Detailed information for compound 1568729

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.384 | Formula: C20H20N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC=C(c1ccc(c(c1)NC(=O)C)OC)c1cc(OC)cc(c1)OC
  • InChi: 1S/C20H20N2O4/c1-13(23)22-19-11-14(5-6-20(19)26-4)18(7-8-21)15-9-16(24-2)12-17(10-15)25-3/h5-7,9-12H,1-4H3,(H,22,23)
  • InChiKey: YPKFRAHOUNLTKO-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Fli-1 protein 0.0223 0.0509 0.2021
Toxoplasma gondii aurora kinase 0.0173 0.0386 0.0716
Echinococcus multilocularis tumor protein p63 0.0329 0.0775 0.0775
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0273 0.1085
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0283
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.1075 0.2634 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0005 0.0022
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0007 0.0027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0005 0.0019
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0021 0.0007 0.0027
Schistosoma mansoni importin beta-1 0.0028 0.0024 0.0093
Giardia lamblia Hypothetical protein 0.0021 0.0007 0.0026
Echinococcus granulosus cpg binding protein 0.006 0.0104 0.0407
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0021 0.0007 0.0036
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.0198 0.0787
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0009
Toxoplasma gondii NEK kinase 0.0021 0.0007 0.0013
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0005 0.002
Brugia malayi Voltage gated chloride channel family protein 0.0021 0.0007 0.0027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.0606 0.2406
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0049 0.0076 0.03
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0429
Brugia malayi Fibronectin type III domain containing protein 0.0021 0.0007 0.0027
Schistosoma mansoni chloride channel protein 0.0021 0.0007 0.0026
Brugia malayi CLC chloride channel protein 0.0021 0.0007 0.0027
Entamoeba histolytica protein kinase, putative 0.0173 0.0386 0.1901
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0042 0.0151
Giardia lamblia Kinase, CAMK CAMKL 0.0049 0.0076 0.0364
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0021 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0134 0.0287 0.1139
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0021 0.0007 0.0013
Loa Loa (eye worm) fli-1 protein 0.0223 0.0509 0.2021
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0082 0.0406
Echinococcus multilocularis histone deacetylase 6 0.1029 0.2519 0.2519
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0021 0.0007 0.0024
Brugia malayi hypothetical protein 0.0021 0.0007 0.0027
Echinococcus granulosus lachesin 0.0023 0.0012 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0256 0.0997
Toxoplasma gondii histone deacetylase HDAC3 0.0832 0.203 0.3765
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0165
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0104 0.0514
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0021 0.0007 0.0027
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.0442 0.1753
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Plasmodium vivax histone deacetylase 2, putative 0.1029 0.2519 0.4674
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0028 0.0111
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0037 0.0145
Mycobacterium ulcerans chorismate synthase 0.218 0.539 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0382 0.1882
Brugia malayi DKFZp564C0469 protein 0.0019 0.0002 0.0009
Loa Loa (eye worm) histone deacetylase 0.1029 0.2519 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0044 0.017
Schistosoma mansoni nuclear hormone receptor 0.002 0.0005 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0112 0.0232 0.0922
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0021 0.0007 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0273 0.1066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0076 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0165
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0019 0.0002 0.0001
Echinococcus multilocularis geminin 0.0165 0.0365 0.0365
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0382 0.1882
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0052 0.0082 0.0082
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.163 0.6353
Loa Loa (eye worm) loechrig isoform VII 0.0236 0.0541 0.2149
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0002 0.0009
Echinococcus multilocularis neuroglian 0.0034 0.0038 0.0038
Brugia malayi Ets-domain containing protein 0.0073 0.0137 0.0543
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0021 0.0007 0.0009
Trypanosoma brucei protein kinase, putative 0.0052 0.0082 0.0327
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0182 0.0408 0.0753
Schistosoma mansoni histone deacetylase hda2 0.1047 0.2565 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0021 0.0007 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Schistosoma mansoni hypothetical protein 0.03 0.0701 0.2734
Schistosoma mansoni neuroglian 0.0023 0.0012 0.0045
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0019 0.0002 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0071 0.0262
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0086 0.017 0.0673
Plasmodium falciparum replication factor C subunit 1, putative 0.0019 0.0002 0.0004
Onchocerca volvulus 0.0021 0.0007 0.0056
Leishmania major CBS domain protein, conserved 0.0021 0.0007 0.0027
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.0232 0.0232
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0132 0.0513
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0017 0.0075
Toxoplasma gondii histone deacetylase HDAC5 0.0423 0.101 0.1873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0005 0.002
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0079 0.0146
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0021 0.0007 0.0017
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0007 0.0027
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0021 0.0007 0.0013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0002 0.001
Echinococcus multilocularis peroxidasin 0.0023 0.0012 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0005 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0005 0.0019
Toxoplasma gondii CBS domain-containing protein 0.0021 0.0007 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0132 0.0513
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0044 0.0215
Echinococcus granulosus hemicentin 1 0.0023 0.0012 0.0045
Echinococcus granulosus 5' AMP activated protein kinase subunit beta 1 0.0061 0.0107 0.0417
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0021 0.0007 0.0008
Plasmodium falciparum histone deacetylase 1 0.0832 0.203 0.3765
Brugia malayi hypothetical protein 0.0019 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0195 0.0441 0.175
Entamoeba histolytica serine/threonine protein kinase, putative 0.0049 0.0076 0.0373
Onchocerca volvulus Alicorn homolog 0.01 0.0203 0.1676
Schistosoma mansoni ran 0.0021 0.0005 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0005 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0005 0.0022
Echinococcus granulosus dual specificity 0.009 0.0178 0.0694
Plasmodium falciparum protein MAM3, putative 0.0021 0.0007 0.0013
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0137 0.0533
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0017 0.0068
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0023 0.0012 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0071 0.0283
