Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0145 | 1 | 1 |
Schistosoma mansoni | triosephosphate isomerase | 0.0091 | 0.4991 | 0.4991 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.6688 | 0.3388 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.6688 | 0.3388 |
Onchocerca volvulus | 0.0109 | 0.6688 | 0.5 | |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0145 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0145 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | triosephosphate isomerase | 0.0091 | 0.4991 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0145 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.6688 | 0.6688 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.6688 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0145 | 1 | 1 |
Plasmodium falciparum | triosephosphate isomerase | 0.0091 | 0.4991 | 0.4991 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0145 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0145 | 1 | 1 |
Plasmodium vivax | triosephosphate isomerase, putative | 0.0091 | 0.4991 | 0.4991 |
Echinococcus granulosus | proteasome prosome macropain | 0.0145 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.6688 | 0.3388 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0145 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0145 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.6688 | 0.3388 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.6688 | 0.3388 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.6688 | 0.3388 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0145 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0145 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0145 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.6688 | 0.6688 |
Chlamydia trachomatis | triosephosphate isomerase | 0.0091 | 0.4991 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.6688 | 0.3388 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.6688 | 0.3388 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.6688 | 0.3388 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0145 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3071 nM | Displacement of [3H]WIN-35,428 from human DAT expressed in N2A cells after 15 mins by photoaffinity labeling | ChEMBL. | 22119468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.