Detailed information for compound 1568660

Basic information

Technical information
  • TDR Targets ID: 1568660
  • Name: 3-[4-methoxy-7-(oxan-4-yl)-1,3-benzothiazol-2 -yl]-1-methyl-1-(1-methylpiperidin-4-yl)urea
  • MW: 418.553 | Formula: C21H30N4O3S
  • H donors: 1 H acceptors: 2 LogP: 2.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1nc(s2)NC(=O)N(C1CCN(CC1)C)C)C1CCOCC1
  • InChi: 1S/C21H30N4O3S/c1-24-10-6-15(7-11-24)25(2)21(26)23-20-22-18-17(27-3)5-4-16(19(18)29-20)14-8-12-28-13-9-14/h4-5,14-15H,6-13H2,1-3H3,(H,22,23,26)
  • InChiKey: ZZBZKKYQZNSJEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-methoxy-7-tetrahydropyran-4-yl-1,3-benzothiazol-2-yl)-1-methyl-1-(1-methyl-4-piperidyl)urea
  • 3-[4-methoxy-7-(4-tetrahydropyranyl)-1,3-benzothiazol-2-yl]-1-methyl-1-(1-methyl-4-piperidinyl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0032 0.0395 0.058
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0123 0.3165 0.3164
Brugia malayi proteasome subunit alpha type 1 0.0129 0.3321 0.3321
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0017 0.0025
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0032 0.0395 0.058
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0097 0.2377 0.3486
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.015 0.3981 0.3981
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0092 0.222 0.222
Trypanosoma brucei proteasome beta 7 subunit 0.0122 0.3115 0.4568
Loa Loa (eye worm) PAS-3 protein 0.0113 0.2854 0.4185
Brugia malayi Proteasome subunit alpha type 1 0.0113 0.2839 0.2839
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.002 0.0017 0.0025
Echinococcus granulosus proteasome prosome macropain 0.0244 0.6819 0.6819
Echinococcus granulosus proteasome subunit beta type 6 0.0129 0.3349 0.3349
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0131 0.3384 0.4963
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0051 0.0074
Giardia lamblia 20S proteasome alpha subunit 1 0.0141 0.3702 0.5429
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0038 0.058 0.085
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0085 0.2013 0.2013
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0032 0.0395 0.058
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0129 0.3336 0.4892
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.014 0.3674 0.5387
Brugia malayi PCI domain containing protein 0.0029 0.0314 0.0314
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0134 0.3484 0.5109
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.014 0.3674 0.5387
Entamoeba histolytica proteasome subunit beta type 1, putative 0.015 0.3981 0.5839
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0122 0.3115 0.4568
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0085 0.2013 0.2013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0118 0.3001 0.4402
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0244 0.6819 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0129 0.3349 0.4911
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0123 0.3165 0.4641
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0244 0.6819 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0177 0.4797 0.7035
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0129 0.3321 0.4871
Plasmodium vivax proteasome subunit beta type-4, putative 0.0122 0.3115 0.4568
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0097 0.2377 0.3486
Echinococcus granulosus Proteasome subunit alpha beta 0.0131 0.3384 0.3384
Plasmodium vivax proteasome subunit beta type-2, putative 0.0123 0.3165 0.4641
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0141 0.3702 0.3702
Leishmania major proteasome beta 2 subunit, putative 0.0123 0.3165 0.4641
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.003 0.0319 0.0468
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0123 0.3165 0.3164
Schistosoma mansoni 26S protease regulatory subunit 6b 0.002 0.0017 0.0017
Toxoplasma gondii heat shock protein hslv, putative 0.0097 0.2377 0.3486
Entamoeba histolytica proteasome regulatory subunit, putative 0.0038 0.058 0.085
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0131 0.3384 0.4963
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0021 0.0053 0.0077
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0244 0.6819 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0244 0.6819 0.6819
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0123 0.3165 0.4641
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0319 0.0468
Plasmodium vivax proteasome subunit alpha type-5, putative 0.014 0.3674 0.5387
Giardia lamblia 20S proteasome alpha subunit 5 0.014 0.3674 0.5387
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0029 0.0314 0.0314
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0033 0.0435 0.0435
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0053 0.0077
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0129 0.3336 0.4892
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.002 0.0017 0.0025
Brugia malayi proteasome subunit alpha type 4 0.0113 0.2854 0.2854
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0129 0.3349 0.4911
Plasmodium vivax proteasome subunit beta type-5, putative 0.0244 0.6819 1
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0032 0.0399 0.0585
Brugia malayi Proteasome A-type and B-type family protein 0.0129 0.3349 0.3349
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0131 0.3384 0.4963