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0071 0.0283
Echinococcus granulosus H:Cl exchange transporter 3 0.0021 0.0007 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0082 0.0406
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0021 0.0007 0.0018
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0017 0.0032
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0042 0.0077
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.0449 0.1751
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0021 0.0007 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0071 0.0129
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0606 0.2987
Entamoeba histolytica protein kinase domain containing protein 0.009 0.0178 0.0877
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Brugia malayi histone deacetylase 11 0.0423 0.101 0.4008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.0442 0.2176
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Echinococcus granulosus expressed conserved protein 0.0184 0.0412 0.1606
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0173 0.0386 0.1504
Plasmodium falciparum serine/threonine protein kinase, putative 0.0173 0.0386 0.0716
Brugia malayi topoisomerase 0.0019 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0009
Brugia malayi hypothetical protein 0.0448 0.1071 0.4252
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0002 0.0011
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0021 0.0007 0.0026
Schistosoma mansoni nephrin 0.0023 0.0012 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0005 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0021 0.0007 0.0036
Trichomonas vaginalis histone deacetylase, putative 0.0832 0.203 1
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0021 0.0007 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0061 0.0113
Echinococcus granulosus histone deacetylase 6 0.1047 0.2565 1
Schistosoma mansoni ets-related 0.0223 0.0509 0.1985
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0023 0.0012 0.0012
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0163 0.0636
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0382 0.1882
Echinococcus multilocularis hemicentin 1 0.0023 0.0012 0.0012
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0021 0.0007 0.0028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0071 0.0129
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0021 0.0007 0.0026
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0024 0.0044
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0005 0.0019
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.0178 0.0707
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0173 0.0386 0.0716
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0273 0.1066
Loa Loa (eye worm) hypothetical protein 0.0297 0.0694 0.2755
Brugia malayi Peroxidasin 0.0023 0.0012 0.0046
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0037 0.0145
Schistosoma mansoni gabp alpha 0.0073 0.0137 0.0533
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0236 0.0541 0.211
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0005 0.0041
Echinococcus multilocularis histone deacetylase 0.1029 0.2519 0.2519
Trypanosoma brucei aurora B kinase 0.0173 0.0386 0.1531
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0023 0.0012 0.0045
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0002 0.0011
Schistosoma mansoni tyrosine kinase 0.0027 0.002 0.0078
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0061 0.0237
Schistosoma mansoni hypothetical protein 0.0081 0.0156 0.0607
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.0178 0.0707
Brugia malayi RNA binding protein 0.0128 0.0273 0.1085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0071 0.0352
Schistosoma mansoni histone deacetylase 1 2 3 0.0423 0.101 0.3936
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.0198 0.0773
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0021 0.0007 0.0018
Echinococcus multilocularis histone deacetylase 7 0.1029 0.2519 0.2519
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.0022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0803 0.1957 0.3628
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0256
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0243 0.0559 0.222
Echinococcus multilocularis snurportin 1 0.03 0.0701 0.0701
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.0198 0.0787
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0021 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0283
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0021 0.0007 0.012
Brugia malayi Histone deacetylase 1 0.0832 0.203 0.8056
Echinococcus multilocularis histone deacetylase 8 0.0423 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0108 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0386 0.1901
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0116 0.0243 0.0917
Echinococcus multilocularis Immunoglobulin 0.0021 0.0007 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0104 0.0514
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0104 0.0414
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0079 0.0146
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0002 0.0008
Echinococcus multilocularis cpg binding protein 0.006 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.009 0.0178 0.0877
Schistosoma mansoni hypothetical protein 0.0062 0.0108 0.0421
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0061 0.0224
Schistosoma mansoni protein kinase subunit beta 0.0114 0.0239 0.0932
Trypanosoma brucei histone deacetylase 2 0.0423 0.101 0.4008
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Giardia lamblia Replication factor C, subunit 1 0.0019 0.0002 0.0002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0044 0.017
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0046 0.007 0.0129
Schistosoma mansoni protein kinase 0.0173 0.0386 0.1504
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0044 0.017
Trypanosoma brucei histone deacetylase, putative 0.1029 0.2519 1
Echinococcus multilocularis muscleblind protein 1 0.0297 0.0694 0.0694
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.0651 0.0651
Giardia lamblia Kinase, NEK 0.0021 0.0007 0.0025
Leishmania major importin beta-1 subunit, putative 0.0023 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Echinococcus granulosus snurportin 1 0.03 0.0701 0.2734
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0005 0.002
Trypanosoma cruzi histone deacetylase 1, putative 0.0832 0.203 0.8056
Toxoplasma gondii NEK kinase 0.0021 0.0007 0.0013
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0214 0.0488 0.0488
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.0232 0.0905
Chlamydia trachomatis CBS domain-containing protein 0.0021 0.0007 0.0008
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0017 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0104 0.0414
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0021 0.0007 0.0028
Trypanosoma cruzi aurora B kinase, putative 0.0173 0.0386 0.1531
Brugia malayi ecdysteroid receptor 0.002 0.0005 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0071 0.0283
Onchocerca volvulus 0.0047 0.0071 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0005 0.002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0053
Entamoeba histolytica hypothetical protein 0.0071 0.0132 0.0649
Echinococcus granulosus histone deacetylase 7 0.1029 0.2519 0.982
Schistosoma mansoni hypothetical protein 0.0071 0.0132 0.0513
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0173 0.0386 0.1901
