Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7737 | 0.5 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7737 | 0.5 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.7737 | 0.7737 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7737 | 0.5 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.7737 | 0.7737 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.7737 | 0.7737 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7737 | 0.5 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.7737 | 0.7737 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | 0.0003 | 0 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.7737 | 0.7737 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.054 nM | Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting | ChEMBL. | 21944973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.