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0118 0.3001 0.4402
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0129 0.3336 0.4892
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0021 0.0051 0.0074
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0017 0.0025
Leishmania major proteasome beta 3 subunit, putative 0.0123 0.3165 0.4641
Plasmodium vivax proteasome subunit beta type-6, putative 0.0129 0.3349 0.4911
Loa Loa (eye worm) proteasome subunit beta type 2 0.0123 0.3165 0.4641
Loa Loa (eye worm) hypothetical protein 0.021 0.5786 0.8485
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0097 0.2377 0.5
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0028 0.0273 0.0401
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0028 0.0273 0.0401
Echinococcus multilocularis proteasome subunit beta type 7 0.0349 1 1
Trichomonas vaginalis 26S proteasome subunit, putative 0.0029 0.0314 0.0461
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0036 0.0498 0.0498
Schistosoma mansoni 26S protease regulatory subunit 0.002 0.0017 0.0017
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0273 0.0401
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.015 0.3981 0.5839
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0051 0.0051
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0033 0.0435 0.0435
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0122 0.3115 0.3115
Schistosoma mansoni 26S proteasome subunit S9 0.0036 0.0498 0.0498
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0028 0.0273 0.0401
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.014 0.3674 0.3674
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.002 0.0017 0.0025
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0129 0.3321 0.4871
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0177 0.4797 0.4797
Plasmodium falciparum proteasome subunit beta type-4 0.0122 0.3115 0.4568
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.003 0.0319 0.0468
Loa Loa (eye worm) proteasome subunit beta type 3 0.0123 0.3165 0.4641
Brugia malayi proteasome subunit beta type 1 0.015 0.3981 0.3981
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0129 0.3336 0.3336
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0053 0.0077
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.014 0.3674 0.5387
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0177 0.4797 0.7035
Echinococcus granulosus subfamily T1A non peptidase ue 0.014 0.3674 0.3674
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.015 0.3981 0.5839
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0122 0.3115 0.4568
Leishmania major hypothetical protein, conserved 0.0048 0.0879 0.1289
Onchocerca volvulus 0.002 0.0017 0.005
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0129 0.3321 0.4871
Giardia lamblia Hypothetical protein 0.0036 0.0498 0.0731
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0395 0.058
Echinococcus multilocularis proteasome subunit alpha type 2 0.0134 0.3484 0.3484
Brugia malayi Probable 26S protease regulatory subunit 4 0.002 0.0017 0.0017
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.003 0.0319 0.0468
Loa Loa (eye worm) proteasome 26S subunit 0.0019 0.0000046814 0.0000068654
Leishmania major proteasome alpha 1 subunit, putative 0.0141 0.3702 0.5429
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0118 0.3001 0.4402
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.6819 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0244 0.6819 1
Toxoplasma gondii proteasome regulatory subunit 0.003 0.0319 0.0468
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0122 0.3115 0.4568
Brugia malayi proteasome subunit alpha type 3 0.0131 0.3384 0.3384
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0036 0.0498 0.0498
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.003 0.0319 0.0319
Leishmania major proteasome beta 5 subunit, putative 0.0244 0.6819 1
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.002 0.0017 0.0025
Toxoplasma gondii proteasome subunit alpha1, putative 0.0141 0.3702 0.5429
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.003 0.0319 0.0319
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.002 0.0017 0.0017
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.015 0.3981 0.5839
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0129 0.3336 0.4892
Loa Loa (eye worm) hypothetical protein 0.0028 0.0273 0.0401
Echinococcus granulosus proteasome subunit alpha type 2 0.0134 0.3484 0.3484
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0017 0.0025
Giardia lamblia 20S proteasome alpha subunit 3 0.0129 0.3336 0.4892
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0141 0.3702 0.5429
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.002 0.0017 0.0025
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0177 0.4797 0.7035
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0048 0.0879 0.1289
Brugia malayi Proteasome A-type and B-type family protein 0.0122 0.3115 0.3115
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0053 0.0053
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0032 0.0395 0.058
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0029 0.0314 0.0461
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0129 0.3321 0.3321
Echinococcus granulosus adhesion regulating molecule 1 0.0092 0.222 0.222
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0028 0.0273 0.0273