Schistosoma mansoni amine oxidase 0.0043 0.0061 0.0237
Onchocerca volvulus 0.0489 0.1172 0.9675
Brugia malayi CXXC zinc finger family protein 0.0057 0.0096 0.0382
Toxoplasma gondii NEK kinase 0.0021 0.0007 0.0013
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0242
Loa Loa (eye worm) chloride channel 3 0.0021 0.0007 0.0027
Trichomonas vaginalis ran, putative 0.0021 0.0005 0.0027
Chlamydia trachomatis chorismate synthase 0.218 0.539 1
Echinococcus granulosus roundabout 2 0.0044 0.0064 0.0251
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.001 0.001
Giardia lamblia 5-AMP-activated protein kinase, beta-1 subunit 0.0114 0.0239 0.117
Chlamydia trachomatis Mg++ transporter 0.0021 0.0007 0.0008
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0023 0.0012 0.0096
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0021 0.0007 0.0029
Loa Loa (eye worm) IMP dehydrogenase 1 0.0021 0.0007 0.0027
Schistosoma mansoni vesicular amine transporter 0.0021 0.0007 0.0026
Trypanosoma brucei unspecified product 0.0054 0.0088 0.0348
Toxoplasma gondii histone deacetylase HDAC4 0.0423 0.101 0.1873
Trypanosoma brucei GMP reductase 0.0021 0.0007 0.0027
Leishmania major protein kinase, putative 0.0173 0.0386 0.1531
Toxoplasma gondii IMP dehydrogenas 0.0021 0.0007 0.0013
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.0178 0.0707
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0042 0.0077
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0005 0.0041
Echinococcus granulosus histone deacetylase 3 0.0832 0.203 0.7911
Loa Loa (eye worm) hypothetical protein 0.0103 0.021 0.0835
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0021 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Leishmania major hypothetical protein, conserved 0.0021 0.0007 0.0027
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0037 0.0148
Loa Loa (eye worm) 5'-AMP-activated protein kinase 0.0114 0.0239 0.0949
Trichomonas vaginalis histone deacetylase, putative 0.0832 0.203 1
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0037 0.0148
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0021 0.0007 0.0026
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0243 0.0559 0.0559
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0063 0.011 0.0438
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0037 0.0133
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.1075 0.2634 1
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0382 0.3152
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0021 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0165 0.0365 0.1422
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0082 0.0406
Leishmania major chloride channel protein, putative 0.0021 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0007 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0005 0.0019
Brugia malayi intracellular kinase 0.0052 0.0082 0.0327
Loa Loa (eye worm) hypothetical protein 0.0086 0.017 0.0673
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0005 0.0005
Loa Loa (eye worm) histone deacetylase 7A 0.1029 0.2519 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0054 0.0214
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0021 0.0007 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0007 0.0034
Trypanosoma cruzi histone deacetylase, putative 0.0423 0.101 0.4008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Echinococcus granulosus contactin 0.0023 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0047 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0524 0.126 0.5003
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0123 0.0486
Echinococcus multilocularis roundabout 2 0.0044 0.0064 0.0064
Trypanosoma cruzi histone deacetylase, putative 0.1029 0.2519 1
Echinococcus granulosus defective proboscis extension response 0.0021 0.0007 0.0026
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0061 0.0113
Leishmania major hypothetical protein, conserved 0.005 0.0079 0.0313
Trypanosoma cruzi GMP reductase 0.0021 0.0007 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0104 0.0414
Mycobacterium tuberculosis Conserved protein 0.0021 0.0007 0.0018
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0005 0.0041
Schistosoma mansoni protein kinase subunit beta 0.0061 0.0107 0.0417
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0021 0.0007 0.0027
Toxoplasma gondii exonuclease III APE 0.0019 0.0002 0.0004
Echinococcus granulosus AMPK beta subunit 0.0114 0.0239 0.0932
Plasmodium vivax chorismate synthase 0.218 0.539 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0002 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0002 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0448 0.1071 0.4252
Echinococcus granulosus dna polymerase kappa 0.006 0.0104 0.0407
Entamoeba histolytica protein kinase , putative 0.0173 0.0386 0.1901
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0242
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0079 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0298 0.0697 0.264
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0021 0.0007 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0005 0.002
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0061 0.0237
Echinococcus granulosus tyrosine protein kinase otk 0.0023 0.0012 0.0045
Brugia malayi CBS domain containing protein 0.0021 0.0007 0.0027
Echinococcus multilocularis GPCR, family 2 0.0062 0.0108 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0037 0.0133
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0037 0.0148
Loa Loa (eye worm) histone deacetylase 1 0.0832 0.203 0.8056
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0008
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0002 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0021 0.0007 0.0029
Giardia lamblia Kinase, CAMK CAMKL 0.0049 0.0076 0.0364
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0071 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Toxoplasma gondii CBS domain-containing protein 0.0021 0.0007 0.0013
Brugia malayi ancient conserved domain protein 2 0.0021 0.0007 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0011
Echinococcus granulosus protein kinase shaggy 0.0052 0.0082 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0071 0.0283
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0021 0.0007 0.0007
Schistosoma mansoni DNA polymerase eta 0.0033 0.0037 0.0145
Brugia malayi hypothetical protein 0.005 0.0079 0.0313
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0052 0.0082 0.0153
Echinococcus granulosus neuroglian 0.0023 0.0012 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0007 0.0034
Trypanosoma cruzi histone deacetylase, putative 0.1029 0.2519 1
Plasmodium falciparum NIMA related kinase 4 0.0021 0.0007 0.0013
Echinococcus multilocularis nibrin 0.0019 0.0002 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.0173 0.0386 0.1901
Schistosoma mansoni septate junction protein 0.0023 0.0012 0.0045
Brugia malayi polk-prov protein 0.0037 0.0047 0.0186
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0049 0.0076 0.03
Schistosoma mansoni septate junction protein 0.0023 0.0012 0.0045
Trypanosoma brucei histone deacetylase 4 0.1029 0.2519 1
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0049 0.0076 0.0076
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0037 0.0148
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0021 0.0007 0.0027
Schistosoma mansoni nephrin 0.0034 0.0038 0.0147
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0061 0.0113
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0024 0.0095
