TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.566 | Formula: C28H32N2O
H donors: 1 H acceptors: 1 LogP: 5.92 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1c1ccccc1)NCC1CCCN(C1)CCCc1ccccc1
InChi: 1S/C28H32N2O/c31-28(27-18-8-7-17-26(27)25-15-5-2-6-16-25)29-21-24-14-10-20-30(22-24)19-9-13-23-11-3-1-4-12-23/h1-8,11-12,15-18,24H,9-10,13-14,19-22H2,(H,29,31)
InChiKey: MMMOKQFLXYDLPR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, nicotinic, alpha 4 (neuronal)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Get druggable targets OG5_128160	All targets in OG5_128160
Onchocerca volvulus	Putative nachr subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0015	0.0422	0.0422
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0422	0.0864
Schistosoma mansoni	dishevelled	0.001	0.0146	0.048
Schistosoma mansoni	hypothetical protein	0.0017	0.051	0.1671
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0101	0.4879	0.4879
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0015	0.0422	0.0422
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.051	0.051
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0515	0.0515
Echinococcus granulosus	GPCR family 2	0.0017	0.051	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0015	0.0422	0.0422
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0146	0.03
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.051	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4879	0.4879
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0422	0.0422
Brugia malayi	Cation transporter family protein	0.0015	0.0422	0.0422
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0146	0.03
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0101	0.4879	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0146	0.048
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0008	0.0059	0.0059
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0146	0.0146
Schistosoma mansoni	hypothetical protein	0.0017	0.051	0.1671
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Onchocerca volvulus		0.0008	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0146	0.03
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.1524	0.1524
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.3053	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0422	0.0864
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0422	0.0864
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0515	0.1056
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0015	0.0422	0.0864
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0008	0.0059	0.0059
Brugia malayi	Cation transporter family protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.3053	0.3053
Echinococcus multilocularis	GPCR, family 2	0.0017	0.051	0.1046
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0515	0.1056
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0015	0.0422	0.0422
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0015	0.0422	0.1381
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0015	0.0422	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0422	0.0864
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0422	0.0864
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.2398	0.2398
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0015	0.0422	0.0422
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0146	0.03
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.0515	0.5
Onchocerca volvulus		0.0015	0.0422	0.0422
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.3053	0.6257
Onchocerca volvulus		0.0008	0.0059	0.0059
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0146	0.03
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0515	0.1056
Onchocerca volvulus		0.0015	0.0422	0.0422
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0515	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Schistosoma mansoni	nAChR subunit	0.0015	0.0422	0.1381
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0422	0.0422
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.051	0.1046
Schistosoma mansoni	nAChR subunit	0.0015	0.0422	0.1381
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0422	0.0422
Entamoeba histolytica	hypothetical protein	0.0008	0.0059	1
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0146	0.048
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.051	0.1046
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0015	0.0422	0.1381
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0515	0.1056
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0422	0.0864
Trichomonas vaginalis	ras GTP exchange factor, son of sevenless, putative	0.0007	0	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0101	0.4879	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0422	0.0422
Schistosoma mansoni	dishevelled	0.001	0.0146	0.048
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1524	0.1524
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0422	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.001	0.0146	0.0146
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.2398	0.2398
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0515	0.5
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0422	0.0422
Schistosoma mansoni	nAChR subunit	0.0015	0.0422	0.1381
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0515	0.1056
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0101	0.4879	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.2398	0.2398
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0515	0.5
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0422	0.0864
Onchocerca volvulus		0.0015	0.0422	0.0422
Loa Loa (eye worm)	RNA binding protein	0.0066	0.3053	0.3053
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0422	0.1381
Loa Loa (eye worm)	hypothetical protein	0.001	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.0515	0.5
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0015	0.0422	0.0864
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.3053	0.3053
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.051	0.1046
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0146	0.0146