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0177 0.4797 0.4797
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0118 0.3001 0.4402
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0113 0.2859 0.4193
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0028 0.0273 0.0273
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0141 0.3702 0.5429
Brugia malayi Ubiquitin interaction motif family protein 0.0021 0.0051 0.0051
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0097 0.2377 0.2377
Giardia lamblia 20S proteasome alpha subunit 2 0.0134 0.3484 0.5109
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.014 0.3674 0.5387
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0123 0.3165 0.3164
Leishmania major proteasome alpha 3 subunit, putative 0.0129 0.3336 0.4892
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0021 0.0053 0.0053
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0033 0.0435 0.0639
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0131 0.3384 0.4963
Giardia lamblia Proteasome subunit beta type 1 0.015 0.3981 0.5839
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.003 0.0319 0.0319
Schistosoma mansoni multiubiquitin binding protein S5a 0.0021 0.0051 0.0051
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0122 0.3115 0.3115
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0033 0.0435 0.0639
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0129 0.3336 0.4892
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0097 0.2377 0.3486
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0021 0.0051 0.0051
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0123 0.3165 0.4641
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0092 0.222 0.222
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0021 0.0053 0.0077
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.014 0.3674 0.5387
Giardia lamblia 20S proteasome alpha subunit 4 0.0177 0.4797 0.7035
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0032 0.0395 0.058
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0122 0.3115 0.3115
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0177 0.4797 0.7035
Plasmodium vivax proteasome subunit beta type-7, putative 0.0118 0.3001 0.4402
Loa Loa (eye worm) RPT-2 protein 0.002 0.0017 0.0025
Leishmania major proteasome alpha 2 subunit, putative 0.0134 0.3484 0.5109
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0097 0.2377 0.3486
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0123 0.3165 0.3164
Plasmodium vivax proteasome subunit beta type-1, putative 0.015 0.3981 0.5839
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0129 0.3336 0.4892
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0129 0.3336 0.3336
Schistosoma mansoni proteasome regulatory subunit-related 0.0032 0.0399 0.0399
Echinococcus multilocularis subfamily T1A non peptidase ue 0.014 0.3674 0.3674
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0131 0.3384 0.4963
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0033 0.0435 0.0435
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0021 0.0053 0.0053
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0244 0.6819 1
Toxoplasma gondii proteasome subunit beta type, putative 0.0244 0.6819 1
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0177 0.4797 0.7035
Toxoplasma gondii PCI domain-containing protein 0.0029 0.0314 0.0461
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0131 0.3384 0.4963
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0122 0.3115 0.4568
Giardia lamblia 26S protease regulatory subunit 6B 0.002 0.0017 0.0025
Toxoplasma gondii proteasome beta subunit 0.0123 0.3165 0.4641
Toxoplasma gondii hypothetical protein 0.0026 0.0208 0.0304
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0129 0.3349 0.4911
Trypanosoma cruzi 20S proteasome subunit 0.0123 0.3165 0.4641
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0131 0.3384 0.4963
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0097 0.2377 0.3486
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0028 0.0273 0.0273
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0129 0.3321 0.4871
Loa Loa (eye worm) hypothetical protein 0.0028 0.0273 0.0401
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0399 0.0585
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.003 0.0319 0.0468
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0028 0.0273 0.0401
Entamoeba histolytica 19S cap proteasome S2 subunit 0.002 0.0034 0.005
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.014 0.3674 0.5387
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0123 0.3165 0.4641
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0129 0.3349 0.3349
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.003 0.0319 0.0468
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0038 0.058 0.058
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0129 0.3349 0.4911
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.003 0.0319 0.0468
Leishmania major proteasome alpha 1 subunit, putative 0.0129 0.3321 0.4871
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.014 0.3674 0.5387
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0177 0.4797 0.7035
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0029 0.0314 0.0461
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0033 0.0435 0.0435