Brugia malayi ancient conserved domain protein 4 0.0021 0.0007 0.0027
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0021 0.0007 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0007 0.0017
Schistosoma mansoni protein kinase subunit gamma 0.0236 0.0541 0.211
Schistosoma mansoni cell adhesion molecule 0.0023 0.0012 0.0045
Leishmania major GTP-binding protein, putative 0.0021 0.0005 0.0022
Brugia malayi Flap endonuclease-1 0.0025 0.0017 0.0068
Loa Loa (eye worm) AUR protein kinase 0.0173 0.0386 0.1531
Brugia malayi RNA, U transporter 1 0.008 0.0153 0.0607
Trypanosoma brucei histone deacetylase 1 0.0832 0.203 0.8056
Brugia malayi nuclear receptor NHR-88 0.002 0.0005 0.002
Trypanosoma cruzi 5'-AMP-activated protein kinase subunit beta, putative 0.0114 0.0239 0.0949
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0186
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0005 0.002
Schistosoma mansoni hypothetical protein 0.0165 0.0365 0.1422
Loa Loa (eye worm) hypothetical protein 0.0251 0.058 0.23
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0123 0.0478
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0112 0.0232 0.1136
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0082 0.0397
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0061 0.0109
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0236 0.0541 0.0541
Leishmania major protein kinase, putative 0.0021 0.0007 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Leishmania major histone deacetylase, putative 0.0832 0.203 0.8056
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0007 0.0029
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0071 0.0262
Onchocerca volvulus 0.0043 0.0061 0.0503
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0021 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0165
Treponema pallidum DNA ligase (lig) 0.0019 0.0002 0.0003
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0071 0.0352
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0243 0.0966
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0386 0.1901
Trypanosoma brucei unspecified product 0.0023 0.0011 0.0045
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0116 0.0243 0.0915
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0273 0.1085
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0049 0.0076 0.03
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0243 0.0559 0.222
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0114 0.0239 0.0949
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.0178 0.0707
Loa Loa (eye worm) histone deacetylase 3 0.0832 0.203 0.8056
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0005 0.002
Giardia lamblia Hypothetical protein 0.0021 0.0007 0.0024
Entamoeba histolytica protein kinase, putative 0.009 0.0178 0.0877
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0609 0.1473 0.2731
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0803 0.1957 0.7425
Trypanosoma brucei histone deacetylase 3 0.1029 0.2519 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0052 0.0082 0.0321
Onchocerca volvulus Tyrosine kinase homolog 0.0504 0.1212 1
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0049 0.0076 0.03
Schistosoma mansoni 3-dehydroquinate synthase 0.0116 0.0243 0.0948
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0074 0.0289
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Plasmodium falciparum histone deacetylase 2 0.1029 0.2519 0.4674
Schistosoma mansoni thyroid hormone receptor 0.002 0.0005 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0178 0.0694
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0021 0.0007 0.0026
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0082 0.0327
Schistosoma mansoni histone deacetylase 0.0832 0.203 0.7911
Echinococcus granulosus roundabout 2 0.0023 0.0012 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0037 0.0134
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0071 0.0352
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.0232 0.0431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0021 0.0007 0.0029
Brugia malayi SWIRM domain containing protein 0.0043 0.0061 0.0242
Schistosoma mansoni cpg binding protein 0.006 0.0104 0.0407
Echinococcus multilocularis roundabout 2 0.0023 0.0012 0.0012
Toxoplasma gondii histone kinase SNF1, putative 0.0049 0.0076 0.014
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0021 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0071 0.0283
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0116 0.0243 0.0448
Giardia lamblia Fructose-bisphosphate aldolase 0.0438 0.1046 0.5151
Leishmania major chloride channel protein, putative 0.0021 0.0007 0.0027
Trypanosoma cruzi GMP reductase 0.0021 0.0007 0.0027
Mycobacterium ulcerans transcriptional regulator 0.0021 0.0007 0.0009
Trichomonas vaginalis STE family protein kinase 0.0021 0.0007 0.0034
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0021 0.0007 0.0013
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0082 0.0397
Schistosoma mansoni roundabout 0.0023 0.0012 0.0045
Chlamydia trachomatis dehyroquinate synthase 0.0116 0.0243 0.0447
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0002 0.0009
Echinococcus multilocularis muscleblind protein 0.0297 0.0694 0.0694
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0108 0.0429
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0061 0.0237
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0061 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0174
Echinococcus multilocularis aurora kinase A 0.0173 0.0386 0.0386
Toxoplasma gondii histone deacetylase HDAC1 0.1029 0.2519 0.4674
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0042 0.0073
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0803 0.1957 0.7426
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0021 0.0007 0.0018
Entamoeba histolytica protein kinase, putative 0.0173 0.0386 0.1901
Brugia malayi MH2 domain containing protein 0.0116 0.0243 0.0966
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Loa Loa (eye worm) hypothetical protein 0.0135 0.029 0.1151
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0044 0.0174
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0054 0.0214
Onchocerca volvulus 0.0048 0.0074 0.0611
Brugia malayi histone deacetylase 1 (HD1) 0.0832 0.203 0.8056
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0114 0.0239 0.0949
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0243 0.0559 0.218
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0044 0.0215
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0021 0.0007 0.0029
Loa Loa (eye worm) carboxylesterase 0.0068 0.0123 0.0486
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0017 0.0068
Echinococcus granulosus acetylcholinesterase 0.0068 0.0123 0.0478
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0002 0.0008
Mycobacterium ulcerans glutaminase 0.0277 0.0644 0.1192
Mycobacterium ulcerans hypothetical protein 0.0047 0.0071 0.0129
Trypanosoma cruzi histone deacetylase, putative 0.1029 0.2519 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0021 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.0068 0.0123 0.0486
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0079 0.0313
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0223 0.0415
Brugia malayi Histone deacetylase family protein 0.1029 0.2519 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0165
Loa Loa (eye worm) AUR protein kinase 0.0173 0.0386 0.1531
Brugia malayi Carboxylesterase family protein 0.0068 0.0123 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0005 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0044 0.0215
