Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0044 | 0.2617 | 0.9294 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0044 | 0.2617 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2815 | 0.4218 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0044 | 0.2617 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.9294 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2815 | 0.2815 |
Brugia malayi | isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.2617 |
Brugia malayi | MH2 domain containing protein | 0.0106 | 0.6975 | 0.6975 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.2815 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.9294 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.9294 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0102 | 0.6675 | 0.6675 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0149 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.2617 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.2815 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.392 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.2815 | 0.2815 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0044 | 0.2617 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0044 | 0.2617 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.2815 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2815 | 0.4218 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0149 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2815 | 0.4218 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0044 | 0.2617 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0106 | 0.6975 | 0.6975 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.2815 | 0.2815 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0106 | 0.6975 | 0.6975 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.2617 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.2815 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.2815 | 0.4218 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.9294 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0044 | 0.2617 | 0.9294 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0044 | 0.2617 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.6675 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.2815 | 0.2815 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.2815 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0044 | 0.2617 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0044 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6675 | 0.6675 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.2815 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 100.19 % | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 100 uM after 24 hrs by MTT assay | ChEMBL. | 22264489 |
IC50 (functional) | > 100 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method | ChEMBL. | 22264489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.