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0134 0.3484 0.5109
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.003 0.0319 0.0319
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0123 0.3165 0.4641
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0036 0.0498 0.0731
Leishmania major proteasome beta-1 subunit, putative 0.0129 0.3349 0.4911
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0033 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0025
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0131 0.3384 0.3384
Toxoplasma gondii PCI domain-containing protein 0.0038 0.058 0.085
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0122 0.3115 0.4568
Giardia lamblia 20S proteasome alpha subunit 6 0.0129 0.3321 0.4871
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0053 0.0053
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0028 0.0273 0.0273
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0122 0.3115 0.4568
Toxoplasma gondii proteasome 26S regulatory subunit 0.002 0.0034 0.005
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.003 0.0319 0.0468
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0017 0.0025
Toxoplasma gondii SAC3/GANP family protein 0.0028 0.0273 0.0401
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0123 0.3165 0.4641
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0017 0.0025
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0038 0.058 0.085
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0123 0.3165 0.4641
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0129 0.3321 0.4871
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0097 0.2377 0.3486
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0122 0.3115 0.4568
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.003 0.0319 0.0468
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0123 0.3165 0.4641
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.002 0.0017 0.0025
Brugia malayi Proteasome subunit alpha type 7-1 0.0177 0.4797 0.4797
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0118 0.3001 0.4402
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.014 0.3674 0.3674
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0129 0.3336 0.4892
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0122 0.3115 0.4568
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0029 0.0314 0.0461
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0129 0.3349 0.4911
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0122 0.3115 0.4568
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0123 0.3165 0.4641
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0032 0.0399 0.0399
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.015 0.3981 0.5839
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0141 0.3702 0.5429
Loa Loa (eye worm) PCI domain-containing protein 0.0029 0.0314 0.0461
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0097 0.2377 0.3486
Entamoeba histolytica proteasome regulatory subunit, putative 0.0036 0.0498 0.0731
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0304
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0033 0.0435 0.0639
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0244 0.6819 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.014 0.3674 0.5387
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0036 0.0498 0.0731
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0123 0.3165 0.4641
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0019 0.0000046814 0.0000068654
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0134 0.3484 0.5109
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0021 0.0051 0.0051
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0038 0.058 0.058
Plasmodium falciparum proteasome subunit beta type-1, putative 0.015 0.3981 0.5839
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0033 0.0435 0.0639
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0028 0.0273 0.0273
Loa Loa (eye worm) RPN-3 protein 0.0038 0.058 0.085
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0021 0.0053 0.0077
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0118 0.3001 0.4402
Echinococcus multilocularis proteasome subunit beta type 6 0.0129 0.3349 0.3349
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0032 0.0395 0.058
Brugia malayi 26S proteasome regulatory subunit rpn11 0.003 0.0319 0.0319
Leishmania major proteasome alpha 7 subunit, putative 0.0177 0.4797 0.7035
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0036 0.0498 0.0731
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0028 0.0273 0.0401
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0129 0.3321 0.3321
Onchocerca volvulus 0.002 0.0017 0.005
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0033 0.0435 0.0639
Echinococcus granulosus proteasome subunit beta t family 0.0123 0.3165 0.3164
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0033 0.0435 0.0639
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0129 0.3321 0.4871
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0021 0.0053 0.0077
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0314 0.0461
Schistosoma mansoni hypothetical protein 0.0029 0.0314 0.0314
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0021 0.0053 0.0077
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0177 0.4797 0.4797
Loa Loa (eye worm) proteasome regulatory particle 0.0036 0.0498 0.0731