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0049 0.0076 0.03
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0007 0.0027
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0061 0.0113
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0021 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Schistosoma mansoni cpg binding protein 0.0057 0.0096 0.0375
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0061 0.0113
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0002 0.001
Trichomonas vaginalis histone deacetylase, putative 0.0832 0.203 1
Brugia malayi Histone deacetylase family protein 0.1029 0.2519 1
Plasmodium vivax replication factor C subunit 1, putative 0.0019 0.0002 0.0004
Brugia malayi Muscleblind-like protein 0.0297 0.0694 0.2755
Loa Loa (eye worm) hypothetical protein 0.0067 0.0122 0.0483
Onchocerca volvulus 0.002 0.0005 0.0041
Schistosoma mansoni histone deacetylase 4 5 0.1029 0.2519 0.982
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0021 0.0007 0.0028
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0832 0.203 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0071 0.0129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0037 0.0133
Schistosoma mansoni histone deacetylase 0.0832 0.203 0.7911
Trichomonas vaginalis glutaminase, putative 0.0277 0.0644 0.3175
Schistosoma mansoni hypothetical protein 0.0081 0.0156 0.0607
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0104 0.0414
Treponema pallidum fructose-bisphosphate aldolase 0.0438 0.1046 1
Brugia malayi Prion-like- 0.0023 0.0012 0.0046
Plasmodium falciparum flap endonuclease 1 0.0025 0.0017 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0071 0.0283
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0273 0.0273
Plasmodium falciparum glycogen synthase kinase 3 0.0052 0.0082 0.0153
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0832 0.203 1
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0021 0.0007 0.0007
Echinococcus multilocularis tyrosine protein kinase otk 0.0023 0.0012 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0005 0.0019
Echinococcus multilocularis Immunoglobulin 0.0021 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0062 0.0108 0.0421
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0566 0.1366 0.5182
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.0651 0.2538
Loa Loa (eye worm) RNA binding protein 0.0128 0.0273 0.1085
Loa Loa (eye worm) histone deacetylase 11 0.0423 0.101 0.4008
Echinococcus granulosus GPCR family 2 0.0062 0.0108 0.0421
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0044 0.0215
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.001
Trypanosoma cruzi histone deacetylase, putative 0.0423 0.101 0.4008
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0023 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.0068 0.0123 0.0486
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0021 0.0007 0.0007
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0002 0.0004
Giardia lamblia DINP protein human, muc B family 0.004 0.0054 0.0256
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0005 0.0019
Plasmodium vivax importin-beta 2, putative 0.0028 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0832 0.203 0.8056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Schistosoma mansoni patched 1 0.0084 0.0163 0.0636
Echinococcus granulosus microtubule associated protein 2 0.0672 0.163 0.6353
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0095
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0023 0.0012 0.0012
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0173 0.0386 0.0386
Schistosoma mansoni cell adhesion molecule 0.0023 0.0012 0.0045
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0116 0.0243 0.0949
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0044 0.017
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0061 0.0109
Echinococcus multilocularis histone deacetylase 6 0.1029 0.2519 0.2519
Echinococcus granulosus serine:threonine kinase SAD 1 0.0049 0.0076 0.0295
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0318 0.0748 0.2968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0005 0.002
Schistosoma mansoni cpg binding protein 0.006 0.0104 0.0407
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0005 0.0005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0054 0.0197
Loa Loa (eye worm) glutaminase 0.0277 0.0644 0.2558
Echinococcus granulosus tumor protein p63 0.0329 0.0775 0.3019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0061 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0005 0.002
Leishmania major DNA polymerase eta, putative 0.0033 0.0037 0.0148
Plasmodium falciparum histone deacetylase, putative 0.1029 0.2519 0.4674
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0021 0.0007 0.0017
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0021 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0009
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0027 0.002 0.008
Echinococcus granulosus H:Cl exchange transporter 7 0.0021 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0382 0.1882
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0021 0.0007 0.0036
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0298 0.0697 0.1294
Toxoplasma gondii histone deacetylase HDAC2 0.0832 0.203 0.3765
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0021 0.0007 0.0009
Echinococcus multilocularis protein patched 0.0084 0.0163 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0382 0.1882
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0044 0.017
Echinococcus multilocularis dnaJ subfamily B 0.0813 0.198 0.198
Entamoeba histolytica hypothetical protein 0.0023 0.0011 0.0053
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0061 0.0237
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0023 0.0012 0.0012
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0044 0.0174
Brugia malayi hypothetical protein 0.0045 0.0067 0.0267
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0273 0.1066
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0076 0.0295
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.0442 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0002 0.001
Echinococcus granulosus histone deacetylase 0.1029 0.2519 0.982
Echinococcus multilocularis histone deacetylase 6 0.1047 0.2565 0.2565
Echinococcus multilocularis dna polymerase eta 0.0033 0.0037 0.0037
Brugia malayi serine/threonine protein kinase 6 0.0173 0.0386 0.1531
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0137 0.0137
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0005 0.001
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0061 0.0223
Echinococcus granulosus flap endonuclease 1 0.0025 0.0017 0.0067
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0002 0.0009
Echinococcus granulosus dnaJ subfamily B 0.0813 0.198 0.7719
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0044 0.0174
Schistosoma mansoni hypothetical protein 0.0062 0.0108 0.0421
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0005 0.0019
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.163 0.163
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0123 0.0123
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0005 0.0019
Plasmodium vivax histone deacetylase, putative 0.1029 0.2519 0.4674
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0009
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0082 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0559 0.218
Plasmodium vivax histone deacetylase 1, putative 0.0832 0.203 0.3765
