 0.0181 0.0504
Schistosoma mansoni hypothetical protein 0.0108 0.0454 0.1253
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0121 0.0118
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.002 0.0045
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0051 0.0133
Echinococcus granulosus expressed conserved protein 0.0107 0.045 0.1244
Loa Loa (eye worm) AMP deaminase 0.062 0.3351 0.9321
Schistosoma mansoni RAR-like nuclear receptor 0.0059 0.0181 0.0495
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0031 0.0022 0.0053
Echinococcus granulosus snurportin 1 0.0319 0.1647 0.4576
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.0766 0.2123
Loa Loa (eye worm) hypothetical protein 0.0114 0.0489 0.1361
Brugia malayi nuclear receptor RXR 0.0031 0.0022 0.0062
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0059 0.0181 0.0504
Mycobacterium ulcerans beta-lactamase 0.0036 0.0051 0.0142
Trichomonas vaginalis adenosine deaminase, putative 0.0663 0.3595 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0061 0.0027
Brugia malayi conserved hypotetical protein 0.0028 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0142
Echinococcus multilocularis FTZ F1 alpha 0.0059 0.0181 0.0178
Echinococcus granulosus geminin 0.0527 0.2827 0.7861
Schistosoma mansoni AMP deaminase 0.062 0.3351 0.932
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1154 0.1151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0059 0.0181 0.0504
Onchocerca volvulus AMP deaminase 2 homolog 0.062 0.3351 0.9321
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1154 0.3203
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0121 0.0198
Brugia malayi nuclear receptor NHR-67 0.0028 0.0003 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0059 0.0181 0.0504
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0121 0.0338
Loa Loa (eye worm) hypothetical protein 0.0663 0.3595 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0188 0.0909 0.252
Trypanosoma cruzi AMP deaminase, putative 0.062 0.3351 1
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0022 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0051 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0337 0.1752 0.4874
Mycobacterium tuberculosis Conserved protein 0.0036 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0454 0.1253
Schistosoma mansoni coup transcription factor 0.0059 0.0181 0.0495
Brugia malayi hypothetical protein 0.0028 0.0003 0.001
Entamoeba histolytica AMP deaminase, putative 0.062 0.3351 0.9321
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0059 0.0181 0.0495
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.062 0.3351 1
Brugia malayi CHE-14 protein 0.0049 0.0121 0.0338
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0061 0.0169
Loa Loa (eye worm) hypothetical protein 0.0098 0.0397 0.1105
Onchocerca volvulus 0.0028 0.0003 0.001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0003 0.001
Onchocerca volvulus 0.0036 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.0337 0.1752 0.4874
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0059 0.0181 0.0495
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0061 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0059 0.0181 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0059 0.0181 0.0504
Brugia malayi beta-lactamase family protein 0.0036 0.0051 0.0142
Trypanosoma cruzi AMP deaminase, putative 0.062 0.3351 1
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0003 0.001
Onchocerca volvulus 0.01 0.0408 0.1135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0059 0.0181 0.0178
Schistosoma mansoni alpha-glucosidase 0.0148 0.0683 0.1892
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0326 0.1688 0.4695
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0112 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.036 0.1879 0.5226
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0051 0.0142
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0003 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0031 0.0022 0.0019
Echinococcus multilocularis adenosine deaminase 0.0663 0.3595 0.3593
Brugia malayi nuclear hormone receptor 0.0028 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0059 0.0181 0.0495
Brugia malayi beta-lactamase 0.0036 0.0051 0.0142
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0003 0.001
Plasmodium falciparum adenosine deaminase 0.0663 0.3595 1
Brugia malayi nuclear receptor NHR-88 0.0028 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0504
Schistosoma mansoni hypothetical protein 0.0047 0.0111 0.0301
Trypanosoma brucei glucosidase, putative 0.0038 0.0061 0.0142
Echinococcus granulosus importin subunit beta 1 0.003 0.0014 0.0028
Mycobacterium tuberculosis Conserved protein 0.0036 0.0051 0.0142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0059 0.0181 0.0495
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0121 0.0328
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0051 0.0142
Brugia malayi photoreceptor-specific nuclear receptor 0.0059 0.0181 0.0504
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0499 0.138
Plasmodium vivax adenosine/AMP deaminase, putative 0.062 0.3351 0.9318
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0031 0.002 0.0055
Echinococcus granulosus ecdysone induced protein 78C 0.0059 0.0181 0.0495
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0051 0.0142
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0059 0.0181 0.0495
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0663 0.3595 1