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0029 0.0289 0.0423
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0141 0.3702 0.5429
Brugia malayi PCI domain containing protein 0.0032 0.0399 0.0399
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0092 0.222 0.3256
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0122 0.3115 0.4568
Echinococcus granulosus proteasome prosome macropain subunit beta 0.015 0.3981 0.3981
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0029 0.0314 0.0461
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0032 0.0399 0.0585
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0129 0.3336 0.3336
Echinococcus multilocularis proteasome subunit alpha type 6 0.0141 0.3702 0.3702
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.003 0.0319 0.0468
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0032 0.0399 0.0585
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0033 0.0435 0.0435
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.002 0.0017 0.0025
Giardia lamblia Proteasome subunit beta type 2 0.0123 0.3165 0.4641
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0129 0.3336 0.4892
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.002 0.0017 0.0025
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0028 0.0273 0.0401
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0032 0.0395 0.0395
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0123 0.3165 0.3164
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0032 0.0399 0.0585
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0177 0.4797 0.7035
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.003 0.0319 0.0319
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.003 0.0319 0.0468
Schistosoma mansoni hypothetical protein 0.021 0.5786 0.5786
Toxoplasma gondii proteasome subunit 0.0129 0.3349 0.4911
Brugia malayi proteasome subunit beta type 3 0.0123 0.3165 0.3164
Toxoplasma gondii proteasome subunit alpha type, putative 0.008 0.184 0.2699
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0036 0.0498 0.0731
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.002 0.0017 0.0025
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.003 0.0319 0.0468
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0032 0.0395 0.058
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0131 0.3384 0.4963
Trypanosoma brucei proteasome alpha 7 subunit 0.0131 0.3384 0.4963
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0134 0.3484 0.5109
Plasmodium falciparum proteasome subunit beta type-5 0.0244 0.6819 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.222 0.3256
Giardia lamblia Proteasome subunit beta type 3 0.0123 0.3165 0.4641
Brugia malayi Proteasome A-type and B-type family protein 0.0244 0.6819 0.6819
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.003 0.0319 0.0468
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0028 0.0273 0.0401
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0021 0.0053 0.0077
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0038 0.058 0.058
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0021 0.0053 0.0053
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0036 0.0498 0.0731
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0124 0.3191 0.3191
Mycobacterium ulcerans proteasome PrcB 0.0244 0.6819 1
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.003 0.0319 0.0319
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0118 0.3001 0.4402
Toxoplasma gondii peptidase, T1 family protein 0.0131 0.3384 0.4963
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0129 0.3349 0.4911
Plasmodium vivax proteasome subunit beta type-3, putative 0.0123 0.3165 0.4641
Brugia malayi proteasome subunit beta type 2 0.0123 0.3165 0.3164
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0141 0.3702 0.5429
Onchocerca volvulus Notchless protein homolog 0.0131 0.3384 1
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.003 0.0319 0.0468
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.002 0.0017 0.0017
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0032 0.0399 0.0399
Brugia malayi 20S proteasome alpha5 subunit 0.014 0.3674 0.3674
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0244 0.6819 0.6819
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.021 0.5786 0.5786
Brugia malayi proteasome subunit alpha type 6 0.0141 0.3702 0.3702
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0244 0.6819 1
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0032 0.0399 0.0585
Echinococcus multilocularis adhesion regulating molecule 1 0.0092 0.222 0.222
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0122 0.3115 0.4568
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0118 0.3001 0.4402
Loa Loa (eye worm) proteasome subunit beta type 1 0.015 0.3981 0.5839
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0036 0.0498 0.0731
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.002 0.0017 0.0017
Giardia lamblia 20S proteasome alpha subunit 7 0.0131 0.3384 0.4963
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0129 0.3321 0.4871
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0129 0.3321 0.4871
Schistosoma mansoni hypothetical protein 0.0085 0.2013 0.2013
Loa Loa (eye worm) PCI domain-containing protein 0.0032 0.0399 0.0585
Toxoplasma gondii proteasome subunit beta type 1, putative 0.015 0.3981 0.5839
Leishmania major proteasome beta 2 subunit, putative 0.0118 0.3001 0.4402