Treponema pallidum Mg2+ transport protein (mgtE) 0.0021 0.0007 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.0178 0.0707
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0104 0.0414
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Echinococcus granulosus aurora kinase A 0.0173 0.0386 0.1504
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0021 0.0007 0.0017
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0052 0.0082 0.0327
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0024 0.0095
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0236 0.0541 0.266
Brugia malayi chloride channel protein 7 0.0021 0.0007 0.0027
Brugia malayi glutaminase DH11.1 0.0277 0.0644 0.2558
Leishmania major inosine-5-monophosphate dehydrogenase 0.0021 0.0007 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0104 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0076 0.0295
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0024 0.0024
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0021 0.0007 0.0026
Brugia malayi hypothetical protein 0.0019 0.0002 0.0009
Brugia malayi putative serine/threonine kinase SADA gamma 0.0049 0.0076 0.03
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0005 0.0019
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0023 0.0012 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.002
Echinococcus multilocularis Protein lozenge 0.0056 0.0094 0.0094
Leishmania major histone deacetylase, putative 0.0832 0.203 0.8056
Loa Loa (eye worm) hypothetical protein 0.0423 0.101 0.4008
Leishmania major serine/threonine-protein kinase, putative 0.0021 0.0007 0.0028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0005 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0005 0.0019
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.0606 0.2406
Echinococcus multilocularis hemicentin 1 0.0023 0.0012 0.0012
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0049 0.0076 0.014
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0005 0.0005
Trichomonas vaginalis histone deacetylase, putative 0.0832 0.203 1
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0076 0.0295
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0071 0.0129
Toxoplasma gondii chorismate synthase, putative 0.218 0.539 1
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0123 0.0478
Schistosoma mansoni histone deacetylase 4 5 0.1029 0.2519 0.982
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0021 0.0007 0.012
Plasmodium falciparum importin beta, putative 0.0028 0.0024 0.0044
Schistosoma mansoni hypothetical protein 0.0134 0.0287 0.1118
Schistosoma mansoni chloride channel protein 0.0021 0.0007 0.0026
Trypanosoma cruzi SNF1-related protein kinase regulatory subunit beta, putative 0.0114 0.0239 0.0949
Brugia malayi nuclear hormone receptor 0.002 0.0005 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0007 0.0027
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0021 0.0007 0.0007
Trypanosoma brucei 5'-AMP-activated protein kinase subunit beta 0.0114 0.0239 0.0949
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0002 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0108 0.0429
Brugia malayi Protein kinase domain containing protein 0.009 0.0178 0.0707
Plasmodium vivax glycogen synthase kinase 3, putative 0.0052 0.0082 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0606 0.2987
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0273 0.1085
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0062 0.0108 0.0421
Schistosoma mansoni cell adhesion molecule 0.0032 0.0033 0.0131
Schistosoma mansoni glutaminase 0.0277 0.0644 0.2512
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0011 0.0053
Loa Loa (eye worm) hypothetical protein 0.0196 0.0442 0.1753
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0163 0.0163
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.0232 0.0905
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0028 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0076 0.0295
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0032 0.0033 0.0131
Echinococcus granulosus importin subunit beta 1 0.0028 0.0024 0.0093
Entamoeba histolytica hypothetical protein 0.0071 0.0132 0.0649
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0021 0.0007 0.0027
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0011 0.0053
Schistosoma mansoni ap endonuclease 0.0019 0.0002 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0007 0.0034
Echinococcus granulosus histone deacetylase 6 0.1029 0.2519 0.982
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0007 0.0007
Onchocerca volvulus 0.0448 0.1071 0.884
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0021 0.0007 0.0018
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0021 0.0007 0.0018
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0011 0.0042
Brugia malayi Carboxylesterase family protein 0.0068 0.0123 0.0486
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0079 0.0313
Leishmania major hypothetical protein, conserved 0.0114 0.0239 0.0949
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0071 0.0264
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0079 0.0313
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0021 0.0007 0.0028
Entamoeba histolytica hypothetical protein 0.0071 0.0132 0.0649
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0037 0.0037
Echinococcus granulosus geminin 0.0165 0.0365 0.1422
Loa Loa (eye worm) AUR protein kinase 0.0173 0.0386 0.1531
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0606 0.2987
Schistosoma mansoni topbp1 0.0019 0.0002 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0037 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0382 0.1882
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0021 0.0007 0.0026
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0037 0.0145
Loa Loa (eye worm) hypothetical protein 0.0605 0.1463 0.5809
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0273 0.1066
Mycobacterium ulcerans cystathionine beta-synthase 0.0021 0.0007 0.0009
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.0701 0.2784
Leishmania major UDP-galactopyranose mutase 0.0043 0.0061 0.0242
Schistosoma mansoni hypothetical protein 0.0813 0.198 0.7719
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Schistosoma mansoni lozenge 0.0056 0.0094 0.0367
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0005 0.002
Brugia malayi Ets-domain containing protein 0.0073 0.0137 0.0543
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0021 0.0007 0.0028
Brugia malayi histone deacetylase 3 (HD3) 0.0832 0.203 0.8056
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0005 0.0022
Echinococcus multilocularis 5' AMP activated protein kinase subunit beta 1 0.0061 0.0107 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0005 0.0005
Giardia lamblia Histone deacetylase 0.0832 0.203 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.0017
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0017 0.0032
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0005 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0047 0.0186
Brugia malayi Calcitonin receptor-like protein seb-1 0.0195 0.0441 0.175
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.0088 0.0348
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0049 0.0076 0.03
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0005 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.0386 0.1504
Mycobacterium tuberculosis Conserved protein 0.0021 0.0007 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0071 0.0129
Brugia malayi hypothetical protein 0.0032 0.0035 0.0137