Echinococcus granulosus tumor protein p63 0.0391 0.2057 0.5717
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0142
Mycobacterium ulcerans hypothetical protein 0.0036 0.0051 0.0142
Onchocerca volvulus 0.0028 0.0003 0.001
Leishmania major hypothetical protein, conserved 0.0036 0.0051 0.0142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Onchocerca volvulus 0.0057 0.0169 0.0469
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0504
Schistosoma mansoni thyroid hormone receptor 0.0059 0.0181 0.0495
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0819 0.2269
Brugia malayi Importin beta-1 subunit 0.003 0.0014 0.0038
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.062 0.3351 1
Leishmania major hypothetical protein, conserved 0.0326 0.1688 0.4695
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0003 0.001
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0819 0.2277
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0022 0.0062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0819 0.0815
Schistosoma mansoni survival motor neuron protein 0.0047 0.0112 0.0302
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0504
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0819 0.0815
Loa Loa (eye worm) hypothetical protein 0.0057 0.0169 0.0469
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0663 0.3595 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0014 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0045
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Echinococcus multilocularis snurportin 1 0.0319 0.1647 0.1644
Echinococcus multilocularis geminin 0.0527 0.2827 0.2824
Entamoeba histolytica hypothetical protein 0.0108 0.0454 0.1262
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1164 0.3236
Trypanosoma brucei AMP deaminase, putative 0.062 0.3351 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0504
Toxoplasma gondii ABC1 family protein 0.0036 0.0051 0.0105
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0059 0.0181 0.0495
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0121 0.0328
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0819 0.2277
Echinococcus multilocularis thyroid hormone receptor alpha 0.0059 0.0181 0.0178
Echinococcus multilocularis expressed conserved protein 0.0107 0.045 0.0447
Mycobacterium ulcerans adenosine deaminase 0.0663 0.3595 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0051 0.0142
Brugia malayi adenosine monophosphate deaminase 0.062 0.3351 0.9321
Loa Loa (eye worm) beta-lactamase 0.0036 0.0051 0.0142
Echinococcus multilocularis tumor protein p63 0.0391 0.2057 0.2054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0059 0.0181 0.0504
Leishmania major AMP deaminase, putative 0.062 0.3351 0.9321
Brugia malayi hypothetical protein 0.0231 0.1154 0.3209
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0059 0.0181 0.0504
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0059 0.0181 0.0495
Entamoeba histolytica AMP deaminase, putative 0.062 0.3351 0.9321
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0489 0.1361
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0061 0.0027
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0061 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0061 0.0027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0061 0.0027
Entamoeba histolytica hypothetical protein 0.0108 0.0454 0.1262
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0051 0.0142
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0059 0.0181 0.0495
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.062 0.3351 1
Schistosoma mansoni hypothetical protein 0.0056 0.0161 0.0439
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Schistosoma mansoni hypothetical protein 0.0067 0.0223 0.061
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0504
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0223 0.0619
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0003 0.001
Brugia malayi ecdysteroid receptor 0.036 0.1879 0.5226
Echinococcus multilocularis AMP deaminase 2 0.062 0.3351 0.3349
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0397 0.1105
Onchocerca volvulus 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.062 0.3351 0.9321
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0157 0.0731 0.0728
Echinococcus granulosus FTZ F1 alpha 0.0059 0.0181 0.0495
Schistosoma mansoni hypothetical protein 0.0527 0.2827 0.7861
Mycobacterium tuberculosis Conserved protein 0.0036 0.0051 0.0142
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0022 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0051 0.0133
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0059 0.0181 0.0178
Schistosoma mansoni hypothetical protein 0.0047 0.0112 0.0302
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.002 0.0016
Schistosoma mansoni importin beta-1 0.003 0.0014 0.0028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0059 0.0181 0.0495
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0003 0.001
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.062 0.3351 0.9321
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.0049 0.0121 0.0338
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0051 0.0142
Echinococcus multilocularis protein dispatched 1 0.0056 0.016 0.0157
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0188 0.0909 0.252
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0059 0.0181 0.0495
Entamoeba histolytica adenosine deaminase, putative 0.0663 0.3595 1
Schistosoma mansoni hypothetical protein 0.0047 0.0111 0.0301
Brugia malayi steroid hormone receptor 0.0059 0.0181 0.0504