Schistosoma mansoni	nAChR subunit	0.0015	0.0422	0.1381
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0515	0.1687
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0422	0.0864
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.051	0.051
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0008	0.0059	0.0194
Schistosoma mansoni	nAChR subunit	0.0015	0.0422	0.1381
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0146	0.048
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0101	0.4879	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Brugia malayi	RNA binding protein	0.0066	0.3053	0.3053
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0515	1
Brugia malayi	DIX domain containing protein	0.001	0.0146	0.0146
Brugia malayi	TAR-binding protein	0.0066	0.3053	0.3053
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0146	0.03
Loa Loa (eye worm)	LGC-31 protein	0.0015	0.0422	0.0422
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0422	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0422	0.0422
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0422	0.0864
Schistosoma mansoni	dep domain containing protein	0.001	0.0146	0.048
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0017	0.051	0.1671
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0515	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0422	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Brugia malayi	hypothetical protein	0.001	0.0146	0.0146
Schistosoma mansoni	hypothetical protein	0.0036	0.1524	0.4993
Echinococcus multilocularis	nAChR subunit	0.0015	0.0422	0.0864
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0146	0.03
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0146	0.0146
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0008	0.0059	0.0194
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0101	0.4879	1
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0146	0.03
Brugia malayi	Cation transporter family protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0146	0.0146
Trichomonas vaginalis	guanine nucleotide exchange factor, putative	0.0007	0	0.5
Echinococcus granulosus	tar DNA binding protein	0.0066	0.3053	0.6257
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0515	0.0515
Schistosoma mansoni	nAChR subunit	0.0015	0.0422	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0422	0.0864
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.3053	1
Onchocerca volvulus	Putative nachr subunit	0.0101	0.4879	0.4879
Schistosoma mansoni	hypothetical protein	0.0017	0.051	0.1671
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0515	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0146	0.03
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0015	0.0422	0.0422
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0422	0.0864
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0008	0.0059	0.0059
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0515	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0015	0.0422	0.1381
Echinococcus granulosus	nAChR subunit	0.0015	0.0422	0.0864
Echinococcus multilocularis	nAChR subunit	0.0008	0.0059	0.0122
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0007	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.3053	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Onchocerca volvulus		0.0015	0.0422	0.0422
Brugia malayi	excitatory GABA receptor EXP-1A	0.0015	0.0422	0.0422
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0146	0.03
Loa Loa (eye worm)	hypothetical protein	0.0199	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0422	0.0422
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0422	0.0422
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0422	0.0422
Schistosoma mansoni	neurotransmitter gated ion channel	0.0008	0.0059	0.0194
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0101	0.4879	0.4879
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0422	0.0422
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.051	0.051
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0199	1	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0515	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0422	0.0864
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0008	0.0059	0.0059
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0015	0.0422	0.0422
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.3053	0.3053
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0146	0.0146
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0422	0.0422
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0015	0.0422	0.0422
Onchocerca volvulus		0.0015	0.0422	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0422	0.0422
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.3053	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0422	0.0864
Onchocerca volvulus		0.001	0.0146	0.0146
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0422	0.0864
Loa Loa (eye worm)	hypothetical protein	0.001	0.0146	0.0146
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0515	0.0515
Brugia malayi	hypothetical protein	0.001	0.0146	0.0146
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0422	0.0864
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0059	0.0059
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0015	0.0422	0.0422
Echinococcus granulosus	nAChR subunit	0.0008	0.0059	0.0122
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0101	0.4879	1
Schistosoma mansoni	nAChR subunit	0.0015	0.0422	0.1381
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0515	0.1056
Loa Loa (eye worm)	GABA receptor subunit	0.0008	0.0059	0.0059
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.3053	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.2398	0.2398

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1	Antagonist activity at human nAChR alpha3/beta4 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysis	ChEMBL.	22285942
IC50 (functional)	= 4.7	Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysis	ChEMBL.	22285942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1950518

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1569014