Entamoeba histolytica protein kinase, putative 0.009 0.0178 0.0877
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0606 0.2987
Echinococcus granulosus peroxidasin 0.0023 0.0012 0.0045
Leishmania major histone deacetylase, putative 0.1029 0.2519 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0273 0.1066
Plasmodium falciparum serine/threonine protein kinase KIN 0.0049 0.0076 0.014
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0021 0.0007 0.0029
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0021 0.0007 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0382 0.1882
Schistosoma mansoni amine oxidase 0.0043 0.0061 0.0237
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0112 0.0232 0.0905
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0405 0.1995
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0002 0.0008
Brugia malayi serine/threonine kinase 12 0.0173 0.0386 0.1531
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0082 0.0406
Echinococcus granulosus histone deacetylase 1 0.0832 0.203 0.7911
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.0198 0.0198
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0182 0.0408 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0021 0.0007 0.0027
Echinococcus granulosus Immunoglobulin 0.0021 0.0007 0.0026
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0021 0.0007 0.0028
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0173 0.0386 0.1901
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0104 0.019
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0195 0.0441 0.175
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0071 0.0264
Echinococcus granulosus neuroglian 0.0034 0.0038 0.0147
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0021 0.0007 0.0028
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0009
Brugia malayi steroid hormone receptor 0.002 0.0005 0.002
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0182 0.0408 0.3887
Entamoeba histolytica Ran family GTPase 0.0021 0.0005 0.0027
Brugia malayi hypothetical protein 0.0071 0.0132 0.0523
Trypanosoma brucei SNF1-related protein kinases, putative 0.0049 0.0076 0.03
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0243 0.0966
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0061 0.0113
Echinococcus granulosus dna polymerase eta 0.0033 0.0037 0.0145
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0005 0.0005
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0609 0.1473 0.2731
Brugia malayi Immunoglobulin I-set domain containing protein 0.0021 0.0007 0.0027
Loa Loa (eye worm) runx1 0.0056 0.0094 0.0373
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0023 0.0012 0.0046
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0182 0.0408 0.0753
Echinococcus multilocularis lachesin 0.0023 0.0012 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0002 0.0004
Schistosoma mansoni ran 0.0021 0.0005 0.0021
Onchocerca volvulus 0.0057 0.0096 0.0794
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0298 0.0697 0.129
Echinococcus multilocularis AMPK beta subunit 0.0114 0.0239 0.0239
Schistosoma mansoni cell adhesion molecule 0.0023 0.0012 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0002 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0037 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0044 0.0044
Schistosoma mansoni chloride channel protein 0.0021 0.0007 0.0026
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0137 0.0543
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0037 0.0148
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0061 0.0061
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0132 0.0132
Schistosoma mansoni topbp1 0.0019 0.0002 0.0009
Loa Loa (eye worm) glutaminase 2 0.0277 0.0644 0.2558
Schistosoma mansoni coup transcription factor 0.002 0.0005 0.0019
Toxoplasma gondii 5'-AMP-activated protein kinase subunit beta-1 family protein, putative 0.0067 0.0122 0.0227
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0023 0.0012 0.0046
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0021 0.0007 0.0013
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0002 0.0011
Echinococcus granulosus acetylcholinesterase 0.0068 0.0123 0.0478
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0002 0.0002
Brugia malayi serine/threonine-protein kinase 6 0.0173 0.0386 0.1531
Plasmodium falciparum NIMA related kinase 2 0.0021 0.0007 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0386 0.1901
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0021 0.0007 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0386 0.1901
Echinococcus granulosus histone deacetylase 8 0.0423 0.101 0.3936
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.0022
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0116 0.0243 0.0917
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0005 0.0019
Brugia malayi hypothetical protein 0.0043 0.0061 0.0242
Echinococcus granulosus nibrin 0.0019 0.0002 0.0009
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0021 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Mycobacterium tuberculosis Conserved protein 0.0021 0.0007 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0108 0.0421
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0005 0.002
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0005 0.002
Entamoeba histolytica serine/threonine protein kinase, putative 0.0021 0.0007 0.0034
Echinococcus multilocularis 0.0043 0.0061 0.0061
Echinococcus granulosus tar DNA binding protein 0.0128 0.0273 0.1066
Treponema pallidum hemolysin (tlyC) 0.0021 0.0007 0.0046
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0052 0.0082 0.0321
Trypanosoma cruzi NIMA-related kinase, putative 0.0021 0.0007 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0165
Trichomonas vaginalis histone deacetylase, putative 0.0832 0.203 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0079 0.0313
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0021 0.0007 0.0028
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0061 0.0113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0005 0.0019
Leishmania major DNA polymerase kappa, putative 0.004 0.0054 0.0214
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0163 0.0648
Echinococcus multilocularis dual specificity 0.009 0.0178 0.0178
Schistosoma mansoni flap endonuclease-1 0.0023 0.0011 0.0043
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0017 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0005 0.002
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0021 0.0007 0.0013
Toxoplasma gondii CBS family protein 0.0021 0.0007 0.0013
Echinococcus multilocularis neuroglian 0.0023 0.0012 0.0012
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0052 0.0082 0.0327
Echinococcus granulosus muscleblind protein 0.0297 0.0694 0.2705
Loa Loa (eye worm) chloride channel protein 7 0.0021 0.0007 0.0027
Trypanosoma brucei unspecified product 0.0023 0.0011 0.0045
Echinococcus multilocularis dna polymerase kappa 0.006 0.0104 0.0104
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0044 0.0044
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0021 0.0007 0.0026
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0044 0.0174
Entamoeba histolytica hypothetical protein 0.0071 0.0132 0.0649
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0071 0.0283
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0021 0.0007 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0079 0.0146
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0044 0.0064 0.0256