Echinococcus granulosus GPCR family 2 0.0031 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0294 0.1508 0.4195
Schistosoma mansoni hypothetical protein 0.0527 0.2827 0.7861
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.1647 0.4581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0059 0.0181 0.0504
Brugia malayi hypothetical protein 0.0028 0.0003 0.001
Trypanosoma brucei AMP deaminase, putative 0.062 0.3351 1
Brugia malayi Adenosine/AMP deaminase family protein 0.0663 0.3595 1
Schistosoma mansoni thyroid hormone receptor 0.0059 0.0181 0.0495
Schistosoma mansoni hypothetical protein 0.0047 0.0111 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0059 0.0181 0.0504
Echinococcus granulosus AMP deaminase 2 0.062 0.3351 0.932
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0061 0.0027
Onchocerca volvulus Adenosine deaminase homolog 0.0663 0.3595 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0061 0.0027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0061 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0061 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0059 0.0181 0.0504
Entamoeba histolytica hypothetical protein 0.0108 0.0454 0.1262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0059 0.0181 0.0504
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0061 0.016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0061 0.0027
Echinococcus multilocularis ecdysone induced protein 78C 0.0059 0.0181 0.0178
Mycobacterium ulcerans lipase LipD 0.0036 0.0051 0.0142
Plasmodium falciparum AMP deaminase, putative 0.062 0.3351 0.9318
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0031 0.0022 0.0062
Schistosoma mansoni nuclear hormone receptor 0.0059 0.0181 0.0495
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0663 0.3595 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0489 0.0486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0397 0.1105
Leishmania major adenine aminohydrolase 0.0663 0.3595 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0059 0.0181 0.0504
Onchocerca volvulus 0.0047 0.0112 0.0311
Brugia malayi hypothetical protein 0.0108 0.0454 0.1262
Loa Loa (eye worm) hypothetical protein 0.0059 0.0181 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0059 0.0181 0.0504
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0454 0.045
Brugia malayi RNA, U transporter 1 0.0085 0.0325 0.0904
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0337 0.1752 0.4874
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0059 0.0181 0.0504
Onchocerca volvulus 0.0326 0.1688 0.4695
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0489 0.1361
Trichomonas vaginalis adenosine deaminase, putative 0.0663 0.3595 1
Echinococcus granulosus adenosine deaminase 0.0663 0.3595 1
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0045
Echinococcus multilocularis GPCR, family 2 0.0031 0.002 0.0016
Trypanosoma cruzi AMP deaminase, putative 0.062 0.3351 1
Onchocerca volvulus 0.0036 0.0051 0.0142
Schistosoma mansoni alpha-glucosidase 0.0148 0.0683 0.1892
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0003 0.001
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0051 0.0142
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0003 0.001
Brugia malayi ecdysone receptor 0.0028 0.0003 0.001
Schistosoma mansoni alpha glucosidase 0.0038 0.0061 0.016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0059 0.0181 0.0178
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0059 0.0181 0.0495
Plasmodium vivax adenosine deaminase, putative 0.0663 0.3595 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0059 0.0181 0.0504
Mycobacterium leprae Probable lipase LipE 0.0036 0.0051 0.0142
Schistosoma mansoni hypothetical protein 0.0047 0.0111 0.0301
Brugia malayi hypothetical protein 0.0031 0.0022 0.0062
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0181 0.0504
Toxoplasma gondii AMP deaminase 0.062 0.3351 0.9318
Entamoeba histolytica hypothetical protein 0.0108 0.0454 0.1262
Onchocerca volvulus 0.0036 0.0051 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0062
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0169 0.046
Brugia malayi nuclear receptor NHR-88 0.0059 0.0181 0.0504
Brugia malayi tailless protein 0.0028 0.0003 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.0067 0.0223 0.0619
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0051 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0062
Brugia malayi nuclear receptor RXR 0.0028 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0337 0.1752 0.4874
Schistosoma mansoni steroid hormone receptor ad4bp 0.0059 0.0181 0.0495
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0663 0.3595 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.1154 0.3209
Schistosoma mansoni patched 1 0.0049 0.0121 0.0328
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0061 0.0169
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0142
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0061 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0061 0.0029
Schistosoma mansoni adenosine deaminase-related 0.0663 0.3595 1
Loa Loa (eye worm) DR-78 0.0028 0.0003 0.001
Echinococcus multilocularis protein patched 0.0049 0.0121 0.0118
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0059 0.0181 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0059 0.0181 0.0504
Loa Loa (eye worm) hypothetical protein 0.006 0.0184 0.0511

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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