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0038 0.058 0.085
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0118 0.3001 0.4402
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0134 0.3484 0.5109
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0033 0.0435 0.0639
Toxoplasma gondii PCI domain-containing protein 0.0036 0.0498 0.0731
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0021 0.0051 0.0074
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0141 0.3702 0.5429
Echinococcus granulosus Proteasome subunit alpha type 7 0.0177 0.4797 0.4797
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0314 0.0461
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0123 0.3165 0.4641
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0032 0.0395 0.0395
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0122 0.3115 0.4568
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0123 0.3165 0.4641
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0025
Echinococcus granulosus proteasome subunit alpha type 6 0.0141 0.3702 0.3702
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0129 0.3321 0.3321
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0032 0.0395 0.0395
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0033 0.0435 0.0639
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0029 0.0314 0.0461
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0021 0.0053 0.0077
Leishmania major proteasome alpha 7 subunit, putative 0.0131 0.3384 0.4963
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0123 0.3165 0.3164
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0021 0.0052 0.0076
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0244 0.6819 1
Leishmania major proteasome beta 7 subunit, putative 0.0122 0.3115 0.4568
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0177 0.4797 0.4797
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0059 0.1198 0.354
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0029 0.0314 0.0314
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.014 0.3674 0.5387
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.002 0.0017 0.0025
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.003 0.0319 0.0468
Echinococcus granulosus proteasome subunit beta type 7 0.0349 1 1
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0038 0.058 0.058
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0349 1 1
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.002 0.0034 0.005
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.002 0.0017 0.0017
Brugia malayi 26S proteasome subunit P45 family protein 0.002 0.0017 0.0017
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0032 0.0399 0.0585
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0036 0.0498 0.0498
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0177 0.4797 0.7035
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.002 0.0017 0.0025
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0134 0.3484 0.5109
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.002 0.0017 0.0025
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0032 0.0399 0.0585
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.002 0.0017 0.0025
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0032 0.0395 0.0395
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0118 0.3001 0.4402
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0038 0.058 0.058
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0177 0.4797 0.7035
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.002 0.0017 0.0025
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0123 0.3165 0.3164
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0131 0.3384 0.3384
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0141 0.3702 0.5429
Trypanosoma brucei proteasome beta 6 subunit 0.015 0.3981 0.5839
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0123 0.3165 0.4641
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0134 0.3484 0.5109
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0032 0.0395 0.058
Brugia malayi proteasome subunit alpha type 2 0.0134 0.3484 0.3484
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0053 0.0077
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.003 0.0319 0.0319
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0028 0.0273 0.0401
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0038 0.058 0.085
Brugia malayi 26S protease regulatory subunit 6A 0.0021 0.0053 0.0053
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0017 0.0025
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.014 0.3674 0.5387
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0129 0.3349 0.4911
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.015 0.3981 0.3981
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0141 0.3702 0.5429
Loa Loa (eye worm) proteasome Regulatory Particle 0.0032 0.0395 0.058
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0134 0.3484 0.3484
Giardia lamblia 26S protease regulatory subunit 6A 0.0021 0.0053 0.0077
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0129 0.3349 0.4911
Toxoplasma gondii proteasome subunit alpha type, putative 0.0129 0.3336 0.4892
Entamoeba histolytica proteasome regulatory subunit, putative 0.0021 0.0051 0.0074

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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