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0021 0.0007 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0002 0.0008
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0002 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0007 0.0029
Echinococcus multilocularis expressed conserved protein 0.0184 0.0412 0.0412
Echinococcus multilocularis protein kinase shaggy 0.0052 0.0082 0.0082
Brugia malayi loechrig isoform VII 0.0236 0.0541 0.2149
Loa Loa (eye worm) hypothetical protein 0.0048 0.0074 0.0294
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0017 0.0084
Brugia malayi Importin beta-1 subunit 0.0028 0.0024 0.0095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Echinococcus granulosus roundabout 2 0.0023 0.0012 0.0045
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0021 0.0007 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.0287 0.1139
Loa Loa (eye worm) hypothetical protein 0.0624 0.151 0.5992
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0148
Giardia lamblia Aurora kinase 0.0173 0.0386 0.1893
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0021 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Schistosoma mansoni hypothetical protein 0.0081 0.0156 0.0607
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0021 0.0007 0.012
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0021 0.0007 0.0026
Leishmania major guanosine monophosphate reductase 0.0021 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.0084 0.0163 0.0648
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0042 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0405 0.1995
Loa Loa (eye worm) hypothetical protein 0.0045 0.0067 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0002 0.0009
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0173 0.0386 0.1901
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0002 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0005 0.002
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0021 0.0007 0.0028
Brugia malayi TAR-binding protein 0.0128 0.0273 0.1085
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0123 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0524 0.126 0.5003
Entamoeba histolytica histone deacetylase, putative 0.0832 0.203 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0061 0.0224
Trichomonas vaginalis histone deacetylase, putative 0.0832 0.203 1
Entamoeba histolytica hypothetical protein 0.0019 0.0002 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0108 0.0108
Echinococcus granulosus histone deacetylase 6 0.1029 0.2519 0.982
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0005 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0005 0.0005
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0061 0.0109
Echinococcus granulosus twitchin 0.0037 0.0046 0.018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0071 0.0129
Schistosoma mansoni thyroid hormone receptor 0.002 0.0005 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0021 0.0007 0.0036
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0002 0.0011
Entamoeba histolytica protein kinase, putative 0.0052 0.0082 0.0406
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0076 0.0373
Onchocerca volvulus 0.0019 0.0002 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0005 0.002
Trypanosoma cruzi histone deacetylase 1, putative 0.0832 0.203 0.8056
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0104 0.0414
Echinococcus multilocularis histone deacetylase 3 0.0832 0.203 0.203
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0017 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0061 0.0113
Mycobacterium ulcerans dehydrogenase 0.0043 0.0061 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0005 0.0005
Onchocerca volvulus 0.0052 0.0082 0.068
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0002 0.0009
Plasmodium vivax histone deacetylase, putative 0.0423 0.101 0.1873
Echinococcus multilocularis roundabout 2 0.0023 0.0012 0.0012
Echinococcus multilocularis histone deacetylase 1 0.0832 0.203 0.203
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.001 0.0039
Brugia malayi CHE-14 protein 0.0084 0.0163 0.0648
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.0442 0.1722
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0606 0.2987
Schistosoma mansoni hypothetical protein 0.0081 0.0156 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0011
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0021 0.0007 0.0026
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0061 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0028 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0163 0.0804
Echinococcus granulosus FTZ F1 alpha 0.002 0.0005 0.0019
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0242
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0096 0.0382
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0021 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0045 0.0067 0.0267
Echinococcus granulosus H:Cl exchange transporter 4 0.0021 0.0007 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0104 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0005 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0108 0.0421
Onchocerca volvulus Histone deacetylase 10 homolog 0.0423 0.101 0.8333
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0023 0.0012 0.0012
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0163 0.0636
Leishmania major histone deacetylase, putative 0.1029 0.2519 1
Echinococcus multilocularis protein dispatched 1 0.0096 0.0193 0.0193
Trypanosoma brucei NIMA-related protein kinase 0.0021 0.0007 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0606 0.2987
Loa Loa (eye worm) hypothetical protein 0.0297 0.0694 0.2755
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0021 0.0007 0.0029
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0832 0.203 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0195 0.0441 0.175
Mycobacterium ulcerans oxidoreductase 0.0043 0.0061 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0007 0.0034
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0044 0.0206
Plasmodium falciparum chorismate synthase 0.218 0.539 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0438 0.1046 0.5155
Schistosoma mansoni hypothetical protein 0.0022 0.001 0.0039
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0298 0.0697 0.129
Loa Loa (eye worm) hypothetical protein 0.0448 0.1071 0.4252
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0021 0.0007 0.0027
Schistosoma mansoni DNA ligase IV 0.0019 0.0002 0.0009
Schistosoma mansoni titin 0.0023 0.0012 0.0045
Schistosoma mansoni histone deacetylase hda2 0.0423 0.101 0.3936
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0023 0.0012 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0005 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0012 0.0046
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0061 0.0061
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0044 0.0174

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.066 uM Inhibition of LPS-induced TNFalpha production in human PBMC preincubated 1 hr prior to LPS stimulation measured after 18 to 20 hrs by ELISA ChEMBL. 21955454
IC50 (functional) = 0.092 uM Cytotoxicity against human HCT116 cells assessed as reduction of [3H]thymidine incorporation after 72 hrs by scintillation counting ChEMBL. 21955454
IC50 (binding) > 10 uM Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins ChEMBL. 21955454

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21955454

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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